41 results about "Tert-butoxy" patented technology

The invention belongs to the field of detection and analysis, and relates to a method for separating and detecting enantiomers in (S)-2-amino-3-[2-(tert-butoxy)-2-oxoacetamido] tert-butyl propionate hydrochloride. According to the method, HPLC is adopted for separation and detection, a polysaccharide derivative chiral chromatographic column is selected as a chromatographic column, a mobile phase A is a weak base aqueous solution, and a mobile phase B is acetonitrile and / or methanol. The method is strong in specificity, high in separation degree, high in accuracy, stable, reliable and high in sensitivity, and a simple, accurate, rapid and reliable detection method is provided for control of impurities in a starting material of (S)-2-amino-3-[2-(tert-butoxy)-2-oxoacetamido] tert-butyl propionate hydrochloride.

The invention relates to a core-shell polyacrylamide nano flocculant as well as a preparation method and application thereof, the flocculant is of a core-shell structure, the shell is a water-soluble polyacrylamide polymer, and the core is cross-linked poly (p-hydroxystyrene); the preparation method comprises the following steps: preparing a poly (p-tert-butoxystyrene-b-polyacrylate) block polymer or a poly (4-acetoxystyrene-b-polyacrylate) block polymer; carrying out hydrolysis and self-assembly on poly (p-tert-butoxystyrene) or poly (4-acetoxystyrene) on the block polymer at the same time in the presence of a trifluoroacetic acid hydrolysis reagent by utilizing a modification induced self-assembly process, and carrying out in-situ crosslinking on poly (p-hydroxystyrene) obtained by hydrolysis by using formaldehyde; and in the presence of a 1, 5, 7-triazabicyclo [4.4. 0] decene-5-ene catalyst, modifying the polyacrylate block by using an amination reagent to prepare the flocculant. Compared with the prior art, the flocculant provided by the invention has the advantages of controllable morphology, stable cross-linkable property and the like.

The invention discloses a method for preparing 3-phenanthrenol. The method comprises coupling a compound 3-tert-butoxyphenylboronic acid and o-bromobenzaldehyde to obtain 3'-tert-butoxy-[1,1'-biphenyl]-2-formaldehyde, then reacting 2-(chloromethoxy)-2-methylpropane with magnesium chips in tetrahydrofuran to generate a Grignard reagent, followed by substitution with 3'-tert-butoxy-[1,1'-biphenyl]-2-formaldehyde, and reflux and water separation with p-toluenesulfonic acid to obtain 3'-tert-butoxy-2-(2"-tert-butoxyvinyl)-1,1'-biphenyl, and finally ring closure with methanesulfonic acid and de-tert-butylation to obtain 3-phenanthrenol. The method introduces tert-butyl protection, thereby increasing steric hindrance and reducing isomers during ring closure, and facilitating deprotection conditions. The obtained product can have a purity of more than 99.0% without the need for column chromatography.

The application provides a high-styrene solution polymerized styrene-butadiene rubber and a preparation method and application thereof, and the preparation method comprises the following steps: mixing styrene, butadiene, an initiator, a structure regulator and a non-polar solvent, and performing a polymerization reaction to obtain solution polymerized styrene-butadiene rubber; wherein the structure regulator comprises at least two of t-butoxy sodium, t-amyl oxy sodium, 2,3-dimethyl-3-pentanol sodium and ethylene glycol disodium, and a crown ether. By using the composite structure regulator, the application can prepare a random high-styrene content solution polymerized styrene-butadiene rubber, and the rubber almost does not contain styrene blocks, and the content of vinyl in the rubber can be adjusted by the addition amount of the structure regulator. Therefore, the solution polymerized styrene-butadiene rubber prepared by the application has good strength and hardness due to the high styrene content, and the random microstructure reduces the glass transition temperature and heat build-up of the raw rubber, and is suitable for the manufacturing of high-performance tires such as new energy vehicle tires.

This invention discloses a method for synthesizing styrene-based photoresist resin, comprising the following steps: adding styrene and p-tert-butoxystyrene to a DES solvent, ultrasonically dispersing the mixture, and then rapidly adding an initiator under an air atmosphere to obtain a styrene-p-tert-butoxystyrene copolymer, i.e., a styrene-based photoresist resin, via anionic polymerization. The preparation method of this invention is simple and the process is easy to control. Using DES as the polymerization solvent allows the reaction to proceed efficiently under ambient air atmosphere. Furthermore, the hydrogen bond network in DES can form a specific interaction with the oxygen atom in the p-tert-butoxy group, resulting in a significant stabilizing effect on this acid-sensitive protecting group and effectively suppressing the removal of the protecting group and the resulting side reactions during anionic polymerization.

