Compound antipruritic ointment as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of external preparations, and provides compound itching-relieving cream as well as a preparation method and application thereof. The compound itching-relieving ointment is prepared from the following components in parts by weight: 3 to 6 parts of rhizoma coptidis, 9 to 15 parts of radix scutellariae, 9 to 15 parts of radix et rhizoma rhei, 3 to 6 parts of herba schizonepetae, 3 to 6 parts of herba menthae, 1 to 3 parts of cortex moutan, 1 to 3 parts of sandalwood and 0.5 to 1 part of borneol. The compound antipruritic ointment has the effects of cooling, relieving itching, detoxifying and diminishing swelling, and is used for treating itching and eczema dermatitis itching caused by biting of various small insects such as mosquitoes and the like. According to the compound antipruritic ointment disclosed by the invention, a plurality of components are in synergistic interaction, so that a multi-target and multi-layer treatment effect is realized. The traditional Chinese medicine composition can be used for cooling, relieving itching, detoxifying and diminishing swelling from the source while quickly relieving itching, and a comprehensive and effective solution is provided for itching.

Description

Technical Field

[0001] This invention belongs to the field of topical preparation technology, and relates to a compound antipruritic ointment, its preparation method and application. Background Technology

[0002] Modern research shows that the tissues that can cause itching include only the skin, mucous membranes, and cornea. It is characterized by paroxysmal itching of the skin, with no fixed location of itching or itching limited to certain parts of the body without primary skin lesions. Some patients may experience secondary damage such as scratch marks, scabs, pigmentation, and lichenification due to repeated scratching, which can even affect the patient's normal life in severe cases.

[0003] Based on neurophysiology, pruritus can be classified as follows: 1) Dermatogenic pruritus, such as urticaria and insect bite dermatitis; 2) Neuropathogenic pruritus, such as postherpetic neuralgia; 3) Neurogenic pruritus, such as cholestatic pruritus; 4) Psychogenic (psychological) pruritus, such as pruritus caused by mental abnormalities such as obsessive-compulsive disorder; 5) Mixed pruritus mediated by two or more mechanisms, such as atopic dermatitis.

[0004] It is generally believed that the causes of itching include both internal and external factors. Internal factors may be related to chronic infections, genetic predisposition to allergies, multi-system diseases, or age-related decline in skin function. External factors are mainly related to food, climate, physical and chemical factors, injuries, and insect bites. To date, the exact pathogenesis of itching remains unclear. Currently, it is generally believed that itching is primarily induced by conductive mediators, their receptors, and conductive pathways.

[0005] Eczema and dermatitis are among the most common skin diseases in clinical practice. The causes of these diseases are relatively complex, and they are related to environmental factors, seasonal changes, dietary habits, and genetic factors. They are characterized by recurrence and chronicity. During flare-ups, patients experience significant itching and are easily tempted to scratch excessively, leading to more severe skin lesions, primarily ulceration and swelling, which significantly impacts their daily life and work. Currently, topical medications are the primary treatment for these diseases.

[0006] Glucocorticoid therapy, as the main treatment for eczema and dermatitis, has many adverse reactions and cannot be used for a long time. Therefore, some scholars believe that traditional Chinese medicine may be an alternative treatment.

[0007] Currently, there are many types of topical products on the market for mosquito bites and itchy skin, which can be mainly divided into the following categories: Chemical drugs: such as ointments or liquids containing ingredients like menthol, camphor, diphenhydramine, and hydrocortisone. For example, patent number CN201910331527.5 (A compound camphor cream and its preparation method) discloses a formula with camphor and menthol as the main antipruritic ingredients.

[0008] Traditional Chinese medicine compound prescriptions: These are mostly made from traditional Chinese medicine formulas that clear heat and detoxify, dispel wind and relieve itching. For example, patent number CN202010364490.9 (A traditional Chinese medicine composition for clearing heat and drying dampness, dispelling wind and relieving itching and its preparation method) discloses a formula with Artemisia capillaris, Taraxacum mongolicum and Sophora flavescens as the main ingredients; patent number CN202211358528.7 (A traditional Chinese medicine composition for treating eczema, preparation method and its formulation) discloses a formula with Eupolyphaga sinensis, Cnidium monnieri, Corydalis yanhusuo and Morus alba as the main ingredients.

[0009] Plant essential oils: Utilizing the natural anti-inflammatory and soothing properties of tea tree oil, lavender oil, etc.

[0010] Existing traditional Chinese medicine ointments for clearing heat and relieving itching mainly rely on a combination of bitter and cold herbs that dry dampness (such as Phellodendron bark and Sophora flavescens) and wind-dispelling herbs (such as Dictamnus dasycarpus root bark). However, these ointments have the following shortcomings: Slow onset of itch relief: Many pure Chinese medicine preparations focus on long-term conditioning, but for acute itching such as mosquito bites that urgently need to be resolved, the immediate itch relief effect is not fast or significant enough.

