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Detection method of new psychoactive substance 5, 6-MDAI

A 6-MDAI and detection method technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of conviction and sentencing deviation, impact on results, uncertainty, etc.

Pending Publication Date: 2020-03-27
INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The representativeness of sampling directly affects the uncertainty of the results, but the current quantitative testing of drugs in vitro, especially the sampling operation before submission, pays little attention to this, which may cause certain deviations in conviction and sentencing

Method used

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  • Detection method of new psychoactive substance 5, 6-MDAI
  • Detection method of new psychoactive substance 5, 6-MDAI
  • Detection method of new psychoactive substance 5, 6-MDAI

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0160] Embodiment 1, detection of 5,6-MDAI in solid powder test material by gas chromatography-mass spectrometry

[0161] 1) Processing of samples

[0162] The seized solid powder test materials were weighed and processed with a high-speed pulverizer at 10,000 rpm for 3 minutes. After sieving, the particle sizes were all less than 80 mesh. Weigh the test material from different parts of the homogenized test material for 3 times, 30 mg each time, add 2 mL of methanol, seal and sonicate for 10 min, shake for 5 min, blow dry under nitrogen protection, and derivatize with trifluoroacetamide, Add 20mL of methanol for gas chromatography-mass spectrometry analysis.

[0163] 2) Setting of detection conditions

[0164] Gas chromatography conditions:

[0165] The carrier gas is helium;

[0166] The chromatographic column is DB-5MS capillary chromatographic column (30m×0.25mm×0.25μm);

[0167] The heating program is as follows: the initial temperature is 100°C, keep for 1min, raise ...

Embodiment 2

[0183] Embodiment 2, detection of 5,6-MDAI in liquid samples by gas chromatography-mass spectrometry

[0184] 1) Processing of samples

[0185] Weigh 2 mL of the seized water-based liquid sample, adjust the pH to 7.5 with 1N NaOH, add 1 mL of chloroform, shake for 5 min, take the organic phase, and analyze it by gas chromatography-mass spectrometry.

[0186] 2) Setting of detection conditions

[0187] Detection conditions are the same as in Example 1.

[0188] 3) Measurement results

[0189] Using the conditions set above to detect the extract, 3 injections, the fragment ion m / z corresponding to the absorption peak at the retention time of 9.811min is 160, 149 and 177, so it is determined that the liquid sample contains 5,6 -MDAI.

Embodiment 3

[0190] Embodiment 3, detection of 5,6-MDAI in blood samples by gas chromatography-mass spectrometry

[0191] 1) Processing of samples

[0192] Weigh 1 mL of the seized blood sample, homogenize it with 4 mL of 2% formic acid, centrifuge at 8000 rpm for 10 min, take the supernatant to a solid-phase extraction column, control the flow rate at 1 mL / min, and sequentially add 1 mL of water, 1 mL of methanol, and 1 mL of acetonitrile Rinse, drain, elute with 1 mL of acetonitrile solution containing 5% ammonia, and pass through a microporous membrane.

[0193] 2) Setting of detection conditions

[0194] Detection conditions are the same as in Example 1.

[0195] 3) Measurement results

[0196] Using the conditions set above to detect the extract, 3 injections, the fragment ion m / z corresponding to the absorption peak with a retention time of 9.802min is 160, 149 and 177, so it is determined that the liquid sample contains 5,6- MDAI.

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Abstract

The invention discloses a detection method of a new psychoactive substance 5, 6-MDAI (5, 6-diphenylmethane diisocyanate). The detection method comprises gas chromatography-tandem mass spectrometry, gas chromatography, liquid chromatography-tandem mass spectrometry, liquid chromatography and the like, and is suitable for detection of 5, 6-MDAI in in-vitro detection materials including solid, liquidand biological sample detection materials including blood, urine, saliva, hair and tissues. The qualitative and quantitative detection method of the new psychoactive substance 5, 6-MDAI provided by the invention is simple to operate, high in sensitivity, wide in instrument selection range, wide in detection concentration range and accurate in qualitative and quantitative result, and the uncertainty range caused by nonuniform samples can be obviously reduced.

Description

technical field [0001] The invention relates to a detection method of a new psychoactive substance 5,6-MDAI, which belongs to the field of criminal investigation drug detection. Background technique [0002] At present, the increasingly serious drug problem has become a global disaster. The proliferation of drugs directly endangers people's physical and mental health, and poses a huge threat to economic development and social progress. Especially for the emerging new psychoactive substances, it is urgent to establish systematic qualitative and quantitative methods to better serve court trials and combat drug crimes. [0003] 5,6-MDAI (5,6-methylenedioxy-2-aminoindan) is a new psychoactive substance that has similar effects to MDMA, but differs in that it induces serotonin The likelihood of deficiencies is reduced, as are the effects of dopamine and norepinephrine buildup. Its structural formula is shown in the following formula I. The representativeness of sampling direc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88G01N30/06G01N30/38
CPCG01N30/06G01N30/38G01N30/88G01N2030/062G01N2030/388
Inventor 郑晓雨郑珲赵彦彪杨虹贤闻武张春水钱振华赵阳李彭刘克林高利生
Owner INST OF FORENSIC SCI OF MIN OF PUBLIC SECURITY
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