The invention discloses a preparation method of an N-hydroxyurea compound, which specifically comprises the following steps: step 1, sequentially carrying out Lossen rearrangement and nucleophilic reaction under the action of alkali by taking Boc NHOH as shown in a formula 1 as an initial reactant, SO2F2 gas as an acylating agent and an amine compound RR 'NH as a nucleophilic reagent to obtain a tert-butoxyurea compound as shown in a formula 2; and 2, removing the tert-butoxy group from the tert-butoxyurea compound to obtain the N-hydroxyurea compound as shown in a formula 3. The innovation point of the invention is that commercialized easily available gas sulfonyl fluoride promotes Lossen rearrangement of tert-butylhydroxylamine to generate a key intermediate tert-butoxy isocyanate, the key intermediate tert-butoxy isocyanate and a substrate amine compound are subjected to a one-pot reaction to obtain the N-hydroxyurea compound, the reaction conditions are simple, the operation is convenient, the compatibility of substrate functional groups is strong, and the application prospect is good.

A composition for forming a charge-transporting thin film containing a charge-transporting precursor having a 9-tert-butoxycarbonylcarbazole structure within the molecule and an organic solvent provides a thin film exhibiting good charge-transporting properties even when sintered at low temperatures. Furthermore, the aforementioned charge-transporting precursor can be used to prepare the composition using a low-polarity solvent that causes less damage to substrates and components made of organic compounds compared to highly polar amide solvents.

The invention discloses a synthesis method of 1H-indazole-7-tert-butyl formate, and belongs to the technical field of organic synthesis. The synthesis method of the 1H-indazole-7-tert-butyl formate comprises the following steps: dissolving 7-carboxyl-1H-indazole in an organic solvent I, then adding 1, 1-di-tert-butoxy-N, N-dimethyl methylamine, heating, and carrying out a stirring reaction to obtain a reaction solution; and performing post-treatment. According to the synthesis method, one-step conversion of indazole carboxylic acid into indazole tert-butyl formate is achieved, reaction conditions are mild, aftertreatment and purification are simple, cost is low, and manufacturability amplification can be achieved.

The invention relates to a modified perfluoropolyether electrolyte with a wide electrochemical window and a lithium ion battery. The modified perfluoropolyether electrolyte is characterized by comprising modified perfluoropolyether and a lithium salt, wherein the structural general formula of the modified perfluoropolyether is A-R-Rf-R-B, in the formula, Rf is a perfluoropolyether chain segment, and perfluoropolyether comprises one or more of K type perfluoropolyether, D type perfluoropolyether, Y type perfluoropolyether or Z type perfluoropolyether; r is a non-fluoroether chain segment, and the non-fluoroether chain segment comprises one or more of a methyleneoxy group, an ethyleneoxy group, a propoxy group, an isopropoxy group, a n-butoxy group, a sec-butoxy group, an isobutoxy group, a tert-butoxy group or a pentyloxy group; a and B are independently selected from one of hydroxyl, methoxyl or benzoate. Compared with the prior art, the modified perfluoropolyether electrolyte is prepared by mixing the modified perfluoropolyether and the lithium salt, and the electrochemical stability window of the modified perfluoropolyether electrolyte is remarkably improved.

The invention relates to the technical field of chemical engineering, in particular to a preparation method and application of a lithium aluminum tri-tert-butoxyhydride-tetrahydrofuran solution. Industrial-grade tert-butyl alcohol is purified through molecular distillation to obtain purified tert-butyl alcohol, the purified tert-butyl alcohol and anhydrous tetrahydrofuran are mixed to prepare a tert-butyl alcohol-tetrahydrofuran solution, and then the tert-butyl alcohol-tetrahydrofuran solution is prepared into the lithium aluminum tri-tert-butoxyhydride-tetrahydrofuran solution. The method comprises the following steps: mixing a lithium aluminum hydride solid with anhydrous tetrahydrofuran, and stirring to obtain a lithium aluminum hydride-tetrahydrofuran suspension; conveying the tert-butyl alcohol-tetrahydrofuran solution and the lithium aluminum hydride-tetrahydrofuran suspension into a microchannel reactor with ultrasonic waves through a double-plunger metering pump, and reacting to obtain a product solution; and stirring the product solution, adding 2, 6-butylated hydroxytoluene, and filtering to obtain a lithium aluminum tri-tert-butoxy hydride-tetrahydrofuran solution. The continuous flow reaction is assisted by ultrasonic waves, high-efficiency and high-selectivity preparation is realized, and a stable solution product is obtained.

