79 results about "Organic acid formation" patented technology

Disclosed herein are methods for the recovery of an organic acid, such as a heat stable lactic acid, from a feed stream which contains at least one of an organic acid amide, an organic acid ammonium salt, or an alkylamine-organic acid complex. The feed stream is mixed with at least one azeotroping agent. The azeotroping agent is a hydrocarbon capable of forming at least one azeotrope with the organic acid that is produced by the thermal decomposition of the amide, ammonium salt, or complex in the feed stream. Preferably the azeotrope is a heteroazeotrope. The mixture of the feed stream and the azeotroping agent is heated to produce a vapor stream. The azeotrope is a component of the vapor stream. The vapor stream can be condensed to a liquid stream, and the organic acid is recovered in the liquid stream that is produced. When the azeotrope is a heteroazeotrope, the vapor stream can be condensed into a liquid stream, which can be separated into a first phase and a second phase. The first phase contains the highest concentration of organic acid and the second phase contains azeotroping agent. The organic acid can be further purified and/or concentrated from the separated first phase or from the liquid stream.

In order to rapidly remove an organic acid dissolved in contaminated water, a coagulant capable of forming a floc with the organic acid in the contaminated water is configured to include an iron oxide bearing an inorganic acid on surface thereof, and an aqueous solution of an acidic-group-containing polymer. Upon removal of the organic acid as a floc from the contaminated water using the coagulant, the iron oxide bearing an inorganic acid on surface is initially added to the contaminated water, and then the aqueous solution of the acidic-group-containing polymer is added to precipitate a floc, and the floc is magnetically separated. A water treatment apparatus enabling removal of an organic substance from contaminated water is provided with a mechanism for stirring the contaminated water, a mechanism for adding an iron oxide bearing an inorganic salt on surface to the contaminated water, a mechanism for adding an aqueous solution of an acidic-group-containing polymer to form a floc, and a mechanism for magnetically separating the formed floc.

A compound with general formula (I), accepted additional salt formed of inorganic and organic acids, its production, medicinal composition and usage are disclosed. It belongs to azithromycin pentadecenic macrolide derivative, R1 represents hydrogen or acetyl or methane; R2 represents fatty hydrocarbon, substituted aromatic fatty hydrocarbon or substituted aromatic heterocyclic fatty hydrocarbon. It can be used to prepare medicines in treatment of bacterial infections.

The invention provides compounds with a general formula (I) or (II), and acceptable salts or esters prepared from the compounds and inorganic acid or organic acid. In the general formula (I) or (II), Ar refers to aromatic heterocyclic hydrocarbyl or substituted aromatic heterocyclic hydrocarbyl; and X refers to hydrogen or fluorine. The compounds have a novel structure; 9-oxime hydroxyl of ketolide is connected with an aromatic heterocyclic hydrocarbon through a propargyl side chain; and the compounds are easy and convenient to synthesize and are suitable for industrial production. Moreover, the compounds have outstanding antibacterial activity on clinically common sensitive bacteria and drugfast bacteria, such as staphylococcus aureus, streptococcus pneumonia, streptococcus pyogenes, staphylococcus epidermidis and the like, can be independently used or serve as one of active ingredients to be mixed with other medicines to treat bacterial infection and the like in various formulations or medication ways. Correspondingly, the invention also provides a preparation method for the compounds, use of the compounds as anti-infective agents and corresponding medicinal compositions.

The invention discloses a processing method of dendrobe health care black tea. A processing technique comprises sorting, cleaning, withering, rolling, incipient drying and re-firing drying. In the technical scheme, room temperature heavy-withering, medium-temperature incipient drying and high temperature re-firing technologies are adopted, overmuch organic acid forming ways caused by fermentation and a high temperature incipient drying process in the traditional technique are avoided, the high temperature re-firing technique is adopted to basically remove herbal flavour of dendrobe leaves and achieve representative high-fired fragrance and sweetness, and thus the dendrobe tea processed in this way is tight in twig, reddish brown and glossy in color, mellow in taste, and good, fragrant and sweet in aftertaste, has effects of nourishing yin and boosting essence, beautifying and detoxifying, nourishing the stomach and intestine, and improving eyesight, and has perfect improvement effects in improving immunity, and relieving insomnia, cardiovascular disease and diabetes.

The invention relates to a novel fifteen-member macrolide derivative which has a general formula (I) and comes from azithromycin, wherein R1 represents hydrogen, acetyl or benzoyl, and R2 and R3 represent an aliphatic group, a substituted aroma aliphatic group or a substituted aroma heterocycle aliphatic group respectively. The invention also relates to an intermediate product and a preparation method thereof, acceptable addition salts formed by the fifteen-member macrolide derivative together with inorganic acid or organic acid, and a preparation method for a medicine compound and the application of the medicine compound to the treatment of bacterial infection.

