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Application of miR-212 to preparation of addiction treatment drug

A mir-212, 1.mir-212 technology, applied in the field of molecular biology and medicine, can solve the problem of amplification of normal biological effects

Inactive Publication Date: 2019-09-27
SHENZHEN KANGNING HOSPITAL SHENZHEN MENTAL HEALTH INST SHENZHEN MENTAL HEALTH CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Normal biological effects of DA are amplified due to blocked reuptake

Method used

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  • Application of miR-212 to preparation of addiction treatment drug
  • Application of miR-212 to preparation of addiction treatment drug
  • Application of miR-212 to preparation of addiction treatment drug

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Embodiment Construction

[0033] The principles and features of the present invention are described below in conjunction with the accompanying drawings, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention. Definition of nouns:

[0034] 1) miRNA enhancer: a nucleic acid substance that increases the amount of corresponding miRNA in cells, such as miRNA mimics, strong promoter-driven miRNA expression vectors, etc.

[0035] 2) miRNA weakening substances: nucleic acid substances that reduce the amount of corresponding miRNA in cells, such as miRNA inhibitors, miRNA-sponge, etc.

[0036] 3) miRNA-sponge: a single-stranded RNA with multiple tandem repeats, each repeating unit has a complementary sequence to all or part of the corresponding miRNA sequence, so it can bind and absorb the corresponding miRNA, reducing the effective concentration of the miRNA in the cell .

[0037] 1. Research on SLC6A3mRNA 3'UTR

[0038] We car...

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PUM

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Abstract

The invention relates to a non-therapeutic application of miR-212 to regulation of DAT (dopamine transporter) gene expression in cells, and further relates to a non-therapeutic method for regulating the DAT gene expression in the cells. The method comprises the step of increasing or reducing the amount of miR-212 in the cells. The invention further relates to an application of miR-212, a miR-212 enhancer or a miR-212 attenuator to preparation of a drug for regulating dopamine uptake of the cells, and further relates to an application of miR-212, the miR-212 enhancer or the miR-212 attenuator to preparation of a drug for treating psychoactive substance addiction.

Description

technical field [0001] The invention relates to the fields of molecular biology and medicine. More particularly, it relates to the use of miR-212 in the preparation of medicaments for the treatment of psychoactive substance addiction. Background technique [0002] Psychoactive substance addiction is a disorder of brain function caused by the use of psychoactive substances that makes it impossible for a person to control their use. Addiction to psychoactive substances is a chronic relapsing disorder usually accompanied by additional psychological or physical symptoms, typically symptoms such as involuntary drug use and withdrawal syndrome. [0003] The neurotransmitter dopamine (DA) controls a variety of functions, including motor, cognition, emotion and reward. A large amount of neuropharmacological evidence in humans and animals shows that the DA system plays an important role in the three stages of the addiction cycle (euphoria, withdrawal, and craving). It is a normal ...

Claims

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Application Information

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IPC IPC(8): A61K31/7105A61K48/00A61K45/06A61P25/36
CPCA61K31/7105A61K45/06A61P25/36
Inventor 贾晓健荣晗杨梅刘慧铭刘铁榜
Owner SHENZHEN KANGNING HOSPITAL SHENZHEN MENTAL HEALTH INST SHENZHEN MENTAL HEALTH CENT
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