30results about How to "Reduce matrix effect" patented technology

The invention provides a method for simultaneously detecting perfluorinated compounds in mouse tissues and organs, and belongs to the technical field of analysis and detection. The method provided by the invention comprises the following steps: mixing a mouse visceral organ tissue sample, an alkaline buffer solution and an internal standard solution, and homogenizing to obtain homogenate; mixing the homogenate with tetrabutylammonium hydrogen sulfate and methyl tert-butyl ether, and carrying out liquid-liquid extraction to obtain extract liquor; and sequentially drying and redissolving the extract liquor, and carrying out ultra-high performance liquid chromatography-tandem mass spectrometry analysis to obtain a result of the perfluorinated compound in the mouse tissue visceral organs. The result of the embodiment shows that the adding standard recovery rate of 14 target objects in the method provided by the invention is 64.9%-120.3%, the RSD of 6 repeated tests is 1.0%-14.0%, the matrix effect of the target objects is 83.7%-134.0%, and the matrix effect is relatively low; and the detection result has excellent accuracy and reproducibility.

The invention relates to the field of environmental chemistry and biological sample analysis, in particular to an analysis method for detecting oxidative stress biomarkers in urine. The analysis method capable of simultaneously detecting dityrosine, 8-hydroxyguanosine, 8-hydroxydeoxyguanosine and 4-hydroxynonenal mercaptouric acid in human urine is provided on the basis of liquid chromatography-tandem mass spectrometry, effective purification of a urine sample is achieved through specific pretreatment, the matrix effect is reduced, and the detection sensitivity is improved. And specific liquid chromatogram parameter conditions are combined, so that simultaneous detection of the four oxidative stress biomarkers is realized. The method is good in selectivity, high in sensitivity and high in detection speed, the problem that polar and non-polar components cannot be measured at the same time at present is solved, the contained oxidative stress biomarkers are more comprehensive and more reasonable, and the oxidative stress damage condition of the organism can be better reflected.

The invention relates to the field of medical detection, in particular to a mass spectrometric detection method for enriching serum human insulin by using specific antibody immunomagnetic beads. According to the present invention, the human insulin in the serum is subjected to immune enrichment by using the magnetic beads coated with the insulin specific antibody, and the concentration level of the human insulin in the serum is accurately determined based on the accurate quantification technology of the isotope dilution liquid chromatography-tandem mass spectrometry platform in combination with the bracket method quantification mode. The pretreatment method provided by the invention is simple and convenient to operate, the absolute recovery rate is excellent, the sensitivity requirement is met, and the mass spectrometry method is an isotope diluent liquid chromatography-tandem mass spectrometry method capable of eliminating interference of structural analogues.

The invention relates to the technical field of chemical analysis, in particular to a chemical analysis method for rapidly measuring niobium and tantalum elements in high-tin ore, which comprises the following steps: preparing a to-be-measured sample melt: weighing a high-tin ore sample, and putting the high-tin ore sample into a corundum crucible containing sodium peroxide for pretreatment to obtain the melt; preparing a to-be-detected sample liquid; adding concentrated hydrofluoric acid and concentrated hydrochloric acid into the melt for acidification; the hydrofluoric acid with high complexing property is selected to replace tartaric acid to serve as a stable complexing agent of niobium and tantalum, the hydrochloric acid acidizes the alkali melt, the nitric acid serves as an oxidizing agent, and a large amount of tin element is removed according to the fact that the hydrochloric acid reacts with tin ions to generate metastannic acid precipitate. The niobium and the tantalum in the high-content tin ore are separated from a large number of tin matrixes, the test accuracy is guaranteed, the influence of the high-content tin matrix effect is avoided, the niobium and the tantalum in the high-content tin ore can be rapidly and efficiently measured, and the method has the advantages of being good in separation effect, high in recovery rate, good in precision and the like.

