195results about "Imino compound preparation" patented technology

The invention discloses a clay stabilizer for a high-temperature environment and a preparation method of the clay stabilizer, and belongs to the technical field of oil field oil extraction auxiliaries. The preparation method comprises the following steps: mixing and stirring quaternary ammonium salt modified silicon dioxide and modified acrylamide according to a mass part ratio of 1: (5-6) to obtain the clay stabilizer. The clay stabilizer is obtained by mixing quaternary ammonium salt modified silicon dioxide and modified acrylamide, so that not only is the anti-swelling performance improved, but also the scouring resistance is improved.

The invention discloses an ether chain modified rhodamine fluorescent dye, an ether chain modified rhodamine fluorescent dye probe and a preparation method and application thereof, through modification of an ether chain, the water solubility of the rhodamine dye is improved, the aggregation quenching effect is reduced, meanwhile, the intramolecular torsional charge transfer (TICT) is reduced through the electron withdrawing effect of oxygen atoms, and the fluorescence sensitivity is improved. Finally, the quantum yield of the rhodamine dye is greatly improved. The quantum yield of ether chain modified oxygen rhodamine water is increased from 0.31 to 0.70, and the quantum yield of silicon-based rhodamine water is increased from 0.19 to 0.41. The rhodamine dye disclosed by the invention has the characteristics of high brightness, easiness in functional derivation and the like, and has application prospects in the fields of fluorescent probes, fluorescent labels, super-resolution fluorescence imaging and the like.

The invention discloses a method for degrading, recycling and reapplying anhydride cured epoxy resin, and relates to the field of epoxy resin and degradation and regeneration thereof. The invention provides a method for catalyzing degradation of anhydride cured epoxy resin, the method can realize rapid and efficient degradation of epoxy resin under mild conditions, and the generated degradation product contains active groups and can be further recycled. The invention further provides a regeneration method of the anhydride cured epoxy resin, the regenerated anhydride cured epoxy resin is good in mechanical property after being degraded, the comprehensive performance of the anhydride cured epoxy resin is slightly different from that of non-degraded anhydride cured epoxy resin, and the recycling value of the anhydride cured epoxy resin is high.

The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).

The invention discloses a bimetallic asymmetric reduction Schiff base catalyst for synthesizing ethylene carbonate and a preparation method of the bimetallic asymmetric reduction Schiff base catalyst. According to the catalyst, a diamine compound is subjected to selective single-side protection, the imine reduction position is controlled, and a bimetallic active center is introduced; the controllable synthesis of a product for reducing the outer side imine and a product for reducing the inner side imine is realized; the obtained product is recrystallized to obtain a monoimine-monoamine type ligand with a clear asymmetric structure, the monoimine-monoamine type ligand and metal salt form a bimetallic catalyst, and the catalyst generates a synergistic effect through double active sites and shows high catalytic activity and excellent product selectivity.

The application provides a triarylmethane derivative, a pigment dispersion liquid, a preparation method thereof and a photoresist, and relates to the field of photoresists. The structural general formula of the triarylmethane derivative is: wherein X1 is selected from one of long-chain alkyl groups with a length of C1-C12, X2 is selected from hydrogen or an alkyl group, X3 is selected from one of H, an alkyl group and an aromatic group, and Q is selected from one of a carboxyl group, a sulfonic acid group and a phosphoric acid group. The triarylmethane derivative can generate strong van der Waals force and pi-pi conjugation effect with pigment molecules in a colorant by virtue of the large-plane conjugated triarylmethane skeleton, so as to be firmly anchored on the surface of the pigment particles; the strong polar functional groups such as the sulfonic acid group in the molecular structure of the triarylmethane derivative are combined with the alkaline dispersant, the side long-chain alkyl groups fully act on the dispersion medium, and the re-aggregation of the nano pigment particles is effectively prevented through strong steric hindrance and electrostatic stabilization mechanism, so that the problem of poor dispersion stability is solved.

The invention provides a Schiff base material of which the molecular structural formula is at least one of the following formulas: the Schiff base material not only has the luminescence characteristic of chiral molecules, but also has the photochromic characteristic of Schiff base, can have the characteristic of intersection luminescence under co-excitation of ultraviolet light and blue-green light, and can be used in a display space of three-dimensional imaging of a static body. The Schiff base material is applied to three-dimensional display of a static body, is high in stability, good in reversibility, low in excitation light source power and low in risk, and can be prepared into devices for commercial application. The invention also provides a preparation method of the Schiff base material and a static body three-dimensional display system containing the Schiff base material.

