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New application of carmustine

A technology of carmustine and cocaine, applied in the field of new medical uses of carmustine, can solve the problems of high recurrence risk of patients and the like

Active Publication Date: 2012-07-18
于龙川
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term withdrawal of psychoactive substances can eliminate physical dependence on psychoactive substances to a certain extent, but patients after withdrawal still have a high risk of relapse

Method used

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  • New application of carmustine
  • New application of carmustine
  • New application of carmustine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1, intravenous injection of carmustine 30mg / kg inhibits the relapse induced by low-dose morphine in rats dependent on morphine

[0020] 1. Materials

[0021] Male SD rats (about 65 days old, Experimental Animal Center, Chinese Academy of Military Medical Sciences) weighing about 270-300 grams.

[0022] Drugs: Morphine Hydrochloride Injection (produced by Shenyang No. 1 Pharmaceutical Factory, stock solution concentration is 10 mg / ml, diluted to 1 mg / ml with sterile normal saline when used), carmustine injection (produced by Tianjin Jinyao Amino Acid Co., Ltd., Dilute to 12.5mg / ml with sterile saline when used).

[0023] The self-medication experimental device used in this experiment was purchased from Anlai Software Technology Co., Ltd., with a size of 29cm×29cm×26cm. It is composed of two parts: the box and the control software. The side wall is made of stainless steel plate, and the bottom plate is made of stainless steel fence. The entire box is placed ...

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PUM

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Abstract

The invention discloses a medicinal application of carmustine, namely application of carmustine in preparation of products for preventing and / or treating psychoactive substance dependence and relapse. A pharmacodynamic test result indicates that after 30mg / kg carmustine is injected through vein, the self-administration relapse of a morphine-induced rat can be effectively inhibited, and the spontaneous activity level of the rat is not influenced, so as to prove that the carmustin has application value in clinical prevention and treatment of psychoactive substance dependence.

Description

technical field [0001] The invention relates to a new medical application of carmustine. Background technique [0002] Dependence on various psychoactive substances is a kind of widespread mental illness. The symptoms of substance dependence are manifested as unrestrained and excessive seeking to take psychoactive substances (including opioids, cocaines, amphetamines and marijuana, etc.). Long-term withdrawal of psychoactive substances can eliminate physical dependence on psychoactive substances to a certain extent, but patients after withdrawal still have a high risk of relapse. At present, there are naltrexone subcutaneous implants, tetrahydroxypalmatine products and compound Chinese herbal medicine preparations that have been patented in China to suppress relapse after drug dependence. [0003] The drug carmustine, also known as Carmusitne, chloroethylnitrosourea, carmustine, BCNU, the English name of the commodity is Carmusitne, and the active ingredient is a small mol...

Claims

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Application Information

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IPC IPC(8): A61K31/17A61P25/30A61P25/36
Inventor 于龙川孔庆瑶
Owner 于龙川
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