[0011] Single efficacy: Some products only focus on "relieving itching", while lacking synergistic effects in "clearing heat and detoxifying" and "reducing swelling", resulting in slow reduction of redness and swelling.

[0012] Inadequate formulation: Some formulations contain too many herbs, with unclear principal, assistant, adjuvant, and guide structures, or are too bitter and cold, which may irritate sensitive skin and affect the patient's experience.

[0013] Limited target population: Some effective products may contain hormones or allergenic chemicals, making them unsuitable for infants and young children. Summary of the Invention

[0014] In view of this, the present invention provides a compound antipruritic ointment, its preparation method and application.

[0015] The present invention also provides a method for preparing the above-mentioned compound antipruritic ointment.

[0016] This invention also provides the application of the above-mentioned compound antipruritic ointment in the preparation of drugs for treating eczema, dermatitis and itching.

[0017] The technical solution adopted by the present invention to achieve the above objectives is as follows: In a first aspect, the present invention provides a compound antipruritic ointment, which, by weight, contains the following components: 3-6 parts of Coptis chinensis, 9-15 parts of Scutellaria baicalensis, 9-15 parts of Rheum palmatum, 3-6 parts of Schizonepeta tenuifolia, 3-6 parts of Mentha haplocalyx, 1-3 parts of Paeonia suffruticosa, 1-3 parts of Santalum album, and 0.5-1 part of Borneol.

[0018] As a preferred technical solution of the present invention, the following components are contained in parts by weight: 5 parts Coptis chinensis, 12 parts Scutellaria baicalensis, 12 parts Rheum palmatum, 5 parts Schizonepeta tenuifolia, 5 parts Mentha haplocalyx, 2 parts Paeonia suffruticosa, 2 parts Santalum album, and 0.8 parts Borneol.

[0019] As a preferred technical solution of the present invention, the following components are contained in parts by weight: 5 parts Coptis chinensis, 9 parts Scutellaria baicalensis, 15 parts Rheum palmatum, 6 parts Schizonepeta tenuifolia, 6 parts Mentha haplocalyx, 1 part Paeonia suffruticosa, 3 parts Santalum album, and 0.5 parts Borneol.

[0020] As a preferred technical solution of the present invention, the following components are contained in parts by weight: 6 parts Coptis chinensis, 15 parts Scutellaria baicalensis, 9 parts Rheum palmatum, 5 parts Schizonepeta tenuifolia, 5 parts Mentha haplocalyx, 2 parts Paeonia suffruticosa, 1 part Santalum album, and 0.8 parts Borneol.

[0021] A second aspect of the present invention provides a method for preparing the above-mentioned compound antipruritic ointment, comprising the following steps: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, and Paeonia suffruticosa, add water and decoct 2-3 times, each time adding 8-10 times the amount of water and decoct for 1-2 hours. Add Schizonepeta tenuifolia, Santalum album, and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Grind the borneol into a powder of 80-120 mesh. Step 3) Concentrate the filtrate from Step 1) into a thick paste and add it to the cream base. After adding the paste, add the borneol powder obtained in Step 2) while stirring. Mix well to obtain the compound antipruritic cream.

[0022] As a preferred embodiment of the present invention, the cream base is one or more of petrolatum, glycerin, lanolin, stearic acid, and beeswax.

[0023] As a preferred technical solution of the present invention, the preparation method of the compound antipruritic ointment includes the following steps: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, and Paeonia suffruticosa, add water and decoct twice, each time adding 8 times the amount of water as medicine and decoct for 1 hour. Add Schizonepeta tenuifolia, Santalum album, and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Grind the borneol into an 80-mesh powder; Step 3) Concentrate the filtrate from Step 1) into a thick paste, add it to the cream base, and then add the borneol powder obtained in Step 2) while stirring. Stir until the mixture is homogeneous to obtain the compound antipruritic cream.

[0024] As a preferred technical solution of the present invention, the preparation method of the compound antipruritic ointment is as follows: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, and Paeonia suffruticosa, add water and decoct 3 times, each time adding 10 times the amount of water and decoct for 2 hours. Add Schizonepeta tenuifolia, Santalum album, and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Grind the borneol into a 120-mesh powder; Step 3) Concentrate the filtrate from Step 1) into a thick paste, add it to the cream base, and then add the borneol powder obtained in Step 2) while stirring. Stir until the mixture is homogeneous to obtain the compound antipruritic cream.

[0025] As a preferred technical solution of the present invention, the preparation method of the compound antipruritic ointment is as follows: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, and Paeonia suffruticosa, add water and decoct 3 times, each time adding 8 times the amount of water and decoct for 1 hour. Add Schizonepeta tenuifolia, Santalum album, and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Grind the borneol into a 100-mesh powder; Step 3) Concentrate the filtrate from Step 1) into a thick paste, add it to the cream base, and then add the borneol powder obtained in Step 2) while stirring. Stir until the mixture is homogeneous to obtain the compound antipruritic cream.

