Liquid chromatograph-mass spectrometer and control method thereof

By using a liquid chromatography-mass spectrometry (LC-MS) system with magnetic separation pretreatment and low-pressure liquid phase fluid delivery, the high cost and high failure rate of ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) equipment have been solved, enabling efficient detection of trace substances.

CN122282977APending Publication Date: 2026-06-26SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
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Patent Information

Application Number
CN202511991189.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2024-12-25
Filing Date
2025-12-25
Publication Date
2026-06-26

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Abstract

This invention relates to the field of medical devices and discloses a liquid chromatography-mass spectrometry (LC-MS) device and a control method for the LC-MS device. The LC-MS device includes a sample storage device, a pretreatment device, a chromatographic element, a mass spectrometry detection device, and a controller. The chromatographic element includes a reagent preparation channel, a reagent transfer assembly, a liquid flow delivery assembly, and a chromatographic column. The liquid flow delivery assembly is used to drive the reagent in the reagent preparation channel through the chromatographic column to adsorb the reagent onto the column, and to drive the liquid flow through the chromatographic column to elute the adsorbed reagent to form the analyte. The pretreatment device uses magnetic separation to pretreatment the sample. The operating pressure of the liquid flow delivery assembly is less than or equal to 20 MPa. This invention reduces the cost of LC-MS devices.
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