The invention relates to a fluorine-based three-dimensional covalent organic framework material as well as a preparation method and application thereof, and belongs to the technical field of covalent organic framework materials. Under the action of a catalyst, a first monomer (the first monomer is selected from a regular tetrahedron-containing amino monomer or a regular tetrahedron-containing aldehyde group monomer) and a second monomer (the second monomer is selected from a fluorine-containing aldehyde group monomer or a fluorine-containing amino monomer) are subjected to a condensation reaction in an organic solvent to obtain the fluorine-based three-dimensional covalent organic framework material. The method comprises the following steps of: preparing a solid-phase microextraction probe by taking the perfluorinated compound as an adsorbent through in-situ growth on the surface of a probe matrix, and then combining the solid-phase microextraction probe with an open-type mass spectrum to detect trace perfluorinated compounds in a complex matrix. The fluorine-based three-dimensional covalent organic framework material disclosed by the invention is good in chemical stability and high in hydrophobicity, has a good adsorption effect on perfluorinated compounds, and is high in repeated utilization rate.

The invention relates to the technical field of biological detection, in particular to a kit and method for detecting NfL, the kit comprises a magnetic bead coated with a capture antibody, a non-functional auxiliary magnetic bead, an NfL detection antibody coupled with a first marker, beta-galactosidase coupled with a second marker, an enzyme reaction luminescent substrate and an NfL standard substance; the capture antibody in the magnetic bead coated with the capture antibody is used for being specifically combined with an NfL antigen; the first marker in the NfL detection antibody coupled with the first marker is connected with the second marker in the beta-galactosidase coupled with the second marker, and the NfL detection antibody is suitable for being specifically combined with an NfL antigen. The kit provided by the invention has the advantages of higher sensitivity, less background signal interference, wider linear range, convenience for full-automatic detection instruments and the like.

The invention belongs to the technical field of spectral analysis, and particularly relates to an XRF (X-Ray Fluorescence) testing method for measuring all components in coal ash and coal gangue extracts-Al / Si oxides, and the testing method comprises the following steps: S1, preparing a standard sample; s2, preparing a standard sample wafer; s3, measuring a standard sample wafer; s4, establishing an application method; and S5, testing the to-be-tested sample. According to the present invention, the Al / Si oxide component test application method is developed and established by using the XRF fluorescence spectrometer, and the application method completely meets the component analysis of various products in the existing fly ash and coal gangue extract-Al / Si oxide production process, and has characteristics of simple operation, accuracy, excellent accuracy and excellent precision, and great feasibility is reserved for the test range of a subsequent extension method.

The invention relates to the field of detection, in particular to a method for determining the residual quantity of methoprene and methoprene in citrus through pre-column derivatization liquid chromatography-tandem mass spectrometry, and the method comprises the following steps: S1, preparation of a standard sample and a to-be-detected sample: S11, preparation of the standard sample, and S12, preparation of the to-be-detected sample; s2, preparation and derivation of a standard sample solution and a to-be-detected sample solution: S21, extraction, S22, purification and S23, derivation; s3, measuring; s4, establishing a linear equation; and S5, analyzing the sample to be detected. The technical problems that in the prior art, the ionization efficiency of methoprene and methoprene in the electrospray process is low due to the non-polar property of methoprene and methoprene, and electrospray ionization tandem mass spectrometry detection of methoprene and methoprene lacks the sensitivity required by trace analysis can be solved. The detection sensitivity of methoprene and methoprene in citrus fruits can be obviously improved.

This invention discloses a method for determining the content of Ophiopogonin C and Ophiopogonin D in Shengmai Yin soft capsules. The method involves simultaneous determination of the content of Ophiopogonin C and Ophiopogonin D in Shengmai Yin soft capsules using UPLC-MS / MS. An Agilent C18 column is used, with the mobile phase being a mixture of an aqueous solution containing 0.05% formic acid and 2 mmol / L ammonium acetate: acetonitrile-methanol (40:60, V / V) (30:70), at a flow rate of 0.3 mL / min. ESI-mode is used, with MRM monitoring of ion pairs. The test sample is prepared by reflux of 80% methanol for 15 min. This method is highly specific, sensitive, rapid, and accurate, effectively controlling the quality of Shengmai Yin soft capsules and filling the gap in the original standard for the quantitative determination of Ophiopogonin C and Ophiopogonin D.