[0026] As a preferred technical solution of the present invention, the preparation method of the compound antipruritic ointment is as follows: Step 1) Mix and grind Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, Paeonia suffruticosa, Santalum album, Schizonepeta tenuifolia, and Mentha haplocalyx into a 120-mesh powder; Step 2) Grind the borneol separately into a 120-mesh powder; Step 3) Add 7 parts petroleum jelly to the 3 parts mixed powder in Step 1). After adding the petroleum jelly, add the camphor powder obtained in Step 2) while stirring. Stir until the mixture is evenly mixed to obtain the compound antipruritic ointment.

[0027] As a preferred technical solution of the present invention, the preparation method of the compound antipruritic ointment is as follows: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, Paeonia suffruticosa, Santalum album, Schizonepeta tenuifolia, and Mentha haplocalyx. Heat 1 part of the herbs with 5 parts of sesame oil to extract the extract, and filter to obtain the sesame oil extract. Step 2) Grind the borneol separately into a 120-mesh powder; Step 3) Add 1 part beeswax to the 4 parts sesame oil extract in Step 1), melt it, cool it to 40 degrees Celsius, add the borneol powder obtained in Step 2), and stir while adding until it is evenly mixed to obtain the compound antipruritic ointment.

[0028] A third aspect of the invention provides the use of the compound antipruritic ointment in the preparation of a medicament for the prevention or treatment of eczema, dermatitis, and itching.

[0029] The present invention also provides the use of the compound antipruritic ointment in the preparation of a medicine for the prevention or treatment of itching caused by insect bites.

[0030] The compound antipruritic ointment of this invention has the effects of cooling and relieving itching, detoxifying and reducing swelling, and is used for itching caused by bites from mosquitoes and other small insects, as well as eczema and dermatitis.

[0031] Coptis chinensis: bitter in taste, cold in nature, enters the heart, spleen, stomach, liver, gallbladder and large intestine meridians. It clears heat and dries dampness, drains fire and detoxifies. It is used for damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever and delirium, excessive heart fire, restlessness and insomnia, blood heat vomiting and nosebleeds, red eyes, toothache, thirst, carbuncles and boils.

[0032] Scutellaria baicalensis: bitter in taste, cold in nature, enters the lung, gallbladder, spleen, large intestine and small intestine meridians. It clears heat and dries dampness, drains fire and detoxifies, stops bleeding and calms the fetus. It is used for cough and asthma due to lung heat, damp heat in the stomach and intestines, jaundice, high fever and excessive drinking, hematochezia, epistaxis, red and swollen eyes, carbuncles and boils, and threatened abortion.

[0033] Rhubarb: Bitter in taste, cold in nature, enters the spleen, stomach, large intestine, liver, and pericardium meridians. It clears heat and promotes bowel movement, cools blood and detoxifies, removes blood stasis and promotes menstruation. It is used for constipation due to excess heat, abdominal pain due to stagnation, incomplete diarrhea, jaundice due to damp heat, hematemesis due to blood heat, red eyes, sore throat, abdominal pain due to intestinal abscess, carbuncles and boils, amenorrhea due to blood stasis, traumatic injuries, and external treatment for burns from water and fire; upper gastrointestinal bleeding.

[0034] Schizonepeta: It has a neutral taste and warm nature. It enters the lung and liver meridians. It can relieve exterior syndromes, dispel wind, promote rash eruption, and eliminate sores. It is used to treat colds, headaches, measles, rubella, and early-stage sores.

[0035] Peppermint: It has a pungent taste, is warm in nature, and is non-toxic. It enters the lung and liver meridians and dispels wind and heat. It is used for symptoms such as influenza, headache, red eyes, fever, sore throat, and swollen and painful gums.

[0036] Moutan bark: bitter and pungent in taste, slightly cold in nature, enters the heart, liver and kidney meridians, clears heat and cools blood, promotes blood circulation and removes blood stasis; used for heat entering the blood, febrile rashes, hematemesis and epistaxis, night fever and morning coolness, bone steaming without sweating, amenorrhea and dysmenorrhea, traumatic injuries, carbuncles and boils, etc.

[0037] Sandalwood: It has a pungent taste and warm properties. It enters the spleen, stomach, heart, and lung meridians. It promotes qi circulation, warms the middle jiao, and relieves stomach pain. It is used to treat symptoms such as cold stagnation of qi and chest discomfort.

[0038] Borneol: pungent and bitter in taste, slightly cold in nature, enters the heart, spleen and lung meridians, opens the orifices and awakens the mind, clears heat and detoxifies, improves eyesight and removes corneal opacity; used for high fever and delirium due to febrile diseases, stroke with phlegm syncope and epilepsy, summer heat and dampness obscuring the clear orifices, sore throat and deafness, mouth sores and tooth swelling, sores, carbuncles and hemorrhoids, red and swollen eyes, and corneal opacity obscuring the vision.

