29 results about "Isobutyraldehyde" patented technology

The utility model belongs to the technical field of chemical solvent preparation, and particularly relates to a tetrahydrofuran purification device. The utility model provides a tetrahydrofuran purification device. The tetrahydrofuran purification device comprises a feed port, a catalytic hydrogenation reaction part, a gas phase discharge port, a liquid phase discharge port, a heavy component removal tower and an absorption tower. In the application, through the catalytic hydrogenation part, the impurity dihydrofuran in the tetrahydrofuran is hydrogenated to generate the tetrahydrofuran, the impurities n-butyraldehyde and isobutyraldehyde are hydrogenated to generate alcohols which are easily separated from the tetrahydrofuran, through determination, the content of the impurity dihydrofuran in the purified tetrahydrofuran is reduced to 3 ppm or below, the alcohols are separated in the heavy component removal tower, and the content of the tetrahydrofuran in the tetrahydrofuran is reduced to 3 ppm or below. The purity and the quality of tetrahydrofuran are effectively improved, and the purification device structure and the purification process are simple.

This invention belongs to the field of homogeneous catalysis technology, and particularly relates to a method for the hydroformylation of propylene to prepare isobutyraldehyde. The method includes: in the presence of a bidentate P-N ligand and a rhodium metal compound, introducing propylene and syngas to carry out a hydroformylation reaction to prepare isobutyraldehyde. The structural formula of the bidentate P-N ligand is as follows: [Insert structural formula here]. Wherein, R1 is selected from one of C2-C4 alkyl groups, substituted or unsubstituted phenyl groups; R2 is selected from one of hydrogen, C1-C4 alkyl groups, alkoxy groups, substituted or unsubstituted phenyl groups. This method provides a highly active P-N ligand, which, while reducing the amount of rhodium catalyst, maintains high activity and can significantly improve the conversion rate of propylene, as well as the selectivity and yield of isobutyraldehyde.

The application relates to establishment and application of an isobutyraldehyde biosensor and belongs to the technical field of bioengineering. yqhD The RFP report system responding to isobutyraldehyde is established, the yqhC gene is rationally designed, a mutant library is constructed through random mutation by using error-prone PCR, isobutyraldehyde is used as a substrate, and through screening of response concentrations and response thresholds, a YqhC mutant without background fluorescence response, with a wider substrate detection range (0-5 g / L) and higher response intensity (24 times) is obtained, and the YqhC mutant is named YqhCm9. The isobutyraldehyde response element (YqhCm9) and the fluorescent protein report element (RFP) are used to construct a high-efficiency and specific isobutyraldehyde biosensor, real-time monitoring of an isobutyraldehyde production process and screening of an isobutyraldehyde production strain can be carried out.

The application provides a detection device for isobutyraldehyde and application and a method for detecting isobutyraldehyde, relates to the technical field of isobutyraldehyde detection, and comprises an automatic sampling part, a catalytic luminescence reactor and a detection instrument; wherein the catalytic layer of the catalytic luminescence reactor comprises nano barium titanate; the detection device has sensitive response, excellent specificity and better stability to isobutyraldehyde, achieves the technical effects of good reproducibility, rapid response, rapid recovery and repeated detection in a short time, and provides guarantee for long-term online accurate detection of the isobutyraldehyde concentration.

The invention discloses a preparation method and application of a 2, 5-diketopiperazine derivative, and belongs to the field of biological medicine. The preparation method comprises the following steps: by taking 1, 4-diacetyl piperazine-2, 5-diketone (II) as an initial raw material, firstly, carrying out condensation reaction on the initial raw material and isobutyraldehyde to prepare a key intermediate (III); meanwhile, 4-amino-1-butanol (IV) is converted into an intermediate (VI) through acylation and oxidation two-step reaction; and finally, carrying out condensation and elimination reaction on the intermediates (III) and VI to prepare the target compound (I). The preparation method provided by the invention has the advantages of reasonable route design, mild conditions and outstanding stereoselectivity. According to the method, on the basis of easily available raw materials, a product mainly comprising a Z configuration is efficiently constructed through a modular strategy and consistent mild base catalysis conditions. Experimental data show that the compound prepared by the invention can inhibit TG accumulation in nematode bodies and reduce nematode fat accumulation, and can be developed into efficient medicines for preventing and treating obesity.

