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Benzoquinone derivatives as well as preparation method and application thereof

A technology of derivatives and benzoquinones, applied in the field of benzoquinone derivatives and their preparation, can solve the problems such as not forming unity

Active Publication Date: 2019-06-21
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many reasons for aging. At present, it is generally believed that aging is the result of comprehensive factors such as stem cell decline, DNA degradation, dietary and mental factors, and active aging genes. However, a unified theory of aging has not yet been formed.

Method used

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  • Benzoquinone derivatives as well as preparation method and application thereof
  • Benzoquinone derivatives as well as preparation method and application thereof
  • Benzoquinone derivatives as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1. The preparation of O. bracteatum compounds 1-7, the specific steps are as follows:

[0033] (1) Put 1.5 kg of dried O. bracteatum in methanol (industrial grade) and extract at room temperature for 3 days (shaking); after concentrated by suction filtration, 120.0 g of methanol extract was obtained.

[0034] (2) Dissolving the obtained extract in water, and extracting the water-soluble matter with ethyl acetate to obtain two components of the water layer and the ethyl acetate layer.

[0035](3) The ethyl acetate layer is separated with a forward silica gel column, with n-hexane: dichloromethane and dichloromethane: methanol solvent system as eluent, the volume ratio is respectively by n-hexane: dichloromethane=100:0 , 80:20, 50:50, 0:100 and dichloromethane: methanol = 98:2, 95:5, 90:10, 0:100 in order to elute, dichloromethane: methanol solvent system volume ratio 95:5 And the fraction eluted at 90:10 is the target fraction I.

[0036] (4) Separating the fraction ob...

Embodiment 2

[0068] Anti-aging activity analysis of compound 1~7 in embodiment 20.bracteatum

[0069] At present, the biological models used for anti-aging research mainly include mice, nematodes, fruit flies and yeast. Yeast is a single-celled eukaryote with a short life cycle, and its complete genome data has been obtained. It is currently a commonly used model organism for aging. Therefore, Saccharomyces cerevisiae was selected as the active system for anti-aging research in this example.

[0070] At the same time, resveratrol is used as a positive control, which is a well-known small molecular compound that shows anti-aging effects in various animal models.

[0071] The steps of the analysis method are as follows:

[0072] (1) Take out the K6001 yeast strain from the refrigerator at -30°C, wash it three times with PBS, 5ml each time, and remove the glycerol therein; then add 1ml PBS, pipette to suspend it, and then add it to 5ml liquid medium (1% yeast powder , 2% peptone, 3% galact...

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Abstract

The invention provides benzoquinone derivatives as well as a preparation method and application thereof. The benzoquinone derivatives are seven benzoquinone active compounds in O.bracteatum; the preparation method comprises the following steps: after the O.bracteatum is crushed, putting in methanol for extraction, filtration and concentration; separating and purifying an extract to obtain the seven benzoquinone anti-aging active compounds. The seven compounds can significantly prolong the replication lives of yeast cells, have anti-aging functions and can be applied to the preparation of an anti-aging drug. The active compounds in the O.bracteatum are researched in aspects of delaying aging or treating aging diseases and have an important practical significance in the research and the development of a new drug, and structural formulas are shown as follows.

Description

technical field [0001] The present invention relates to the field of medical technology, and relates to seven anti-aging active compounds in O. bracteatum and their preparation methods and applications, in particular to benzoquinone derivatives and their preparation methods and applications Background technique [0002] According to the World Health Organization, between 2017 and 2050, the world's population over the age of 65 will double, from 11% to 22%. At the same time, the absolute number of people over the age of 60 will increase from 605 million. to 2 billion. At present, population aging has become a very serious social problem in our country, seriously affecting the development of our society, economy and other aspects. With the rapid increase of the aging population, the incidence of age-related diseases is also increasing, so finding anti-aging drugs has become a top priority. [0003] Aging is a phenomenon in which the body's physiological and psychological ada...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/00C07D493/08A61P39/06
Inventor 戚建华法鲁克.乌默潘彦君
Owner ZHEJIANG UNIV
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