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Ornidazole gargarisma and preparation method

A technology of ornidazole and mouthwash, which is applied in the field of ornidazole mouthwash and its preparation, can solve problems such as inability to directly apply mouthwash, achieve high safety, enhance drug efficacy, and overcome the effect of bitter taste

Inactive Publication Date: 2005-11-16
GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect on treating oral anaerobic bacteria is higher than that of metronidazole and tinidazole, but the existing marketed dosage forms are generally tablets and injections, which cannot be directly applied to mouthwash

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0023] Example 1. Ornidazole 1.0g

[0024] Menthol 0.1g

[0025] Stevia 0.1g

[0026] Citric acid 2.0g

[0027] Macrogol 400 60ml

[0028] Tween 80 0.5ml

[0029] LN1110 lemon essence 0.5ml

[0030] Water up to 1000ml

example 2

[0031] Example 2. Ornidazole 2.0g

[0032] Menthol 0.1g

[0033] Stevia 1.0g

[0034] Citric acid 2.0g

[0035] Polyethylene glycol 400 80ml

[0036] Tween 80 0.8ml

[0037] LN1110 lemon essence 1.0ml

[0038] Water up to 1000ml

example 3

[0039] Example 3. Ornidazole 3.0g

[0040] Menthol 0.2g

[0041] Stevia 2.0g

[0042] Citric acid 2.0g

[0043] Macrogol 400 100ml

[0044] Tween 80 1.0ml

[0045] LN1110 lemon essence 1.0ml

[0046] Water up to 1000ml

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PUM

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Abstract

An ornidazole gargle for treating the non-general-infection oral diseases, such as periodontal disease, is prepared from ornidazole, menthol, rebaudiose, citric acid, polyethanediol 400, Tween-80 and water.

Description

【Technical field】 [0001] The invention relates to medicines, in particular to an ornidazole mouthwash and a preparation method thereof. 【Background technique】 [0002] Periodontitis, pericoronitis, pharyngitis and upper respiratory tract infection are common clinical infectious diseases, which affect the oral function of patients and endanger the health of the whole body. Among these infections, the infection rate of anaerobic bacteria is as high as 96.67% to 100%. In order to achieve better curative effect in disease treatment, patients are required to use mouthwash after clinical treatment. Therefore, choosing a suitable anti-anaerobic mouthwash has become an important link in the treatment of oral anaerobic infectious diseases. In the 1950s and 1960s, the compound Dobell solution (mouthwash) prepared by various hospitals in my country was used as a hospital medicine for the treatment of periodontitis, pericoronitis, Pharyngitis and bedridden patients control and prevent ...

Claims

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Application Information

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Inventor 张碧玫高津福孙庚林李正翔姜红
Owner GENERAL HOSPITAL OF TIANJIN MEDICAL UNIV