This invention discloses a dual-wavelength excited Schiff base photo-switching material, a photochromic material, its preparation method, and its applications. The Schiff base photo-switching material of this invention is obtained by reflux reaction of 4-halosalicylaldehyde and a primary amine. Due to the p-π conjugation of the halogen atom with the benzene ring, the electron cloud density at the para position of the halogen atom is slightly higher than that at the meta position, making it easier for the Schiff base to undergo enol-keto configuration conversion, thus improving the luminescence efficiency of the material. Simultaneously, the amino group in the primary amine is not directly connected to the benzene ring, avoiding the conjugation of the C=N bond with the benzene ring on the primary amine side, improving the switching speed, and thus reducing the aggregation-induced fluorescence quenching phenomenon of the material molecules. The Schiff base photo-switching material and photochromic material provided by this invention can be applied in two-dimensional or three-dimensional display devices, light-controlled switching elements, multi-emissivity anti-counterfeiting materials, three-dimensional data storage, and other fields.

The invention provides an alpha-diimine ligand compound, an alpha-diimine nickel catalyst and a preparation method and application of the alpha-diimine ligand compound and the alpha-diimine nickel catalyst, and belongs to the technical field of organic synthesis. Wherein R1 is selected from hydrogen, methoxyl or tertiary butyl; r2 is selected from methyl, ethyl or isopropyl; and R3 is selected from hydrogen or methyl. The alpha-diimine nickel catalyst prepared by adopting the alpha-diimine ligand compound can catalyze olefin to carry out homopolymerization reaction or copolymerization reaction, so that not only is excellent catalytic performance shown, but also a polyolefin material obtained by catalyzing olefin monomer homopolymerization reaction has excellent elastic recovery performance; and the catalyst has certain application potential in olefin polymerization industry.

The invention provides an aldehyde insect pheromone derivative, which takes a compound containing at least one primary amine group as a carrier, and aldehyde insect pheromone forms an imine derivative with the compound through chemical reaction. The invention also provides a preparation method, application and a release method of the aldehyde insect pheromone derivative. According to the aldehyde insect pheromone derivative provided by the invention, aldehyde insect pheromones are treated in a chemical reaction manner, the stability of the aldehyde insect pheromones can be remarkably improved, slow release and controlled release of the pheromones can also be realized, the carrier material is wide in source, more in selectivity, convenient and economical, and in addition, the aldehyde insect pheromone derivative has good application prospects. The aldehyde insect pheromone derivative provided by the invention can also realize combined fixation and release of various pheromones, so that trapping, prevention and control of various insects can be realized.

The objective of the present invention is to provide a method for producing a carbonyl halide safely and efficiently. The method for producing a carbonyl halide according to the present invention is characterized in comprising the step of irradiating a light to a halomethane having 1 or more halogeno groups selected from the group consisting of chloro, bromo and iodo in the presence of oxygen and ozone.

The invention discloses a preparation method of liquid aliphatic secondary amine, which comprises the following steps: 1, carrying out reductive alkylation reaction on aliphatic secondary amine, 3, 3-dimethyl-2-butanone and hydrogen under the action of a platinum-carbon catalyst and a sulfur-containing organic matter; and 2, filtering the reaction mixture, and carrying out vacuum distillation to obtain the target product. According to the method, hydrogen is used as a reducing agent, the process is green and environment-friendly, side reactions are few, and the purity of the prepared aliphatic secondary amine can reach 98% or above. The preparation method comprises the following steps: dissolving trace dimethyl sulfoxide in an ethanol solution to form a dimethyl sulfoxide-ethanol dispersion mixed solution, adding the dimethyl sulfoxide-ethanol dispersion mixed solution into a high-pressure hydrogenation reaction kettle, fully mixing the dimethyl sulfoxide-ethanol dispersion mixed solution with an obtained imine mixture, and adding a platinum-carbon catalyst. The preparation method of the liquid aliphatic secondary amine, which is disclosed by the invention, has the advantages of high catalyst selectivity and strong activity, and is suitable for producing the liquid aliphatic secondary amine.