The invention relates to application of a bromoethyl pillar [5] arene crystal material as an adsorbent in n-butyraldehyde adsorption, and belongs to the technical field of adsorption separation materials. The bromoethyl pillar [5] arene crystal material is used as an adsorbent to efficiently adsorb n-butyraldehyde, the structural formula of the bromoethyl pillar [5] arene crystal material is shown in the specification, the chemical property of the bromoethyl pillar [5] arene crystal material is stable, n-butyraldehyde can be separated from gaseous butyraldehyde isomers with the purity of 99.1%, and the bromoethyl pillar [5] arene crystal material can be recycled without losing any performance. Moreover, the separation method of the butyraldehyde isomer is simple in process operation and low in equipment requirement; in addition, rectification operation is not needed, energy consumption is low, energy is saved, and the production cost of n-butyraldehyde and isobutyraldehyde is reduced.

The invention discloses a method for preparing isobutyraldehyde by catalyzing methanol and ethanol through a composite metal oxide catalyst, and particularly relates to a method for preparing isobutyraldehyde by catalyzing methanol and ethanol through an aldol condensation reaction by taking V2O5 as a main metal oxide catalyst. The introduced metal oxides comprise one or more of TiO2, Al2O3, ZrO2, SiO2, La2O3 and Nb2O5, and the composite metal oxide catalyst mainly containing V2O5 is prepared by one or more methods of mechanical grinding and is used for preparing isobutyraldehyde from methanol / ethanol. The method has the advantages that the metal oxide is introduced to optimize the oxygen supply activity and restore the oxidation capacity of the vanadium catalyst, so that the product selectivity is improved.

The application discloses a method for catalyzing propylene hydroformylation by using a Zn-modified Rh-based molecular sieve catalyst. The method comprises the following steps: placing the Zn-modified Rh-based molecular sieve catalyst and an organic solvent in a high-pressure reaction kettle, replacing the air in the kettle after sealing, then introducing a mixed gas, heating to 60-120 DEG C, and reacting for 0.5-2.0 h under stirring and a total pressure of 1.0-5.0 MPa to obtain n-butyraldehyde and isobutyraldehyde. In the preparation of the catalyst, ethylenediamine is used as a bimetallic complexing agent, and Rh and Zn are controllably co-encapsulated in S-1 molecular sieve crystals through a one-step hydrothermal crystallization method, and the molar ratio of Zn / Rh is continuously adjusted in a wide range of 0.25-8.9. The catalyst has excellent performance under mild reaction conditions and has a good industrial application prospect.

The present application relates to a method for separating high-purity n-butyl aldehyde from mixed butyl aldehyde of carbonyl synthesis product, comprising the following steps: adding reaction inhibitor to the product of carbonyl synthesis reaction after separating catalyst, part of which enters high-pressure rectifying column, and the other part enters low-pressure rectifying column, n-butyl aldehyde product is obtained from the side line of high-pressure rectifying column and the bottom of low-pressure rectifying column, and iso-butyl aldehyde product is obtained from the top of high / low-pressure column. The present application adds reaction inhibitor to improve product purity, solves the problem of easy polymerization of mixed butyl aldehyde by using the characteristics of low-temperature decomposition of butyl aldehyde trimer, separates high-purity n-iso-butyl aldehyde from mixed butyl aldehyde with low energy consumption, and has low equipment investment cost and can create high economic benefits.

The invention relates to the technical field of building waterproof coatings, and discloses an environment-friendly latent curing agent and a preparation method thereof, an environment-friendly polyurethane waterproof coating raw material composition, an environment-friendly polyurethane waterproof coating and a preparation method thereof. The preparation method of the environment-friendly latent curing agent comprises the following steps: (1) in the presence of a solvent, carrying out first mixing on an aldehyde compound and an amine compound to obtain an intermediate I; the aldehyde compound is a combination of an aldehyde compound I and an aldehyde compound II in a content molar ratio of (1-2.5): 1; the aldehyde compound I is benzaldehyde and / or isobutyraldehyde, and the aldehyde compound II is nonanal and / or capraldehyde; and (2) carrying out dehydration condensation reaction on the intermediate I to obtain the environment-friendly latent curing agent. The environment-friendly polyurethane waterproof coating prepared by the preparation method disclosed by the invention has better environment-friendly performance and also has good mechanical properties.

