175 results about "Tert-butoxy" patented technology

The invention discloses a folate-polyethylene glycol-polylactic acid segmented copolymer micelle encapsulated with a hydrophobic anticancer drug and a preparation method of the segmented copolymer micelle. The preparation method comprises the steps as follows: bis-amino polyethylene glycol polymer is prepared firstly; mono amino polyethylene glycol tert-butyl ester polymer is prepared by the bis-amino polyethylene glycol polymer; the mono amino polyethylene glycol tert-butyl ester polymer is cross-linked with lactide to obtain tert-butoxy acylamino polyethylene glycol-polylactic acid polymer, and the tert-butoxy acylamino polyethylene glycol-polylactic acid polymer reacts with trifluoroacetic acid to obtain amino-terminated polyethylene glycol-polylactic acid polymer; and the amino-terminated polyethylene glycol-polylactic acid polymer and activated folate react away from light to obtain the folate-polyethylene glycol-polylactic acid polymer. The compound has hydrophilia , biocompatibility and water solubility of the hydrophobic segment, material absorption and cell adhesion of protein can be reduced, the circulation time of the drug in blood is prolonged, and the formed copolymer has modificability; a tumor target compound with low molecular weight and hydrophilic polyethylene glycol-4000 segmer are bonded to form a hydrophilic segment; and the hydrophobic segment is polylactic acid, and the hydrophobic anticancer drug is embedded into the hydrophobic segment, so that the toxic and side effects are reduced.

The invention provides an environmental-friendly method for preparing 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate, which comprises a condensation reaction and a Tishchenko reaction of isobutyraldehyde, wherein condensation products of the isobutyraldehyde are subjected to the Tishchenko reaction under the catalytic action of tert-butoxy anion-pillared layered magnesium-aluminum anionic clay to generate 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate. The preparation method has the advantages of high single-pass yield, high selectivity of target products, a few by-products, mild reaction conditions, catalyst recycling and environmental-friendly synthetic process.

The synthesis of anticancer medicine Raltitrexed with 2, 5-thienyl diformic acid and diethyl glutamate as initial material and through six reaction steps of monocondensation, rearrangement, N-methylation, e;limination of tert-butoxy carbonyl group, condensation with 6-bromomethyl-2-methyl-4-quinbolone and saponification. The present invention has total yield of 18.1%, higher than that of available synthesis line, less reaction steps, mild condition and simple operation, and is suitable for mass production.

The invention relates to a preparation method of palbociclib. The method comprises the following steps: carrying out N-acetoacetylation reaction by using cyclopentylamine and an acetoacetylation agent to obtain N,N-di(acetoacetyl) cyclopentylamine (II), carrying out intramolecular condensation on N,N-di(acetoacetyl) cyclopentylamine (II) in the presence of an alkaline reagent to obtain N-cyclopentyl-3-acetyl-4-methyl-6-hydroxy-2-pyridone (III), enabling N-cyclopentyl-3-acetyl-4-methyl-6-hydroxy-2-pyridone (III) to react with a formylation reagent to prepare N-cyclopentyl-3-acetyl-4-methyl-5-formyl-6-chlorine-2-pyridone (IV), carrying out pyrimidine ring reaction by using N-cyclopentyl-3-acetyl-4-methyl-5-formyl-6-chlorine-2-pyridone (IV) and N-(5-(4-tert-butoxy carbonyl-1-hexahydropyrazinyl)-2-pyridyl) guanidine sulfate (V), and then hydrolyzing under the alkaline condition to prepare palbociclib. The preparation method of palbociclib is easily available in raw materials, short in process, simple and convenient to operate and safe and environmentally friendly in process.

The invention relates to a method for preparing a water-soluble taxane medicament and application thereof. In the water-soluble taxane compounds with a formula I structure, R1 is phenyl or alkoxide, R2 is acetyl or hydrogen atoms, and R3 is directly directed or 4-amino benzyloxy formyl.