The application discloses a Salen catalyst which has a structure shown in formula (I-1). The Salen catalyst is a polynuclear catalyst, two or more mononuclear catalysts can be connected into the polynuclear catalyst through a group containing an amide bond, the catalytic efficiency, the resolution yield, the recovery rate and the activity after recovery of the catalyst can be improved, the polynuclear catalyst after recovery can be mixed with a fresh polynuclear catalyst for use, and the resolution yield is high, and the polynuclear catalyst can be recycled and reused for multiple times. In addition, when the polynuclear catalyst participates in a resolution reaction, an excessive amount of water is not needed, the reaction yield can be improved, the time for resolving an end epoxy compound can be shortened, the prepared product has high purity and few impurities, and the problem of difficult purification of a final product can be solved.

The present invention disclosed 3-substituted phenylamidine compounds of general formula (I), wherein R1, R2, R3, R4, R4a, R4b, A and E have the same meanings as defined in description. The present invention further discloses methods for their preparation and use of the compounds of general formula (I) as a crop protection agent.

The objective of the present invention is to provide a method for producing a carbonyl halide safely and efficiently. The method for producing a carbonyl halide according to the present invention is characterized in comprising the step of irradiating a light to a halomethane having 1 or more halogeno groups selected from the group consisting of chloro, bromo and iodo in the presence of oxygen and ozone.

The invention discloses a face-to-face binuclear cobalt complex and a preparation method and application thereof, and belongs to the technical field of organic synthesis and catalysis, the face-to-face binuclear cobalt complex is a crystal material A or a crystal material B, the chemical formula of the crystal material A is C68H68Co2N4O6, and the chemical formula of the crystal material B is C54H76Co2N6O6; the face-to-face dual-core cobalt complex comprises a crystal material A and a crystal material B. The center distance between two metal cobalt of the crystal material A is 4.821, a ligand is connected with the two metal centers in a bridging mode to form a large cavity, the dual-metal cobalt complex is formed, the two metal cobalt are subjected to synergistic activation at + 2 valence, and the dual-metal cobalt complex is formed. And hydroxyl radicals can be generated through homolysis. Wherein the ligand of the crystal material B is connected with two metal cobalt centers in a carbon chain bridging mode, the coordination environment of each metal cobalt center is in an octahedral configuration, the distance between the two metal centers is 5.720, the two metal centers are in + 3 valence at the same time, and the binuclear cobalt complex is formed.

The application discloses a method for preparing alpha-deuterated-alpha-trifluoromethyl amine compounds by organic catalysis. The chiral product can be prepared by a betaine inner salt catalyst based on a cinchona alkaloid skeleton or a tertiary amine catalyst based on a cinchona alkaloid skeleton. The racemic product can be prepared by a non-chiral tertiary amine catalyst, a phase transfer catalyst or a crown ether. Meanwhile, the deuterium substitution reaction process adopts organic catalysis, has no transition metal residue risk, simple and mild conditions, good functional group compatibility, and the product is easy to purify. The method is suitable for the synthesis of alpha-deuterated-alpha-trifluoromethyl amine compounds of different types of substitution including alkyl and aryl, has high deuterium substitution rate and good selectivity.

The invention discloses a synthesis method of olefin epoxide and a used catalyst. According to the synthesis method, a complex of a Schiff base ligand and metal ions is adopted as a catalyst, and the structural formula of the Schiff base ligand is shown in the specification. According to the synthesis method, a solvent is not needed, the catalyst dosage is small, the reaction condition is mild, and meanwhile the olefin conversion rate and the target product selectivity are remarkably improved.

The present invention, in particular, is based on formula (I) [Formula 1] JPEG2026512768000067.jpg31160 (wherein the formula, the substituents are as defined in claim 1) This provides a process for preparing the compound.

The application discloses a kind of vinylidene acenaphthene double asymmetric alpha-diimine chemical intermediates and catalyst prepared from it, intermediate and the preparation method and application of catalyst. 2,4,6-tri-tert-butyl aniline is used as raw material, in the presence of catalyst, under the condition of 120 DEG C, the vinylidene acenaphthene double asymmetric alpha-diimine chemical intermediate with structure as shown in formula (I) is obtained.Compared with prior art, the application uses commercially available, low-cost and storage condition loose 2,4,6-tri-tert-butyl aniline instead of high-cost, storage harsh 2,4-di-tert-butyl aniline as reaction raw material, which effectively reduces the raw material procurement threshold and comprehensive production cost, and simplifies the storage condition.The raw material of the method is easy to obtain, low in cost, easy to operate, high in yield, and suitable for industrial scale-up production.