The invention relates to a preparation method of moxifloxacin hydrochloride, which comprises the steps of: (a) in an organic solvent, carrying out condensation on 1-cyclopropyl-6, 7-difluoro-8-methoxy-4-oxo-1, 4-dihydro-3-quinoline carboxylic acid and (S, S)-2, 8-diazabicyclo (4. 3. 0) nonane under the catalysis of tertiary amine to produce 1-cyclopropyl-6-fluoro-1, 4- dihydro-8-methoxy-7-((4aS, 7aS) octahydro-6H-pyrrole (3, 4-b) pyridine-6-group)-4-oxo-3- quinoline carboxylic acid; (b) in an organic solvent, reacting1-cyclopropyl-6-fluoro-1, 4- dihydro-8-methoxy-7-((4aS, 7aS) octahydro-6H-pyrrole (3, 4-b) pyridine-6-group)-4-oxo-3-quinoline carboxylic acid with pure chiral organic acid to produce easily purified complex salt; and (c) reacting the complex salt with hydrochloric acid or hydrogen chloride gas in water solution of a water-soluble organic solvent to produce moxifloxacin hydrochloride of a certain crystal form. The method has the advantages that reaction route is simple, raw materials are cheap and easy to obtain, reaction conditions are mild and easy to control; therefore, the method is suitable for industrial production.

The invention discloses a 4''-benzimidazole-5-formacyl-ester carbazate clarithomycin derivative shown in the formula (I) and a pharmaceutically-acceptable salt. R1 is hydrogen, acetyl or benzoyl; R2 is hydrogen, fatty alkyl, halogenated hydrocarbon or substituted aromatic radical; and R3 is hydrogen, fatty alkyl, halogen, halogenated hydrocarbon, benzyl or substituted benzyl. The invention also relates to a prepared intermediate product and a preparation method thereof, a pharmaceutically-acceptable salt formed with inorganic or organic acid, a medicine composition and application to treating bacterial infection. The derivative represents relatively strong in-vitro antibacterial activity to sensitive staphylococcus aureus, sensitive streptococcus pneumoniae and sensitive streptococcus pyogenes and represents obviously enhanced antibacterial activity to drug-resistant streptococcus pneumoniae derivated by different drug-resistant genes.

The invention relates to preparation of novel fluoro thiazole hydrazone compounds I to IV, combination of the compounds and application thereof to anti-tumor and/or anti-cancer medicine. The invention also relates to a preparation method of the compound. The general chemical formula of the compound is shown as the accompanying drawing, wherein R1, R2 and R3 in the general chemical formula are respectively one kind of materials from H, Br, F and CF3; R1 in the first compound I is Br, and the R2 and the R3 are H; the R1 in the compound II is H, and the R2 and the R3 are F; the R2 in the compound III is CF3; the R1 and the R3 are H; the R2 in the compound IV is H, and the R1 and the R3 are CF3. The invention also relates to a salt containing at least one compound and a physically acceptable inorganic acid or organic acid; if proper, a pharmaceutically acceptable excipient and/or a diluting agent or an excipient can be used. The invention also relates to a formula-shown compound medication preparation containing at least one kind of the compound shown by the structure formula and the salt thereof. The preparation type is tablets, capsules, infusion solutions, suppositories, patches, powder, supensoid agents.

The invention relates to an absorbent of harmful gas generated during material fermentation in the organic fertilizer production process, and the absorbent is a composite aqueous solution formed by sulfates of trace element copper, iron, manganese and zinc, and inorganic acid or organic acidity. The solution can absorb a lot of harmful gas ammonia, hydrogen sulfide, sulfur dioxide and organic harmful gas released in the material fermentation process, and after the harmful gas absorbing solution is detected to be qualified, the solution can be directly used for producing liquid type macro and medium trace element water-soluble fertilizer, and raw materials of water-soluble fertilizer after drying, thereby effectively using macroelement N and medium element S, and avoiding losses of macroelement and medium element in the traditional deodorizing technology and environment pollution.

The invention discloses an azithromycin derivative shown in the formula (I) and a pharmaceutically acceptable salt thereof, wherein R1 represents hydrogen, acetyl or benzoyl, R2 represents hydrogen, aliphatic hydrocarbon, substituted aromatic alkyl, substituted aromatic heterocyclic alkyl, halogen, nitryl, alkoxy or-AR7, R3 represents OR5, R4 represents hydroxyl; or, R3 and R4 can form a ring with a structure that X represents oxygen and nitrogen; R5 represents nitrogen or CONHR6, R6 represents aliphatic hydrocarbon, substituted aromatic alkyl or substituted aromatic heterocyclic alkyl, and R7 represents aliphatic hydrocarbon, substituted aromatic alkyl or substituted aromatic heterocyclic alkyl; n is from 1 to 6, A is one of -O-,-CO-,-CONR8-,-NHCO- and -S-. The invention further relates to a prepared intermediate and a method thereof, an acceptable salt thereof forming with inorganic or organic acid, a drug composite and application thereof in the treatment of bacterial infection.

