Isotope psychoactive substance labeled compound and preparation method and application thereof

A technology of active substances and compounds, which is applied in the field of preparation and application of reference substances of psychoactive substances, and can solve the problems of low detection accuracy and sensitivity of psychoactive substances
CN113321701APending Publication Date: 2021-08-31无锡诺平医药科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
无锡诺平医药科技有限公司
Publication Date
2021-08-31

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Abstract

The invention discloses an isotope psychoactive substance labeled compound and a preparation method and application thereof. The isotope psychoactive substance labeled compound can be used for an internal standard for measuring the content of a psychoactive substance 2-(1-(5-fluoropentyl)-indole-3-amide)-3,3-dimethyl methyl butyrate in a hair sample. 2-(1-(5-fluoropentyl)-indole-3-amide)-3,3-dimethyl methyl butyrate is subjected to qualitative detection according to the retention time and ion pair matching, and specifically, corresponding compounds are subjected to quantitative detection according to the chromatographic peak area of the 2-(1-(5-fluoropentyl)-indole-3-amide)-3,3-dimethyl methyl butyrate. When the isotope labeled compound is used as the internal standard substance, the matrix effect of a detected material can be reduced, and the isotope psychoactive substance labeled compound has a good application prospect in the aspects of judicial expertise and the like.
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Description

technical field

[0001] The invention belongs to the technical field of preparation and application of psychoactive substance standard substances, and specifically relates to an isotope

[0002] Labeled compound of prime psychoactive substance and its preparation method and use. Background technique

[0003] For the detection of trace and trace substances in test materials, liquid chromatography-mass spectrometry combined with isotope labeling

[0004] Isotope dilution mass spectrometry of quasi-substance internal standard is the most common and efficient detection method. isotopically labeled

[0005] The standard substance is used as an internal standard, and the isotope-labeled internal standard and the compound to be tested have complete chemical properties except molecular weight.

[0006] All consistent, therefore, isotope dilution mass spectrometry can achieve high detection accuracy and sensitivity, is a trace

[0007] Indispensable tool for accurate detection of ...

Claims

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