70results about How to "Industrial Production Safety" patented technology

The invention discloses a fault detection method based on an analytic hierarchy process and weighted vote decision fusion. According to the method, firstly, multiple classifiers are selected as fusion sub-classifiers, multiple classifier models are established through a training data set, corresponding evaluation indexes are obtained according to the classification result of each classifier, and then multiple classifiers are scored and sequenced with the analytic hierarchy process, so that each classifier is endowed with the corresponding weight. Finally, multiple classifier decision results are integrated with a weighted vote fusion method, and the final fault detection result is obtained. Compared with other methods at present, the fault detection method has the advantages that the monitoring effect of the industrial process is improved, mastering and operation confidence of a process operator for the process are enhanced, the limitation of single fault detection methods is overcome to a great extent, and automatic implementation of the industrial process is better facilitated.

The invention discloses an industrial process fault classification method based on self-adaption integrated semi-supervision Fisher discrimination. The method comprises the steps of when off-line modeling is conducted, firstly conducting off-line modeling on unlabeled data, and constituting a semi-supervision random training subset by combining labeled data with the unlabeled data; when iteration training is conducted on a sub classifier each time, conducting semi-supervision Fisher dimensionality reduction to obtain a Fisher discrimination matrix, and obtaining a posterior probability matrix, a combined weight of the sub classifier and a sample weight of the labeled data during next time iteration with the labeled sample data after dimensionality reduction according to a Bayesian statistics method; adopting the posterior probability matrix of the labeled data and a label of the matrix as a training set of a fusion algorithm K near neighbor; during online classification, calling each sub classifier to obtain the posterior probability matrix of an online sample to be detected, and inputting the posterior probability matrix into a fusion K near neighbor classifier with the weight to obtain a final result. Compared with an existing method, the industrial process fault classification method based on the self-adaption integrated semi-supervision Fisher discrimination improves the fault classification result of an industrial process, and more facilitates automated implementation of the industrial process.

The invention discloses a method for synthesizing oseltamivir phosphate without using nitrine. The method comprises the following steps of: sequentially performing an epoxy ring-opening reaction, a hydroxyl acylation reaction, an intramolecular substitution reaction for ring formation, a selective ring-opening reaction, a reaction for removing tertiary-butyl and a phosphoric acid salt forming reaction on a raw material namely (3R, 4R, 5S)-4,5-epoxy-3-(1-ethyl-propoxy)-1-cyclohexene-1-ethyl ester carboxylate to obtain a product namely oseltamivir phosphate. The method is safe and high in efficiency and yield; compared with the prior art, the method has the biggest advantage that toxic explosive chemicals such as sodium azide and trimethyl-phosphine are not used, and is rich in raw material source and capable of performing large-scale production, so that the method can better meet requirements for strategic reserve of medicaments for preventing and treating bird flus by all human beings.

The invention relates to a novel 5-nitrosalicylic acid preparation process adopting a microchannel continuous flow reactor and belongs to the technical field of organic synthesis. According to the process, salicylic acid is taken as a raw material, concentrated nitric acid or a mixture of concentrated nitric acid and glacial acetic acid is taken as a nitrification reagent, the raw material and the nitrification reagent are injected into a reaction module of the microchannel reactor by a metering pump respectively, a material discharged from the reactor is directly injected into ice water, solids are separated out, and 5-nitrosalicylic acid is obtained through water washing. Continuous, efficient, safe and energy-saving industrial production is realized with the microchannel continuous flow process, the preparation process is simple, conditions are mild, retention time is short, product quality is stable, consumed acid content is reduced, yield is high and reaches 75% or higher, and industrial popularization and application are greatly facilitated.

The present invention relates to extraction process and medicinal application of sessile stemona alkaloid. Sessile stemona alkaloid is extracted through the following steps: 1. extracting with alcohol solution or acid aqua; and 2. purifying with cation exchange resin. The sessile stemona alkaloid product has the sessile stemona alkaloid content over 50 %. The extracting process uses alcohol, no toxic organic solvent and reusable cation exchange resin, and has high safety and low cost. The medicine composition with the sessile stemona alkaloid may be used in treating skin diseases and diseases of respiratory tract, and in preventing and controlling plant diseases and pests.

