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Oleanane saponin compounds and purpose thereof

A technology for oleanane and compound, which is applied in the field of new oleanane saponins compounds, can solve unseen problems and the like, and achieve the effects of preventing and treating liver diseases, simple preparation method and low cost

Active Publication Date: 2012-03-28
FENGXIAN CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oleanane saponins Bakkenolide-Va and Bakkenolide-V have been extracted and isolated from safflower horse chestnut b , they have anti-cytotoxic activity (see: Melek FR, Miyase T, Abdel Khalik SM, El-Gindi MR. New furostanol saponins from Smilax aspera L. and their in vitro cytotoxicity. Fitoterapia.2003; 63: 401.), But so far there is no report on the extraction and separation of oleanane saponins aescin A and aescin B from safflower horse chestnut

Method used

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  • Oleanane saponin compounds and purpose thereof
  • Oleanane saponin compounds and purpose thereof
  • Oleanane saponin compounds and purpose thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1. Preparation of Compound Aescin A and Aescin B

[0017] 1. Preparation of Extract Extract

[0018] Take 20kg of safflower horse chestnut medicinal material, extract by percolation with 75% ethanol aqueous solution for 6 times as usual, combine the percolation liquid, concentrate under reduced pressure until it has no alcohol smell, and extract the obtained suspension with petroleum ether and dichloromethane successively. 3 times, the petroleum ether extract and the dichloromethane extract were combined respectively, and the dichloromethane extract was concentrated under reduced pressure to obtain 200 g of the extract extract;

[0019] 2. Separation and purification

[0020] 200 g of the above extract was subjected to repeated silica gel column (100 mesh silica gel) chromatography, and gradient elution was carried out with chloroform:methanol=30:1~1:1 as the eluent, and the collected concentrations were 30:1; 20:1 1; 10:1; 1:1 part of the eluate, the fourth p...

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Abstract

The invention relates to oleanane saponin compounds aescin A and aescin B extracted and separated from aesculus carnea, and a purpose thereof. The oleanane saponin compounds have a chemical general formula as the following. The R group represents =O or -OH. As a result of experiments, the compounds has activities such as malignant tumor inhibiting, body immunity improving, liver disease preventing and curing, cardio-cerebrovascular disease preventing and curing, and diabetes mellitus preventing and curing. The invention provides novel medicine resources for treating malignant tumors, improving body immunities, and preventing and curing liver diseases, cardio-cerebrovascular diseases or diabetes mellitus.

Description

technical field [0001] The invention relates to the technical field of medicine, and relates to novel oleanane saponin compounds aescin A and aescin B extracted and separated from Aesculus pavia L. and uses thereof. Background technique [0002] Aesculus carnea is a deciduous tree belonging to the genus Aesculus in the Aesculaceae family. It is commonly used in the treatment of corneal clouding, iridocyclitis, dizziness, and skin itching due to wind-heat. It is a commonly used medicine for traumatic injuries among the people. Oleanane saponins Bakkenolide-Va and Bakkenolide-V have been extracted and isolated from safflower horse chestnut b , they have anti-cytotoxic activity (see: Melek FR, Miyase T, Abdel Khalik SM, El-Gindi MR. New furostanol saponins from Smilax aspera L. and their in vitro cytotoxicity. Fitoterapia.2003; 63: 401.), But so far there is no report on the extraction and separation of oleanane saponins aescin A and aescin B from Aesculus safflower. Conten...

Claims

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Application Information

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IPC IPC(8): C07J63/00C07H15/256A61K31/704A61P35/00A61P37/04A61P1/16A61P9/00A61P9/10A61P3/10A61P3/04A61P3/06
Inventor 孙振亮贾万程冯景吴瑛鞠爱群
Owner FENGXIAN CENT HOSPITAL
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