33 results about "Polylactic acid polymer" patented technology

The invention discloses a preparation method of a curing agent with biological self-healing capability, which comprises the following steps: preparing a bacillus pasteurii bacterial solution, preparing the bacillus pasteurii bacterial solution into an endophytic spore solution, immersing polyvinyl alcohol fibers into a sodium alginate / endophytic spore solution, taking out the polyvinyl alcohol fibers, immediately immersing the polyvinyl alcohol fibers into a calcium acetate solution, drying the polyvinyl alcohol fibers to obtain core fibers with a hydrogel coating, and curing the core fibers with the hydrogel coating to obtain the curing agent with biological self-healing capability. The preparation method comprises the following steps: taking magnesium phosphate cement as a raw material, immediately immersing the magnesium phosphate cement into a chloroform solution of a polystyrene and polylactic acid polymer blend, drying to obtain a coated microbial liquid, premixing urea and glucose, doping the premixed urea and glucose into the magnesium phosphate cement, uniformly stirring, adding the coated microbial liquid, and uniformly stirring to obtain the product. According to the invention, phosphate cement is adopted as the curing agent, has the advantages of high strength, short setting time, strong durability, low alkalinity, good biocompatibility and the like, and compared with the curing agent in the prior art, the curing agent not only has a good curing effect, but also has a crack self-healing function, and is especially suitable for reinforcing foundation soil.

The present application relates to degradable extrusion webs, composites and polymer blend compositions thereof, and uses thereof. A degradable extruded web includes a plurality of interconnected strands, at least a portion of the strands being made from a polymer blend comprising a polylactic acid polymer composition, a polybutylene succinate, and a degradation additive comprising a degradation agent in a carrier resin. The present disclosure also relates to turf and methods of making turf using such degradable extrusion webs.

This disclosure relates to crystalline forms of 3-acyl-buprenorphine derivatives and sustained release injectable pharmaceutical compositions for treatment of opioid dependence, pain or depression, including an aqueous suspension of crystalline 3-acyl-buprenoprhine, or a pharmaceutically acceptable salt thereof, wherein the composition does not include an organic solvent, a polylactide polymer, a polyglycolide polymer, or a copolymer of polylactide and polyglycolide. This disclosure also includes 3-acyl-buprenoprhine or a pharmaceutically acceptable salt thereof prepared in a controlled release matrix, including poly(lactide-co-glycolide), sucrose acetoisobutyrate, lecithin, diolein and a combination of two or more thereof.

The application discloses a lactic acid polymerization process based on neural network prediction, and relates to prediction of lactic acid polymerization conditions. The process adopts a superimposed shadow sampling uniform design method, controls lactic acid polymerization reaction time, catalyst content and reaction temperature, obtains lactic acid polymers with different molecular weights, and trains and predicts a neural network by using obtained test data. The predicted data is in good agreement with the test data. The application greatly simplifies the test exploration process, saves test time and cost, and has wide application prospects in the field of biological chemical synthesis.

An article is described comprising a first film layer comprising polylactic acid polymer (semicrystalline polylactic acid polymer; amorphous polylactic acid polymer; or a mixture thereof); a second (e.g. polyvinyl acetate) polymer having a Tg of at least 25° C.; plasticizer. In some embodiment, the film layer further comprises inorganic pigment and / or hydrolysis stabilizer. In other embodiments, the film has a net melting endotherm, ΔHnm1, of less than 10 J / g. Also described are methods of making a graphic film.

The invention provides a resin composition and a molded article thereof. A resin composition according to the present invention contains a graft copolymer (A) and a thermoplastic resin (B) (excluding the graft copolymer (A) and a polylactic acid polymer (D)). ) and a fatty acid compound (C).

The present invention relates to a resin composition comprising a graft copolymer (A), a thermoplastic resin (B) (excluding the graft copolymer (A) and a polylactic acid polymer (D)), and a fatty acid compound (C).

The present invention relates to a resin composition comprising a graft copolymer (A), a thermoplastic resin (B) (excluding the graft copolymer (A) and a polylactic acid polymer (D)), and a fatty acid compound (C).

The present invention provides a nonwoven fabric that is biodegradable and has a good pleat retaining property, and an application thereof. The present invention relates to a nonwoven fabric comprising at least one fiber layer (I) which contains a polylactic acid polymer and which has an average fiber diameter of 10-30 μm, wherein in polarized Raman spectroscopy of the fiber layer (I), the value I / / / I⊥, which is the ratio of the peak intensity I / / at 872 cm−1 of a Raman spectrum measured with polarized light parallel to a fiber axis, to the peak intensity I at 872 cm−1 of a Raman spectrum measured with polarized light perpendicular to the fiber axis, is not more than 1.80. The present invention also relates to a filter material comprising the nonwoven fabric, and a filter for foods, an air filter, and a mask which each comprise the filter material.