The invention discloses equipment for manufacturing isobutyric acid and a manufacturing method of isobutyric acid. The equipment for manufacturing isobutyric acid comprises a reaction tank, an air inlet pipe, an air outlet pipe and a stirrer. The gas inlet pipe is connected with the reaction tank and is used for introducing working gas into the reaction tank; and the gas outlet pipe is connected with the reaction tank and is used for guiding the reacted gas out of the reaction tank. The stirrer is arranged in the reaction tank and comprises a hollow shaft and a plurality of blades; the hollow shaft is provided with a first end and a second end which are oppositely arranged, the first end is provided with an air exhaust hole and exposed out of the liquid level of the reaction tank, and the second end is provided with an air exhaust hole and immersed in the liquid level. The other end, opposite to the reaction tank, of the gas outlet pipe is connected with the condenser so as to condense the reaction gas to obtain isobutyraldehyde and tail gas, and isobutyraldehyde can be conveyed back to the reaction tank through the pump to continue the reaction, so that the conversion rate is increased.

A method for preparing neopentyl glycol, the method including: feeding a feed stream containing formaldehyde and isobutyraldehyde to an aldol reactor and subjecting the feed stream to an aldol condensation reaction in the presence of a catalyst to obtain a first reaction product containing hydroxypivaldehyde; feeding the first reaction product to an aldol purification column; feeding the aldol purification column upper discharge stream to a decanter and separating an organic phase stream containing unreacted isobutyraldehyde and the catalyst and an aqueous phase stream containing a catalyst salt; feeding the aqueous phase stream to a saponification reactor to reduce the catalyst salt to a catalyst and recover the catalyst; and feeding the aldol purification column lower discharge stream to a hydrogenation reactor and subjecting the aldol purification column lower discharge stream to a hydrogenation reaction to obtain neopentyl glycol.

This invention relates to a method for preparing methyl isopentyl ketone, comprising the following steps: acetone and isobutyraldehyde are mixed and passed through a fixed-bed reaction section packed with a layered metal oxide condensation catalyst; acetone and isobutyraldehyde are recovered by distillation for reuse; the condensation product enters a fixed-bed hydrogenation section, where it reacts with hydrogen under the action of a hydrogenation catalyst to obtain methyl isopentyl ketone. This invention separates the key reaction steps of condensation and hydrogenation. Firstly, the condensation catalyst designed based on the aldehyde-ketone condensation mechanism has higher condensation selectivity, forming the MIAK hydrogenation precursor, thus avoiding the self-condensation reaction of acetone and isobutyraldehyde and also avoiding the conversion of acetone to alcohol.

The application discloses coffee essence, atomized liquid and electronic atomization device, and belongs to the field of electronic atomizers. The coffee essence comprises 2-acetylpyrrole, vanillin, methylcyclopentenolone, maltol, furfuryl acetate, guaiacol, isopentyl alcohol propylene glycol solution, furfuryl mercaptan, 2-ethyl-3,5-dimethylpyrazine, isovaleric acid propylene glycol solution, 2,3,5-trimethylpyrazine, isobutyraldehyde, 2-methyl-3-(methylthio)pyrazine, isoamyl aldehyde, trigonellin, 4-hydroxy-2,5-dimethyl-3(2H)-furanone, 5-methylfurfural, dimethyl sulfide, 2-acetylfuran, 5-hydroxyethyl-4-methylthiazole, 2-acetylpyrazine, 4-ethylguaiacol, acetic acid, propionic acid, acetaldehyde propylene glycol solution, 4-methyl-5-(2-acetyloxyethyl)-thiazole and propylene glycol. The coffee essence has good stability, good compatibility and can accurately restore the real coffee roasting aroma.