The present invention relates to nanometer ferromanganese oxidation composite electrode materials for a super capacitor and a preparation method thereof. The materials are made through combination of the manganese oxide and the ferric oxide through a solvothermal method, wherein the mass percent of the manganese oxide is 40-60%. The concrete preparation steps comprise: dissolving the manganese source and the iron source in the deionized water, adding the organic acid to form dispersed and uniform solution, adjusting the pH to be neutral, heating the solution to allow the solution to gradually change to the viscous gel, continuing heating the gel until becoming a block, and after drying, obtaining the nanometer ferromanganese oxidation composite electrode materials through calcination. The nanometer ferromanganese oxidation composite electrode materials are good in cycle stability and high in specific capacity, and are used in a super capacitor device to greatly improve the whole electrochemical performance.

The invention provides a pregnane alkaloid derivative with an effect of resisting breast cancer cell metastasis or a pharmaceutically acceptable salt thereof. The structure of the pregnane alkaloid derivative is shown by a general formula I in the specification, wherein R1 and R2 are independently selected from hydrogen, straight-chain or branched alkyl with the carbon atom number of 1-8, naphthenic base, unsaturated alkyl, benzyl and benzene ring substituted benzyl respectively; or R1R2N is piperidyl or pyrrolyl; R3 and R4 are independently selected from hydrogen and hydroxyl respectively; or R3R4 together represents carbonyl oxygen atoms; R5 and R6 are different substituting groups and are independently selected from hydrogen or methyl respectively; and the pharmaceutically acceptable salt is a salt formed with inorganic acid or organic acid, wherein the inorganic acid or organic acid is selected from hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, methane sulfonic acid, benzene methane sulfonic acid, oxalic acid, tartaric acid, maleic acid, citric acid or ascorbic acid. The invention also provides an application of the pregnane alkaloid derivative in preparation of a medicament for resisting breast cancer metastasis.

The present invention relates to preparation process of isocollidine preparation for eye. Through mixing isocollidine and inorganic acid or organic acid to form soluble isocollidine, dissolving in water, adding osmotic pressure regulator to osmotic pressure 280-320 mOsm/kg, adding hydrochloric acid or sodium hydroxide solution to regulate pH value to 3.0-7.0, adding water via stirring and sterilizing, solution for eye is obtained; or, gel as excipient is further added to obtain gel for eye. The isocollidine preparation for eye may be used to replace atropine, which has serious toxic side effect, for mydriasis, may be used also in regulating eyesight, treating pseudomyopia of teenage and eliminate eye fatigue, and is safe, effective and controllable.

A component of a substrate processing apparatus that performs plasma processing on a substrate includes a base mainly formed of an aluminum alloy containing silicon. A film is formed on the surface of the base by an anodic oxidation process which includes connecting the component to an anode of a power supply and immersing the component in a solution mainly formed of an organic acid. The film is impregnated with ethyl silicate.

The invention relates to preparation of novel bromophenol-thiazole compounds I-IV, combination of the novel bromophenol-thiazole compounds, and application of the novel bromophenol-thiazole compounds in anti-tumor and/or anti-cancer pharmaceuticals. The invention also relates to a preparation method of the compounds, wherein chemical structures of the compounds have a general formula as follows: (shown in the figure), R1, R2 and R3 in the general formula are respectively selected from one of H, F, CF3 and Br, wherein R3 in the compound I is H, R1 and R2 are F; R1 in the compound II is H, R2 is CF3 and R3 is H; R3 in the compound III is Br, R1 and R2 are F; R1 and R2 in the compound IV are H, and R3 is Br. The invention further relates to salt formed by at least one of the compounds or physiologically acceptable inorganic acid or organic acid thereof, if appropriate, a pharmaceutically acceptable excipient and/or diluent or excipient; the invention further relates to an administering dosage form containing at least one of the compounds or the salt thereof, wherein the dosage form is tablet, capsule, infusion solution, suppository, patch, powder, suspension and the like.

The invention provides a macrolide and carbostyril heterocomplex. The macrolide and carbostyril heterocomplex is characterized by comprising compounds shown in the formula I and the formula II, or thecompounds shown in the formula I and the formula II and salt formed by inorganic acid or organic acid and accepted by pharmacy, the macrolide and carbostyril heterocomplex can better adapt to industrial production and has good activity of resisting sensitive bacteria and drug-resistance bacteria on clinically common streptococcus pneumoniae, staphylococcus aureus, streptococcus pyogenes, catarrhmoraxella catarrhalis, haemophilus influenza and other pathogenic bacteria which are capable of resisting erythrocin, and clinical bacterial pneumonia or pneumonia caused by other microorganisms (suchas mycoplasma, legionella and the like) and other tissue infections can be effectively treated.

The present invention relates to preparation of a novel water-soluble fertilizer through absorbing harmful gases produced by material fermentation during organic fertilizer production process with an absorption agent, wherein the absorption agent is a composite aqueous solution formed by a sulfate of a trace element such as copper, iron, manganese and zinc and an inorganic acid or an organic acid, a large amount of harmful gases released during a material fermentation process can be absorbed with the solution, and the solution absorbing the harmful gases is directly used for preparing the novel water-soluble fertilizer, wherein the harmful gases comprise ammonia, hydrogen sulfide, sulfur dioxide and the like. With the process, macro element N and medium element S in the harmful gases are effectively utilized, and macro element and medium element loss and environment pollution caused by the traditional deodorizing process are avoided.