300results about "Imino compound preparation" patented technology

The invention provides a preparation method of a chain extender containing an imine bond and application of the chain extender in thermosetting polyurethane, and the preparation method comprises the following steps: under anhydrous and anaerobic conditions, mixing a reagent A and a reagent B, adding a solvent, reacting at 25-40 DEG C for 4-6 hours, cooling to room temperature, and carrying out rotary evaporation to remove the solvent to obtain the chain extender, wherein the reagent A is a derivative of benzene, one substituent group is an aldehyde group, at least one of the other five substituent groups is a hydroxyl group or an aldehyde group, and the reagent B is an organic compound containing both amido and hydroxyl group or an organic compound containing both amido and hydroxyl group. When the chain extender is used for preparing thermosetting polyurethane, imine bonds and carbamate bonds can be introduced into one monomer at the same time, so that the thermosetting polyurethane can maintain original excellent mechanical properties, solvent resistance and thermal stability, and also has self-healing and recyclable capabilities; the compatibility is good, and the performance and the application range of the thermosetting polyurethane are widened.

The invention relates to the technical field of medical chemistry, in particular to a bridge oxygen site regulatively modified rhodamine anti-cancer fluorescent compound as well as a preparation method and application thereof. The invention develops the rhodamine anti-cancer fluorescent compound of which the meso site is functionalized by tetraarylethene and the bridge oxygen site can be regulated and modified, the fluorescent compound has adjustable red light-near infrared fluorescence emission and excellent fluorescence quantum yield, and the quantum yield can be as high as 99%; the fluorescent compound specifically targets mitochondria, and mainly inhibits growth of tumor cells by inducing para-apoptosis; under irradiation of 655 nm near-infrared laser, ferroptosis is further triggered, efficient treatment of tumor cells is achieved through chemical-photodynamic synergistic effect, and a new treatment thought is provided for overcoming tumor drug resistance.

The invention discloses a clay stabilizer for a high-temperature environment and a preparation method of the clay stabilizer, and belongs to the technical field of oil field oil extraction auxiliaries. The preparation method comprises the following steps: mixing and stirring quaternary ammonium salt modified silicon dioxide and modified acrylamide according to a mass part ratio of 1: (5-6) to obtain the clay stabilizer. The clay stabilizer is obtained by mixing quaternary ammonium salt modified silicon dioxide and modified acrylamide, so that not only is the anti-swelling performance improved, but also the scouring resistance is improved.

The invention discloses an ether chain modified rhodamine fluorescent dye, an ether chain modified rhodamine fluorescent dye probe and a preparation method and application thereof, through modification of an ether chain, the water solubility of the rhodamine dye is improved, the aggregation quenching effect is reduced, meanwhile, the intramolecular torsional charge transfer (TICT) is reduced through the electron withdrawing effect of oxygen atoms, and the fluorescence sensitivity is improved. Finally, the quantum yield of the rhodamine dye is greatly improved. The quantum yield of ether chain modified oxygen rhodamine water is increased from 0.31 to 0.70, and the quantum yield of silicon-based rhodamine water is increased from 0.19 to 0.41. The rhodamine dye disclosed by the invention has the characteristics of high brightness, easiness in functional derivation and the like, and has application prospects in the fields of fluorescent probes, fluorescent labels, super-resolution fluorescence imaging and the like.

The invention relates to a reaction type closed diamine chain extender, dual-curing photosensitive resin, a 3D printed part and a preparation method, the reaction type closed diamine chain extender is obtained through reaction of a diamine chain extender and a functional monomer, the functional monomer at least comprises a functional group A, a functional group B and a functional group C, the functional group A is an aldehyde group or a ketone group and is used for reacting with an amino group in the diamine chain extender; and a functional group B containing a photocurable unsaturated bond. The reactive closed diamine chain extender provided by the invention participates in a photocuring process, so that the strength of a material in a photocuring stage is improved, the product yield in a printing process is ensured, no by-product is generated during subsequent heat treatment, and the mechanical property of a final finished product is not influenced. The dual-curing photosensitive resin can be stably stored for a long time, the mechanical property of the material can be remarkably improved through the photocuring-heat treatment synergistic effect, and the dual-curing photosensitive resin can be used for photocuring 3D printing technologies such as sinking type SLA and pull-up type DLP and LCD at the same time.

