18 alpha-glycyrrhetinic o-phthalate, and preparation and use thereof

A technology of glycyrrhetic acid and phthalate, applied in pharmaceutical formulations, medical preparations containing active ingredients, digestive system, etc., can solve the problem of slow biotransformation, inability to produce inflammatory mediators, and inability to immediately exert curative effects, etc. problems, to achieve strong anti-inflammatory, reduce production costs, reduce tissue damage
CN101486751AInactive Publication Date: 2009-07-22HANGHZOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
0 Cites 9 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HANGHZOU HOSPITAL OF TRADITIONAL CHINESE MEDICINE
Publication Date
2009-07-22
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to an 18Alpha-glycyrrhetinic acid o-phthalate, a method for preparing the 18Alpha-glycyrrhetinic acid o-phthalate and the application thereof in drugs. The invention aims at providing an 18Alpha-glycyrrhetinic acid o-phthalate which has safe use, strong pharmacological activity, and fast effect, and a method for preparing the 18Alpha-glycyrrhetinic acid o-phthalate; and the method has the advantages of simple process, and high product quality and yield. The technical proposal provided by the invention is as follows: the 18Alpha-glycyrrhetinic acid o-phthalate is characterized by being a pentacyclic triterpenoid derivative of o-phthalic acid which has the chemical name of 3-(1-carboxy-2-oxidation phenoxy)-11-O-18Alpha-oleanane-12-ene-29-formate, the molecular weight of 618.8, and the molecular formula of C38H 50O7 question mark R.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a 18α-glycyrrhetinic acid phthalate; at the same time, the invention also relates to a preparation method of the 18α-glycyrrhetinic acid phthalate and its application in medicine. Background technique

[0002] Glycyrrhizic acid is the most important active ingredient in natural licorice. Since licorice is a well-known and widely used natural medicine, research on its active ingredient glycyrrhizic acid and its salts has been quite in-depth. At present, studies have shown that licorice contains two epimers, 18α and 18β, but most of the glycyrrhizic acid in licorice is in the 18β configuration, and the 18α epimer only exists in a small amount in licorice. middle. It has been confirmed by clinical trials that the use of 18β-glycyrrhizinic acid injection can inhibit the activity of phospholipase A2 and block the metabolism of arachidonic acid in the initial stage, so that prostaglandins, leukotrienes and other inflammatory mediato...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More