The embodiment of the present application discloses a preparation method of nor-tropine alcohol. The method comprises the following steps: performing demethylation reaction on tropinone and chloroethyl chloroformate in the presence of a solvent, performing vacuum concentration and evaporation, and obtaining demethyltropinone; performing reduction reaction on the demethyltropinone and lithium tri-t-butoxyaluminum hydride in the presence of a solvent, and obtaining the nor-tropine alcohol. The present application adopts a new type of reducing agent lithium tri-t-butoxyaluminum hydride, which is safe, not sensitive to air and water, and simple in post-treatment, thus avoiding safety hazards from the source. The present application avoids the use of dangerous Raney nickel and does not need to use an autoclave, so that the production capacity is greatly improved. The present application performs the reaction under low-temperature conditions, is low in energy consumption, can effectively reduce production cost, and is moderate in reaction conditions, safe and simple in operation, and is conducive to large-scale industrial production.

The present invention provides processes for the preparation 2-(t-butoxy)-4-(3-methyl-3-(5-methylsulfonyl)isoindolin-2-yl)butyl)phenol The disclosed processes overcome drawbacks of prior art methods by providing safer, more efficient synthetic routes with improved yields and reduced impurity levels. A key improvement includes a novel photochemical bromination process using continuous flow technology. The invention also encompasses novel intermediates including compounds of Formula 12 and 13. The processes eliminate the use of hazardous reagents, reduce reaction times, and provide better control over product purity, making them suitable for large-scale pharmaceutical manufacturing.

The invention discloses a continuous synthesis method of p-tert-butoxychlorobenzene, and belongs to the technical field of organic synthesis. The method comprises the following steps: continuously pumping a parachlorophenol solution and an isobutene solution into a tower reactor for reaction, and continuously feeding a reaction solution into an extraction tower for separation and purification. According to the invention, the tower reactor is combined with continuous extraction, so that the whole process from reaction to post-treatment is continuous, and the production efficiency is greatly improved; according to the method, efficient reaction can be realized under mild conditions, the process control is stable, side reaction is effectively inhibited, and the product yield is high; meanwhile, equipment is safe and reliable, the comprehensive production cost is remarkably reduced, and the method is suitable for industrial large-scale application.

The invention belongs to the technical field of organic synthesis, and particularly relates to a method for continuously preparing (2R, 4S)-5-(biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid, which comprises the following steps: dissolving and mixing, S2, carrying out hydrogenation reaction, S3, quenching and concentrating, S4, crystallizing and filtering, and S5, continuously drying: carrying out vacuum drying on a filter cake to obtain a target product (2R, 4S)-5-(biphenyl-4-yl)-4-[(tert-butoxycarbonyl) amino]-2-methylpentanoic acid. According to the present invention, the continuous hydrogenation reaction, the crystallization and the drying process are performed on the (4S, 4S)-5-(biphenyl-4-yl)-4-[(t-butoxycarbonyl) amino]-2-methylpentanoic acid, such that the batch interval time of the traditional intermittent production is avoided, the productivity per unit time is significantly improved, the method is suitable for industrial amplification, and the reaction time is shortened due to the use of the fixed bed reactor or the micro-channel mixer.

A method for producing a compound represented by formula (2) includes obtaining a compound represented by formula (1) by chemically reacting a compound represented by formula (4) with a compound represented by formula (3), and hydrolyzing the obtained compound represented by formula (1). (In formulae (1) to (4), R1 and R2 are each independently a hydrogen atom, a substituted or unsubstituted C1-6 alkyl group, or the like, R3 is a substituted or unsubstituted C1-6 alkyl group, or the like, and Z is a tert-butoxycarbonyloxy group, a halogen group, or a 1H-imidazole-1-group).

