Operative wound healing promoting gel dressing and preparation method thereof

A surgical wound healing and gel technology, applied in the field of medical materials, can solve the problems of damaged new tissue, high replacement frequency, and large thickness of bandage, and achieve the effect of promoting healing, good compatibility, and reducing tissue adhesion.

Inactive Publication Date: 2018-08-24
胡张艳
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these dressings are different in shape and properties, and have different effects, they all have a certain effect on preventing the occurrence of postoperative adhesions, but these dressings are easy to dry after absorbing liquid, causing damage to new tissues when they are removed. It has brought great pain to the patient, and the amount of fluid absorption is small, the thickness of the bandage is large, the air permeability is poor, and the replacement frequency is high

Method used

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  • Operative wound healing promoting gel dressing and preparation method thereof
  • Operative wound healing promoting gel dressing and preparation method thereof
  • Operative wound healing promoting gel dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Preparation of collagen solution:

[0029] Dissolve collagen powder (bovine Achilles tendon collagen, from Sigma-Aldrich (Shanghai) Trading Co., Ltd.) in 1mol / L acetic acid ethanol solution (100ml), then add vitamin E (1.8g), 6-ring Hexyl-1-hydroxy-4-methyl-2(1H)-pyridone (3.6g), 0.002% wt (based on the weight of the mixed solution) of N-hydroxysuccinimide and povidone iodine (3.6g) , fully stirred to obtain a collagen solution;

[0030] (2) Preparation of electrospun mesh:

[0031] ① 12wt% (based on the weight of the mixed solution) of poly(lactic-co-glycolic acid) copolymer, 3wt% (based on the weight of the mixed solution) of hydroxypropyl chitosan, 5wt% (based on the weight of the mixed solution) of polycaprolactone Dissolve 3wt% (based on the weight of the mixed solution) of medical chitosan in a mixed solution of tetrahydrofuran (30ml) and N,N-dimethylformamide (60ml), stir the solution, and then add 3wt% (based on the weight of the mixed solution) Based on ...

Embodiment 2

[0040] (1) Preparation of collagen solution:

[0041] Dissolve collagen powder (bovine Achilles tendon collagen, from Sigma-Aldrich (Shanghai) Trading Co., Ltd.) in 1mol / L acetic acid ethanol solution (120ml), then add vitamin E (2.2g), 6-ring Hexyl-1-hydroxy-4-methyl-2(1H)-pyridone (4.4g), 0.002% wt (based on the weight of the mixed solution) of N-hydroxysuccinimide and povidone-iodine (4.4g) , fully stirred to obtain a collagen solution;

[0042] (2) Preparation of electrospun mesh:

[0043] ① 14wt% (based on the weight of the mixed solution) of poly(lactic-co-glycolic acid) copolymer, 5wt% (based on the weight of the mixed solution) of hydroxypropyl chitosan, 7wt% (based on the weight of the mixed solution) of polycaprolactone Dissolve 3wt% (based on the weight of the mixed solution) of medical chitosan in a mixed solution of tetrahydrofuran (40ml) and N,N-dimethylformamide (80ml), stir the solution, and then add 3wt% (based on the weight of the mixed solution) Based on tr...

Embodiment 3

[0053] (1) Preparation of collagen solution:

[0054] Dissolve collagen powder (bovine Achilles tendon collagen, from Sigma-Aldrich (Shanghai) Trading Co., Ltd.) in 1mol / L acetic acid ethanol solution (120ml), then add vitamin E (2.2g), 6-ring Hexyl-1-hydroxy-4-methyl-2(1H)-pyridone (4.4g), 0.002% wt (based on the weight of the mixed solution) of N-hydroxysuccinimide and povidone-iodine (4.4g) , fully stirred to obtain a collagen solution;

[0055] (2) Preparation of electrospun mesh:

[0056] ① 12wt% (based on the weight of the mixed solution) of poly(lactic-co-glycolic acid) copolymer, 5wt% (based on the weight of the mixed solution) of hydroxypropyl chitosan, 5.2wt% (based on the weight of the mixed solution) of polycaprolactone Dissolve the ester and 4.1wt% (based on the weight of the mixed solution) of medical chitosan in a mixed solution of tetrahydrofuran (40ml) and N,N-dimethylformamide (80ml), stir the solution, and then add 3wt% (mixed The electrospinning solution...

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Abstract

The invention provides operative wound healing promoting gel dressing and a preparation method thereof. The operative wound healing promoting gel dressing is prepared from a collagen solution and an electrospinning web, wherein the collagen solution is prepared from collagen powder, an acetic ethanol solution, vitamin E, 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone, N-hydroxyl succinimide and povidone-iodine; the electrospinning web is prepared from poly(lactic-co-glycolic acid), hydroxypropyl chitosan, polycaprolactone, medical chitosan, triethylene-glycol dimethacrylate and 2-hydroxyl-2-methyl-phenylacetone. The operative wound healing gel dressing disclosed by the invention has the advantages of biological degradability, very good physiological adaptation, strong antibacterial property, ability in promoting operative wound healing and epithelial cell growth and strong anti-adhesion property.

Description

Technical field [0001] The invention relates to the technical field of medical materials, in particular to a gel dressing for promoting surgical wound healing and a preparation method thereof. Background technique [0002] Surgery means that doctors use medical instruments to resect and suture the patient's body, and use knives, scissors, needles and other instruments to operate on parts of the human body. It is the main treatment method of surgery, commonly known as "surgery". Surgery is a procedure that destroys the integrity of tissue (incision) or restores tissue whose integrity has been compromised (suturing). The purpose of surgery is to treat or diagnose diseases, such as removing diseased tissue, repairing damage, transplanting organs, improving the function and shape of the body, etc. The skin is the barrier between the human body and the external environment, protecting various tissues and organs in the body from external physical, mechanical, chemical and pathoge...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/26A61L15/20A61L15/44A61L15/46A61L15/62A61L15/42
CPCA61L15/20A61L15/26A61L15/28A61L15/325A61L15/42A61L15/44A61L15/46A61L15/62A61L2300/202A61L2300/404C08L5/08C08L67/04
Inventor 胡张艳
Owner 胡张艳
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