The invention discloses a method for degrading, recycling and reapplying anhydride cured epoxy resin, and relates to the field of epoxy resin and degradation and regeneration thereof. The invention provides a method for catalyzing degradation of anhydride cured epoxy resin, the method can realize rapid and efficient degradation of epoxy resin under mild conditions, and the generated degradation product contains active groups and can be further recycled. The invention further provides a regeneration method of the anhydride cured epoxy resin, the regenerated anhydride cured epoxy resin is good in mechanical property after being degraded, the comprehensive performance of the anhydride cured epoxy resin is slightly different from that of non-degraded anhydride cured epoxy resin, and the recycling value of the anhydride cured epoxy resin is high.

The present disclosure relates to the fields of chemistry and medicine, more particularly to processes for making 4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-prop-2-ynyl-1,3-thiazol-2-amine (Compound 1), pharmaceutically acceptable salts, and crystalline forms thereof, for the treatment of congenital adrenal hyperplasia (CAH).

The invention belongs to the technical field of analysis and detection of liquid nutritional agents, and provides a coniferous and cypress hydroformylation salicyl ester molecular device and a preparation method and application thereof. The method comprises the following steps: mixing a coniferyl aldehyde solution, a dehydrating agent dispersion liquid and a salicyl ester derivative solution, and carrying out a dehydration condensation reaction on the mixed solution to obtain the coniferyl hydroformylated salicyl ester molecular device. The coniferous hydroformylated salicylate molecular device has the advantages of high viscosity sensitivity coefficient, stable chemical structure, strong visualization effect, release of stable optical signals in a wide pH range, insensitivity to the polarity of the solvent, and good solvent tolerance; the device can be used as a molecular tool for in-situ measurement of viscosity in a nutritional agent microenvironment, detection can be realized without depending on shearing and relative movement in the measurement process, consumption of a large amount of samples can be avoided, the whole process is rapid, efficient and convenient, and viscosity change of a liquid nutritional agent containing a large amount of pseudoplastic fluid can be effectively measured.

The invention relates to the field of viscosity detection, and provides a fluorescent probe for detecting the viscosity of mask essence as well as a preparation method and application of the fluorescent probe. 4, 4 '-(iminomethylene) bis (N, N-dimethylaniline) which is slightly soluble in water reacts with acid to form auramine hydrochloride, the water solubility of the auramine hydrochloride fluorescent probe is greatly enhanced, the probe in a water phase is converted into heat (non-radiation decay) due to twisted intramolecular charge transfer and excited state energy caused by benzene ring rotation, and fluorescence quenching is shown; when the viscosity of the solvent is increased, rotation of the benzene ring is blocked, excited state energy cannot be converted into heat and is dissipated in a radiation attenuation mode, fluorescence is enhanced, and viscosity detection of the mask essence with the main component being water is achieved based on the principle. According to the present invention, the method has characteristics of simple synthesis, stable property, no interference of solvent polarity during detection, long-term storage and long-term use, rapid and high-specificity viscosity response ability, and quantitative analysis of viscosity.

The invention discloses an application of a SiC QDs catalyst in a photocatalytic benzylamine oxidative coupling reaction. The catalyst takes SiC as a raw material. The preparation method specifically comprises the following steps: dispersing SiC in a hydrofluoric acid-nitric acid mixed aqueous solution, heating to 100 DEG C in a hydrothermal kettle, maintaining for 1-6 hours, taking out, cooling to room temperature, diluting with deionized water, carrying out ultrasonic oscillation, carrying out centrifugal acid removal to obtain neutral large particles, dispersing into deionized water, carrying out ultrasonic treatment, centrifuging, taking supernatant, and carrying out freeze drying treatment to obtain the SiC-based composite material. The SiC QDs catalyst is obtained. By applying the SiC QDs catalyst, the benzylamine can be efficiently subjected to photocatalytic oxidative coupling in an air atmosphere. Compared with the traditional metal photocatalyst, the metal-free nano photocatalyst prepared by the method has the advantage that the catalyst cost is greatly reduced.

