15 results about "Left coronary artery" patented technology

The utility model relates to the technical field of medical instruments, in particular to a coronary arterial cardioplegic fluid perfusion device which comprises a shunt bag, a main perfusion tube is fixedly connected onto the shunt bag, an exhaust tube is fixedly connected onto the main perfusion tube, the main perfusion tube is communicated with the inside of the exhaust tube, a bacterial membrane connector is arranged at the front end of the exhaust tube, and the bacterial membrane connector is fixedly connected with the shunt bag. A bacterial membrane is fixedly connected into the bacterial membrane connector, a protective connector is movably connected to the front end of the bacterial membrane connector, a gathering opening is fixedly connected into the protective connector, a protective plate is arranged at the front end of the protective connector, and heating ring cloth is movably connected to the outside of the flow dividing bag. The device has the advantages that the exhaust pipe is horizontally arranged, the bacterial membrane connector and the protective connector are arranged at the front end of the exhaust pipe, dust and bacteria can be prevented from entering the shunting bag, the device is easy to operate, the risk of coronary intima injury can be effectively reduced, and during perfusion operation of the device, a left coronary artery and a right coronary artery can be subjected to synchronous perfusion and independent perfusion.

The invention relates to the field of biological medicine, in particular to a GDF-15 defect-based modeling method which comprises the following steps: ligating left coronary anterior descending branches of a plurality of GDF-15 knockout mice, and respectively establishing myocardial ischemia reperfusion models based on recombinant GDF-15 and normal saline; the method comprises the following steps: taking a myocardial tissue sample, and treating the sample at a pre-plating temperature and a pre-plating duration to obtain myocardial cells; detecting an AMPK signal channel expressed by the myocardial tissue protein; determining whether the activity of the AMPK signal path is inhibited or not based on the phosphorylation state value, and determining the osmotic pump rate; or, detecting the ROS level of the myocardial cells to obtain a captured image, determining the state of the myocardial cells based on the gray value of the image, and determining the stability of the state of the myocardial cells according to the oxidative stress index of the captured image; carrying out an anoxic experiment to obtain a fluorescence image; and determining the myocardial cell purity based on the fluorescence signal intensity, adjusting the osmotic pump rate, or adjusting the pre-plating time length or the pre-plating temperature, so that the accuracy of GDF-15 defect modeling drug administration is improved.

The invention discloses a method for constructing a chronic heart failure co-disease depression animal model through composite intervention, and belongs to the technical field of disease animal model construction. Firstly, a left anterior descending coronary branch ligation operation is performed on a mouse to construct a heart failure model, and then a depression model is constructed by constraining mouse superposition. After composite modeling, the systolic function of the mouse is obviously reduced, the activity ability is weakened, and myocardial fibrosis and hippocampal tissue damage occur, which indicates that the heart failure co-disease depression model is successfully modeled. The animal model construction method has a good application prospect in research on the pathogenesis, biomarkers and treatment means of heart failure co-disease depression.

The application belongs to the technical field of medical image processing, and discloses a coronary artery origin anomaly automatic identification method, device, equipment and storage medium. The method comprises the following steps: determining an aorta segmentation binary image, a coronary artery multi-class segmentation image, an aortic sinus multi-class segmentation image and an aorta center line according to a coronary CTA image; intercepting the aortic sinus multi-class segmentation image to obtain a maximum aorta cross section; respectively performing inflation processing on a left coronary artery segmentation image and a right coronary artery segmentation image, and determining distances from a left centroid of a left connected domain and a right centroid of a right connected domain to the maximum aorta cross section as a first plane distance and a second plane distance based on the inflated left coronary artery segmentation image, the inflated right coronary artery segmentation image and the aorta segmentation binary image; and determining that the origin anomaly is a coronary artery high position when determining that the first plane distance or the second plane distance is greater than a preset distance. Through the above method, the coronary artery origin anomaly can be automatically identified.