The invention provides a method and a kit for detecting blood concentration of compound sulfamethoxazole and metabolite thereof. According to the method, a methanol precipitator is combined with Oasis PRiME HLB reversed-phase solid-phase extraction, the centrifugal process of plasma treatment is reduced, traditional activation and balance steps are omitted, time is saved, meanwhile, the method is more environmentally friendly, and the extraction recovery rate of a to-be-detected substance can be improved; gradient elution is replaced by isocratic elution, the balance returning time is avoided, the overall operation time is shorter, the separation application is not influenced, the operation time is only 6 minutes, all the to-be-measured substances can be accurately and simultaneously measured only by 1 microliter, and the peak appearance time is 2 minutes. According to the invention, trimethoprim, sulfamethoxazole and metabolites thereof sulfamethoxazole-N-acetyl and 4-nitro sulfamethoxazole in human plasma can be monitored at the same time by using a treatment method and a computer method.

The invention belongs to the field of analytical chemistry, and provides a method for simultaneously determining 10 tryptophan metabolites through liquid chromatography-mass spectrometry, differentiated pretreatment schemes are designed aiming at different biological matrixes such as excrement, serum, colon tissue and NCM460 inflammatory cells through a liquid chromatography-tandem mass spectrometry technology, matrix interference is effectively eliminated, and the method for simultaneously determining 10 tryptophan metabolites through liquid chromatography-mass spectrometry is provided. A quantitative analysis method with high sensitivity and high selectivity is established; the method is successfully applied to an ulcerative colitis (UC) rat model and a lipopolysaccharide (LPS)-induced NCM460 inflammation model, and a technical means is provided for revealing a metabolic regulation mechanism of medicine intervention on UC; the method solves the technical problem that various metabolites in a tryptophan metabolic pathway are difficult to detect in the prior art, is suitable for metabolic mechanism research, drug intervention effect evaluation and large-scale detection of clinical samples of inflammatory bowel diseases such as UC, and provides a technical basis for systematic research of a tryptophan metabolic network.

The invention belongs to the technical field of magnetic solid-phase extraction and analysis. The invention provides a method for quantitatively detecting bisphenol pollutants in traditional Chinese medicines for soil and roots based on a magnetic MOF (at) COF porous composite material combined with LC-MSMS. The method comprises the steps of preparation of the magnetic MOF (at) COF porous composite material, sample pretreatment and LC-MSMS detection and quantitative analysis. The magnetic MOF (COF) porous composite material disclosed by the invention has rich hierarchical pore structures and high specific surface area, not only retains regular pore channels and active sites of a metal organic framework (MOF), but also is connected with a covalent organic framework (COF), so that the stability of the material is greatly improved. Meanwhile, the material is mild in preparation condition, low in cost and excellent in adsorption performance. Compared with the existing method, the detection method provided by the invention has the advantages of more thorough extraction, lower detection limit, higher recovery rate, simpler operation and lower cost, and is suitable for two matrixes of soil and root system traditional Chinese medicines.

The invention provides a method for detecting Hainanmycin residues in poultry meat, eggs and egg products and a pretreatment method, and belongs to the technical field of food detection. The pretreatment method comprises the following steps: (1) adding a sample to be detected into an extraction solvent for extraction; (2) adding anhydrous magnesium sulfate and sodium chloride; (3) centrifuging to obtain supernate; (4) loading the supernate onto a solid-phase extraction small column, purifying and collecting to obtain first effluent; (5) loading an extraction solvent onto the small solid-phase extraction column, collecting to obtain a second effluent, and combining all the effluent; and (6) concentrating, redissolving and filtering all the effluent to obtain a sample solution to be detected. The invention further discloses a method for detecting Hainanmycin residues through liquid chromatography-mass spectrometry after a sample is pretreated, the method has the advantages of being rapid, efficient, low in detection limit and good in reproducibility, the blank of a method for detecting Hainanmycin in animal-derived food is filled, and the method is suitable for trace detection of Hainanmycin.

The present application belongs to the field of chromatographic packing, discloses an adsorbing packing for purification column and its preparation method and use. A polyethylene oxide and clay composite material, the composite material comprises the following raw materials by weight: inorganic salt modified clay 4000-8000 parts, quaternary ammonium salt compound 50-100 parts, polyethylene oxide 1 part. The present application also provides an adsorbing packing for purification column, which can effectively and selectively adsorb protein, lipid and other impurities in the pretreatment extraction liquid for mycotoxin detection, has a small matrix effect, and has a high absolute recovery rate for several typical mycotoxin target objects.

