5-fluorouracil drug-loading microspheres and preparation method thereof
A technology of fluorouracil and drug-loaded microspheres is applied in the field of coating 5-fluorouracil drug-loaded microspheres with biodegradable polymer materials and the preparation field thereof, which can solve the problem of the lack of sustained-release preparations, the disadvantage of the body, and the drug-loading capacity of the microspheres. Low problems, to achieve the effect of good compatibility and dispersion
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[0019] The preparation of 5-fluorouracil drug-loaded microspheres is as follows:
[0020] a Preparation of composite solution
[0021] Dissolve 5-fluorouracil in an alcohol solvent, magnetically stir for 1 hour to 2 hours under sealed conditions to obtain a solution with a mass percentage of 5-fluorouracil of 0.05 wt% to 1 wt%. Then, press 5-fluorouracil and α -The mass ratio of cyanoacrylate is 1 / 100-50 / 100, adding α-cyanoacrylate, and stirring under sealed conditions for 2 hours to 3 hours to obtain a composite of 5-fluorouracil and α-cyanoacrylate Solution.
[0022] b Electrostatic spray into a ball
[0023] The composite solution obtained in step a is sucked into the spinning dope tube for electrostatic spinning, the flat-bottomed round glass container is placed on the magnetic stirrer platform, and the conductive ring electrode is built in the flat-bottomed round glass container, and the flat-bottomed round glass The ratio of the diameter of the bottom surface of the container ...
Example Embodiment
[0027] Example one:
[0028] a Preparation of composite solution
[0029] Dissolve 5-fluorouracil in an alcohol solvent, stir magnetically for 1 hour under sealed conditions to obtain a solution with a mass percentage of 5-fluorouracil of 0.05 wt%, and then press 5-fluorouracil and α-methyl cyanoacrylate in the solution Add methyl α-cyanoacrylate in a mass ratio of 1 / 100, and stir for 2 hours under sealed conditions to obtain a composite solution of 5-fluorouracil and methyl α-cyanoacrylate;
[0030] b Electrostatic spray into a ball
[0031] The composite solution obtained in step a is sucked into the spinning dope tube for electrostatic spinning, the flat-bottomed round glass container is placed on the magnetic stirrer platform, and the conductive ring electrode is built in the flat-bottomed round glass container, and the flat-bottomed round glass The ratio of the diameter of the bottom surface of the container to the diameter of the conductive ring electrode is 5 / 4. The conductive...
Example Embodiment
[0033] Embodiment two:
[0034] a Preparation of composite solution
[0035] Dissolve 5-fluorouracil in an alcohol solvent, and magnetically stir for 1 hour under sealed conditions to obtain a solution with a mass percentage of 5-fluorouracil of 0.1% by weight. Then, in the solution, press the mixture of 5-fluorouracil and α-ethyl cyanoacrylate. Add ethyl α-cyanoacrylate in a mass ratio of 10 / 100, and stir for 2 hours under sealed conditions to obtain a composite solution of 5-fluorouracil and ethyl α-cyanoacrylate;
[0036] b Electrostatic spray into a ball
[0037] The composite solution obtained in step a is sucked into the spinning dope tube for electrostatic spinning, the flat-bottomed round glass container is placed on the magnetic stirrer platform, and the conductive ring electrode is built in the flat-bottomed round glass container, and the flat-bottomed round glass The ratio of the diameter of the bottom surface of the container to the diameter of the conductive ring electro...
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