The invention discloses a triarylmethane type I photosensitive dye as well as a synthesis method and application thereof. The structure of the dye is shown as a general formula I; intramolecular charge separation is optimized by regulating substituent groups, and the generation efficiency of superoxide anions and hydroxyl radicals is remarkably improved. According to the synthesis method, 4-diphenylaminobenzaldehyde or 4-vinyl benzaldehyde is used as a raw material, efficient preparation is achieved through the steps of condensation, oxidation and the like, the raw material is easy to obtain, and operation is easy and convenient. The dye has strong absorption at the wavelength of 600-630 nm, is suitable for red light triggered photodynamic therapy (PDT), especially keeps high reactive oxygen yield under the hypoxic condition, and breaks through the oxygen dependence limitation of traditional PDT. Experiments show that the dye can induce ferroptosis of tumor cells, has the functions of fluorescence imaging and treatment, and has wide application prospects in the fields of antitumor drugs, in-vivo fluorescence labeling, photoresponsive functional preparations and the like.

The invention discloses a bimetallic asymmetric reduction Schiff base catalyst for synthesizing ethylene carbonate and a preparation method of the bimetallic asymmetric reduction Schiff base catalyst. According to the catalyst, a diamine compound is subjected to selective single-side protection, the imine reduction position is controlled, and a bimetallic active center is introduced; the controllable synthesis of a product for reducing the outer side imine and a product for reducing the inner side imine is realized; the obtained product is recrystallized to obtain a monoimine-monoamine type ligand with a clear asymmetric structure, the monoimine-monoamine type ligand and metal salt form a bimetallic catalyst, and the catalyst generates a synergistic effect through double active sites and shows high catalytic activity and excellent product selectivity.

The application provides a triarylmethane derivative, a pigment dispersion liquid, a preparation method thereof and a photoresist, and relates to the field of photoresists. The structural general formula of the triarylmethane derivative is: wherein X1 is selected from one of long-chain alkyl groups with a length of C1-C12, X2 is selected from hydrogen or an alkyl group, X3 is selected from one of H, an alkyl group and an aromatic group, and Q is selected from one of a carboxyl group, a sulfonic acid group and a phosphoric acid group. The triarylmethane derivative can generate strong van der Waals force and pi-pi conjugation effect with pigment molecules in a colorant by virtue of the large-plane conjugated triarylmethane skeleton, so as to be firmly anchored on the surface of the pigment particles; the strong polar functional groups such as the sulfonic acid group in the molecular structure of the triarylmethane derivative are combined with the alkaline dispersant, the side long-chain alkyl groups fully act on the dispersion medium, and the re-aggregation of the nano pigment particles is effectively prevented through strong steric hindrance and electrostatic stabilization mechanism, so that the problem of poor dispersion stability is solved.

The invention discloses a method for preparing a remote oxyimidization product based on an olefin 1, 5-HAT strategy, the product and application, and belongs to the technical field of organic synthesis.The method comprises the following steps that unactivated olefin containing a benzoyl skeleton, oxime carbonate, a catalyst and an organic solvent are mixed and then stirred to react under the illumination condition, the solvent is removed after the reaction is finished, and the remote oxyimidization product is obtained. And carrying out purification treatment to obtain the remote oxyimidization product. The method provided by the invention not only is simple and convenient to operate, but also is green and environment-friendly, and provides a novel and potential synthesis strategy for constructing a complex compound skeleton containing a C-N bond and a C-O bond and realizing a remote position bifunctionalization reaction.

The invention provides a Schiff base material of which the molecular structural formula is at least one of the following formulas: the Schiff base material not only has the luminescence characteristic of chiral molecules, but also has the photochromic characteristic of Schiff base, can have the characteristic of intersection luminescence under co-excitation of ultraviolet light and blue-green light, and can be used in a display space of three-dimensional imaging of a static body. The Schiff base material is applied to three-dimensional display of a static body, is high in stability, good in reversibility, low in excitation light source power and low in risk, and can be prepared into devices for commercial application. The invention also provides a preparation method of the Schiff base material and a static body three-dimensional display system containing the Schiff base material.