This invention relates to a method for detecting metal elements in electronic-grade boron-aluminum doped source samples. The method includes microwave digestion of the sample and inductively coupled plasma atomic emission spectrometry (ICP-AES) to detect the metal element content. By optimizing sample pretreatment and instrument detection conditions, this invention achieves high-precision determination of multiple metal elements in electronic-grade boron-aluminum doped sources. The accuracy, precision, and sensitivity of the detection results meet the requirements for ultra-trace detection of semiconductor-grade and photovoltaic-grade boron-aluminum doped sources.

The invention discloses a method for rapidly analyzing tobacco leaf glucose based on a reflection spectrum, which comprises the following steps: S1, extraction: taking a flue-cured tobacco sample in a centrifuge tube, adding ultrapure water, carrying out vortex oscillation at room temperature, standing, taking extract liquor, centrifuging, passing through a water-based filter membrane to obtain extract liquor, and diluting the extract liquor to obtain a to-be-analyzed solution; s2, analysis: selecting a glucose determination method by the test strip-portable reflectometer, after the determination is started, immersing two reaction areas of the glucose test strip into a to-be-analyzed solution, inserting the glucose test strip into an instrument adapter of the reflectometer in the later period of the reaction, enabling the reaction areas to face an instrument display screen, and reading a measured value of glucose concentration from the instrument display screen; s3, calculating: calculating the percentage content of glucose in the flue-cured tobacco according to a formula. The method combines the advantages of the test strip and the portable reflectometer, realizes rapid and accurate determination of the glucose content in the tobacco leaves, and has the advantages of simple operation, low cost and convenient on-site detection compared with the traditional method.

The invention discloses a breast milk analysis method with high coverage rate and non-targeted metabonomics and application thereof, and belongs to the field of detection and analys.The breast milk analysis method comprises the following steps that a milk sample is pretreated, dried and redissolved, UHPLC-QTOF-MS positive and negative ion mode analysis is conducted, and in the UHPLC-QTOF-MS positive and negative ion mode analysis, adopted chromatographic columns comprise a T3 chromatographic column and an HILIC chromatographic column. The analysis method provided by the invention is simple and convenient to operate, can quickly and efficiently treat the breast milk sample, is suitable for high-throughput analysis, and remarkably improves the detection efficiency. Meanwhile, through the step of combining protein precipitation with concentration, the matrix effect is effectively reduced, the detection sensitivity and reproducibility are improved, and the data reliability is ensured.

The invention relates to the technical field of biological products, in particular to a preparation method of a myocardial marker composite quality control substance, which comprises the following steps: firstly, treating serum to prepare a quality control substance matrix liquid, further testing the concentration of myocardial markers in the quality control substance matrix liquid, screening out low-concentration-value human serum and high-concentration-value human serum, and determining the concentration of the myocardial markers in the quality control substance matrix liquid. Selecting a positive myocardial marker pure product to prepare a myocardial marker substance control solution without pure product addition and a myocardial marker substance control solution with pure product addition, synthesizing the corresponding myocardial marker substance control solution, adding disodium hydrogen phosphate dodecahydrate and sodium dihydrogen phosphate dihydrate, adjusting the pH value, sequentially adding corresponding elements, and uniformly mixing to obtain the myocardial marker substance. According to the myocardial marker substance control substance provided by the invention, the matrix effect in different detection methodologies can be effectively reduced; the stability of a detection result can be remarkably improved, and the preparation method has the characteristics of good stability and uniformity, high redissolution speed, low viscosity, small matrix effect and simplicity and convenience in preparation.

The invention discloses a method for detecting aceclodine in a biological sample and application of the aceclodine in pharmacokinetics. The detection method comprises the following steps: taking a biological sample, adding 0.1-10 times of an aqueous solution containing a stabilizer into the biological sample, and uniformly mixing to obtain a biological sample solution; quantitatively transferring the biological sample solution, sequentially adding the internal standard substance working solution and the organic solvent, uniformly mixing in a vortex manner, and centrifuging; quantitatively transferring the obtained supernatant, adding pure water, uniformly mixing by vortex, centrifuging, and taking the supernatant to obtain a biological sample test solution; preparing a series of vinegar clinidine standard test solutions for the standard curve; and performing test analysis on the biological sample test solution and a series of vinegar clinidine standard test solutions for the standard curve by liquid chromatography-tandem mass spectrometry (LC-MS / MS). According to the invention, the method for detecting the aceclodine in the biological sample is applied to the pharmacokinetic research of the aceclodine in the living body, so that the technical blank in the aspect of aceclodine detection at present is filled up.