The invention discloses a supervision-based industrial process fault detection method of a linear dynamic system model, and is applied to fault detection under the condition of obtainable quality variables in an industrial process. By use of the linear dynamic system model and the quality variables, the linear dynamic system model with supervision is established, and the dynamics of a process and the randomness of data are taken into consideration. Compared to other conventional methods, the method provided by the invention not only improves the fault detection effect of the industrial process, but also enhances the grasp of process operators for process states, and enables industrial production to be safer and product quality to be more stable; and the reliance of the conventional fault detection method on process knowledge is improved to a quite large degree, and automatic implementation of the industrial process is better facilitated.

The invention discloses a preparation method of Minodronic acid hydrate, which comprises the following steps: carrying out ketonic group protection on a compound (VII) to obtain a compound (VI), carrying out nucleophilic substitution reaction on the compound (VI) and 2-aminopyridine to obtain a compound (V), carrying out ketonic group deprotection on the compound (V), and carrying out cyclization reaction to obtain a compound (IV); and hydrolyzing the compound (IV) to obtain a compound (III), carrying out diphosphorylation on the compound (III) to obtain a compound (II), and recrystallizing the compound (II) to obtain the Minodronic acid hydrate (I). The synthetic route disclosed by the invention has the advantages of sufficient initial raw material sources, low cost, environment-friendly reagents used in the reaction process, safe industrial production, mild reaction conditions, fewer side reaction, simple after-treatment and no need of special or complex reaction equipment, is convenient to operate, and can easily implement industrial production.

The invention relates to the field of medicaments, in particular to a method for preparing 5-aminolevulinic acid hydrochloride. The method of the invention comprises the following steps of: performing monoester esterification on succinic anhydride serving as a raw material and methanol to obtain a compound A1; performing condensation reaction on the compound A1 and ethyl potassium malonate under the action of N,N-dicarbonylimidazole to obtain a compound A2; performing hydroxylamine amination reaction on the compound A2 and sodium nitrite under the action of glacial acetic acid to obtain a compound A3; reducing the compound A3 by using Zn powder to obtain a compound A4; and hydrolyzing the compound A4 in the solution of hydrochloric acid to obtain the 5-aminolevulinic acid hydrochloride. The method of the invention has the characteristics of readily available raw material, low reaction cost, high yield, safe industrial production and the like.

The invention provides a preparation method of alvimopan and an intermediate for synthesizing the alvimopan. The preparation method comprises the following steps of: designing a process route through a two-chain method, respectively synthesizing initial raw materials, then condensing and hydrolyzing to obtain the alvimopan. The method can be used for directionally synthesizing a single optical isomer through N-alkylation reaction under an alkaline condition, the configuration change of the chiral centers of the raw materials and the product can not be generated both in reaction conditions anda post-processing method, and the obtained product can be hydrolyzed into the alvimopan under the mild alkaline condition.

The invention discloses an efficient traceless gene knockout method for saccharomyces cerevisiae. By optimizing the forward homologous sequence, galactose concentration and galactose induction time ina traceless gene knockout system, the probability of homologous recombination of the second step reaches 6.86*10<-4>. Haploids alpha 5 of saccharomyces cerevisiae AY15 serves as starting strains, BAT2 genes serves as the target gene, efficient and traceless knockout of wild saccharomyces cerevisiae genes BAT2 is achieved, through a liquor fermentation experiment, the contents of n-propanol, isobutanol and isoamyl alcohol of the modified strains are reduced by 20.32%, 47.85% and 23.14% respectively compared with these of parent strains, and the aim of low yield of higher alcohols is achieved.The method can be widely used in genetic modification of yeast and other microorganisms, because obtained mutants have no exogenous genes left and thus can be safely used in industrial production, anda useful reference is provided for gene knockout directly conducted on industrial strains.

