The invention relates to a method for preparing a hypoglycemic
drug mitiglinide calcium. According to the method, under the temperature of -5 DEG C-10 DEG C, 30-60g of 2-benzylidene-3-(cis-perhydro-isoindolyl-2-carbonyl)propionic acid is dissolved in 200-500 milliliters of a reaction
solvent, 2-5 g of a S-configuration aminoalcohol catalyst, 8-15 g of a
borohydride and 15-25 g of trimethylchlorosilane are added, the materials are stirred for a reaction for 4-8 hours,
pressure reduction is carried out for
steaming the
solvent, 400-600 milliliters of water and 4-6 milliliters of
hydrochloric acid are added,
ethyl acetate is used for extraction, an extract is merged, the extract is dried and concentrated to obtain a concentrate, the concentrate is dissolved in 400-600 mL of
ethanol with
mass concentration of 75-95%, 3-5 g of
sodium hydroxide is added, after stirring and dissolving the materials, 8-12 g of
calcium chloride is added, precipitate is obtained, and then the precipitate is subjected to pumping
filtration to obtain
mitiglinide calcium. The preparing method has the advantages of simple process, energy saving and
environmental protection, can greatly increase the overall yield and obviously reduce the production cost, is easy to industrial production, is an innovation of a
medicine for treating diabetes, and has large economic and
social benefits.