Matrix standard correction-gas chromatography-mass spectrum combination assay method for 12 types of phthalic acid ester in hot melt adhesive

Abstract

The invention discloses a matrix standard correction-gas chromatography-mass spectrum combination assay method for 12 types of phthalic acid ester in a hot melt adhesive. The method is characterized by comprising the following steps: cutting a hot melt adhesive sample into pieces by use of scissors, putting into n-hexane, extracting under ultrasonic wave, treating a liquid supernatant through centrifugation-dispersion solid-phase extraction and purification, and subsequently quantitatively detecting the content of the 12 types of phthalic acid ester in the hot melt adhesive by adopting an internal standard method by use of a matrix standard correction-gas chromatography-mass spectrometry (GC/MS). The method has the advantages of simplicity, convenience, rapidness, high sensitivity and good repeatability; the detection limit is 0.3-16.0 mg/kg, the limit of quantitation is 0.8-48.0 mg/kg, the average adding standard recovery is 92.13%-103.13%, and the mean relative deviation (RSD) is 3.84%-13.74%.

Description

[0001] Technical field [0002] The present invention involves the method of measurement method of hot melting glue chemical composition, which specifically involves the test method of the base standard correction of 12 types of phenyl acid ester in a hot melting glue-Qi phase chromatography-mass spectrometry combined method. [0003] Background technique [0004] Diabenate (PAES) is commonly used in toys, food packaging materials, ethylene flooring, wallpaper, cleaner, lubricant, and personal care products (Anal BioanalChem, 2003, 375: 527 ~ 533.).PAES is a type of endocrine interference hormone that can cause cell mutations, cancer and teratogenic. It is confirmed in the study of in vitro toxic science to have the effect of weak estrogen, which can cause damage to the male reproductive systemA series of male reproductive toxicity such as reducing and genital malformations, and increasing the incidence of female breast cancer (Environment. Health. Perspect., 2003, 111 (2): 139 ~...

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Problems solved by technology

[0005] Hot-melt adhesives are widely used in the fields of wood and paper material binding, vehicles, ships, and building interior decoration, and there is a po

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