[0039] This invention is based on the traditional Chinese medicine theory of "clearing heat and dispelling wind, cooling blood and relieving itching." The ointment is applied to itchy, red, and swollen skin through dermal administration. Borneol and menthol, as potent transdermal penetration enhancers and cooling agents, first act on the skin surface, quickly bringing a cooling sensation and numbing peripheral nerves, thus immediately relieving itching. The medicinal components in the ointment (extracts of rhubarb, scutellaria, and coptis, etc.) are absorbed transdermally through hair follicles, sebaceous glands, and sweat glands, entering the subcutaneous tissue. The principal ingredients, rhubarb, scutellaria, and coptis, are bitter and cold in nature, possessing powerful heat-clearing, detoxifying, dampness-drying, and fire-purging effects, directly eliminating the pathogenic "heat toxins" and eliminating redness and inflammation at the root. The assistant ingredient, peony bark, clears heat, cools blood, invigorates blood circulation, and disperses blood stasis, enhancing the heat-clearing power of the principal ingredients. Simultaneously, by invigorating blood circulation, it promotes local blood flow, accelerating the dissipation of inflammatory substances, thereby reducing swelling. The adjuvant herbs are Schizonepeta tenuifolia, Mentha haplocalyx, and Santalum album. Schizonepeta tenuifolia dispels wind and releases the exterior, Mentha haplocalyx dispels wind, clears heat, promotes rash eruption, and relieves itching, while Santalum album promotes qi circulation and relieves pain. Together, these three herbs dispel wind, guide the medicine upwards, and enhance the antipruritic effect. Synergistic effect: The whole formula works together to treat the root cause by "clearing heat and detoxifying" and the symptoms by "reducing swelling and relieving itching," thus treating both the root cause and the symptoms. It provides rapid and lasting relief from itching and redness caused by mosquito bites or eczema dermatitis.

[0040] This product is a compound formula made entirely of traditional Chinese medicine, following the principles of monarch, minister, assistant, and guide, with no chemical additives. Clinical feedback on its efficacy is excellent.

[0041] Technical problem to be solved: To address the issues of limited efficacy and slow onset of action in existing traditional Chinese medicine antipruritic products.

[0042] The specific formula uses rhubarb, scutellaria, and coptis as the "chief herbs," focusing on clearing heat and detoxifying; peony bark as the "assistant herb," ​​assisting in clearing heat and promoting blood circulation to reduce swelling; and schizonepeta, peppermint, and sandalwood as the "adjuvant herbs," dispelling wind and relieving itching, regulating qi and opening the orifices, and guiding the other herbs directly to the affected area. This formula has a clear structure and strong synergistic effect.

[0043] Synergistic application of borneol and peppermint Technical problems solved: Addressing the pain points of patients who experience poor transdermal absorption and unsatisfactory immediate antipruritic effects from pure Chinese medicine preparations.

[0044] Specific formulation: A small amount of highly effective borneol and peppermint are added to the formula. Borneol not only has heat-clearing and analgesic effects, but it is also a recognized "adjuvant" that can significantly enhance the transdermal absorption rate of other drugs. Peppermint provides an immediate cooling sensation and quickly relieves itching. The "post-addition" method is used in the preparation to avoid the loss of active ingredients due to volatilization during high-temperature extraction, thus ensuring efficacy.

[0045] Optimization of medicinal ingredients and dosage Technical problem to be solved: Avoid skin irritation that may be caused by excessively bitter or cold ingredients or too many medicinal flavors in the formula.

[0046] Specific plan: Eight carefully selected medicinal herbs, simple yet potent. The dosage of bitter and cold herbs is controlled to avoid excessive bitterness and coldness; although sandalwood is used in small quantities, its volatile components promote the flow of qi and penetrate the body, helping the medicine to spread and releasing a soothing aroma, thus enhancing the product experience.

[0047] The beneficial effects of the compound antipruritic ointment of this invention are as follows: Rapid relief from itching: The immediate action and strong transdermal absorption of borneol and menthol produce a cooling sensation quickly after application, effectively numbing nerve endings and rapidly relieving itching.

[0048] Significant effects in reducing swelling and detoxifying: The powerful combination of the principal herbs (rhubarb, scutellaria, and coptis) and the assistant herbs (peony bark) can effectively clear heat toxins, inhibit inflammatory reactions, and promote the reduction of redness and swelling.

[0049] The formula is scientific and addresses both the symptoms and the root cause: This treatment not only targets the symptom of itching (treating the symptoms), but also eliminates the root cause by "clearing heat, detoxifying, and cooling the blood" (treating the root cause), making the therapeutic effect more consolidated.

[0050] High safety and wide applicability: As a pure traditional Chinese medicine preparation, it contains no hormones and has few side effects. With clear indications of contraindications and cautions for pregnant women, it provides a relatively safe natural option for infants, young children, and people with allergies.

[0051] Patient experience is positive: the ointment is easy to apply, has a cooling sensation and sandalwood fragrance, and feels comfortable to use.

[0052] This product can also be used for skin redness, swelling, heat and pain caused by various reasons, which belong to the category of excessive heat and toxins in traditional Chinese medicine.