The invention relates to a triazine ring-containing polymer, a method for producing the triazine ring-containing polymer, and a non-photosensitive liquid composition. The present invention addresses the problem of providing: a triazine ring-containing polymer capable of providing a molded article having a high refractive index and excellent light resistance or heat resistance; a method for producing the triazine ring-containing polymer; and a non-photosensitive liquid composition containing the triazine ring-containing polymer. [Solution] A liquid crystal composition containing a compound having a tert-butoxycarbonyloxy group, a triazine ring-containing polymer having a structural unit having a structure in which an aromatic group of a tert-butoxycarbonylamino group, a hydroxyl group protected by an acetal protecting group, or a carboxyl group protected by an acid-dissociable group is bonded to a triazine ring via a specific linking group, a polymer containing a triazine ring contains a structural unit that includes a structure in which an aromatic group is bonded to the triazine ring via a specific linking group and that is different from the structural unit, or a terminal group having a specific structure is bonded, or the weight-average molecular weight of the polymer containing the triazine ring is 4,000-20,000 (inclusive).

The invention discloses a functionalized ethylene-vinyl alcohol copolymer and a preparation method thereof. The structure of the functionalized ethylene-vinyl alcohol copolymer is shown as a formula 1, wherein M is selected from one of a tert-butoxy group, a tert-pentyloxy group and a copolymer of ethylene and polyvinyl alcohol; x is 0-1, y is 0-1, z is 0-1, and the sum of molar ratios of x, y and z is 1; the weight-average molecular weight of the ethylene-vinyl alcohol copolymer is 20000 to 100000 g / mol; the molecular weight distribution of the ethylene-vinyl alcohol copolymer is 1.0 to 3.0; the ethylene content in the ethylene-vinyl alcohol copolymer is 20 to 50 mol%. The preparation method of the copolymer comprises the following steps: mixing an initiator, peroxide containing acrylic acid, a solvent and vinyl acetate, blowing nitrogen to remove oxygen, introducing ethylene gas, and carrying out pressurized polymerization to obtain the ethylene-vinyl acetate copolymer, and mixing the ethylene-vinyl acetate copolymer, an organic solvent and a catalyst, carrying out alcoholysis reaction, washing with water, filtering and drying to obtain the ethylene-vinyl alcohol copolymer.

The invention provides a synthesis process of a tetrafluoroisoxazoline herbicide, which comprises the following steps: (1) preparing an intermediate product 5, 5-dimethyl-3-(methylthio)-4, 5-dihydroisoxazole; (2) preparing an intermediate 3-((chloromethyl) thio)-5, 5-dimethyl-4, 5-dihydroisoxazole; (3) preparing an intermediate, namely 1, 4-di-tert-butoxy-2, 3, 5, 6-tetrafluorobenzene; (4) preparing 2, 3, 5, 6-tetrafluoro-1, 4-hydroquinone; (5) preparing 2, 3, 5, 6-tetrafluoro-4-methoxyphenol, and preparing 2, 3, 5, 6-tetrafluoro-4-methoxyphenol; (6) preparing 3-(((4-(methoxyl)-2, 3, 5, 6-tetrafluorophenoxyl) methyl) sulfenyl)-5, 5-dimethyl-4, 5-dihydroisoxazole, and (7) preparing the 3-(((4-(methoxyl)-2, 3, 5, 6-tetrafluorophenoxyl) methyl) sulfenyl)-5, 5-dimethyl-4, 5-dihydroisoxazole; and (7) preparing the herbicide. The synthesis process is simple to operate, the raw materials are simple and easy to obtain, the product yield is relatively high, the emission of three wastes is less, and the method is suitable for process production.

The invention provides a preparation method of spirolactone, and relates to the technical field of organic synthesis. The preparation method of spirolactone provided by the invention comprises the following steps: taking 4-androstene-3, 17-diketone as a raw material, carrying out nucleophilic addition reaction on the 4-androstene-3, 17-diketone and an organic zinc reagent 3-tert-butoxy-3-oxypropyl zinc bromide, then carrying out elimination-lactonization under the catalysis of trifluoroacetic acid, and completing lactonization while removing tert-butyl; then sequentially carrying out etherification reaction and oxidative dehydrogenation reaction to obtain canrenone, and finally carrying out addition reaction on canrenone and thioacetic acid to obtain spirolactone. The preparation method provided by the invention provides a novel construction method of 21-carboxylic acid-gamma-lactone, the method is good in specificity, the total mass yield of spirolactone is greater than 92%, and the total mass yield is high; moreover, the HPLC purity of the spirolactone prepared by the preparation method provided by the invention is greater than 99.7%, which is far higher than the purity of the spirolactone prepared by the existing process.

