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Preparation method and application of antibacterial glass coating of antibacterial bone fracture plate

A technology of antibacterial glass and bone plate, applied in the field of bioengineering, can solve the problems of poor effect and non-antibacterial properties, and achieve the effects of easy operation, high antibacterial efficiency, and promotion of bone cell growth

Inactive Publication Date: 2012-03-21
TONGJI UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

They are usually not antimicrobial and require oral antimicrobial medication, which is less effective

Method used

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  • Preparation method and application of antibacterial glass coating of antibacterial bone fracture plate
  • Preparation method and application of antibacterial glass coating of antibacterial bone fracture plate
  • Preparation method and application of antibacterial glass coating of antibacterial bone fracture plate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 : Preparation and in vitro characterization of copper-containing borate glass antibacterial bone plate coating

[0034] (1) Preparation of borate glass with 0.25% copper content

[0035] Weigh 1.888g anhydrous sodium carbonate, 12.311g anhydrous potassium carbonate, 6.921g basic magnesium carbonate, 10.698g calcium carbonate, 13.149g strontium carbonate, 9.632g silicon dioxide, 39.652g boric acid, 5.558g sodium dihydrogen phosphate, 0.192 g copper sulfate. After grinding, mix well to get the raw ingredients. The original ingredients were placed in a platinum crucible and kept at 1150°C for 120 min, and after taking it out, the resulting clear glass liquid was poured on a preheated steel plate to obtain a glass block. The obtained glass blocks are coarsely crushed by a horizontal ball mill, finely crushed by a ball mill, crushed by a jet mill, vibrating and sieved to obtain a glass powder with a particle size of 0.05-20 microns.

[0036] (2) Preparation of...

Embodiment 2

[0045] Example 2 : Release of antibacterial ions and antibacterial performance of zinc-containing borate glass antibacterial coating

[0046] According to the method described in Example 1, in the glass formula, copper sulfate is replaced by zinc sulfate, and 0.472g, 0.944g, 1.416g, and 1.888g of zinc sulfate are added respectively to prepare three kinds of borates with different zinc contents Glass, and further prepared zinc-containing borate glass antibacterial coating bone plates with zinc ion mass percentages of 0.5%, 1.0%, 1.5%, and 2.0%.

[0047] The prepared coating block was divided into every 1cm 2 The ratio of the surface area to 100 ml solution was soaked in SBF solution (Kokubo method, pH=7.25), placed in a 37°C incubator, and samples were taken out after 1d, 2d, 4d, and 7d. The concentration of zinc ions in the soaking solution was detected by inductively coupled plasma optical emission spectroscopy (ICP-OES, Optima 2100DV; PerkinElmer, Shelton, CT). Draw a gr...

Embodiment 3

[0054] Example 3 : Antimicrobial and bone growth-stimulating properties of silver-containing borate glass antimicrobial coatings in animals

[0055] According to the method described in Example 1, in the glass formula, copper sulfate is replaced by silver sulfate, and 0g, 0.269g, and 0.595g silver sulfate are added respectively to prepare three kinds of borate glasses with different silver contents, and then Bone plates with silver-containing borate glass antibacterial coating were prepared with silver ion mass percentages of 0.0%, 0.5%, and 1.0%.

[0056] Use pure titanium bone plate (no glass), no silver (BG coated titanium plate) and 0.5% silver (BG-0.5Ag coated titanium plate), 1.0% (BG-1Ag coated titanium plate) antibacterial Antimicrobial Coated Bone Plates of Borate Glass for In Vivo Animal Experiments. The experimental animals are New Zealand white rabbits with a body weight of 2-3 kg, and the number of experimental animals used in each group is 10. Animals were we...

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Abstract

The invention relates to a preparation method and application of an antibacterial glass coating of an antibacterial bone fracture plate. The method comprises the following steps: preparing sterile ion-containing borate bioactive glass, crushing the glass, and screening into glass powder with a certain size; adding a liquid-phase solvent, adhesive and stabilizer to the glass powder to prepare uniform glass slurry; coating the glass slurry to the surface of a titanium or titanium alloy bone fracture plate by utilizing a mechanical immersion method or a low temperature spraying method, drying with infrared ray or heat, and curing the slurry to the surface of the bone fracture plate; and volatilizing the solvent and the additives by virtue of high temperature sintering treatment, re-melting the residual glass powder to form molten glass, and adhering to the surface of the bone fracture plate to form the antibacterial glass coating capable of resisting bacteria and promoting tissue growth. The preparation method has the advantages of simple production process, easiness in operation, low cost and scale production; and the antibacterial glass coating has the functions of effective antibacterial performance and bioactivity in promotion of bone cell growth.

Description

technical field [0001] The invention belongs to the technical field of bioengineering, and in particular relates to a preparation method and application of an antibacterial glass coating for an antibacterial bone plate. Background technique [0002] Pure titanium and titanium alloys (Ti6Al4V) are widely used as load-bearing implant materials, such as bone plates, due to their excellent mechanical properties and biocompatibility. The disadvantage of this type of material is that it cannot be directly bonded to human bone, and due to the presence of vanadium, it has certain toxicity. At the same time, taking the bone plate as an example, the main method for treating fractures at present is to implant the bone plate to perform internal fixation of the fracture. However, there are a large number of postoperative infections in internal fixation of fractures. According to literature reports, the infection rate is about 5% to 20%. Among them, the infection of board nails will ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/54A61B17/58C03C3/064C23D5/02C23D7/00
Inventor 黄文旵赵欣周萘王德平张长青程相国
Owner TONGJI UNIV
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