Application of oleanane type pentacyclic triterpene ester derivative for preparing anti-aging medicine

A technology of pentacyclic triterpenoids and oleanane, which is applied in the field of medicine to achieve the effect of prolonging the reproductive life of yeast and delaying aging

Inactive Publication Date: 2014-12-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Application of oleanane type pentacyclic triterpene ester derivative for preparing anti-aging medicine
  • Application of oleanane type pentacyclic triterpene ester derivative for preparing anti-aging medicine
  • Application of oleanane type pentacyclic triterpene ester derivative for preparing anti-aging medicine

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Experimental program
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Effect test

Embodiment 1

[0023] compound I-1a and I-1b The preparation method:

[0024]

[0025] Dissolve compound (1) with 2 ml dichloromethane and 2 ml pyridine in a 25 ml eggplant-shaped bottle [3 , 23,28-trihydroxy-12-oleanene-3 - Caffeate (3 ,23,28-trihydroxy-12-oleanene-3 -caffeate)] (10 mg), add 0.5 mg DMAP (4-dimethylaminopyridine), stir, add 100 μl acetic anhydride, spin to dry the reaction solution, perform solvent distribution with water and ethyl acetate, recover the ester layer, and use PTLC And HPLC purification ester layer sample, obtain compound I-1a and I-1b .

[0026] compound I-1a Physical and chemical properties: white solid, high resolution mass spectrum shows that its molecular formula is C 47 h 64 o 10 (HR ESI-TOF-MS m / z (M+Na) + Calcd. for C 47 h 64 o 10 Na: 811.4392, Found: 811.4422); 1 H NMR (500 MHz, CDCl 3 ) 7.57 (d, J = 16.0 Hz, 1H), 7.39 (dd, J = 1.88, 8.34 Hz, 1H), 7.35 (d, J = 1.8 Hz, 1H), 7.21 (d, J = 8.4 Hz, 1H), 6.34 (d, J ...

Embodiment 2

[0041] Saccharomyces cerevisiae has many similar structures with animal and plant cells that are also eukaryotes, and is easy to cultivate. Yeast is used as a model organism for the study of eukaryotes, and it is also one of the most understood organisms. Many important proteins in the human body were first found in yeast and their homologues, including proteins related to cell cycle, signaling proteins and protein processing enzymes. Its asymmetric division is often used to study its replicative lifespan, but requires the removal of daughter cells with a micromanipulator before the mother cell divides. The mutant strain of Saccharomyces cerevisiae (K6001) discovered by Stefanie, Jarolim et al. In the glucose medium, only the mother cell can divide to produce daughter cells, and the daughter cells cannot produce offspring, so just count the number of daughter cells under the microscope. The replicative lifespan of K6001 yeast cells could be determined. Therefore, K6001 yeast ...

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Abstract

The invention provides an application of an oleanane type pentacyclic triterpene ester derivative in preparation of a medicine for delaying aging and treating aging disease, and the medicine is prepared by a pharmaceutical acceptable carrier or an excipient of the oleanane type pentacyclic triterpene ester derivative. The oleanane type pentacyclic triterpene ester derivative can obviously prolong the activity of yeast replicability life, and be used for preparing the medicine for delaying aging and treating aging disease. A structural formula of the oleanane type pentacyclic triterpene ester derivative is shown as following.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to oleanane-type pentacyclic triterpene ester derivatives and their applications in medicines such as delaying aging and treating aging diseases, and health food. Background technique [0002] According to statistics, China is currently the only country in the world with an elderly population exceeding 100 million. Data show that the current global elderly population is about 739 million, and China’s elderly population is about 178 million, accounting for 18% of the global elderly population. By 2025, the total elderly population will exceed 300 million. It is estimated that by 2050, the global elderly population will be about 2.016 billion, China is about 437 million, accounting for about 21.6% of the world's elderly population, China's average annual increase of 10 million elderly population. The sharp increase in the elderly population, followed by the increase in s...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P39/00
Inventor 戚建华唐瑞琪向兰曹时宁
Owner ZHEJIANG UNIV
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