The invention discloses p-methoxybenzylamine as well as a preparation method and application thereof, and belongs to the field of acyclic or carbocyclic compounds. The preparation method comprises the following steps: (1) adding p-methoxybenzaldehyde into a reaction container, sequentially adding an ethanol solution and ammonia water, heating and stirring, and reacting at 50-90 DEG C in a normal pressure environment; after the reaction, carrying out reduced pressure distillation to obtain p-methoxybenzylimine; the molar ratio of the p-methoxybenzaldehyde to the ammonia water is 1: (1-1.3); (2) dissolving p-methoxybenzylimine in methanol, adding a sodium hydroxide solution and 4-dimethylaminopyridine, then adding sodium borohydride, and reacting at the temperature of 0-30 DEG C under normal pressure; after the reaction is completed, adding acid into a product for hydrolysis; and adjusting the product to be alkalescent, extracting, drying, filtering and distilling to obtain the p-methoxybenzylamine. A new strategy for synthesizing p-methoxybenzylamine is introduced, the reaction does not involve high temperature, and the reaction conditions are milder and more controllable.

The invention relates to the field of chemical organic synthesis, and particularly discloses a synthesis method of 1-bromo-4-(tert-butyl) naphthalene. In the technical scheme, after a compound 1 is coupled to obtain a mixed solution containing a compound 2, the mixed solution containing the compound 2 can be directly used as a raw material to synthesize a compound 3 without a refining and purifying step of the compound 2; according to the present invention, the intermediate compound 2 is prevented from being lost so as to improve the yield, the generation of the isomer is not found during the bromination process through the pre-occupation of the tert-butyl in the compound 4 synthesis process of the compound 3, the yield of the target product compound 4 is high, and finally the compound 5 can be obtained through the deamination and simple distillation of the compound 4.

To provide a new compound (general formula (A)) having a naphthalenone skeleton and a method for producing the same. (In general formula (A), R1 represents an alkyl group having 6-13 carbon atoms, and R 2 represents a hydrogen atom or an alkyl group having 1-4 carbon atoms.)

The invention belongs to the technical field of liquid-phase benzylamine compound catalytic oxidation application catalysts, and particularly relates to application of a two-dimensional boron oxide alkene nanosheet catalyst to preparation of imine by catalyzing oxidative coupling of benzylamine compounds. In the reaction, a benzylamine compound is used as a substrate, no solvent is used, oxygen is used as an oxygen source, a two-dimensional boron oxide alkene nanosheet is used as a catalyst, the reaction temperature is 80-100 DEG C, the reaction time is 10-30 hours, and the oxygen pressure is normal pressure. The catalytic system does not involve the introduction of any metal active center, the cost of the catalytic system is effectively reduced, the introduction of trace metal impurities in the product is avoided, and the two-dimensional boron oxide alkene nanosheet shows higher selectivity than other boron-based catalysts, shows higher catalytic activity than corresponding graphene oxide, and has a good application prospect. And compared with some current metal catalytic systems, the catalyst also has obvious catalytic activity advantage.

The application belongs to the technical field of optical functional materials, and provides a low-temperature organic Schiff base crystal material with adjustable light emission and a preparation method thereof. The application adopts a naphthyl Schiff base core structure and a halogen substituent group precise regulation strategy, realizes wide-range and reversible spectral regulation from blue shift (-30 nm) to red shift (+92 nm). On this basis, the prepared crystal has excellent mechanical flexibility and elasticity in a deep low-temperature environment, and the composite film also exhibits stable light emission performance, effectively solving the core material problem of flexible low-temperature photoelectric devices. Moreover, the crystal preparation route is simple, does not need complex catalysts or inert protection, and is low in cost, and has a significant industrialization prospect. Finally, with the unique low-temperature adjustable light emission and flexible integration performance, the series of crystal materials prepared by the application have broad application potential in the fields of flexible low-temperature optical sensing, intelligent identification and display, optical anti-counterfeiting and encryption and the like.