The invention provides a method for detecting various catecholamines in plasma, which comprises the following steps: 1) taking a plasma sample, adding a catecholamine isotope internal standard solution, uniformly mixing, and performing ultrafiltration on the mixed solution to obtain filtrate; (2) carrying out liquid chromatography-tandem mass spectrometry detection on the filtrate; the contents of various catecholamines are obtained; the catecholamine is prepared from at least one of epinephrine, noradrenaline, methoxy epinephrine, dopamine, methoxy noradrenaline and 3-methoxytyramine; the isotope internal standard solution contains a stabilizer; the stabilizer solution comprises ascorbic acid, hydrochloric acid and methanol. The detection method provided by the invention is simple, can realize automation and is short in time consumption; the method can be used for rapid extraction of massive samples.

The invention relates to a method for extracting steroid hormones in serum, and belongs to the technical field of biomedical detection. According to the method, a protein precipitation method is adopted, and methanol, zirconium sulfate heptahydrate and dextran sodium sulfate in a specific proportion are used as protein precipitants, so that protein and phospholipid are effectively settled, the matrix effect is reduced, the detection accuracy is improved, meanwhile, pollution to a chromatographic column and an instrument is reduced, and the service life is prolonged.

The invention discloses a method for rapidly determining multiple anesthetics and metabolites thereof in aquatic products based on QTRAP mass spectrometry. The method comprises the following steps: (a) preparing a series of matrix standard working solutions; (b) taking a sample to be detected, adding a formic acid acetonitrile solution and water mixed solution, and performing ultrasonic extraction and centrifugation; enabling the supernate to pass through a PRiME HLB solid-phase extraction column, taking effluent, and fixing the volume by using ammonium formate, so as to obtain a to-be-detected sample solution of the aquatic product; and (c) adopting an MRM-IDA-EPA mode, determining the series of matrix standard working solutions and the aquatic product to-be-detected sample solution through QTRAP mass spectrometry, performing qualitative determination through automatic comparison with a secondary mass spectrum standard spectrum library of nine anesthetics and three anesthetic metabolites, performing quantification according to an MRM data peak area, and calculating the content of each substance. The method disclosed by the invention can effectively meet the detection requirements of anesthetics and metabolites thereof in sudden and large-batch aquatic products, the detection efficiency is improved, and the detection limit is reduced.

This invention discloses a method for detecting bromofenac in ginger, belonging to the field of pesticide residue detection technology. The method includes: homogenizing and extracting ginger samples using an acetonitrile solution containing a hydrophobic deep eutectic solvent; adding a salting-out agent to obtain a supernatant through separation; purifying the supernatant using a boric acid-functionalized magnetic carbon nanotube metal-organic framework composite material as an adsorbent via a temperature-switching adsorption process, first removing phenolic interference through thermal adsorption, then removing lipids through freeze precipitation; and finally detecting the supernatant using liquid chromatography-tandem mass spectrometry. This invention effectively solves the problem of severe matrix interference from phenols and lipids in ginger, and features high recovery rate, low matrix effect, high sensitivity, and simple operation.

The invention relates to the field of environmental chemistry and biological sample analysis, in particular to an analysis method for detecting an organic ultraviolet absorbent and metabolites thereof in urine. The method comprises the following steps: carrying out enzymolysis on a urine sample, adding an internal standard substance, extracting and purifying 24 organic ultraviolet absorbents and metabolites thereof in the sample in an extraction manner, and detecting the content of a target substance in the urine sample through a high performance liquid chromatography-mass spectrometer. The method is easy to operate and high in accuracy and reliability, eight types of 24 organic ultraviolet absorbents and metabolites thereof can be detected at the same time at a time, part of substances are reported for the first time, and the method has wide practical application value and significance for evaluating the residual conditions of the organic ultraviolet absorbents and metabolites thereof in the human body.

