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Gel taking 3 beta, 12, 13- trihydroxy- oleanane-28-acid as active ingredient

A technology for oleanane and active ingredient, which is applied in the gel field with 3β,12,13-trihydroxy-oleanane-28-acid as the active ingredient, can solve the swelling of mouse ears caused by undisclosed xylene Model treatment effects, unpublished applications, etc.

Inactive Publication Date: 2009-09-23
刘冬东
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent application CN200710194191.X discloses a kind of 3β, 12,13-trihydroxy-oleanane-28-acid (I) that has undergone structural transformation of oleanolic acid, and discloses that the compound paraxylene The mouse ear swelling model has an inhibitory effect, but the specific therapeutic effect of compound (I) p-xylene-induced mouse ear swelling model is not disclosed in this application, nor is its application in the treatment of specific diseases disclosed

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Gel preparation

[0025] 3β,12,13-Trihydroxy-oleanane-28-acid (I) 1g, dissolved in ethanol

[0026] Carbopol 940 2g Ethanol 10g Glycerin 50g Polysorbate 802g

[0027] Ethylparaben 1g Sodium hydroxide 4g Distilled water added to 1000g

[0028] Mix Carbopol with polysorbate 80 and 300ml of distilled water, dissolve sodium hydroxide in 100ml of water, add the supernatant and stir evenly, then dissolve ethylparaben and compound (I) in ethanol, add gradually and stir evenly, make up the remaining Amount of water is stirred evenly to obtain a transparent gel.

Embodiment 2

[0030] Gel preparation

[0031] 3β,12,13-Trihydroxy-oleanane-28-acid (I) 2g, dissolved in ethanol

[0032] Carbopol 934 5g Ethanol 20g Glycerin 50g Polysorbate 80 5g

[0033] Ethylparaben 1g Sodium hydroxide 4g Distilled water added to 1000g

[0034] Mix Carbopol with polysorbate 80 and 300ml of distilled water, dissolve sodium hydroxide in 100ml of water, add the supernatant and stir evenly, then dissolve ethylparaben and compound (I) in ethanol, add gradually and stir evenly, make up the remaining Amount of water is stirred evenly to obtain a transparent gel.

Embodiment 3

[0036] Gel preparation

[0037] 3β,12,13-trihydroxy-oleanane-28-acid (I) 5g, dissolved in ethanol

[0038] Carbopol 940 10g Ethanol 50g Glycerin 50g Polysorbate 80 10g

[0039] Ethylparaben 1g Sodium hydroxide 4g Distilled water added to 1000g

[0040] Mix Carbopol with polysorbate 80 and 300ml of distilled water, dissolve sodium hydroxide in 100ml of water, add the supernatant and stir evenly, then dissolve ethylparaben and compound (I) in ethanol, add gradually and stir evenly, make up the remaining Amount of water is stirred evenly to obtain a transparent gel.

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PUM

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Abstract

The invention relates to a gel taking 3 beta, 12, 13- trihydroxy- oleanane-28-acid as active ingredient, and provides a gel composition. The gel is characterized by containing the 3 beta, 12, 13- trihydroxy- oleanane-28-acid (I) taken as the active ingredient as well as one or more auxiliary material(s) which can be applicable to the gel, and the content of the 3 beta, 12, 13- trihydroxy- oleanane-28-acid in the gel composition is 0.01-2%.

Description

Technical field: [0001] 3β,12,13-Trihydroxy-oleanane-28-acid as active ingredient in gel [0002] The invention designs the application of a pentacyclic triterpenoid compound in the preparation of medicaments for treating skin diseases. Background technique: [0003] Pentacyclic triterpenoids, such as oleanolic acid (OA), is a chemical component of natural products, widely present in Hedyotis diffusa, hawthorn, clove, jujube, female Since the drug was first used in the treatment of hepatitis in the 1970s, researchers have continuously discovered its new pharmacological effects, and conducted in-depth research to make it widely used in clinical practice. application. Tian Liting et al. (Overview of the pharmacological effects of oleanolic acid, Chinese Journal of Traditional Chinese Medicine, 2002.12; 884-885) disclosed various uses of oleanolic acid in pharmacology, mainly including liver protection, detoxification, hypoglycemic , lipid-lowering effect, anti-viral effect,...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/56A61K47/38A61P17/00
Inventor 刘冬东
Owner 刘冬东
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