The application discloses an (S)-lenalidomide-5-position derivative, a synthetic method and application thereof, and the application comprises the following steps: removing a tert-butyloxycarbonyl protective group of a compound 1 under acidic conditions to obtain a compound 2; in the presence of an organic amine, the compound 2 is provided with a benzyloxy carbonyl protective group to obtain a compound 3; the compound 3 is subjected to an amination reduction reaction with L-glutamine tert-butyl ester to obtain a compound 4; the compound 4 is subjected to ring closing under acidic conditions to obtain a compound 5; the compound 5 is subjected to a hydrogenation debenzyl-oxy carbonyl reaction with hydrogen under the action of an acid condition and a hydrogenation catalyst to obtain a compound 6; the compound 6 and 7 are subjected to an amination reduction reaction to obtain a compound 8; and the compounds 5, 6 and 8 are (S)-lenalidomide 5-position derivatives. The synthetic method is simple in post-treatment, less in racemization, high in yield, free of toxic pollutants, and safe and environmentally friendly.

The application belongs to the field of fine chemical industry, and discloses a deprotection method of p-tert-butoxyphenethyl methyl ether, which comprises the following steps: heating p-tert-butoxyphenethyl methyl ether under the action of a solid acid catalyst to perform a deprotection reaction, so as to obtain p-(2-methoxy)ethyl phenol; the solid acid catalyst comprises aluminum phosphate and basic metal oxides modified on the aluminum phosphate, and the metal elements contained in the basic metal oxides include one or more of K, Ca, Na, Ba or Mg. The application has the advantages of less three-waste emissions, low operation cost, high production efficiency, and can be used for continuous production of p-(2-methoxy)ethyl phenol, and higher temperature and higher air speed can be adopted.

The present disclosure describes crystalline forms of 2-(tert-butoxy)-4-(3-methyl-3-(5-(methylsulfonyl)isoindolin-2-yl)butyl)phenol fumarate salts and pharmaceutical compositions of same. Also described are methods of using the crystalline forms treating Alzheimer's Disease, Dementia with Lewy Bodies and Dry age-related macular degeneration in a subject in need thereof, comprising administering the crystalline form to the subject. Methods of making the solid forms are also described.

The embodiment of the invention discloses a preparation method of nortropine. The method comprises the following steps: carrying out a demethylation reaction on tropinone and chloroethyl chloroformate in the presence of a solvent, and carrying out vacuum concentration and evaporation to dryness to obtain demethylated tropinone; the preparation method comprises the following steps: carrying out reduction reaction on demethylated tropinone and lithium tri-tert-butoxy aluminum hydride in the presence of a solvent to obtain the nortropine alcohol. According to the method, a novel reducing agent lithium tri-tert-butoxy aluminum hydride is adopted, the reducing agent is safe and insensitive to air and water, aftertreatment is simple, and potential safety hazards are avoided from the source; the use of dangerous Raney nickel is avoided, and an autoclave is not needed, so that the production capacity is greatly improved; the reaction is carried out under a low-temperature condition, the energy consumption is low, the production cost can be effectively reduced, the reaction condition is mild, the operation is safe, simple and convenient, and large-scale industrial production is facilitated.

The invention discloses waterborne polyurethane with a dual tackifying function on silica gel as well as a preparation method and application of the waterborne polyurethane, and relates to the technical field of high polymer materials. Comprising 50 to 80 parts of macromolecular polyol, 15 to 20 parts of isocyanate, 1 to 5 parts of a hydrophilic chain extender, 0.5 to 2 parts of a micromolecular chain extender, 1 to 5 parts of a double bond-containing hydroxyl monomer compound, 1 to 5 parts of a tert-butoxysilane chain extender, 0.5 to 1.5 parts of a post chain extender, 1 to 2.5 parts of a neutralizer and 0.2 to 0.35 part of an organic bismuth catalyst. The hydroxyl monomer compound containing double bonds is pentaerythritol triacrylate; and the tert-butoxy silane chain extender is tert-butyl trimethyl hydroxyethoxy silane. According to the invention, silane groups, hydrophobic chain segments and polymerizable double bonds are introduced into WPU chain segments through molecular design, and the chemical bonding and physical adsorption capacities of the WPU chain segments and silica gel are improved, so that the problems of weak interface bonding force, complex process and the like are solved.