The invention provides a poly (butylene succinate) / polylactic acid polymer, which has a structure as shown in the following formula: wherein R1 is alkyl containing 1-3 benzene rings or alkyl containing at least one ester bond; r2 and R3 are respectively and independently selected from alkyl groups of C1-C8; x, m and n are integers not less than 1, and m / (m + n) = 0.0001-0.1. The preparation method comprises the following steps: firstly preparing poly (butylene succinate) with a side group containing a furan substituent and polylactic acid with two ends containing maleimide substituents, and then mixing, melting and extruding the poly (butylene succinate) and the polylactic acid. The polymer has a Diels-Alder bond, and the Diels-Alder bond is subjected to a reverse dissociation reaction at a high temperature, so that the polymer has good repeated processability and degradability, and the problem that a material cannot be repeatedly processed due to permanent crosslinking of a traditional coupling agent is avoided.

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses rasagiline pamoate long-acting sustained-release microspheres and a preparation method thereof, the long-acting sustained-release microspheres comprise rasagiline pamoate and a polylactic acid polymer, and the long-acting sustained-release microspheres have a good sustained-release effect. The preparation method comprises the following steps: firstly, preparing rasagiline into pamoate so as to reduce the solubility of rasagiline; in the preparation process of the long-acting sustained-release microspheres, the drug release rate is regulated and controlled by adjusting the proportion of the low-molecular-weight polylactic acid, the sudden drug release phenomenon is reduced by reducing the curing temperature, and the preparation process is suitable for industrial large-scale production. The finally obtained long-acting sustained-release microsphere composition can be used for preparing a medicine for treating Parkinson's disease.

The invention relates to a process for producing a lactic acid-based polymer, which process comprises copolymerizing lactide with a cyclic dimer of another alpha-hydroxy acid as a copolymerized monomer of opposite alpha-carbon chirality.

The present invention provides a biomedical fully degradable polylactic acid polymer-based composite product and a preparation method thereof. The preparation method comprises mixing 85 to 90 parts of polylactic acid polymer and 5 to 15 parts of polydioxanone by weight, performing pre-melt blending treatment by a single screw extruder, performing secondary pre-melt blending treatment by a twin screw extruder, and then preparing the polylactic acid polymer-based composite product by micro injection molding. The preparation method only uses polylactic acid polymer and polydioxanone, which originally have poor compatibility, as raw materials to prepare the composite product. Without adding a compatibilizer / toughening agent and other additives / fillers, a polylactic acid polymer-based composite micro-product having fully degradable characteristics and taking into account mechanical properties and biocompatibility can be prepared.

Degradable extruded nettings are provided. Degradable extruded nettings may include a plurality of interconnected strands, at least some of the strands being made from a polymeric blend, the polymeric blend including a polylactic acid polymer composition, polybutylene succinate, and a degradation additive, the degradation additive including a degrader in a carrier resin are provided. Grass sod and methods for preparing grass sod using such degradable extruded nettings are also provided.

The application provides a composite microsphere preparation method for medical cosmetic injection fillers, and belongs to the technical field of chemical treatment methods.The application comprises the following steps: preparing an oil phase by mixing polylactic acid polymers and inorganic particles; preparing a polyvinyl alcohol or Tween 80 surfactant aqueous solution as a water phase; performing shearing emulsification in a supergravity equipment to form a solid-in-oil-in-water emulsion; promoting the volatilization of an organic solvent by mechanical stirring at room temperature; removing residues by centrifugal washing; obtaining the composite microspheres by freeze-drying; determining and evaluating the particle size distribution; mixing the composite microspheres with cross-linked sodium hyaluronate gel to prepare injection fillers; and evaluating the biocompatibility and collagen regeneration efficiency, and optimizing the formula according to the evaluation results. The technical problem of poor preparation stability of the composite microspheres in the medical cosmetic injection fillers is solved, and finally, the medical cosmetic injection fillers with high consistency between batches and good preparation stability are obtained.

Degradable extruded nettings include a plurality of interconnected strands, at least some of the strands being made from a polymeric blend, the polymeric blend including polylactic acid polymer composition, polybutylene adipate terephthalate polymer composition, polylactic acid-polybutylene compatibilizer, and a degradation additive, the degradation additive including a degrader in a carrier resin.

A process for the production of a nonwoven fabric. In particular, it relates to the production of a nonwoven fabric having desirable tactile and haptic as well as mechanical properties, as well as to the nonwoven fabric itself. The process requires the selection of specific polylactic acid polymers and corresponding process conditions.