The invention discloses a method for synthesizing 5-(N, N-dibenzyl amino acetyl) salicylamide, which comprises the following steps: by taking benzaldehyde and benzylamine as raw materials and ethanol as a solvent, heating to a reaction temperature by using a micro-channel reactor, and reacting to obtain N-benzylidene benzylamine after the reaction is finished; taking the prepared N-benzylidene benzylamine as a raw material, adding hydrogen and a palladium carbon catalyst, reacting, and discharging the hydrogen after the reaction to obtain dibenzylamine; 5-bromoacetyl salicylamide and the prepared dibenzylamine are taken as raw materials, K2CO3 is taken as an acid-binding agent (or a deep eutectic solvent is used for replacing the acid-binding agent), acetonitrile is taken as a solvent, the materials are dropwise added under a low-temperature condition, a temperature rise reaction is carried out after dropwise adding is completed, the pH value of an obtained solid is adjusted with diluted hydrochloric acid to be acidic, then filtering, washing and drying are carried out, and the target product 5-(N, N-dimethyl-N, N-dimethyl formamide) is obtained. The compound is N, N-dibenzyl amino acetyl) salicylamide. The method has the advantages that the method is simple, the microchannel reactor is used, the product yield is high, the purity is high, and industrial production is easy.

The invention belongs to the field of synthesis and preparation of Schiff base single crystals, and particularly relates to a p-xylylene-bis (4-amino-3-methylphenol) Schiff base single crystal and a preparation method thereof. The p-xylylene-bis (4-amino-3-methylphenol) Schiff base single crystal is a Schiff base formed by condensation of one molecule of p-phthalaldehyde and two molecules of 4-amino-3-methylphenol, and is a completely symmetrical bis-Schiff base, and the molecular structural formula of the p-xylylene-bis (4-amino-3-methylphenol) Schiff base single crystal is C22H20N2O2. The compound has good optical performance, can be used as a reaction intermediate product for synthesis of epoxy resin, and has important significance for research of high-thermal-conductivity epoxy resin; and the new single crystal can show excellent photoelectric properties, thermal stability or magnetism, and promotes the innovation of photoelectric devices or spintronics devices.

The application relates to the technical field of organic synthesis, and discloses a method and system for preparing p-phenylenediamine antidegradants. The method comprises the following steps: (1) performing a dehydration condensation reaction on RT pesi and acetone in the presence of molecular sieves to obtain a first mixed solution containing a Schiff base; (2) performing a hydrogenation reaction on the first mixed solution containing the Schiff base in the presence of a hydrogenation catalyst to obtain a second mixed solution; and (3) performing separation crystallization on the second mixed solution to obtain an antidegradant 4010NA and an antidegradant 6PPD. The method and system can coproduce the antidegradants 4010NA and 6PPD, the proportion of 4010NA and 6PPD in the products can be flexibly controlled within a certain range compared with a one-step condensation hydrogenation process, the proportion of 6PPD in the products is increased, and the prepared antidegradant products are high in purity.

The application discloses a novel amino acid surfactant and a preparation method thereof. The novel amino acid surfactant has a hydrophobic part formed by a catechol compound and a hydrophilic part formed by an amino acid. The preparation method comprises the following steps: subjecting ortho-benzoquinone obtained by oxidizing the catechol compound to Michael addition reaction and Schiff base reaction with the amino acid, so that the catechol and the amino acid are covalently connected, and the novel amino acid surfactant is obtained. The preparation method has the advantages of short reaction time, simple process and low energy consumption. The prepared surfactant has the advantages of novel structure, high biological safety and excellent surface performance.

The invention discloses a preparation method of cinacalcet hydrochloride. The preparation method comprises the following steps: 1) carrying out a reaction on 3-(3-trifluoromethylphenyl) propanol and phosphorus oxychloride; first post-treatment: extracting the product obtained in the step 1) by using an organic solvent, drying and concentrating to obtain 1-(3-chloropropyl)-3-trifluoromethyl benzene; (2) carrying out substitution reaction on the 1-(3-chloropropyl)-3-trifluoromethyl benzene obtained by the first post-treatment and (R)-1-(1-naphthyl) ethylamine; the product obtained in the second step is subjected to extraction, drying and concentration through an organic solvent and then subjected to a salt forming reaction with hydrochloric acid, and cinacalcet hydrochloride is obtained.According to the method, it is guaranteed that the product has the good yield and high purity, meanwhile, the impurity content, especially oxidation impurities, is remarkably reduced, and the appearance color and luster of cinacalcet hydrochloride are effectively improved.