The invention provides an individualized mouth containing device for radiotherapy and a manufacturing method thereof. The device comprises an oral stent and silicon rubber, the oral stent comprises supporting columns, upper dental arch grooves, a lower dental arch groove, a tongue depressor, a ventilation channel and a handle. The oral stent is matched with the oral cavity in size and shape duringmouth opening, the supporting columns are arranged at the two sides of the oral stent, and the upper dental arch grooves and the lower dental arch groove are formed in the upper and lower portions ofthe supporting columns respectively; the tongue depressor connected with the lower dental arch groove is arranged on the rear end of the lower dental arch groove, the ventilation channel is formed between the supporting columns at the two sides, and the handle which is connected with the lower dental arch groove is further arranged between the supporting columns at the two sides; the silicon rubber wraps the upper dental arch grooves, the lower dental arch groove and the tongue depressor; individualized manufacturing is achieved through the oral stent and the silicon rubber, the fixing precision is improved at the same time, a patient bites and wears the device conveniently, the manufacturing method is simple, and clinical popularization is facilitated.