The invention concerns an article comprising a flame retardant polylactic acid polymer composition which comprises, (i) a polylactic acid polymer substrate; (ii) an effective flame retarding amount of at least one sterically hindered amine; and (iii) an effective flame retarding amount of a phosphorus compound selected from at least one of phosphinate, phosphonate, and alkali metal hypophosphite, wherein the at least one sterically hindered amine is a sterically hindered amine ether or sterically hindered amine ester, and wherein the article is - a film having a thickness of up to 5 mm or - a fibre having a diameter of up to 200 µm or a tape having a thickness of up to 5 mm. In addition, the invention also includes a method of producing the article comprising a flame- retardant lactic acid and the use of the sterically hindered amine ether or sterically hindered amine ester in conjunction with the phosphorus compound for increasing the flame retardancy of the said article.

The invention discloses a multi-arm polymer coupled prodrug, a nano-micelle thereof, a preparation method and application, a hydrophobic drug is structurally modified by multi-arm polylactic acid to construct a prodrug, and a multi-arm polylactic acid prodrug is prepared. Specifically, the multi-arm polylactic acid is prepared by taking small molecules with different hydroxyl numbers as initiators and carrying out ring-opening polymerization reaction on the initiators and lactide; the multi-arm type polymer coupling prodrug is formed by performing carboxyl modification on multi-arm type polylactic acid through succinic anhydride and then performing esterification reaction on the multi-arm type polylactic acid and hydroxyl of a hydrophobic drug. Compared with a traditional single-arm polylactic acid polymer prodrug, the multi-arm polylactic acid prodrug has the unique space structure advantage, the encapsulation efficiency, the drug loading capacity and the stability of polymer nano-micelles are remarkably improved, and the multi-arm polylactic acid prodrug has the advantages of high permeability and the retention effect and high bioavailability. The enrichment of the polymer nano-micelle at a tumor part is effectively improved; and the systematic toxic and side effects of the polymer nano-micelle are reduced.

An article is described comprising a first film layer comprising polylactic acid polymer (semicrystalline polylactic acid polymer; amorphous polylactic acid polymer; or a mixture thereof); a second (e.g. polyvinyl acetate) polymer having a Tg of at least 25° C.; plasticizer. In some embodiment, the film layer further comprises inorganic pigment and / or hydrolysis stabilizer. In other embodiments, the film has a net melting endotherm, ΔHnm1, of less than 10 J / g. Also described are methods of making a graphic film.

The present invention discloses a method for preparing a curing agent with biological self-healing ability, which comprises the following steps: first preparing a bacillus pasteurianus liquid, then preparing an endospore solution, then immersing a polyvinyl alcohol fiber in a sodium alginate / endospore solution, taking it out and immediately immersing it in a calcium acetate solution, drying it, obtaining a core fiber with a hydrogel coating, immediately immersing it in a chloroform solution of a polystyrene and polylactic acid polymer blend, drying it, obtaining a coated microbial liquid, pre-mixing urea and glucose, adding them to magnesium phosphate cement, stirring them evenly, then adding the coated microbial liquid, stirring them evenly, and obtaining the product. The present invention adopts phosphate cement as a curing agent, which has the advantages of high strength, short setting time, strong durability, low alkalinity, good biocompatibility, etc. Compared with the curing agent in the prior art, the curing agent not only has a good curing effect, but also has a crack self-healing function, and is particularly suitable for reinforcing foundation soil.

The present disclosure relates to a method of preparing a polylactic acid polymer, and more particularly, to a method of preparing a polylactic acid polymer having a desired high molecular weight by using a specific catalyst in a lactide ring-opening polymerization reaction.

Disclosed herein are polylactic acid polymer blend compositions and methods of making and using such compositions.

The invention discloses a method for continuously synthesizing high-molecular-weight polylactic acid through a melt polycondensation method under a low vacuum degree, and belongs to the field of polylactic acid. The method comprises the following specific experimental steps: (1) preparing a lactic acid oligomer, namely dehydrating a lactic acid raw material at the temperature of 100-170 DEG C, and reacting for 5-9 hours to obtain the lactic acid oligomer; (2) melt polycondensation: under the protection of N2, at the temperature of 160-200 DEG C and under relatively low vacuum, reacting the lactic acid oligomer with binary acid, and carrying out carboxyl end capping on the lactic acid oligomer; and (3) carrying out chain extension reaction on the carboxyl-terminated lactic acid polymer and epoxy resin at 160-200 DEG C under 200-600 Pa for 1-6 hours to obtain the high-molecular-weight polylactic acid. The method for preparing the polylactic acid is simple in process, low in cost, few in side reaction, short in polymerization time, high in yield, mild in synthesis mode and easy for large-scale industrialization, the molecular weight of the obtained polylactic acid is 90000-2400000, and the material can be applied to the field of biodegradable mulching films.