The invention discloses an electrolyte, a preparation method and a sodium ion battery using the electrolyte. The electrolyte comprises an organic solvent, a functional cosolvent, a functional additive and conductive sodium salt, the organic solvent is composed of 1, 2-diethoxyethane and 1, 2-di-tert-butoxy ethane; the functional cosolvent is adiponitrile; the functional additive is p-nitroanisole; the conductive sodium salt is composed of sodium bis (fluorosulfonyl) imide and sodium hexafluorophosphate or sodium difluoro (oxalato) borate. The preparation method comprises the following steps: pretreating raw materials (dehydration and vacuum drying), proportionally mixing the organic solvent and the cosolvent in an inert atmosphere, adding the conductive sodium salt, stirring and dissolving, adding the functional additive, uniformly stirring, curing and filtering to obtain the electrolyte. Through unique collaborative design of non-fluorinated components, stable operation of the electrolyte under ultrahigh voltage and efficient regulation and control of an interface are realized.

Disclosed is a catalyst combination comprising at least two catalysts useful to aid in curing a moisture curable silicone polymer composition, which may comprise: a first catalyst comprising a titanium (IV) diisopropoxide bis (acetylacetonate); and a second catalyst comprising tert-butoxy titanium (IV); wherein the described catalyst combination is useful in a moisture-curable silicone polymer reaction, optionally wherein the curable material comprises a moisture-curable organosiloxane, a moisture-curable silane-modified polymer, or a combination thereof, and preferably the catalyst combination, and the composition comprising the catalyst combination is free of tin.

The invention relates to the technical field of medicine analysis and detection, in particular to a method for detecting related substances of (S)-2-amino-3-[2-(tert-butoxy)-2-oxoacetamido] tert-butyl propionate hydrochloride. The detection method comprises the following steps: detecting by adopting a high performance liquid chromatography; wherein the chromatographic conditions are as follows: a chromatographic column is an octadecyl silane bonded silica gel chromatographic column; an aqueous solution of alkali is used as a mobile phase A, acetonitrile and / or methanol is used as a mobile phase B, and gradient elution is carried out. The detection method disclosed by the invention can be used for accurately, stably, reliably and sensitively analyzing and detecting impurities existing in a process route based on (S)-2-amino-3-[2-(tert-butoxy)-2-oxoacetamido] tert-butyl propionate hydrochloride, and has very important significance on quality research and control of the INR101 injection.

The present invention provides a preparation method of chiral trans-N-BOC-1-aminocyclopentane-3-carboxylic acid, the preparation method comprising the following steps: (1) esterifying (1R, 4S)-4-((tert-butoxycarbonyl)amino)cyclopent-2-enecarboxylic acid with methanol to obtain compound 1; (2) reacting compound 1 with a base and di-tert-butyl dicarbonate to obtain compound 2; (3) reacting compound 2 with potassium carbonate to obtain compound 3; (4) reacting compound 3 with sodium borohydride and a catalyst to obtain compound 4; (5) hydrolyzing compound 4 with a base to obtain the chiral trans-N-BOC-1-aminocyclopentane-3-carboxylic acid. Compared with the prior art, the preparation method provided by the present invention has significantly fewer reaction steps and processes, a simpler overall process, a higher total yield, a significantly reduced production cost, and is suitable for industrial production.

The invention provides an antibacterial waterproof thermal insulation composite fabric and a preparation process thereof, and belongs to the technical field of fabrics. Comprising an inner-layer antibacterial fabric, a middle-layer heat preservation fabric and an outer-layer waterproof fabric. The preparation method comprises the following steps: carrying out nucleophilic substitution reaction on 1, 3-di (tert-butoxycarbonyl)-2-methyl-2-isothiourea and ethanolamine under the catalysis of hydrochloric acid to prepare an antibacterial intermediate, and then carrying out addition reaction on the antibacterial intermediate and isophorone diisocyanate to obtain the antibacterial agent with antibacterial guanidyl and a flexible polymer chain. Then preparing an antibacterial agent into an antibacterial treatment solution, treating the pretreated cotton fabric, grafting the antibacterial agent on the cotton fabric through a covalent bond combination method, removing a protective group through an acidification process, exposing high-activity protonated guanidyl, and destroying a negatively charged bacterial cell membrane through electrostatic adsorption by the protonated guanidyl, so that the antibacterial treatment solution can be used for treating the cotton fabric. Therefore, intracellular substances are leaked, and sterilization is realized, so that the inner-layer cotton fabric has a long-acting antibacterial effect.