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Mitiglinide preparation and preparing method

A technology of mitiglinide calcium preparations, which is applied in the field of mitiglinide calcium preparations and its preparation, can solve problems such as easy to fly, low efficacy intensity, and low specific gravity of mitiglinide calcium, and achieve good dissolution and Stability, good stability, uniform effect of drug particles

Inactive Publication Date: 2006-03-08
周卓和
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the specific gravity of mitiglinide calcium is low, it is easy to fly, and it is difficult to sieve. At the same time, mitiglinide calcium has poor water solubility and cannot be quickly dispersed in water. It is difficult to fully dissolve as a drug, which makes its active ingredient release slowly. Lead to low efficacy intensity, which is not conducive to the treatment of diabetes

Method used

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  • Mitiglinide preparation and preparing method
  • Mitiglinide preparation and preparing method
  • Mitiglinide preparation and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Get 5 g of mitiglinide calcium and 10 g of micropowder silica gel, pass through a 100-mesh sieve after mixing, and set aside;

[0047] Pass 30g of lactose, 15g of microcrystalline cellulose, 15g of starch, and 5g of low-substituted hydroxypropyl cellulose through a 100-mesh sieve, and mix;

[0048] Mix the above two mixed fine powders to make them uniform;

[0049] 2% hypromellose E 15The aqueous solution is a soft material made of an adhesive, and granulated with a 24-mesh sieve. The wet granules are air-dried at 60° C., and the dry granules are sized with a 22-mesh sieve. They are packed in No. 3 hard capsule shells to obtain 1000 capsules.

Embodiment 2-5

[0051] With reference to the preparation method of Example 1, each component was prepared in accordance with the following dosages to prepare 1000 mitiglinide calcium capsules.

[0052]

Embodiment 6

[0054] Take 5 g of mitiglinide calcium and 20 g of starch, pass through a 100-mesh sieve after mixing, and set aside;

[0055] Pass 30g of lactose, 30g of microcrystalline cellulose, and 10g of low-substituted hydroxypropyl cellulose through a 100-mesh sieve, and then mix;

[0056] Mix the above two mixed fine powders to make them uniform;

[0057] 2% hypromellose E 15 The aqueous solution is a soft material made of adhesive, granules are sieved with a 24-mesh sieve, the wet granules are air-dried at 60°C, and the dry granules are granulated with a 22-mesh sieve;

[0058] Add 5 g of carboxymethyl starch sodium and 1 g of magnesium stearate, mix well, and press with a φ6.5 mm punch to make 1000 tablets.

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Abstract

The present invention relates to a miglenei calcium preparation and its preparation method. Its composition includes (by weight portion) 5 portions of miglenei calcium, 5-10 portions of micropowder silicon gel, 20-30 portions of lactose, 15-30 portions of microcrystalline cellulose, 15-25 portions of starch, 5 portions of low-substituted hydroxypropyl cellulose and proper quantity of 2% hydroxypropyl methyl cellulose E15 solution as adhesive and proper quantity of water. Its preparation method includes the steps of sieving, mixing, granulating and after-treatment, etc.

Description

technical field [0001] The invention relates to a mitiglinide calcium preparation and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Diabetes is a common and frequently-occurring disease, and the number of its patients is increasing rapidly with the improvement of people's living standards, population aging, changes in lifestyle, and advances in diagnostic techniques. According to the relevant data of WHO, the prevalence rate, disability rate, mortality rate and degree of harm of diabetes rank the third among non-communicable diseases, and it has become the third serious threat to human health after cardiovascular and cerebrovascular diseases and tumors. This disease not only brings great suffering to patients, greatly affects the quality of life, but also brings a heavy economic burden to the society. Therefore the majority of clinicians and diabetic patients are eagerly looking forward to having more and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/404A61K9/48A61K9/20A61P3/10
Inventor 周卓和
Owner 周卓和
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