Provided is a laminate containing a polylactic acid polymer, which is excellent in durability and elongation properties. The laminate includes a first resin layer and a second resin layer. The first resin layer contains a polylactic acid polymer, a (meth)acrylic block copolymer, and a plasticizer. A content of the plasticizer is about 1 mass% or more and less than about 10 mass%. The second resin layer contains at least one selected from the group consisting of a (meth)acrylic resin, a resin having a urethane bond, and a vinyl chloride-vinyl acetate copolymer resin. The laminate has a portion to which the first resin layer and the second resin layer are directly applied.

The invention relates to the field of high polymer materials, and discloses a lactic acid polymer three-dimensional fiber membrane as well as a preparation method and application thereof. The fiber membrane has a diffraction peak when 2theta is equal to 11-13 degrees through XRD (X-Ray Diffraction) measurement, the half-peak width of the diffraction peak is 0.5-1.5 degrees, and the diffraction peak belongs to a stereocomplex crystal (110) SC. The three-dimensional fiber membrane has a three-dimensional composite structure and can regulate and control molecular chain conformation, so that the lactic acid copolymer three-dimensional composite fiber membrane has excellent biodegradability and also has excellent piezoelectric property and mechanical property.

A branched polylactic acid polymer that has improved rheological properties, and a method for preparing same, and provides a branched polylactic acid polymer including a derived unit from a polylactic acid polymer, having an average number of long-chain branches per molecule of 3-10, and having a mass flow rate of 1-20 g / 10 min measured at 190° C. and a load of 2.16 kg in accordance with ASTM D1238 conditions.

The invention discloses a polylactic acid-based material and a preparation method thereof, and belongs to the technical field of controllable degradable bio-based materials. The polylactic acid-based material comprises a polylactic acid polymer, polypeptide and polyethylene glycol ketal, polypeptide is embedded into a main chain of a polylactic acid polymer, and polyethylene glycol ketal and a molecular chain of the polylactic acid polymer form crosslinking and end capping through hydrogen-bond interaction. The polylactic acid-based material is applied to the aspects of short-term, medium-term and long-term use products such as food packaging, 3D printing and electronic appliances, the problem that an existing polyester material cannot keep stable and controllably degraded in the use period at the same time is solved, the polylactic acid-based material can keep stable in the use period, and degradation can be selectively accelerated or slowed down in different environments after the polylactic acid-based material is abandoned.

The present invention discloses a cellulose-grafted polyisoprene-block-polylactic acid copolymer thermoplastic elastomer and a preparation method thereof. Under the condition of a catalyst, cellulose and lactide are reacted in solvent A to obtain modified cellulose; the modified cellulose is dissolved in solvent A and reacted with carbon disulfide and 2-bromoethanol to obtain a cellulose macromolecular chain transfer agent; under the conditions of solvent B and a catalyst, the cellulose macromolecular chain transfer agent and lactide monomer are subjected to a ring-opening reaction to obtain a cellulose-grafted polylactic acid polymer; under the conditions of solvent C and an initiator, the cellulose-grafted polylactic acid and isoprene monomer are subjected to a reversible addition-fragmentation chain transfer radical polymerization reaction to obtain a cellulose-grafted polyisoprene-block-polylactic acid copolymer thermoplastic elastomer. The cellulose-grafted polyisoprene-block-polylactic acid copolymer thermoplastic elastomer in the present invention has excellent mechanical properties.

The present application relates to the field of new polymer materials, and specifically discloses a degradable expandable polylactic acid polymer foam material and a preparation method thereof, comprising the following raw materials: a polylactic acid-starch-polyamide blended modified mixture, polylactic acid foam material waste scraps, a foaming agent, a nucleating agent, and an activator; the preparation method comprises the following steps: melt-mixing polylactic acid, acylated starch, and polyamide in proportion to obtain a polylactic acid-starch-polyamide blended modified mixture, weighing the polylactic acid-starch-polyamide blended modified mixture, the polylactic acid foam material waste scraps, a foaming agent, a nucleating agent, and an activator, mixing them, extruding and pelletizing to obtain a foaming masterbatch, and foaming and molding; the present application has the characteristics of improving the expandability of the polylactic acid material, and obtaining a polylactic acid foam material with a more uniform pore size distribution, a small pore size, and excellent mechanical properties.