The invention belongs to the technical field of biological medical polymer materials and discloses a pH- and redox-response macromolecule nano prodrug based on CD44 receptor tumor targeting and preparation method and application thereof. The molecular structure of the macromolecule nano prodrug is as shown in general formula (1), wherein R is one of the structures as shown in the specifications; mand n are respectively side chain polymerization degree and peptide chain polymerization degree, and x is the repetitive unit number; when R1 is phenyl, R2 is acetyl; when R1 is tert-butoxy, R2 is hydrogen. The macromolecule nano prodrug is applicable to the precise delivery of antitumor drugs and the preparation of drugs for inhibiting tumor cell proliferation; after the macromolecule nano prodrug forms nano-micelles in water through self-assembling, tumor tissue is actively identified, the nano-micelles are devoured by cancer cells, the low-pH and high-concentration GSH environments in thecancer cells allow the acylhydrazone bond and disulfide bond in the structure of the nano-micelles to break, the nano-micelles disassemble to accelerate the release of chemotherapy drugs, and the cancer cells are finally killed.

A film forming apparatus comprises a processing chamber for holding therein a to-be-processed substrate, a first gas supplying means for supplying into the processing chamber a first vapor source including a metal alkoxide having a tertiary butoxyl group as a ligand, and a second gas supplying means for supplying into the processing chamber a second vapor source including a silicon alkoxide source, wherein the first gas supplying means and the second gas supplying means are connected to a pre-reaction means for causing pre-reactions of the first vapor source and the second vapor source, and the film forming apparatus is configured to supply the first vapor source and the second vapor source after the pre-reactions into the processing chamber.

The invention relates to N-boc-L-isoleucine synthetic method. It belongs to chemical engineering technique field. Its features are as follows: using BOC acid anhydride as raw material to increase production efficiency, reduce production cost; adding NaOH solution to shorten production cycle; the yield of L-isoleucine can reach 105.2% which is higher than literature disclosed for over 20%.

The invention relates to a novel chiral iron complex, in particular to a novel axial chiral iron complex of a nitrogen ligand. The novel chiral iron complex has the following structural formula: wherein m+n is between 2 and 3; m is an integer from 0 to 3; n is an integer from 0 to 3; X and Y are halogens, C1-C8 carboxylate radials, sulfate radicals, perchlorate radicals, 4-(3,5-bi-trifluoromethylphenyl) borate radials, 4-(pentafluoro phenyl) borate radials, 4(perfluoro tert-butoxy ) aluminum ions, 4(hexafluoro isopropoxy) aluminum ions, hexafluoro phosphate radicals, hexafluoro antimonate radials, tetrafluoro borate radials or trifluoro methanesulfonic acid radials; and X and Y are the same or different. The invention also provides a method for preparing the novel chiral iron complex. The novel axial chiral iron complex of the nitrogen ligand can catalyze the insertion reaction of dissymmetrical O-H bonds of alpha-diazotate and show high activity and enantioselectivity.

A resist underlayer film-forming composition has high solubility in a solvent used at a lithography process for exhibiting good coating film forming properties and able to decrease a sublime generated during formation of a film. A resist underlayer film-forming composition having a novolac resin having a structure group (C) obtained by a reaction of an aromatic ring structure of an aromatic ring-containing compound (A) with a vinyl group of an aromatic vinyl compound (B). The aromatic vinyl compound (B) is represented by Formula (1), and is specifically styrene, 2-vinylnaphthalene, 4-tert-butylstyrene, or 4-tert-butoxystyrene.

The structure group (C) is represented by Formula (2).

The aromatic ring-containing compound (A) is an aromatic amine compound or a phenolic hydroxy group-containing compound. The novolac resin is a resin produced by a reaction of the aromatic amine compound or the phenolic hydroxy group-containing compound with aldehyde or ketone.

The invention discloses a polymer solid electrolyte and a preparation method thereof. The polymer solid electrolyte comprises a polymer matrix, a lithium salt and an inorganic filler, wherein the polymer matrix is PVDF or a mixture of PVDF and PEO, the lithium salt comprises a lithium salt A, and the lithium salt A is lithium tri-tert-butoxy aluminum hydride (LTTBA) or lithium triethylborohydride(LTEB) or a mixture of the LTTBA and the LTEB. The invention also discloses a preparation method of the polymer solid electrolyte. A lithium battery containing the polymer solid electrolyte has the excellent cycle performance and rate capability and good interface stability.

