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Silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent and preparation method thereof

A low-molecular-weight, composite microsphere technology, applied in the fields of botanical equipment and methods, biocides, disinfectants, etc., can solve the problem of large particle size of microspheres, and achieve the effect of simple preparation process, high lethality, and avoidance of agglomeration

Active Publication Date: 2016-04-20
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The advantage of this method is that no toxic organic solvents are used in the preparation process, but the particle size of the microspheres is relatively large

Method used

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  • Silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent and preparation method thereof
  • Silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent and preparation method thereof
  • Silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Add 2.00g of chitosan with a deacetylation degree of 90% to 50mL of 20.0g / L acetic acid aqueous solution, stir well and let it stand overnight until completely dissolved; Stir continuously for 3h to degrade chitosan. The degraded chitosan was precipitated with 30 mL of 20% NaOH aqueous solution, washed successively with 40 mL of deionized water and 20 mL of absolute ethanol, and dried at 80 °C to constant weight to obtain a viscosity-average molecular weight of 6.0×10 5 low molecular weight chitosan.

[0052] Dissolve 0.40g of low molecular weight chitosan in 20mL of 10.0g / L acetic acid aqueous solution, add dropwise 1mL of silver nitrate aqueous solution with a concentration of 0.2mol / L, stir for 30min, and then add dropwise a vanillin solution with a concentration of 50.0g / L (solvent volume ratio: V 水 :V 乙醇 =1:2) 2mL, continued to stir for 1h to obtain silver / low molecular weight chitosan composite latex.

[0053] According to sorbitan monooleate (Span-80) and alk...

Embodiment 2

[0060] Add 2.00g of chitosan with a deacetylation degree of 90% to 50mL of 20.0g / L acetic acid aqueous solution, stir well and let it stand overnight until completely dissolved; Stir continuously for 3h to degrade chitosan. The degraded chitosan was precipitated with 30 mL of 20% NaOH aqueous solution, washed successively with 40 mL of deionized water and 20 mL of absolute ethanol, and dried at 80 °C to constant weight to obtain a viscosity-average molecular weight of 4.3×10 5 low molecular weight chitosan.

[0061] Dissolve 0.40g of low molecular weight chitosan in 20mL of 10.0g / L acetic acid aqueous solution, add dropwise 1mL of silver nitrate aqueous solution with a concentration of 0.3mol / L, stir for 30min, and then add dropwise a vanillin solution with a concentration of 50.0g / L (solvent volume ratio: V 水 :V 乙醇 =1:2) 2mL, continued to stir for 1h to obtain silver / low molecular weight chitosan composite latex.

[0062] According to sorbitan monooleate (Span-80) and alk...

Embodiment 3

[0065] Add 3.00g of chitosan with a deacetylation degree of 90% to 50mL of 20.0g / L acetic acid aqueous solution, stir well and let it stand overnight until completely dissolved; Stir continuously for 3h to degrade chitosan. The degraded chitosan was precipitated with 50 mL of 20% NaOH aqueous solution, washed successively with 50 mL of deionized water and 20 mL of absolute ethanol, and dried at 80 °C to constant weight to obtain a viscosity-average molecular weight of 3.3×10 5 low molecular weight chitosan.

[0066] Dissolve 0.40g of low molecular weight chitosan in 20mL of 10.0g / L acetic acid aqueous solution; add dropwise 1mL of silver nitrate aqueous solution with a concentration of 0.3mol / L, stir for 30min, and then add dropwise a vanillin solution with a concentration of 50.0g / L (solvent volume ratio: V 水 :V 乙醇 =1:2) 3mL, continued to stir for 1h to obtain silver / low molecular weight chitosan composite latex.

[0067] According to sorbitan monooleate (Span-80) and alk...

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Abstract

The invention provides a silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent and a preparation method thereof. Low-molecular-weight chitosan is used as a raw material, and a low-molecular-weight chitosan acetic acid solution, a silver nitrate solution and a vanillic aldehyde ethanol solution are mixed to form composite sol; then paraffin is used as a continuous phase, sorbitan monooleate and alkylphenol ethoxylates are used as a compound emulsifier, a silver / low-molecular-weight chitosan sol is used as a monomer, and sodium tripolyphosphate is used as a cross-linking agent for preparing an emulsion system for emulsification crosslinking, and finally washing and drying are performed, so that the silver-loaded low-molecular-weight chitosan composite microsphere antibacterial agent is obtained. Due to the fact that the low-molecular-weight chitosan is used as the raw material, nanometer silver particles can enter microspheres, and the antibacterial activity of the composite antibacterial agent is obviously improved. The obtained antibacterial agent has the broad-spectrum bactericidal activity, and has the efficient fatality rate for both escherichia coli and staphylococcus aureus.

Description

technical field [0001] The invention belongs to the technical field of preparation of antibacterial new materials, in particular to a silver-loaded low molecular weight chitosan composite microsphere antibacterial agent and a preparation method thereof. Background technique [0002] Low molecular weight chitosan has good biocompatibility and degradability, high water solubility, super antibacterial effect and remarkable moisturizing and moisture absorption ability in microenvironment, and has no toxic and side effects. However, as a bacteriostatic agent, chitosan has defects such as insufficient heat resistance and easy elution. The combination of organic and inorganic bacteriostatic agents can not only make up for the deficiency of chitosan, but also help to entrap the toxicity of inorganic bacteriostatic agents. , and in the compound system, the inherent antibacterial activity of organic and inorganic antibacterial agents will be significantly improved. [0003] Nano-silv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/16A01N43/16A01N25/10A01P1/00
CPCA01N25/10A01N43/16A01N59/16A01N2300/00
Inventor 安静罗青枝王德松李雪艳殷蓉张艳艳郭桂真
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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