[0053] This invention's compound antipruritic ointment features a synergistic effect of multiple components, achieving multi-target and multi-level therapeutic effects. While rapidly relieving itching, it also addresses the root cause by providing cooling relief, detoxification, and swelling reduction, offering a comprehensive and effective solution for itching. Attached Figure Description

[0054] Figure 1 The average number of scratches by mice in each group was compared. Different lowercase letters above the bars indicate significant differences between different groups (P < 0.05).

[0055] Figure 2 The average scratching time of mice in each group was compared. Different lowercase letters above the bars indicate significant differences between different groups (P < 0.05). Detailed Implementation

[0056] The following non-limiting embodiments are intended to enable those skilled in the art to gain a more comprehensive understanding of the present invention, but do not limit the invention in any way. The following content is merely an exemplary description of the scope of protection claimed by the present invention, and those skilled in the art can make various changes and modifications to the present invention based on the disclosed content, and such changes should also fall within the scope of protection claimed by the present invention.

[0057] When numerical ranges are given in the embodiments, it should be understood that, unless otherwise stated in the invention, both endpoints of each numerical range and any value between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used in this invention have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0058] The present invention will be further described below by way of specific embodiments. Unless otherwise specified, all chemical reagents and components used in the embodiments of the present invention are obtained through conventional commercial channels. Products from different manufacturers do not have a significant impact on the efficacy.

[0059] Example 1: A compound antipruritic ointment Coptis chinensis 5 parts, Scutellaria baicalensis 12 parts, Rheum palmatum 12 parts, Schizonepeta tenuifolia 5 parts, Mentha haplocalyx 5 parts, Paeonia suffruticosa 2 parts, Santalum album 2 parts, Borneol 0.8 parts.

[0060] Preparation method: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, and Paeonia suffruticosa, add water and decoct twice, each time adding 8 times the amount of water as medicine and decoct for 1 hour. Add Schizonepeta tenuifolia, Santalum album, and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Grind the borneol into an 80-mesh powder; Step 3) Concentrate the filtrate from Step 1) into a thick paste, add it to the cream base, and then add the borneol powder obtained in Step 2) while stirring. Mix well to obtain the compound antipruritic cream.

[0061] The base is a thick paste consisting of 3 parts by weight of glycerin and 5 parts by weight of petrolatum.

[0062] Example 2: A compound antipruritic ointment Coptis chinensis 5 parts, Scutellaria baicalensis 9 parts, Rheum palmatum 15 parts, Schizonepeta tenuifolia 6 parts, Mentha haplocalyx 6 parts, Paeonia suffruticosa 1 part, Santalum album 3 parts, Borneol 0.5 parts.

[0063] Preparation method: Step 1) Mix and grind Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, Paeonia suffruticosa, Santalum album, Schizonepeta tenuifolia, and Mentha haplocalyx into a 120-mesh powder; Step 2) Grind the borneol separately into a 120-mesh powder; Step 3) Add 7 parts petroleum jelly to the 3 parts mixed powder in Step 1). After adding the petroleum jelly, add the camphor powder obtained in Step 2) while stirring. Stir until the mixture is evenly mixed to obtain the compound antipruritic ointment.

[0064] Example 3: A compound antipruritic ointment Coptis chinensis 6 parts, Scutellaria baicalensis 15 parts, Rheum palmatum 9 parts, Schizonepeta tenuifolia 5 parts, Mentha haplocalyx 5 parts, Paeonia suffruticosa 2 parts, Santalum album 1 part, Borneol 0.8 parts.

[0065] Preparation method: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, Paeonia suffruticosa, Santalum album, Schizonepeta tenuifolia, and Mentha haplocalyx. Heat 1 part of the herbs with 5 parts of sesame oil to extract the extract, and filter to obtain the sesame oil extract. Step 2) Grind the borneol separately into a 120-mesh powder; Step 3) Add 1 part beeswax to the 4 parts sesame oil extract in Step 1), melt it, cool it to 40 degrees Celsius, add the borneol powder obtained in Step 2), and stir while adding until it is evenly mixed to obtain the compound antipruritic ointment.

[0066] Example 4: A compound antipruritic ointment Coptis chinensis 6 parts, Scutellaria baicalensis 9 parts, Rheum palmatum 12 parts, Schizonepeta tenuifolia 3 parts, Mentha haplocalyx 3 parts, Paeonia suffruticosa 1 part, Santalum album 1 part, Borneol 0.5 parts.

[0067] Preparation method: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, and Paeonia suffruticosa, add water and decoct 3 times, each time adding 10 times the amount of water and decoct for 2 hours. Add Schizonepeta tenuifolia, Santalum album, and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Grind the borneol into a 120-mesh powder; Step 3) Concentrate the filtrate from Step 1) into a thick paste, add it to the cream base, and then add the borneol powder obtained in Step 2) while stirring. Stir until the mixture is homogeneous to obtain the compound antipruritic cream.