This invention discloses a dual-wavelength excited Schiff base photo-switching material, a photochromic material, its preparation method, and its applications. The Schiff base photo-switching material of this invention is obtained by reflux reaction of 4-halosalicylaldehyde and a primary amine. Due to the p-π conjugation of the halogen atom with the benzene ring, the electron cloud density at the para position of the halogen atom is slightly higher than that at the meta position, making it easier for the Schiff base to undergo enol-keto configuration conversion, thus improving the luminescence efficiency of the material. Simultaneously, the amino group in the primary amine is not directly connected to the benzene ring, avoiding the conjugation of the C=N bond with the benzene ring on the primary amine side, improving the switching speed, and thus reducing the aggregation-induced fluorescence quenching phenomenon of the material molecules. The Schiff base photo-switching material and photochromic material provided by this invention can be applied in two-dimensional or three-dimensional display devices, light-controlled switching elements, multi-emissivity anti-counterfeiting materials, three-dimensional data storage, and other fields.

The invention provides an alpha-diimine ligand compound, an alpha-diimine nickel catalyst and a preparation method and application of the alpha-diimine ligand compound and the alpha-diimine nickel catalyst, and belongs to the technical field of organic synthesis. Wherein R1 is selected from hydrogen, methoxyl or tertiary butyl; r2 is selected from methyl, ethyl or isopropyl; and R3 is selected from hydrogen or methyl. The alpha-diimine nickel catalyst prepared by adopting the alpha-diimine ligand compound can catalyze olefin to carry out homopolymerization reaction or copolymerization reaction, so that not only is excellent catalytic performance shown, but also a polyolefin material obtained by catalyzing olefin monomer homopolymerization reaction has excellent elastic recovery performance; and the catalyst has certain application potential in olefin polymerization industry.

The invention provides an aldehyde insect pheromone derivative, which takes a compound containing at least one primary amine group as a carrier, and aldehyde insect pheromone forms an imine derivative with the compound through chemical reaction. The invention also provides a preparation method, application and a release method of the aldehyde insect pheromone derivative. According to the aldehyde insect pheromone derivative provided by the invention, aldehyde insect pheromones are treated in a chemical reaction manner, the stability of the aldehyde insect pheromones can be remarkably improved, slow release and controlled release of the pheromones can also be realized, the carrier material is wide in source, more in selectivity, convenient and economical, and in addition, the aldehyde insect pheromone derivative has good application prospects. The aldehyde insect pheromone derivative provided by the invention can also realize combined fixation and release of various pheromones, so that trapping, prevention and control of various insects can be realized.

The invention provides a Schiff base material of which the molecular structural formula is shown in the specification, and the Schiff base material has ultrafast reversible photochromic characteristic, can emit light at a light source intersection under the combined action of a photochromic light source and a ketone tautomer fluorescence excitation light source, and is a light-emitting material adaptable to three-dimensional display application. The photochromic property of the Schiff base material is stable and not prone to failure, the Schiff base material is high in transparency and light in color in media such as solutions, epoxy resin and polymethyl methacrylate, display patterns are not shielded, and the Schiff base material is high in practical value in in-vivo three-dimensional display application. The invention also provides a preparation method of the Schiff base material and a bulk three-dimensional display system containing the Schiff base material.

The objective of the present invention is to provide a method for producing a carbonyl halide safely and efficiently. The method for producing a carbonyl halide according to the present invention is characterized in comprising the step of irradiating a light to a halomethane having 1 or more halogeno groups selected from the group consisting of chloro, bromo and iodo in the presence of oxygen and ozone.

The invention discloses a preparation method of liquid aliphatic secondary amine, which comprises the following steps: 1, carrying out reductive alkylation reaction on aliphatic secondary amine, 3, 3-dimethyl-2-butanone and hydrogen under the action of a platinum-carbon catalyst and a sulfur-containing organic matter; and 2, filtering the reaction mixture, and carrying out vacuum distillation to obtain the target product. According to the method, hydrogen is used as a reducing agent, the process is green and environment-friendly, side reactions are few, and the purity of the prepared aliphatic secondary amine can reach 98% or above. The preparation method comprises the following steps: dissolving trace dimethyl sulfoxide in an ethanol solution to form a dimethyl sulfoxide-ethanol dispersion mixed solution, adding the dimethyl sulfoxide-ethanol dispersion mixed solution into a high-pressure hydrogenation reaction kettle, fully mixing the dimethyl sulfoxide-ethanol dispersion mixed solution with an obtained imine mixture, and adding a platinum-carbon catalyst. The preparation method of the liquid aliphatic secondary amine, which is disclosed by the invention, has the advantages of high catalyst selectivity and strong activity, and is suitable for producing the liquid aliphatic secondary amine.