The present invention belongs to the technical field of analysis and detection, and specifically relates to an analysis method for the content of N-nitroso diclofenac genotoxic impurities in chemical drugs. The analysis method uses a triple quadruple liquid-mass spectrometer to determine the content of N-nitroso diclofenac impurities in chemical drugs, using a 50 vol% acetonitrile aqueous solution (containing 0.1 vol% formic acid) as a solvent and dichloromethane as an extractant, and uses a standard curve method to analyze the content of N-nitroso diclofenac impurities. By dissolving the test sample with a solvent first and then extracting it with an extractant, the problems of low impurity limit, complex and easy interference of the test sample matrix, and easy false positive caused by the impurity structure being similar to the main component of the test sample are overcome, and at the same time, the sensitivity of N-nitroso diclofenac impurities is improved by high performance liquid chromatography-mass spectrometry, and the detection method is efficient and accurate.

The invention provides a method for detecting oxalic acid in urine by adopting an HPLC-ESI-MS / MS. The method comprises the following steps: S1, taking a collected sample, adding oxalic acid-1, 2-13C as an internal standard of oxalic acid, mixing an internal standard solution and the collected sample according to a ratio of 2: 1, performing vortex for 5 minutes, and performing centrifugation for 5 minutes at 4000 rpm to obtain a urine sample; s2, detecting the sample by using a liquid chromatography tandem mass spectrometer; s3, adopting stable isotope labeled oxalic acid-1, 2-13C as an internal standard of oxalic acid, preparing a series of standard substances with different concentrations, making a standard curve, taking the concentration of an oxalic acid working standard solution as an X axis, taking a peak area ratio of the standard to the internal standard of a read result as a Y axis, carrying out linear regression analysis, and obtaining a regression equation through '1 / x2' weight; and substituting the area ratio of the oxalic acid in the sample to the internal standard peak into the standard curve equation, and calculating the concentration of the oxalic acid in the urine sample. According to the method, derivatization, solid-phase extraction, acidification and other operations are not needed, the analysis technology is greatly simplified, the detection time is shortened, and the sample stability is improved.

The invention discloses an anti-mullerian hormone quality control product as well as a preparation method and application thereof, and belongs to the technical field of anti-mullerian hormone detection. The anti-mullerian hormone quality control product provided by the invention is composed of an anti-mullerian hormone antigen and a quality control product matrix liquid, wherein the quality control product matrix liquid comprises a buffer solution, bovine serum albumin, a surfactant S9, polyoxyethylene alkyl ether, double-glycoside peptide and a preservative. The quality control product provided by the invention is few in additives, simple in components and low in cost, can reduce the matrix effect to the maximum extent, has good uniformity and stability, effectively prolongs the shelf life of the quality control product, and has a good application prospect.

The invention provides a purification magnetic bead, a preparation method thereof and application of the purification magnetic bead in grain heavy metal detection. According to the purification magnetic bead, magnetic Fe3O4 particles serve as an inner core, a shell wrapped by an epoxy group is formed through a polymerization reaction, and a multi-amino adsorption group is further evenly grafted to the shell; wherein the multi-amino adsorption group is formed by constructing an amino functional compound, and the amino functional compound is selected from one or more of triethylenetetramine, hexamethylenediamine and a polyethyleneimine oligomer with the molecular weight of 1000 or below. The purification magnetic bead provided by the invention has excellent adsorption performance on metal ions and a rice matrix in rice, especially has relatively high adsorption performance on copper ions, and has relatively weak adsorption capacity on As, so that in the application of electrochemical detection of the arsenic content in grains, the masking effect of copper on arsenic and the interference effect of the matrix can be effectively reduced, and the detection accuracy is improved. The arsenic detection accuracy is improved.

The application discloses an artificial urine buffer matrix and a preparation method and application thereof. The artificial urine buffer matrix comprises urea, uric acid, alpha-hydroxy acid, amino acid, ions and sugar. The artificial urine buffer matrix can eliminate background interference, guarantee the immune reaction detection of small molecules, proteins and other biomarkers in urine, and has small matrix effect.

The present invention relates to a method for determining the residual amount of perfluoroalkyl acid pollutants in vegetables. The present invention aims to solve the problems of cumbersome operation, low efficiency, poor accuracy, significant matrix effect, and weak matrix applicability in existing methods and technologies for analyzing perfluoroalkyl acid pollutants in vegetables, and establishes a new method through innovative inventions and technical optimization in the pretreatment and instrumental analysis process. The established method will be suitable for rapid screening and precise quantitative analysis of perfluoroalkyl acid pollutants in vegetables with large sample volumes and on a large scale, and will greatly improve the efficiency of analysis and detection, and effectively improve accuracy.