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Effective part of seesile stemona alkaloid and its application

A technology of effective parts and alkaloids, which is applied in the field of effective parts of alkaloids and pharmaceutical preparations containing effective parts of alkaloids, can solve problems such as unfavorable large-scale production, and achieve low cost, safe production and high purity. Effect

Inactive Publication Date: 2007-12-19
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be known from the above reports that it is found that a large number of organic solvent extraction methods such as chloroform are used in the current extraction process, and the extraction amount is only 0.33% to 0.44%, which is not conducive to large-scale production

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Stemone medicinal materials 2000g, crushed, and extracted with pH 1 acid aqueous solution, take the supernatant through HZ004 type positive exchange resin, resin: medicinal materials (1:3), first eluted with deionized water to remove water-soluble impurities, If there is no polysaccharide reaction, eluting with a solution of ammonia and ethanol at a ratio of 2:1, until the reaction of potassium bismuth iodide becomes negative, stop the elution, the eluate is recovered under reduced pressure to dryness, crushed, and the total alkaloids are extracted物35g.

Embodiment 2

[0020] 100kg of Stemona medicinal materials, crushed, and extracted with 90% ethanol. Recover ethanol under reduced pressure to obtain thick extract. Heat and dissolve in a 1% hydrochloric acid water bath. The best dosage is 1 ml of 1% hydrochloric acid per gram of medicinal material. Centrifuge the acid water solution and take the supernatant. Pass it through JK008 positive exchange resin (resin: medicinal material 1:4) and wash with deionized water first. Removal of water-soluble impurities, until there is no polysaccharide reaction, eluting with a solution of ammonia and ethanol at a ratio of 1:1, until the reaction of potassium bismuth iodide becomes negative, stop the elution, and recover the eluate under reduced pressure to dryness and pulverize to obtain The total alkaloid extract of Stemona is 1.5kg.

Embodiment 3

[0022] Stemone alkaloid effective part ointment

[0023] Stemone alkaloid 1g, stearic acid 15g, lanolin 2g, liquid paraffin 25ml, triethanolamine 2g, glycerol 5ml, distilled water 50ml.

[0024] Take the Stemona alkaloid and grind it evenly with a small amount of liquid paraffin, and set aside. Put the stearic acid, lanolin and liquid paraffin in a container, heat it in a water bath until it melts, and continue heating to 70~80℃; take another triethanolamine, glycerin and distilled water, heat it to 70~80℃, and slowly pour stearic acid, etc. The mixture is stirred in the same direction as it is added, and Stemona alkaloids are added to emulsify and coagulate. For external use, it is used to kill demodex mites that parasitize the human body.

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Abstract

The present invention relates to extraction process and medicinal application of sessile stemona alkaloid. Sessile stemona alkaloid is extracted through the following steps: 1. extracting with alcohol solution or acid aqua; and 2. purifying with cation exchange resin. The sessile stemona alkaloid product has the sessile stemona alkaloid content over 50 %. The extracting process uses alcohol, no toxic organic solvent and reusable cation exchange resin, and has high safety and low cost. The medicine composition with the sessile stemona alkaloid may be used in treating skin diseases and diseases of respiratory tract, and in preventing and controlling plant diseases and pests.

Description

Technical field [0001] The invention relates to an effective part of a traditional Chinese medicine and application of a pharmaceutical preparation thereof, and in particular to an effective part of a stemone alkaloid and a pharmaceutical preparation containing the effective part of a stearin alkaloid and an application thereof. technical background [0002] After consulting domestic and foreign literature reports on Stemona, it is found that there are few extraction methods for the total alkaloid of Stemona. Lin Wenhan {[1] Lin Wenhan, Ye Yang, Xu Rensheng. The structure study of new alkaloids in Stemona angustifolia. Organic Chemistry, 1991, 11:500-3; [2] Lin Wenhan, Xu Rensheng. Zhong Qiongxin Stemone alkaloids Chemical Research of Stemone I. The new alkaloids of Stemona sclerophylla. Acta Chimica Sinica, 1991, 49: 927-31. [3] Wenhan Lin, Rensheng Xu, Qiongxin Zhong. The chemistry of alkaloids of St. Research on the structure of bases. Acta Chimica Sinica, 1991, 49: 1034-37.} ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/904A61K8/97A61K9/00A61K9/06A61K9/02A61P17/00A61P15/02A61P33/02A61P33/14A61P11/00A61P31/06A61Q19/00A01N65/00A01P17/00A01P7/02A01P7/04C07G5/00
Inventor 张彤张亚中陶建生季光
Owner SHANGHAI UNIV OF T C M
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