The invention discloses a multi-arm
polymer coupled
prodrug, a nano-
micelle thereof, a preparation method and application, a
hydrophobic drug is structurally modified by multi-arm
polylactic acid to construct a
prodrug, and a multi-arm
polylactic acid prodrug is prepared. Specifically, the multi-arm
polylactic acid is prepared by taking small molecules with different hydroxyl numbers as initiators and carrying out ring-opening
polymerization reaction on the initiators and
lactide; the multi-arm type
polymer coupling prodrug is formed by performing carboxyl modification on multi-arm type polylactic acid through
succinic anhydride and then performing
esterification reaction on the multi-arm type polylactic acid and hydroxyl of a
hydrophobic drug. Compared with a traditional single-arm
polylactic acid polymer prodrug, the multi-arm polylactic acid prodrug has the unique space structure
advantage, the encapsulation efficiency, the
drug loading capacity and the stability of
polymer nano-micelles are remarkably improved, and the multi-arm polylactic acid prodrug has the advantages of high permeability and the retention effect and high
bioavailability. The enrichment of the polymer nano-
micelle at a tumor part is effectively improved; and the systematic toxic and side effects of the polymer nano-
micelle are reduced.