Method for preparing flamazine/bacterial cellulose composite wound dressing

A technology of silver sulfadiazine and bacterial cellulose, which is applied in the field of biomedical materials and medical devices, can solve the problems of lack of competitiveness of high-end products, no series of products, poor water permeability and moisture absorption, etc., and achieves controllable particle size distribution, good Good antibacterial activity, antibacterial effect

Active Publication Date: 2010-12-08
UNIV OF SCI & TECH BEIJING +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the domestic dressing industry has a single variety, no series of products, and lack of functionality. It is mainly low-end products and lacks competitiveness in high-end products.
[0007] In view of the characteristics of silver sulfadiazine and bacterial fiber and the respective problems of wound dressings at home and abroad, the present invention adopts a unique composite process to prepare silver sulfadiazine / bacterial cellulose composite wound dressing, which solves the antibacterial problem of bacterial cellulose on the one hand, and at the same time It overcomes the problems of poor water permeability, air permeability or drainage, and poor moisture absorption effect existing in the existing silver sulfadiazine agent

Method used

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  • Method for preparing flamazine/bacterial cellulose composite wound dressing
  • Method for preparing flamazine/bacterial cellulose composite wound dressing
  • Method for preparing flamazine/bacterial cellulose composite wound dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0038] Cut the commercially available bacterial cellulose film produced by Acetobacter xylinum into a bacterial cellulose sample of 10 × 10 cm, the steps are as follows:

[0039] Step 1. Pretreatment of the bacterial cellulose membrane: washing the bacterial cellulose membrane prepared by the above-mentioned Acetobacter xylinum with clear water for several times to remove the culture medium and impurities on the surface of the membrane. Then soak the membrane in 0.1mol / L NaOH solution, boil at 80°C for 60min, and wash out the bacteria and residual culture medium in the bacterial cellulose membrane. Then soak the bacterial cellulose membrane in 0.05mol / L NaOH solution, boil at 80°C for 30min, and then rinse with distilled water several times; figure 1 It is the microstructure diagram of bacterial cellulose, showing the unique nano-network structure of bacterial cellulose.

[0040] Step 2. Purification of the bacterial cellulose membrane: the bacterial cellulose membrane after ...

Embodiment 2

[0046] The commercially available bacterial cellulose film produced by Acetobacter xylinum was cut into 10×10 cm bacterial cellulose samples.

[0047] Step 1. Pretreatment of the bacterial cellulose membrane: washing the bacterial cellulose membrane prepared by Acetobacter xylinum with clear water several times to remove the culture medium and impurities on the surface of the membrane. Then soak the membrane in 0.1mol / L NaOH solution, boil at 90°C for 60min, and wash out the bacteria and residual culture medium in the bacterial cellulose membrane. Then soak the bacterial cellulose membrane in 0.05mol / L NaOH solution, boil at 90°C for 30min, and then rinse with distilled water several times;

[0048] Step 2. Purification of the bacterial cellulose membrane: the bacterial cellulose membrane after the above pretreatment is sterilized by ultraviolet rays to meet the sterilization requirements of the process. The bacterial cellulose membrane after the above disinfection is soaked ...

Embodiment 3

[0054] The commercially available bacterial cellulose film produced by Acetobacter xylinum was cut into 10×10 cm bacterial cellulose samples.

[0055] Step 1. Pretreatment of the bacterial cellulose membrane: washing the bacterial cellulose membrane prepared by Acetobacter xylinum with clear water several times to remove the culture medium and impurities on the surface of the membrane. Then soak the membrane in 0.1mol / L NaOH solution, boil at 95°C for 60min, and wash out the bacteria and residual culture medium in the bacterial cellulose membrane. Then soak the bacterial cellulose membrane in 0.05mol / L NaOH solution, boil at 95°C for 30min, and then rinse with distilled water several times;

[0056] Step 2. Purification of the bacterial cellulose membrane: the bacterial cellulose membrane after the above pretreatment is sterilized by ultraviolet rays to meet the sterilization requirements of the process. The bacterial cellulose membrane after the above disinfection is soaked ...

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Abstract

The invention provides a method for preparing flamazine/bacterial cellulose composite wound dressing, which comprises the following steps of: performing pretreatment and purification treatment on a bacterial cellulose membrane to obtain purified bacterial cellulose; preparing flamazine suspension with the granularity of 50 to 5,000 nm under dark condition; reacting the bacterial cellulose membrane with the flamazine suspension to form a flamazine/bacterial cellulose composite membrane; and performing drying treatment to obtain a dry flamazine/bacterial cellulose composite membrane, or performing extruding dehydration to obtain a wet flamazine/bacterial cellulose composite membrane with different water content values to prepare the flamazine/bacterial cellulose composite wound dressing. The prepared flamazine/bacterial cellulose composite wound dressing has high mechanical performance, high antibacterial property, and high water and air permeability or good drainage and moisture absorption effects, can promote the drying, scabbing and healing of wound, and is used for preventing and treating the secondary wound infection of second-degree and third-degree burn or scald.

Description

technical field [0001] The invention relates to the related fields of biomedical materials and medical devices, in particular to a preparation method and application of a silver sulfadiazine / bacterial cellulose composite wound dressing. Background technique [0002] Silver Sulfadiazine (Silver Sulfadiazine), N-2-pyrimidinyl-4-aminobenzenesulfonamide silver salt Molecular formula: C 10 h 9 AgN 4 o 2 S, white or off-white crystalline powder; easy to deteriorate when exposed to light or heat. Silver sulfadiazine is insoluble in water, ethanol, chloroform or ether. [0003] Silver sulfadiazine is a commonly used drug for the prevention and treatment of burn wound infection, and the commonly used clinical dosage forms include cream, ointment, suspension, powder and so on. Silver sulfadiazine is a short-acting sulfa drug for the treatment of systemic infections, which has the antibacterial effect of sulfadiazine and the astringent effect of silver salt. It has a wide antibac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44
Inventor 郑裕东吴健彭帅郭佳杨槐奚廷斐费浩何欣扬刘向阳
Owner UNIV OF SCI & TECH BEIJING
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