This invention belongs to the fields of chemical material synthesis and biomedicine, and provides a method for synthesizing α-ketovaline calcium. This method uses environmentally friendly and low-cost diethyl oxalate as a raw material. The pKa value is precisely controlled through a mixed alkali system to suppress the self-condensation side reaction of isobutyraldehyde. After the condensation reaction at 55-60℃, formic acid is generated through alkaline degradation. Byproducts are completely removed using a 1:1 redox reaction of 30% hydrogen peroxide and formic acid, replacing the traditional high-energy-consuming distillation process. The product yield reaches 78.1%, and the purity is ≥99.8%, demonstrating significant advantages in terms of economy, environmental friendliness, and industrial feasibility.

The application provides a co-production device and process of isobutyraldehyde and n-butyraldehyde, and particularly relates to the technical field of olefin hydroformylation industry. The co-production device comprises a purification device, a hydroformylation device, a falling film evaporator device, a rectifying tower A, a rectifying tower B and a rectifying tower C which are sequentially connected; the bottom of the rectifying tower A is connected with the rectifying tower B; the bottom of the rectifying tower B is connected with the rectifying tower C. The co-production device realizes the production and separation of isobutyraldehyde and n-butyraldehyde simultaneously in one set of co-production device, effectively reduces energy consumption, is simple in equipment, high in production capacity and suitable for large-scale industrial production. Meanwhile, the obtained n-butyraldehyde and isobutyraldehyde products have a purity of more than 99.8 mol%, and a water content of less than 0.1 mol%, are higher in purity and meet the demand of high-end n-butyraldehyde and isobutyraldehyde products on the market.

The present application provides a hydroformylation catalyst and a method for preparing isobutyraldehyde. The hydroformylation catalyst comprises a metal compound and a phosphine-containing ligand containing specific sulfur. The method is: adding a substrate and a hydroformylation catalyst into a high-pressure reaction kettle, then introducing synthesis gas into the high-pressure reaction kettle, heating and reacting to prepare the corresponding formylation product. The catalyst has high regioselectivity, can reduce the n-iso isomer ratio of aldehyde in the product of olefin hydroformylation reaction, realize low n-iso ratio in the process of preparing butyraldehyde by propylene hydroformylation, and has high stability in the reaction.

The application provides a multi-tube parallel filling oxidizer and a preparation method of isobutyric acid, and relates to the field of preparation of isobutyric acid. In the multi-tube parallel filling oxidizer, oxygen and isobutyraldehyde are countercurrently contacted, the contact efficiency is improved, and the oxidation reaction is rapidly reacted; and on the basis of circulating cooling water, an outer circulation heat exchange system is additionally arranged, so that the temperature of reactants can be better controlled, the occurrence of a side reaction is greatly reduced, and the product purity is improved.

The application relates to the technical field of isobutyraldehyde detection, in particular to application of hydroxyapatite in detection of isobutyraldehyde. The application provides application of hydroxyapatite in detection of isobutyraldehyde, and also provides a preparation method of the hydroxyapatite. It is found that the hydroxyapatite has good responsiveness, specificity, stability and reproducibility in detection of isobutyraldehyde, and the application of the hydroxyapatite is expanded.

This invention provides a coffee flavoring and its preparation method, comprising 0.1 parts of furanone, 2-acetylpyrazine, vanillin, ethanol, 3-methylthiopropional, 2-methoxy-4-vinylphenol, 2-ethyl-3-methylpyrazine, 2-ethyl-3,5-dimethylpyrazine, furfuryl mercaptan, β-damascone, p-cresol, hexanoic acid, 2-methylbutyric acid, 2,3-pentanedione, methyl furfuryl disulfide, 3-mercapto-3-methylbutyl formate, terpineol, 1-octen-3-ol, isobutyraldehyde, furfural, 5-methylfurfural, isovaleraldehyde, linalool, 2-methoxy-3-isobutylpyrazine, phenylacetaldehyde, eugenol, 2,3,5-trimethylpyridinium, guaiacol, 4-ethylguaiacol, an amino acid composition, glycerol, water, and coffee extract. The coffee flavoring of this invention has a strong three-dimensional aroma, rich layers, and high overall aroma realism and harmony.

