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Compound preparation containing benidipine hydrochloride and valsartan and application thereof

A technology of benidipine hydrochloride and benidipine hydrochloride, applied in compound preparations and their applications, compound preparations containing benidipine hydrochloride and valsartan and their application fields, can solve the problem of affecting the curative effect of drugs, inaccurate dosage, drug Increased side effects and other issues, to achieve the effect of improving the antihypertensive effect, reducing the dosage of drugs, and increasing tolerance

Active Publication Date: 2012-02-29
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] When using benidipine hydrochloride or valsartan clinically now, there are often the following problems: 1. When a single drug is used, the drug dosage must be increased to ensure the curative effect, which will inevitably lead to a significant increase in side effects of the drug; 2. When the drug is used in combination , because there is no pharmaceutical preparation that meets the combined dosage, the clinical dosage is not accurate, which affects the efficacy of the drug

Method used

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  • Compound preparation containing benidipine hydrochloride and valsartan and application thereof
  • Compound preparation containing benidipine hydrochloride and valsartan and application thereof
  • Compound preparation containing benidipine hydrochloride and valsartan and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 1 part by weight of benidipine hydrochloride, 20 parts by weight of valsartan, 30 parts by weight of lactose, 20 parts by weight of microcrystalline cellulose, 20 parts by weight of pregelatinized starch, 76 parts by weight of sodium carboxymethyl starch, croscarmellose 30 parts by weight of sodium, 2 parts by weight of hypromellose, and 1 part by weight of magnesium stearate.

[0020] The raw materials and auxiliary materials are respectively pulverized through 80-mesh sieves, and the hypromellose is prepared with purified water to a suitable concentration as a binder for later use. Except for magnesium stearate, other raw and auxiliary materials are mixed uniformly by the method of equal incremental dilution, and the soft material is made of the prepared adhesive, granulated through a 20-mesh sieve, fully dried at 65°C, and granulated with a 20-mesh sieve. Add the prescribed amount of magnesium stearate, mix evenly, compress into tablets, and coat with film to obtain ...

Embodiment 2

[0022] 2 parts by weight of benidipine hydrochloride, 20 parts by weight of valsartan, 30 parts by weight of microcrystalline cellulose, 43 parts by weight of pregelatinized starch, 50 parts by weight of super carboxymethyl starch sodium, 3 parts by weight of povidone K30, stearin Magnesium acid 2 parts by weight.

[0023] The raw materials and auxiliary materials were crushed through an 80-mesh sieve, and the povidone K30 was prepared with purified water to a suitable concentration as a binder for later use. Except for magnesium stearate, mix other raw and auxiliary materials uniformly by the method of equal incremental dilution, use the prepared adhesive to make a soft material, pass through a 24-mesh sieve to granulate, dry fully at 65°C, and granulate with a 24-mesh sieve. Add the prescribed amount of magnesium stearate, mix evenly, compress into tablets, and coat with film to obtain the product. Each tablet contains 2 mg of benidipine hydrochloride and 20 mg of valsartan...

Embodiment 3

[0025] 2 parts by weight of benidipine hydrochloride, 40 parts by weight of valsartan, 30 parts by weight of lactose, 25 parts by weight of microcrystalline cellulose, 25 parts by weight of pregelatinized starch, 56 parts by weight of sodium carboxymethyl starch, croscarmellose 18 parts by weight of sodium, 3 parts by weight of hypromellose, and 1 part by weight of magnesium stearate.

[0026] The raw materials and auxiliary materials are respectively crushed through an 80-mesh sieve, and the hypromellose is prepared with purified water to a suitable concentration as a binder for later use. Except for magnesium stearate, other raw and auxiliary materials are mixed uniformly by the method of equal incremental dilution, and the soft material is made of the prepared adhesive, granulated through a 16-mesh sieve, fully dried at 70°C, and granulated with a 16-mesh sieve. Add the prescribed amount of magnesium stearate, mix evenly, compress into tablets, and coat with film to obtain ...

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Abstract

The invention discloses a compound preparation containing benidipine hydrochloride and valsartan and an application thereof, wherein benidipine hydrochloride and valsartan are used as effective medicinal components of the preparation. Prepared by combination of drugs, the compound preparation for reducing pressure has good curative effects, less side effect and high cost performance, is taken once a day, is convenient to take, and can be used to raise drug compliance of patients. The preparation provided by the invention can be made into different oral dosage forms. Due to synergy and complementation of drugs, the treatment effect of the compound preparation is enhanced. The preparation provided by the invention has an obvious effect of treating hypertension and also can be applied to treat angina pectoris and protect kidney function. The preparation can be routinely used for patients with hypertension, myocardial infarction, heart failure, proteinuria, diabetes and the like, and is especially suitable for patients who are not tolerant to ACE inhibitor. The preparation is cheap, is simple to prepare, and is convenient for popularization and application.

Description

technical field [0001] The invention relates to a compound preparation and an application thereof, in particular to a compound preparation containing benidipine hydrochloride and valsartan and an application thereof, belonging to the technical field of biomedicine. Background technique [0002] Hypertension is the most prevalent disease in the world today, and the prevalence of hypertension in our country continues to increase, and it has become one of the important public health problems in our country. In order to promote research and development units to develop more ideal antihypertensive drugs, the World Health Organization (WHO), the International Hypertension League (ISH), health administrative departments and academic groups in Europe, the United States, China and other countries, based on a large number of evidence-based medicine The results of the study revised the previously established guidelines for the treatment of hypertension, emphasizing the mainstream view ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4545A61K31/41A61P9/12
Inventor 马全龙初茂忠王浩骅许东升孙山王淑云梁海勇
Owner SHANDONG SBOND PHARMA
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