The application discloses a Salen catalyst which has a structure shown in formula (I-1). The Salen catalyst is a polynuclear catalyst, two or more mononuclear catalysts can be connected into the polynuclear catalyst through a group containing an amide bond, the catalytic efficiency, the resolution yield, the recovery rate and the activity after recovery of the catalyst can be improved, the polynuclear catalyst after recovery can be mixed with a fresh polynuclear catalyst for use, and the resolution yield is high, and the polynuclear catalyst can be recycled and reused for multiple times. In addition, when the polynuclear catalyst participates in a resolution reaction, an excessive amount of water is not needed, the reaction yield can be improved, the time for resolving an end epoxy compound can be shortened, the prepared product has high purity and few impurities, and the problem of difficult purification of a final product can be solved.

The present invention disclosed 3-substituted phenylamidine compounds of general formula (I), wherein R1, R2, R3, R4, R4a, R4b, A and E have the same meanings as defined in description. The present invention further discloses methods for their preparation and use of the compounds of general formula (I) as a crop protection agent.

The present disclosure relates to a process of preparation of 2-amino alcohol of formula I comprising: i) reacting 2-hydroxyketone or 2-hydroxyaldehyde of formula II in presence of an aminating agent and a solvent under condition to obtain imine intermediate; and ii) processing by hydrogenation the imine intermediate in presence of a metal catalyst and H2 under condition to obtain 2-amino alcohol of Formula I.

The objective of the present invention is to provide a method for producing a carbonyl halide safely and efficiently. The method for producing a carbonyl halide according to the present invention is characterized in comprising the step of irradiating a light to a halomethane having 1 or more halogeno groups selected from the group consisting of chloro, bromo and iodo in the presence of oxygen and ozone.

This disclosure concerns wild-type and engineered D-Ala-D-Ala ligases (Ddls) and their use for synthesising mycosporine-like amino acids (MAAs), such as MAAs derived from a mycosporine-glutamine backbone and MAAs with hydrophobic side groups. Also disclosed are compositions and uses of the synthesised MAAs.

The invention discloses a face-to-face binuclear cobalt complex and a preparation method and application thereof, and belongs to the technical field of organic synthesis and catalysis, the face-to-face binuclear cobalt complex is a crystal material A or a crystal material B, the chemical formula of the crystal material A is C68H68Co2N4O6, and the chemical formula of the crystal material B is C54H76Co2N6O6; the face-to-face dual-core cobalt complex comprises a crystal material A and a crystal material B. The center distance between two metal cobalt of the crystal material A is 4.821, a ligand is connected with the two metal centers in a bridging mode to form a large cavity, the dual-metal cobalt complex is formed, the two metal cobalt are subjected to synergistic activation at + 2 valence, and the dual-metal cobalt complex is formed. And hydroxyl radicals can be generated through homolysis. Wherein the ligand of the crystal material B is connected with two metal cobalt centers in a carbon chain bridging mode, the coordination environment of each metal cobalt center is in an octahedral configuration, the distance between the two metal centers is 5.720, the two metal centers are in + 3 valence at the same time, and the binuclear cobalt complex is formed.

The application discloses a method for preparing alpha-deuterated-alpha-trifluoromethyl amine compounds by organic catalysis. The chiral product can be prepared by a betaine inner salt catalyst based on a cinchona alkaloid skeleton or a tertiary amine catalyst based on a cinchona alkaloid skeleton. The racemic product can be prepared by a non-chiral tertiary amine catalyst, a phase transfer catalyst or a crown ether. Meanwhile, the deuterium substitution reaction process adopts organic catalysis, has no transition metal residue risk, simple and mild conditions, good functional group compatibility, and the product is easy to purify. The method is suitable for the synthesis of alpha-deuterated-alpha-trifluoromethyl amine compounds of different types of substitution including alkyl and aryl, has high deuterium substitution rate and good selectivity.

The invention discloses a synthesis method of olefin epoxide and a used catalyst. According to the synthesis method, a complex of a Schiff base ligand and metal ions is adopted as a catalyst, and the structural formula of the Schiff base ligand is shown in the specification. According to the synthesis method, a solvent is not needed, the catalyst dosage is small, the reaction condition is mild, and meanwhile the olefin conversion rate and the target product selectivity are remarkably improved.