A process comprises a) subjecting propylene to hydroformylation in the presence of a homogeneous hydroformylation catalyst in a hydroformylation reactor to form a reaction liquid; b) withdrawing a hydroformylation effluent stream from the hydroformylation reactor; c) separating the hydroformylation effluent stream into a raw hydroformylation product stream and a reactor return stream comprising the homogeneous hydroformylation catalyst; and returning the reactor return stream to the hydroformylation reactor; and d) subjecting the raw hydroformylation product stream to work-up to obtain a mixed butyraldehyde stream; and rectifying the mixed butyraldehyde stream in a distillation column so as to obtain an n-butyraldehyde stream and an isobutyraldehyde stream. The process comprises withdrawing a stream of reaction liquid from the hydroformylation reactor, circulating the reaction liquid stream through a cooling loop including at least one heat exchanger, wherein the reaction liquid stream is heat exchanged against a bottoms stream of the distillation column that is recycled through the heat exchanger and returned to the distillation column, to transfer heat from the reaction liquid stream to the bottoms and to obtain a cooled reaction liquid stream, and returning the cooled reaction liquid stream to the hydroformylation reactor. The process allows for an efficient heat integration.

The invention relates to a preparation method of an interleukin-23 receptor peptide inhibitor and a chiral intermediate thereof, in particular to a method for preparing an L-penicillamine derivative, and the L-penicillamine derivative can be used for preparing the interleukin-23 receptor peptide inhibitor. On one hand, the invention relates to a method for preparing a compound shown as a formula I. The method comprises the following steps: brominating isobutyraldehyde, substituting bromine atoms on the isobutyraldehyde with benzyl mercaptan and the like, then converting aldehyde groups into nitrile ammonia by using sodium cyanide, and finally converting nitrile groups into carboxylic acid by using nitrilase, so as to obtain the benzyl and the like substituted L-penicillamine derivative. The invention also relates to a penicillamine derivative shown as a formula I-Fmoc obtained by protecting free amino groups on the L-penicillamine derivative with Fmoc, and a polypeptide which is prepared from the penicillamine derivative shown as the formula I-Fmoc and has a general name of Icotrokinra. Some steps of the method have the characteristics of high purity and high yield.

The invention discloses a V-Co-Mo three-metal catalyst, a preparation method and application of the V-Co-Mo three-metal catalyst in low-temperature oxidative desulfurization of fuel oil, the V-Co-Mo three-metal catalyst takes mesoporous gamma-Al2O3 or a mesoporous silicon-based material SBA-15 as a carrier to load metals V, Co and Mo, the preparation method is simple, the oxidative desulfurization temperature is low, and when the V-Co-Mo three-metal catalyst is applied to the low-temperature oxidative desulfurization of the fuel oil, the V-Co-Mo three-metal catalyst can be applied to the low-temperature oxidative desulfurization of the fuel oil. A small amount of an auxiliary agent isobutyraldehyde is added into an oxidation system, so that the activation of oxygen is more facilitated, finally, a deep desulfurization effect is achieved under a low-temperature condition close to normal temperature, thiophene sulfides in fuel oil are oxidized into corresponding sulfone substances, and the oxidation efficiency is improved. And then isobutyraldehyde and sulfone substances are extracted and separated from the fuel oil by using an extracting agent to obtain the low-sulfur fuel oil, so that the stability of an oil product and the safety of a production process are facilitated.

The present invention relates to the technical field of drug synthesis, and in particular to a method for synthesizing 2,2-dimethylpentanedioic acid. The method comprises the following steps: (1) uniformly mixing isobutyraldehyde, acrylonitrile, and tetrahydrofuran, cooling the mixture to 0-5°C, dropwise adding a sodium hydroxide aqueous solution, then carrying out a reaction while maintaining the temperature, heating to 50-55°C for a reaction, and separating a cyanoaldehyde intermediate; (2) uniformly mixing the cyanoaldehyde intermediate, water, and potassium dihydrogen phosphate, cooling the mixture to 0-5°C, and adding hydrogen peroxide; and dropwise adding a sodium chlorite aqueous solution, then heating to 23-28°C, carrying out a reaction while maintaining the temperature, dropwise adding a sodium bisulfite aqueous solution to quench the reaction, and separating a cyanic acid intermediate; and (3) uniformly mixing the cyanic acid intermediate with sulfuric acid, heating the mixture to 95-100°C while stirring, carrying out a reaction while maintaining the temperature, cooling to room temperature, and separating a crude 2,2-dimethylpentanedioic acid product; and adding cyclohexane for crystallization to obtain a product. The synthesis route of the present invention is simple and novel, the raw materials used have low prices, the synthesis method is simple and convenient to operate, and the product yield is relatively high.