The invention discloses a physical modification method and preparation of a soluble soybean polysaccharide (SSPS), and belongs to the field of agricultural and sideline product processing. According to the physical modification method, octenyl succinic anhydride and the soybean polysaccharide are subjected to chemical reaction so as to obtain a novel soybean polysaccharide with amphipathic characteristics. The physical modification method comprises following steps: firstly, a hexametaphosphate is taken as a cross-linking agent to realize crosslinking esterification of the soluble soybean polysaccharide; at a pH value ranging from 8.0 to 8.5, octenyl succinic anhydride (OSA) is used for hydrophobic modification of an obtained crosslinked soybean polysaccharide; an obtained ocentyl succinic anhydride-soluble soybean polysaccharide ester (OSA-SSPS) crude product is extracted with ethyl acetate, and is subjected to rotary evaporation, and freeze drying or spray drying, and then is smashed so as to obtain a finished product. After appropriate physical modification, the obtained soybean polysaccharide possesses both hydrophilicity and hydrophobicity, and the stabilizing effect of steric hindrance is achieved preferably. Application range can be widened further; and the obtained product is widely applied to the fields such as food, cosmetic, weaving, papermaking, and pharmacy industry.

The invention belongs to the field of medicaments and in particular relates to a process for enriching total alkaloids of sessile stemona root. The process is an extraction and purification process of membrane separation and macroporous resin coupling technology, obviously improves the separation and purification efficiency of macroporous resin on main medicinal active components, prolongs the service life of the macroporous resin, improves the yield and the quality of products, and remarkably reduces the preparation cost of the products; the membrane separation and macroporous resin coupling technology can effectively remove proteins, polysaccharide and other macromolecular impurity compositions in crude extract of the sessile stemona root, and obviously improves the purity and the quality of the total alkaloids of the extract of the sessile stemona root; other toxic organic solvents except ethanol are not used in the whole extraction and separation process, the membrane separation efficiency is good, the process is performed at low temperature, the antipollution is strong, the regeneration and cleaning are easy, the process is favorable for a subsequent process for further purification by adopting the macroporous resin, the macroporous resin can be repeatedly used, the industrialized production is safe and the cost is low; and the prepared alkaloid of the sessile stemona root has high purity.

The invention discloses a preparation process of methyl 4-methoxyacetoacetate, comprising the following process steps: step 1, taking anhydrous toluene as a solvent, adding a methanol solution of sodium methoxide in the solvent as a base, at room temperature, dropwise adding methyl 4-chloroacetoacetate in the solvent, after dropwise adding, stirring, heating to 65-70 DEG C during stirring, and reacting for 3 to 5 hours to obtain a sodium salt of methyl 4-methoxyacetoacetate; step 2, acidifying the sodium salt, adjusting with acid to achieve the pH of 5-6, stirring for 30 min, and adjusting thepH to 3-4 to obtain a toluene layer and an aqueous layer, washing the toluene layer to neutral with a saturated sodium chloride solution, performing reduced pressure distillation to remove toluene and obtain a crude product of methyl 4-methoxyacetoacetate, and performing reduced pressure distillation on the crude product to obtain a target product with the purity of 99 percent. The invention discloses the preparation process of methyl 4-methoxyacetoacetate to realize effective, high-quality and low-cost synthesis.

The invention relates to a method for extracting, separating and purifying anthocyanin from blueberry peel and residues and belongs to the technical field of agriculture and food science. Effective ingredients are separated and extracted from fruit processing waste residues, so the method is also relevant to three-waste utilization. According to the method, edible alcohol is used for extracting anthocyanin crude extracts from blueberry peel and residues at 45 to 50 DEG C, and in addition, AB-8 macroporous resin is used for separation and purification. The method provided by the invention has the characteristics that the technology is novel, the operation and the production are simple and convenient, the low cost is low, the yield is high, the environment-friendly effect is realized; and the utilization rate of blueberry fruits is improved, the content of the anthocyanin in the separated product is greater than or equal to 26 percent, the requirements of various function food, health care food, medicine and food additives on the anthocyanin are met, and wide purposes are realized.

