6 results about "HEART INFARCTION" patented technology

The invention discloses a myocardial infarction early warning and emergency treatment system, and belongs to the technical field of medical treatment and emergency rescue, and the system comprises a data collection module which is used for collecting various physiological parameters of a user in real time through a wearable device; the analysis module is used for receiving and analyzing the physiological parameters and calculating a myocardial infarction risk score and a prediction time window of the user; the early warning module is used for giving out graded early warning and voice self-rescue guidance according to the myocardial infarction risk score; the alarm module is used for automatically triggering an alarm process when an emergency situation is detected; the AI emergency guidance module is used for providing augmented reality visual emergency guidance for field rescuers; and the cloud platform is used for data storage, model optimization and security management. According to the invention, risk quantitative scoring and time window prediction are realized, an early warning gateway is greatly brought forward, and precious time is won for patient intervention and medical treatment.

The invention belongs to the technical field of myocardial repair hydrogel materials, and particularly relates to oxygen-producing hydrogel for myocardial repair and a preparation method of the oxygen-producing hydrogel. The preparation method comprises the following steps: carrying out a modification reaction on GelMA and KH570 in a PBS buffer solution to prepare KH570-GelMA, carrying out an oxidation reaction on cobalt chloride, strontium chloride, sodium hydroxide and sodium hypochlorite in an aqueous solution to prepare a CoOOH-Sr nanosheet, mixing the CoOOH-Sr nanosheet with the KH570-GelMA solution, introducing a photoinitiator, and carrying out in-situ curing to prepare the oxygen-producing hydrogel. Through modification of GelMA by KH570, regulation and control of crosslinking density, improvement of hydrogel porosity and introduction of CoOOH-Sr functional molecules, controllable oxygen production is realized, local hypoxia is relieved, cellular compatibility and biological activity of the hydrogel are improved, myocardial cell proliferation and tissue regeneration are promoted, and a hydrogel patch in an injection or patch form can be constructed to adapt to myocardial infarction model application.

The present invention relates to 4-oxoretinoate for use in treatment or prevention of cardiac dysfunction, heart failure, or adverse cardiac remodelling after myocardial infarction or impaired cardiac blood flow. The present invention also relates to 4-oxoretinoate for use in treatment of coronary artery disease, or of ischemia-reperfusion injury.

The invention discloses a construction method of an intermingled phlegm and blood stasis type myocardial infarction or cerebral infarction animal model, which comprises the following steps: selecting a healthy mouse, inducing an intermingled phlegm and blood stasis state by adopting a method of combining high-fat feeding with epinephrine hydrochloride subcutaneous injection, and feeding for 28 days; 1 mg / kg of epinephrine hydrochloride is subcutaneously injected every day on the 21th day, and the injection is continued for 7 days; establishing a myocardial infarction model by adopting a left coronary artery anterior descending branch ligation method, and establishing a cerebral infarction model by adopting a middle cerebral artery suture method; the invention further discloses an animal model of phlegm and blood stasis type myocardial infarction or cerebral infarction and application of the animal model to preparation of drugs for preventing or treating phlegm and blood stasis type myocardial infarction or cerebral infarction. According to the method, the phlegm-blood stasis type myocardial infarction or cerebral infarction animal model is successfully induced, the standard and objective judgment of the model state is realized by matching with an evaluation scale, the modeling method is simple, the repeatability is high, the evaluation system is scientific and reasonable, and the method has good research and application prospects.

The utility model discloses a first-aid oxygen cylinder for cardiovascular diseases, and relates to an oxygen supply device for family rescue of patients with myocardial infarction in the acute stage. Comprising an oxygen cylinder body (1), an elastic head hoop (3), an elliptical annular sliding body (4), an oxygen pipe bracket (5) and a pipe clamp (6), an annular body is fixedly sleeved on the oxygen cylinder body; the other ends of the two elastic steel sheets are overlapped to form an elastic head band with an annular structure, and the section of the overlapped position of the elastic steel sheets is of an oval structure; the elliptical ring-shaped sliding body is sleeved outside the two overlapped arc-shaped bulges, the upper end of the oxygen pipe bracket formed by the arc-shaped steel sheets is fixed with the elliptical ring-shaped sliding body, and the lower end of the oxygen pipe bracket is fixed with the pipe clamp; and the tail end of the oxygen pipe is clamped in the pipe clamp. The problems that an existing household oxygen inhalation tube oxygen supply device cannot be correctly worn on a patient in time, and an existing oxygen supply device used in a small family supplies oxygen to the patient through a mask, so that the oxygen supply concentration is too high, and the negative effect on myocardial infarction acute stage rescue is achieved are solved.

The application relates to the field of biological medicine, and discloses application of stanniocalcin 2 in preparation of myocardial infarction treatment drugs. It is found for the first time that overexpression of stanniocalcin 2 can promote survival and proliferation of myocardial cells after heart infarction, and it is further found that STC2 drives survival and proliferation of myocardial cells after heart infarction by combining with PURA. Therefore, a new treatment target for heart repair after heart infarction is expected to be provided.