[0068] The base is a thick paste consisting of 5 parts by weight of glycerin and 3 parts by weight of petrolatum.

[0069] Example 5: A compound antipruritic ointment Coptis chinensis 3 parts, Scutellaria baicalensis 12 parts, Rheum palmatum 15 parts, Schizonepeta tenuifolia 3 parts, Mentha haplocalyx 3 parts, Paeonia suffruticosa 2 parts, Santalum album 2 parts, Borneol 1 part.

[0070] Preparation method: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, and Paeonia suffruticosa, add water and decoct 3 times, each time adding 10 times the amount of water and decoct for 2 hours. Add Schizonepeta tenuifolia, Santalum album, and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Grind the borneol into a 120-mesh powder; Step 3) Concentrate the filtrate from Step 1) into a thick paste, add it to the cream base, and then add the borneol powder obtained in Step 2) while stirring. Stir until the mixture is homogeneous to obtain the compound antipruritic cream.

[0071] The base is a thick paste consisting of 3 parts by weight of glycerin and 3 parts by weight of petrolatum.

[0072] Example 6: A compound antipruritic ointment Coptis chinensis 5 parts, Scutellaria baicalensis 15 parts, Rheum palmatum 9 parts, Schizonepeta tenuifolia 5 parts, Mentha haplocalyx 5 parts, Paeonia suffruticosa 3 parts, Santalum album 3 parts, Borneol 1 part.

[0073] Preparation method: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, and Paeonia suffruticosa, add water and decoct 3 times, each time adding 10 times the amount of water and decoct for 2 hours. Add Schizonepeta tenuifolia, Santalum album, and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Grind the borneol into a 120-mesh powder; Step 3) Concentrate the filtrate from Step 1) into a thick paste, add it to the cream base, and then add the borneol powder obtained in Step 2) while stirring. Stir until the mixture is homogeneous to obtain the compound antipruritic cream.

[0074] The base is a thick paste consisting of 5 parts by weight of glycerin and 4 parts by weight of petrolatum.

[0075] Comparative Example 1 Coptis chinensis 5 parts, rhubarb 12 parts, schizonepeta tenuifolia 5 parts, mint 5 parts, peony bark 2 parts, sandalwood 2 parts, borneol 0.8 parts.

[0076] Compared with Example 1, the difference is that it does not contain Scutellaria baicalensis, while the other components and their amounts remain the same.

[0077] Everything else is the same as in Example 1.

[0078] Comparative Example 2 Coptis chinensis 5 parts, Scutellaria baicalensis 12 parts, Schizonepeta tenuifolia 5 parts, Mentha haplocalyx 5 parts, Paeonia suffruticosa 2 parts, Santalum album 2 parts, Borneol 0.8 parts.

[0079] Compared with Example 1, the difference is that it does not contain rhubarb, while the other components and their amounts remain the same.

[0080] Everything else is the same as in Example 1.

[0081] Comparative Example 3 Coptis chinensis 5 parts, Scutellaria baicalensis 12 parts, Rheum palmatum 12 parts, Schizonepeta tenuifolia 5 parts, Mentha haplocalyx 5 parts, Borneol 0.8 parts.

[0082] Compared with Example 1, the difference is that it does not contain peony bark or sandalwood, while the other components and their amounts remain the same.

[0083] Everything else is the same as in Example 1.

[0084] Comparative Example 4 Lithospermum erythrorhizon 6 parts, Scutellaria baicalensis 6 parts, Coptis chinensis 5 parts, Phellodendron chinense 10 parts, Schizonepeta tenuifolia 10 parts, Saposhnikovia divaricata 10 parts, Mentha haplocalyx 6 parts, Prunus mume 10 parts, Smilax glabra 15 parts, Dictamnus dasycarpus 1

[0085] Preparation method: Step 1) Mix Lithospermum erythrorhizon, Scutellaria baicalensis, Coptis chinensis, Phellodendron chinense, Saposhnikovia divaricata, Prunus mume, Smilax glabra, and Dictamnus dasycarpus, add water and decoct twice, adding 8 times the amount of water each time and decocting for 1 hour. Add Schizonepeta tenuifolia and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Concentrate the filtrate from Step 1) into a thick paste, add 3 parts by weight of glycerin and 5 parts by weight of petroleum jelly while stirring to obtain an antipruritic ointment.

[0086] Animal experiments 1. Experimental Methods Seventy-two KM mice, weighing 18-22g, were fed a standard diet and had free access to water. After one week of acclimatization, eight mice were randomly selected as the blank control group based on their weight, and the remaining mice were used as the model group.

[0087] Three days before the experiment, a 2cm×3cm hairless area was prepared on the back of the neck of mice. The model group and each drug treatment group applied cotton balls soaked in AE solution (acetone and ether 1:1) to the shaved area on the back of the neck of mice for 15s at 9:00 and 16:00 every day, and then applied pure water to the same area for 30s. The blank group applied pure water to the skin of mice twice a day. All groups were treated continuously for 7 days.

