Preparation process of atorvastatin calcium
A technology of atorvastatin calcium and preparation process, applied in the field of chemical synthesis, can solve the problems of generating impurities and reducing the yield of condensate, and achieve the effects of improving yield, reducing impurities and reducing cost
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0012] In a 2L reaction flask, add 600ml of n-heptane, 200ml of tetrahydrofuran, and 200ml of toluene, add 14.6g of pivalic acid while stirring, raise the temperature to 40°C, then add 60.1g of ATS-9, and react at 40°C for 1 hour. Then add 83.5g M-4, raise the temperature to 85°C, and react for 24 hours. After completion of the reaction, concentrate under reduced pressure until no distillate evaporates, add 500ml of ethyl acetate to dissolve, wash with 100ml of saturated sodium bicarbonate solution and 100ml of saturated saline solution, add 50g of anhydrous sodium sulfate and dry for 2 hours, recover ethyl acetate under reduced pressure , concentrated until no distillate was evaporated. Add 500ml of isopropanol to dissolve, concentrate under reduced pressure until no distillate evaporates; repeat the operation 2 times. Add 550ml of isopropanol to dissolve, add dropwise 400ml of water, drop to 25-30°C, filter with suction, wash the filter cake with 300ml of isopropanol-water ...
Embodiment 2
[0014] In a 2L reaction flask, add 600ml of n-heptane, 200ml of tetrahydrofuran, and 200ml of toluene, add 14.6g of pivalic acid while stirring, raise the temperature to 40°C, then add 60.1g of ATS-9, and react at 55°C for 2 hours. Then add 83.5g M-4, raise the temperature to 90°C, and react for 24 hours. After completion of the reaction, concentrate under reduced pressure until no distillate evaporates, add 500ml of ethyl acetate to dissolve, wash with 100ml of saturated sodium bicarbonate solution and 100ml of saturated saline solution, add 50g of anhydrous sodium sulfate and dry for 2 hours, recover ethyl acetate under reduced pressure , concentrated until no distillate was evaporated. Add 500ml of isopropanol to dissolve, concentrate under reduced pressure until no distillate evaporates; repeat the operation 2 times. Add 550ml of isopropanol to dissolve, add dropwise 400ml of water, drop to 25-30°C, filter with suction, wash the filter cake with 300ml of isopropanol-water...
Embodiment 3
[0016] In a 2L reaction flask, add 600ml of n-heptane, 200ml of tetrahydrofuran, and 200ml of toluene, add 14.6g of pivalic acid while stirring, raise the temperature to 40°C, then add 60.1g of ATS-9, and react at 75°C for 0.5 hours. Then add 83.5g M-4, raise the temperature to 92°C, and react for 20 hours. After completion of the reaction, concentrate under reduced pressure until no distillate evaporates, add 500ml of ethyl acetate to dissolve, wash with 100ml of saturated sodium bicarbonate solution and 100ml of saturated saline solution, add 50g of anhydrous sodium sulfate and dry for 2 hours, recover ethyl acetate under reduced pressure , concentrated until no distillate was evaporated. Add 500ml of isopropanol to dissolve, concentrate under reduced pressure until no distillate evaporates; repeat the operation 2 times. Add 550ml of isopropanol to dissolve, add dropwise 400ml of water, drop to 25-30°C, filter with suction, wash the filter cake with 300ml of isopropanol-wat...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com