The invention relates to a method for preparing aucubin by adopting decoction dregs after extracting chlorogenic acid from folium cortex eucommiae. The method comprises the steps: extracting an aucubin crude extract from decoction dregs of folium cortex eucommiae after extracting chlorogenic acid by utilizing edible ethanol, and separating and purifying the aucubin crude extract by utilizing NKA-2 macroporous resin to obtain an aucubin extract. According to the method, the aucubin is safely and toxicity-freely extracted and separated by adopting edible ethanol, so that can the aucubin extracts in different purity specifications be safely and effectively produced in an industrialization manner and can the waste be changed into treasure, but also the high-value utilization of safe, simple, reasonable and economical eucommia ulmoides resource and the industrialized production of series products can be actually realized, and the green production concept and strategy of cycling economy can be adequately reflected.

The invention relates to a method for synthesizing cinepazide. The method comprises: obtaining 3,4,5-trimethoxy cinnamoyl piperazine through the reaction of 3,4,5-trimethoxy cinnamic acid and piperazine; obtaining cinepazide through the reaction of 3,4,5-trimethoxy cinnamoyl piperazine and chloroacetyl pyrrolidine; and forming salts from cinepazide and maleic acid optionally. The method provided by the invention has the advantages of short route, simple operation, not high requirements for production equipment, environment-friendly reagents used, high reaction yield, high purity of obtained products and suitability for industrial scale production.

Plant (10) and system for the automatic horizontal assembly of photovoltaic panels (30) with front-back-contact solar cells (300-1) of crystalline silicon, of the type called H-type, the contacting being carried out at a temperature lower than 150 DEG C also with the prefixing of conductive elements onto the encapsulating layer; the present invention solves the main problems of the conventional stringing systems and provides high production capacity with a precise positioning of the components. The plant (10) is made up of single workstations (100A-I) of the modular type which are arranged sequentially in a linear series, individually equipped according to the specific working process, being adjacent and laterally open to be crossed by the conveying line (110) of the trays (109) containing the panels being worked; after the automatic assembly in said plant (10), the panels are ready to be rolled in conventional furnaces.

The invention relates to an intelligent monitoring system for high and low temperature heat exchange in a dilute acid concentrating process. The system comprises a monitoring controller, a first temperature induction module, a second temperature induction module, a storage module, a wireless transmission module, a first early warning module, a second early warning module, a display module, a login verification module and a communication module; the monitoring controller receives information, sets a temperature threshold, and emits early warning information according to the received information; the first and second temperature induction modules monitor temperatures of an air inlet and an exhaust vent of a heat exchanger; the first and second early warning modules receive alarming instructions that the temperatures of the air inlet and the exhaust vent of the heat exchanger are lower than a threshold from the monitoring controller, and raise the alarm according to the instruction; and the communication module can sends early warning information to a user in real time. According to the invention, the heat exchanger is effectively prevented from obstruction caused by that SO2, SO3 and water vapor form a condensing acid and solid scales, and industrial production is safe, stable and efficient.

The invention discloses a gene traceless editing carrier and application of the gene traceless editing carrier to organism gene editing. The gene traceless editing carrier consists of a genome homology sequence A, a promoter sequence, a cell wall protein CWP1 gene sequence, a resistance screening report gene sequence and a genome homology sequence B. By aiming at the problems that during the saccharomyces cerevisiae traditional gene knockout, screening markers are remained, the multigene knockout research is inconvenient, and the exogenous gene is remained, the invention provides a saccharomyces cerevisiae efficient gene traceless editing method. The method can be used for saccharomyces cerevisiae gene editing and can also be applicable to other microorganisms of the gene editing principle. The gene traceless editing carrier can be used for studying the function and metabolic mechanism of the yeast gene; no any exogenous gene is remained at an obtained mutant strain; the gene tracelessediting carrier can be safely used for industrial production.