[0088] After modeling, the mice were randomly divided into four groups according to their body weight: model control group, experimental group 1, experimental group 2, experimental group 3, control group 1, control group 2, control group 3, and control group 4, with 8 mice in each group.

[0089] Each treatment group applied the corresponding medication every morning. Experiment 1 applied the antipruritic cream of Example 1, Experiment 2 applied the antipruritic cream of Example 2, Experiment 3 applied the antipruritic cream of Example 3, Control 1 applied the antipruritic cream of Comparative Example 1, Control 2 applied the antipruritic cream of Comparative Example 2, Control 3 applied the antipruritic cream of Comparative Example 3, and Control 4 applied the antipruritic cream of Comparative Example 4.

[0090] Mice in the model control group and the blank control group were smeared with equal amounts of physiological saline once a day for 7 consecutive days.

[0091] 2. Indicator Testing Observation of pruritus behavior Mice were placed in a transparent acrylic box to observe and record their scratching behavior and latency. The observation room was a closed and quiet environment, and mice were moved in one day in advance to allow them to acclimatize. The observation lasted for 30 minutes, and the entire process was recorded using a high-definition digital camera. Each scratching action was recorded as the mouse scratching the injection site with its forepaw or hind paw off the ground until it stopped (continuous scratching was recorded as one instance). The average of 8 mice was taken as the number of scratches.

[0092] 3. Statistical Methods Data processing was performed using GraphPad Prism 7.0 software, with the measurement data presented in... ±s indicates the mean. One-way ANOVA was used for comparisons between groups, and P < 0.05 was considered statistically significant.

[0093] 4. Experimental Results 4.1 Comparison of average scratching frequency and average scratching duration among different groups of mice Table 1 Comparison of average scratching frequency and average scratching duration among different groups of mice. Note: Different lowercase letters in the same column indicate significant differences between different groups (P < 0.05).

[0094] Compared with the blank control group, the average number of scratches and the average scratching duration of mice in the model control group were significantly increased.

[0095] Compared with the model control group, the average number of scratches and average scratching duration were significantly reduced in experimental groups 1, 2, 3, and the control group. Compared with control groups 1-4, the average number of scratches and average scratching duration were significantly reduced in experimental groups 1, 2, and 3. The results are shown in Table 1. Figure 1 , Figure 2 .

[0096] The compound antipruritic ointment of this invention significantly improves the average number of scratches and the average scratching duration in mice with chronic itching, effectively relieving itching.

[0097] Comparative Example 1 does not contain Scutellaria baicalensis, Comparative Example 2 does not contain Rheum palmatum, Comparative Example 3 does not contain Paeonia suffruticosa or Santalum album, and the formulation of Comparative Example 4 is different from that of the present invention. As can be seen from the data of the embodiments of the present invention, the complete formulation of the present invention can achieve the best therapeutic effect. Deleting some components or changing the components will significantly affect the therapeutic effect of the composition. The components of the present invention play a synergistic role.

[0098] Clinical observation of the efficacy of the traditional Chinese medicine composition of the present invention on patients with eczema and dermatitis Sixty patients with eczema and dermatitis were selected and divided into two groups according to their treatment methods: a traditional Chinese medicine treatment group and a Western medicine treatment group. Baseline data such as disease course, age, gender, and underlying diseases were compared between the two groups, and no statistically significant differences were found (P>0.05), allowing for comparative study.

[0099] The Western medicine treatment group received routine Western medicine treatment, including triamcinolone acetonide ointment, twice daily, for 2 weeks.

[0100] The traditional Chinese medicine treatment group was treated with the compound antipruritic ointment of Example 1, twice a day, for 2 weeks.

[0101] Two weeks after treatment, the efficacy of the treatment was observed, with the following specific criteria: Markedly effective: The patient's itching and skin lesions completely disappeared, and the patient's life returned to normal; Effective: The patient's itching and skin lesions improved to some extent, but the symptoms had a slight impact on their life; Ineffective: The patient's itching and skin lesions remained unchanged, seriously affecting their life. The total clinical effective rate was the sum of the markedly effective rate and the effective rate.

[0102] Comparison of clinical efficacy between the two groups: After 2 weeks of treatment, the total effective rate was 93.33% in the traditional Chinese medicine treatment group and 80.00% in the Western medicine treatment group. The total effective rate of the traditional Chinese medicine treatment group was higher than that of the Western medicine treatment group. See Table 2.

[0103] Table 2 Comparison of efficacy between the traditional Chinese medicine treatment group and the Western medicine treatment group. Conclusion: The total effective rate of the traditional Chinese medicine treatment group was 93.33%, while that of the Western medicine treatment group was 80.00%. The total effective rate of the traditional Chinese medicine treatment group was higher than that of the Western medicine treatment group, and the clinical symptoms were significantly relieved. The effect was significantly better than that of similar clinical drugs, providing a better product for the treatment of eczema and dermatitis patients.