The invention provides a tert-butoxycarbonyl dihydroartemisine, which is characterized by that said invention provides its structural formula, and it is made up by using dihydroartemisine as initiation raw material, and making it and double tertiary butyl dicarbonate implement acidation reactino in organic solvent. The invented mecicine composition for resisting parasitic disease contains tert-butoxycarbonyl dihydroartemisine with therapeutic effective dose and pharmaceutically-acceptable carrier. Said invented product is high in therapeutical effect and low in toxicity, can be used for preventing and curing the parasitic diseases of schistosomiasis and malaria, etc.

The invention discloses cefotetan disodium and a preparation method of an intermediate of cefotetan disodium. Commercially-available raw materials, namely, 4-(1-amino-3-tert-butoxy-1,3-dioxo-2-alkenyl)-1,3-dithietane-2-carboxylic acid (2) and 7-MAC (3) are subjected to a condensation reaction to obtain a compound (4), and then the compound (4) is subjected to deprotection and salification to obtain cefotetan disodium (1). The invention further provides a preparation method of the compound (2). In the route, no chloride agent contaminating the environment in a conventional route is used, and the preparation method has the advantages of being simple in process route and environmentally friendly, lowering the process cost and increasing the total product yield and is suitable for industrial production.

Example embodiments of the present invention relate to a method of forming a dielectric thin film and a method of fabricating a semiconductor memory device having the same. Other example embodiments of the present invention relate to a method of forming a ZrO₂ thin film and a method of fabricating a capacitor of a semiconductor memory device using the ZrO₂ thin film as a dielectric layer. A method of forming a ZrO₂ thin film may include supplying a zirconium precursor on a substrate maintained at a desired temperature, thereby forming a chemisorption layer of the precursor on the substrate. The zirconium precursor may be a tris(N-ethyl-N-methylamino)(tert-butoxy) zirconium precursor. The substrate having the chemisorption layer of the precursor may be exposed to the plasma atmosphere of oxygen-containing gas for a desired time, thereby forming a Zr oxide layer on the substrate, and a method of fabricating a capacitor of a semiconductor memory device having the ZrO₂ thin film.

The invention discloses an M20 methanol gasoline power performance improver which is prepared by mixing 18.0-31.0 percent of 1,1-dimethyl cyclopentane, 15.0-29.5 percent of 4-trifluorometoxybenzene methanol, 15.0-24.5 percent of bi(diethylamine) phenyl phosphine, 13.0-24.0 percent of 3-amino-N-methyl benzylamine, 10.0-20.5 percent of tert-butoxy bi(dimethylamino) methanol and 9.0-19.5 percent of 2-acetyl benzofuran at normal temperature. Additives adopted by the M20 methanol gasoline power performance improver have a remarkable effect on improvement of the engine power of M20 methanol gasoline, and the common M20 methanol gasoline is added with 0.3-1.0 percent of the additives, and thus the power performance like acceleration is obviously better than that of the same model number of common methanol gasoline.

The present invention relates to an arbekacin synthesis method. According to the arbekacin synthesis method, di-tert-butyl dicarbonate is adopted as a protection agent, tert-butyloxycarbonyl protection is performed on three amino groups on the sites C3, C2' and C6' of 3',4'-dideoxy-3',4' didehydro-kanamycin B, difference between the remaining free amino groups on the site 1 and the site 3' is adopted to directly and selectively introduce the side chain on the amino group on the site 1, the amino-protected 1-tert-butoxy amide-3-hydroxybutyric acid is directly adopted as an acylation reagent of the amino group on the site 1, and hydrolysis with an acid is adopted to remove the tert-butyloxycarbonyl protection. According to the present invention, the operations of the method are simple, the reaction condition and the protection group removing condition are mild, the separation purification of the product obtained from the reaction is easy compared with the separation purification of the product obtained by adopting other types of the amino acid protection agents, the one-pot reaction is adopted, the concurrent deprotection is adopted, the product yield is high, the production cost is reduced, the industrial production is easily achieved, and hydrazine hydrate and other hazardous compounds are not used so as to provide the advantages of low environment pollution.

