Preparation of mitiglinide calcium and its quality control method

A mitiglinide calcium and quality technology, applied in the field of preparation and detection of hypoglycemic drugs, can solve problems such as harsh conditions, unsuitable for industrial production, and complex synthetic routes
CN100441570CInactive Publication Date: 2008-12-10天津汉康医药生物技术有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
天津汉康医药生物技术有限公司
Publication Date
2008-12-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a preparation and quality control method of Mitiglinide Calcium comprising steps: 1,synthesis of cis- cyclohexyl-1,2-dimethylacid imide; 2,synthesis of cis-hexa-hydrogen isoindole; 3,synthesis of alpha-benzyldiethyl malonate; 4,synthesis of benzylsuccinic acid; 5,S- benzylsuccinic acid methylbenzylamine salt; 6,synthesis of s- benzylsuccinic acid; 7,synthesis of (2S)-2- benzyl-3-(cis-hexa-hydrogen isoindole-2- carbonyl) propanoic acid; 8,synthesis of Mitiglinide Calcium; 9,purity of Mitiglinide Calcium. This invention also contains the method for quality control of Mitiglinide Calcium comprising steps: watching deseription, messureing specific rotation, authenticating, checking, content messureing for Mitiglinide Calcium.
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Description

Technical field

[0001] The invention relates to a method for preparing and detecting a blood glucose lowering drug, in particular to a method for preparing and quality control of mitiglinide calcium. Background technique

[0002] Diabetes is a common and frequently-occurring disease, and the number of its patients is increasing rapidly with the improvement of people's living standards, aging of the population, changes in lifestyles and advances in diagnostic technology. According to relevant data from the WHO, the prevalence, disability, mortality, and damage of diabetes ranks the third among non-communicable diseases. It has become the first serious threat to human health after cardiovascular and cerebrovascular diseases and tumors. Three major diseases, this disease not only brings great pain to the patients, the quality of life is greatly affected, but also brings a heavy economic burden to the society.

[0003] At present, the oral hypoglycemic agents clinically used to treat...

Claims

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