Sitagliptin impurity and preparation and detection method thereof

A technology for sitagliptin impurities and impurities, which is applied in the field of sitagliptin impurities and preparation, and achieves the effects of mild reaction conditions, guaranteed safety and reliability, and simple operation.
CN106478637AActive Publication Date: 2017-03-08NANJING CHIA TAI TIANQING PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANJING CHIA TAI TIANQING PHARMA
Publication Date
2017-03-08

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Abstract

The present invention provides sitagliptin impurity compound I and a preparation method and application thereof in the quality control study of sitagliptin. The sitagliptin impurity compound I is as follows: (R)-3-amino-N-[(R)-4-oxy-4-(3-(trifluoromethyl)-5, 6-dihydro-[1, 2, 4] triazole[ 4, 3-a] pyrazine-7(8H)-yl)-1-(2, 4, 5-trifluorophenyl) butyl-2-yl)-4-(2, 4, 5-trifluorophenyl) butyramide.
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Description

technical field

[0001] The invention relates to the field of medicine and chemical industry, in particular to an impurity of sitagliptin, a preparation method and a detection method thereof. Background technique

[0002] Diabetes is a series of diseases such as sugar, protein, fat, water and electrolyte caused by genetic factors, immune dysfunction, microbial infection and its toxins, free radical toxins, mental factors and other pathogenic factors acting on the body to cause hypofunction of pancreatic islets. Metabolic disorder syndrome is clinically characterized by hyperglycemia. In typical cases, symptoms such as polyuria, polydipsia, polyphagia, and weight loss may occur, namely "three excesses and one deficiency".

[0003] Sitagliptin Phosphate, the chemical name is 7-[(3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6, 7,8-Tetrahydro-3-trifluoromethyl-1,2,4-triazolo[4,3-a]pyrazine phosphate monohydrate, an oral antihyperglycemic agent for DPP-IV inhibitors The d...

Claims

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