The utility model discloses a device for improving the purity of butyraldehyde, which comprises a rectifying tower, a condenser, an isobutyraldehyde return tank and an n-butyraldehyde receiving tank, in the separation process of mixed butyraldehyde, n-butyraldehyde is extracted from a side extraction pipeline in the middle of the rectifying tower, heavy components such as heavy components and terpolymers are extracted from the bottom of the rectifying tower, and the purity of butyraldehyde is improved.

The application provides a neopentyl glycol preparation system and method based on micro-interface reinforcement, and belongs to the field of neopentyl glycol preparation. The system comprises a condensation reactor comprising a formaldehyde feed port, an isobutyraldehyde feed port and a first catalyst feed port; a product separator comprising a condensation product inlet and a hydroxyl neopentanal outlet, the condensation product inlet being in communication with the condensation reactor; and a hydrogenation reactor, the inside of the hydrogenation reactor being sequentially provided from top to bottom with an internal fixed plate, a fixed bed layer and a micro-interface reaction generator, the hydrogenation reactor being in communication with the hydroxyl neopentanal outlet, and the micro-interface reaction generator being in communication with hydrogen. The system is provided with the micro-interface reaction generator for breaking air into micron-scale micro-bubbles and releasing the micro-bubbles into the inside, so as to increase the phase interface mass transfer area between raw materials in the reaction process, make the two phases fully contact, increase the concentration of the dissolved gas in the liquid phase, shorten the reaction time, and thus greatly improve the reaction efficiency and save energy.

The invention provides a method for extracting neopentyl glycol from wastewater, in the method, the wastewater comes from wastewater generated at the top of a neopentyl glycol light component removal tower, the content of the neopentyl glycol in the wastewater is about 10-15%, the generated wastewater directly enters a stripping tower, the stripping tower is filled with Pall ring filler, the neopentyl glycol in the wastewater is purified by raising the feeding position, and the neopentyl glycol in the wastewater is purified. According to the method, a light component removal tower is adopted, a 65-75% neopentyl glycol aqueous solution is produced at the bottom of the tower, a clear solution containing methanol and isobutyraldehyde is discharged from the top of the tower, neopentyl glycol in wastewater is separated at the pressure of 10-20 kPa and the temperature of 90-100 DEG C, and the recovered neopentyl glycol aqueous solution directly enters the light component removal tower through a returned material. According to the method, neopentyl glycol in the wastewater can be effectively recovered, the production cost is reduced, and the production benefit is increased.

This invention provides a hydrolysis-resistant catalyst for increasing the production of isobutyraldehyde through propylene hydroformylation and its application. The catalyst comprises a ligand and a metal center compound. The ligand has the structure shown in Formula I. The catalyst system of this invention is characterized by hydrolysis resistance and high stability. It is used to catalyze the reaction of propylene with syngas, exhibiting high reactivity, good selectivity, low metal catalyst dosage, and high propylene conversion rate. The positive-to-isobutyraldehyde ratio can reach 1.0 to 1.1:1, thereby achieving the goal of increasing isobutyraldehyde production.

This invention provides a low-energy-consumption isobutyraldehyde separation system, comprising an atmospheric distillation column and a pressurized distillation column connected by a thermally coupled pipeline. This invention utilizes thermal coupling technology to use the steam generated in the pressurized distillation column as a heat source for the atmospheric distillation column, significantly reducing energy consumption. Furthermore, the optimized internal structure and distributor design improve separation efficiency and reduce equipment investment and operating costs. Compared with existing technologies, this invention represents a significant advancement in energy saving, separation efficiency, and operational stability, making it suitable for large-scale industrial production.