Silver-iodide-doped bioactive glass as well as preparation method and application of silver-iodide-doped bioactive glass

A technology of bioactive glass and silver iodide, which is applied in the field of biomedicine and can solve the problems of lack of sterilization/bacteriostasis

Inactive Publication Date: 2013-09-18
王林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of them have the function of sterilization / bacteriostasis

Method used

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  • Silver-iodide-doped bioactive glass as well as preparation method and application of silver-iodide-doped bioactive glass
  • Silver-iodide-doped bioactive glass as well as preparation method and application of silver-iodide-doped bioactive glass
  • Silver-iodide-doped bioactive glass as well as preparation method and application of silver-iodide-doped bioactive glass

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0053] Preparation of two kinds of bioactive glasses without silver iodide:

[0054] 1. Weigh SiO 2 9.5g, CaO4.0g, P 2 o 5 1.2g, Na 2 O3.0g, K 2 O0.8g, placed in a covered amber crucible, heated to 1350°C for 2h to melt and homogenize. Then it is poured into deionized water at 0° C. for quenching, the sintered material is hammered, ground, and passed through a 200-mesh sieve to obtain the non-silver iodide-doped bioactive glass.

[0055] 2. Weigh Ca(NO 3 ) 2 4H 2 O 15g, Na 2 O2.5g is added to appropriate amount of deionized water and ethanol, with NH 3 Adjust pH to 10~12 with water to obtain liquid C; take another 25ml of ethyl orthosilicate and 5ml of triethyl phosphate, add appropriate amount of absolute ethanol in turn, stir and dissolve to obtain liquid D; slowly add liquid C at 60°C In liquid D, put it in a magnetic stirrer and stir it at 300r / min for 5h, let it stand for aging for 72h, put it in a blast dryer at 105°C for 48h, and centrifuge to obtain a precipi...

Embodiment 1

[0057] Weigh 15g of non-silver iodide-doped bioactive glass, place it in 100ml of absolute ethanol, and stir it ultrasonically for 20min to make the mixture uniform, and obtain suspension A. Weigh 3.5 g of silver nitrate, add it into solution A, and stir ultrasonically for 10 minutes to obtain suspension B. Weigh 2.0 g of iodine and 2.5 g of potassium iodide and add them into solution B; in a water bath at 60°C, stir ultrasonically for 30 min, and then centrifuge. First wash the precipitate twice with an appropriate amount of deionized water, then wash twice with an appropriate amount of absolute ethanol, dry in a blast drying oven at 65°C for 36 hours, take it out, cool to room temperature, and then dry it in a freeze dryer for 48 hours to obtain Silver iodide-doped bioactive glass powder with a particle size of <50 μm (all the above raw materials are analytically pure).

Embodiment 2

[0059] Weigh 15g of bioactive glass and place it in 100ml of absolute ethanol, stir ultrasonically for 20min to make the mixture uniform, and obtain suspension A. Weigh 3.5 g of silver nitrate, add it into solution A, and stir ultrasonically for 10 minutes to obtain suspension B. Weigh 2.0 g of iodine and 2.5 g of potassium iodide and add them into solution B; in a water bath at 60°C, stir ultrasonically for 30 min, and then centrifuge. First wash the precipitate twice with an appropriate amount of deionized water, then wash it twice with an appropriate amount of absolute ethanol, dry it in a blast drying oven at 65°C for 36 hours, take it out and cool it to room temperature, and then dry it in a freeze dryer for 48 hours to obtain granules. Silver iodide-doped bioactive glass powder with a diameter of <50 μm (all the above raw materials are analytically pure).

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Abstract

The invention discloses silver-iodide-doped bioactive glass as well as a preparation method and an application of the silver-iodide-doped bioactive glass. The weight ratio of the silver iodide of silver-iodide-doped bioactive glass to the silver iodide of non-silver-iodide-doped bioactive glass is (90-100) to (1-10). The preparation method comprises the following steps of: weighing silver nitrate, potassium iodide and iodine according to a weight ratio of AgI; adding the non-silver-iodide-doped bioactive glass into absolute ethanol, ultrasonically processing, and fully dispersing; adding silver nitrate at first and then adding potassium iodide and iodine; uniformly ultrasonically stirring, centrifuging, filtering, washing deposits by de-ionized water, carrying out freeze drying, grinding, and sieving to obtain the silver-iodide-doped bioactive glass. The silver-iodide-doped bioactive glass is applied to preparation of drugs for preventing and treating various diseases. The silver-iodide-doped bioactive glass can be used for effectively promoting healing of human hard and soft tissue injury and inhibiting/killing bacteria, contains bioactive glass particles and silver iodide crystals, and is convenient to store, carry and use.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a silver iodide-doped bioactive glass and its preparation method and application. Background technique [0002] Normally, the growth and reproduction of various microorganisms in the human epidermis, oral cavity, vagina, etc. maintain a dynamic balance. When the body's defense function declines, bone, skin or mucous membrane damage, long-term application of antibiotics or immunosuppressants, it will lead to imbalance of flora and related diseases. The number of bacteria in the lesion area is an important factor affecting the healing of the disease. Excessive bacterial colonies produce high concentrations of bacterial waste, chronic inflammation, increased exudate, increased tissue necrosis, and enlarged areas of infection. When the number of bacteria burdened per gram of tissue is greater than 10 5 When it is left or right, its wound (ulcer surface) generally does not he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/38A61P31/04A61P17/02A61L27/10A61L27/54
Inventor 戴凯玲王林
Owner 王林
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