The invention discloses a method for preparing a semaglutide side chain. The preparation method comprises the following steps: protecting amino of an initial raw material 2-(2-aminoethoxy) ethanol byusing R1; then carrying out nucleophilic substitution reaction with alpha halogenated ester to prolong a carbon chain; preparing an aliphatic chain with two protected ends by a one-pot method; removing a protecting group at one end of each aliphatic chain and condensing to obtain a compound 7; removing the R1 protecting group to obtain a compound 8, performing condensation reaction on the compound8 and fluorenylmethoxycarbonyl-L-glutamic acid 1-tert-butyl ester to obtain a compound 10, removing the fluorenylmethoxycarbonyl, performing amidation condensation reaction on the compound 10 and 18-(tert-butoxy)-18-oxooctadecanoic acid to obtain a compound 13, and removing the R2 protecting group to obtain a target product chain 1. Compared with solid-phase synthesis, the method disclosed by theinvention is lower in cost and wider in selection of protecting groups, and has industrial production and application prospects.

The invention discloses an anti-tumor medicine conjugate, a preparation method, nano-micelle preparation thereof and application. The structural formula of the conjugate provided by the invention is represented by the formula (I), and the conjugate is formed by connecting 7-ethyl-10-hydroxy camptothecin with a paclitaxel anti-tumor medicine through a connection bond, wherein L is the connection bond, R1 is phenyl or tert-butoxy, R2 is acetyl, H or methyl, and R3 is H or methyl. The steps are simple, the preparation cost is low, the stability is high, and the safety is high; the requirement on clinical medication is met; the anti-tumor medicine conjugate is suitable for large-scale industrial production. The invention further discloses nano-micelle consisting of the anti-tumor medicine conjugate represented by the formula (I) and an amphiphilic polymer and application of the nano-micelle in tumor resistance; an in-vitro test shows that the nano-micelle is good in tumor resisting effect and has relatively high market prospect and value.

The invention discloses an entecavir derivative and a preparation method thereof. The chemical name of the entecavir derivative is 2-amino-9-[(1S, 3R, 4S)-4-hydroxy-2-methylene cyclopentyl]-1,9-dihydro-6H-purine-6-one-3-methyl hydroxyl-L-valine ester, namely valerian entecavir for short. The preparation method comprises the following steps: reacting 0.5-5 equivalent of (S)-2-(tert-butoxy carbonyl-amino)-3-methylbutyric acid, 0.5-5 equivalent of dicyclohexyl carbodiimide, and 0.01-0.5 equivalent of 4-dimethylamino-pyridine with 0.5-5 equivalent of entecavir in dimethylformamide for 0.5-240 hours; separating and purifying by silica gel column chromatography after reaction, and then deprotecting to obtain a target product. The valerian entecavir prepared by the method has the advantages of being good in water solubility and targeting property, and low in toxicity on other organs, can achieve high liver distribution, and is a stable prodrug of the entecavir.

The invention discloses tert-butoxy ethyl dithiocarbonate and a preparation method and application thereof, wherein the preparation method comprises the following steps of: using 2-tert-butoxy ethanol, carbon disulfide and caustic alkali as raw materials, reacting for 0.5-6 hours at a reaction temperature of 0-70 DEG C to generate the tert-butoxy ethyl dithiocarbonate; the preparation method has the advantages of wide raw material source, low cost, simple operation, no waste water generation, high product yield and easy achievement of industrial production. As a collecting agent, the tert-butoxy ethyl dithiocarbonate has stronger collecitng capacity and selectivity for sulfide minerals such as copper sulfide, lead-zinc mineral, nickel sulfide mineral, copper molybdenum mineral and the like.