The invention provides a low-pressure-drop Z-type radial centrifugal flow fixed bed reactor which includes: a cylindrical pressure container, an inner cylinder, an outer cylinder, and a catalyst bed,wherein the inner cylinder, the outer cylinder and the cylindrical pressure container are arranged coaxially. An interlayer is formed between the outer wall surface of the inner cylinder and inner wall surface of the outer cylinder. The catalyst bed is formed by enclosing a lower support seal, the inner cylinder and the outer cylinder; the lower support seal is arranged in the cylindrical pressurecontainer and located on the bottom of same. The inner cylinder is communicated with a gas inlet to form a bypass path of reaction gas. A reaction gas collection flow path is formed between the outerwall surface of the outer cylinder and the inner wall surface of the cylindrical pressure container and is connected to the gas outlet. The bypass path is a diameter-variable flow path. The whole inner cylinder is provided with pores while a part of the outer cylinder is provided with pores. The reaction gas flows from the inner cylinder to the exterior radially via the bypass path and passes through the catalyst bed, then flows into the collection flow path and flows out of the fixed bed reactor through the outer cylinder. In the reactor, the flowing path of the reaction gas is Z-like in shape.

The invention provides Chufeng ointment and an application thereof in treatment of maternal nipple cracking. The Chufeng ointment comprises, by weight, 1 parts of an egg yolk oil extract, 0.5-1.5 parts of sesame oil and 1.5-2.5 parts of pure natural lanolin. The preparation method of the egg yolk oil includes: boiling an egg, peeling the egg to take the yolk, crushing the yolk, performing cold leaching or ultrasonic extraction with food-grade ethyl acetate, and depressing an obtained extracting solution to have ethyl acetate recovered to obtain the egg yolk extract. The Chufeng ointment prepared with the method is applicable to treatment of maternal nipple cracking, and an indigenous method having a long history of medication in traditional Chinese medicine books is displayed in a modern way; the preparation method of the Chufeng ointment is simple in process, the Chufeng ointment is suitable for the special group of mothers and babies at the particular period of the suckling period and free from side effects for the mothers and babies, breast-feeding is unaffected, and safety and effectiveness are achieved.

The invention provides a method for purifying a compound as shown in a formula 1. The method comprises the following step of enabling an alkali and alcohol mixed solution to come into contact with the compound as shown in the formula 1. When the method is utilized, the compound as shown in the formula I can be efficiently purified.

The invention provides a preparation method of a compound as described in the formula 1. The method comprises the steps of (1) contacting a compound as described in the formula 2 and a compound as described in the formula 3 in the existence of alkali to obtain a compound as described in the formula 4; and (2) directly contacting a reaction product obtained in the step (1) and paraformaldehyde to obtain the compound as described in the formula 1, wherein weak acid is added in the reaction product before the reaction product obtained in the step (1) is in contact with the paraformaldehyde so that the residual alkali in the reaction product can be neutralized. By using the method, the compound as described in the formula 1 can be effectively prepared.

The invention discloses a preparation method and a production line of a graphene heat conduction film, and relates to the field of heat conduction device preparation. The preparation method of the graphene heat conduction film comprises the following steps: S1, uniformly stirring and mixing a carbon source and a heat conduction enhancer; S2, carrying out electrical discharge machining on the mixedcarbon source and heat conduction enhancer to obtain doped graphene sheets; S3, screening the doped graphene sheets to obtain graphene coarse sheets; S4, cleaning and drying the graphene coarse sheets; S5, blending the cleaned and dried graphene coarse sheets with an N-methyl pyrrolidone solution to obtain carbon thick slurry; S6, carrying out blade coating on the carbon thick slurry to form a graphene film; and S7, carrying out discharge hot-pressing treatment on the graphene film to obtain the graphene heat conduction film. A wide carbon source is processed to prepare the heat conduction film, so that a solution is provided for solving the heat dissipation problem of next-generation electronic devices, and the industrial requirements of easiness in operation, high efficiency and low cost are met.