[0104] The preferred embodiments of the present invention have been described in detail above, but the present invention is not limited to the embodiments described. Those skilled in the art can make various equivalent modifications or substitutions without departing from the spirit of the present invention, and these equivalent modifications or substitutions are all included within the scope defined by the claims of this application.

Claims

1. A compound antipruritic ointment, characterized in that, The compound antipruritic ointment contains the following components by weight: 3-6 parts Coptis chinensis, 9-15 parts Scutellaria baicalensis, 9-15 parts Rheum palmatum, 3-6 parts Schizonepeta tenuifolia, 3-6 parts Mentha haplocalyx, 1-3 parts Paeonia suffruticosa, 1-3 parts Santalum album, and 0.5-1 part Borneol.

2. The compound antipruritic ointment according to claim 1, characterized in that, The compound antipruritic ointment is made from the following components by weight: 5 parts Coptis chinensis, 12 parts Scutellaria baicalensis, 12 parts Rheum palmatum, 5 parts Schizonepeta tenuifolia, 5 parts Mentha haplocalyx, 2 parts Paeonia suffruticosa, 2 parts Santalum album, and 0.8 parts Borneol.

3. The compound antipruritic ointment according to claim 1, characterized in that, The compound antipruritic ointment is made from the following raw materials, by weight: 5 parts Coptis chinensis, 9 parts Scutellaria baicalensis, 15 parts Rheum palmatum, 6 parts Schizonepeta tenuifolia, 6 parts Mentha haplocalyx, 1 part Paeonia suffruticosa, 3 parts Santalum album, and 0.5 parts Borneol.

4. The compound antipruritic ointment according to claim 1, characterized in that, The compound antipruritic ointment is made from the following raw materials, by weight: 6 parts Coptis chinensis, 15 parts Scutellaria baicalensis, 9 parts Rheum palmatum, 5 parts Schizonepeta tenuifolia, 5 parts Mentha haplocalyx, 2 parts Paeonia suffruticosa, 1 part Santalum album, and 0.8 parts Borneol.

5. The method for preparing the compound antipruritic ointment according to any one of claims 1-4, characterized in that, The preparation method includes the following steps: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, and Paeonia suffruticosa, add water and decoct 2-3 times, each time adding 8-10 times the amount of water and decoct for 1-2 hours. Add Schizonepeta tenuifolia, Santalum album, and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Grind the borneol into a powder of 80-120 mesh; Step 3) Concentrate the filtrate from Step 1) into a thick paste, add it to the cream base, and then add the borneol powder obtained in Step 2) while stirring. Mix well to obtain the compound antipruritic cream.

6. The method for preparing the compound antipruritic ointment according to claim 5, characterized in that, The preparation method includes the following steps: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, and Paeonia suffruticosa, add water and decoct twice, each time adding 8 times the amount of water as medicine and decoct for 1 hour. Add Schizonepeta tenuifolia, Santalum album, and Mentha haplocalyx later and decoct together. Filter and combine the filtrates. Step 2) Grind the borneol into an 80-mesh powder; Step 3) Concentrate the filtrate from Step 1) into a thick paste, add 3 parts by weight of glycerin and 5 parts by weight of petroleum jelly, and then add the borneol powder obtained in Step 2) while stirring. Stir until well mixed to obtain the compound antipruritic ointment.

7. The method for preparing the compound antipruritic ointment according to claim 5, characterized in that, The preparation method includes the following steps: Step 1) Mix and grind Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, Paeonia suffruticosa, Santalum album, Schizonepeta tenuifolia, and Mentha haplocalyx into a 120-mesh powder; Step 2) Grind the borneol separately into a 120-mesh powder; Step 3) Add 7 parts petroleum jelly to the 3 parts mixed powder in Step 1). After adding the petroleum jelly, add the camphor powder obtained in Step 2) while stirring. Stir until the mixture is evenly mixed to obtain the compound antipruritic ointment.

8. The method for preparing the compound antipruritic ointment according to claim 5, characterized in that, The preparation method includes the following steps: Step 1) Mix Coptis chinensis, Scutellaria baicalensis, Rheum palmatum, Paeonia suffruticosa, Santalum album, Schizonepeta tenuifolia, and Mentha haplocalyx. Heat 1 part of the herbs with 5 parts of sesame oil to extract the extract, and filter to obtain the sesame oil extract. Step 2) Grind the borneol separately into a 120-mesh powder; Step 3) Add 1 part beeswax to the 4 parts sesame oil extract in Step 1), melt it, cool it to 40 degrees Celsius, add the borneol powder obtained in Step 2), and stir while adding until it is evenly mixed to obtain the compound antipruritic ointment.

9. The use of the compound antipruritic ointment according to any one of claims 1-4 in the preparation of a drug for the prevention or treatment of eczema, dermatitis, and pruritus.

10. Use of the compound antipruritic ointment according to any one of claims 1-4 in the preparation of a medicine for the prevention or treatment of pruritus caused by insect bites.

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