The present invention proposes a coronary artery blood supply evaluation system based on a parabola three-dimensional coordinate system, which includes locating the intersection point A of the parabola corresponding to the blood supply of the left anterior descending coronary artery determined by the coronary angiography results and the parabola corresponding to the blood supply of the right coronary artery in the X-axis plane in the parabola three-dimensional coordinate system. 1， The vertical axis marks the blood flow of the left coronary artery circumflex branch B, and the area S enclosed by the parabola F1(x) passing through the polar coordinates A1 and B is drawn RAC That is, the "coronary artery abundance area". Area S RAC The slope of the tangent line of polar coordinate A1 can intuitively reflect the coronary blood flow characteristics of the sample heart. By simulating different coronary revascularization schemes before implementing revascularization, the effects of different revascularization schemes can be intuitively demonstrated, allowing the optimal revascularization strategy to be selected. Furthermore, this parabolic three-dimensional coordinate system can simultaneously represent multiple sample data, making it suitable for studying coronary blood flow characteristics in large sample sizes.

A guide catheter is adapted for providing improved backup support while accessing an ostium of a patient's left coronary artery. The guide catheter includes an elongate shaft having a proximal shaft portion and a power zone shaft portion. The elongate shaft includes an inner polymeric layer extending through the proximal shaft portion and the power zone shaft portion, and outer polymeric layer, and a braid that is disposed between the inner polymeric layer and the outer polymeric layer and extends through the proximal shaft portion and the power zone shaft portion, the braid having a first PIC count within the power zone shaft portion and a second PIC count within the proximal shaft portion. The elongate shaft is biased into a primary curve disposed distal of the power zone shaft portion and a coplanar secondary curve disposed within the power zone shaft portion.

A guide catheter (10) adapted for providing improved backup support while accessing an ostium of a patient's left coronary artery. The catheter includes an elongate shaft (12) having a proximal shaft portion (18) and a power zone shaft portion (20). The elongate shaft includes an inner polymeric layer (30) extending through the proximal shaft portion and the power zone shaft portion, and outer polymeric layer (38), and a braid (34) that is disposed between the inner polymeric layer and the outer polymeric layer extending through the proximal shaft portion and the power zone shaft portion, the braid having a first PIC count within the power zone shaft portion and a second PIC count within the proximal shaft portion. The elongate shaft is biased into a primary curve (22) disposed distal of the power zone shaft portion and a coplanar secondary curve (24) disposed within the power zone shaft portion.

The embodiment of the invention discloses a coronary blood vessel recognition method and device, electronic equipment and a storage medium. The method comprises the following steps: acquiring a coronary artery blood vessel image, and extracting a coronary artery center line from the coronary artery blood vessel image; based on the coronary artery center lines, segmenting coronary artery blood vessels in the coronary artery blood vessel image to obtain a plurality of blood vessel segments, and detecting a left coronary artery center line and a right coronary artery center line in the coronary artery center lines; based on the left coronary artery center line, multiple left coronary artery blood vessel segments corresponding to the left coronary artery center line in the multiple blood vessel segments are identified, and names corresponding to the multiple left coronary artery blood vessel segments are obtained; based on the right coronary artery center line, multiple right coronary artery blood vessel segments corresponding to the right coronary artery center line in the multiple blood vessel segments are recognized, and names corresponding to the multiple right coronary artery blood vessel segments are obtained. According to the technical scheme of the embodiment of the invention, the accuracy of coronary blood vessel recognition can be remarkably improved.

The invention discloses a construction method of an intermingled phlegm and blood stasis type myocardial infarction or cerebral infarction animal model, which comprises the following steps: selecting a healthy mouse, inducing an intermingled phlegm and blood stasis state by adopting a method of combining high-fat feeding with epinephrine hydrochloride subcutaneous injection, and feeding for 28 days; 1 mg / kg of epinephrine hydrochloride is subcutaneously injected every day on the 21th day, and the injection is continued for 7 days; establishing a myocardial infarction model by adopting a left coronary artery anterior descending branch ligation method, and establishing a cerebral infarction model by adopting a middle cerebral artery suture method; the invention further discloses an animal model of phlegm and blood stasis type myocardial infarction or cerebral infarction and application of the animal model to preparation of drugs for preventing or treating phlegm and blood stasis type myocardial infarction or cerebral infarction. According to the method, the phlegm-blood stasis type myocardial infarction or cerebral infarction animal model is successfully induced, the standard and objective judgment of the model state is realized by matching with an evaluation scale, the modeling method is simple, the repeatability is high, the evaluation system is scientific and reasonable, and the method has good research and application prospects.

The invention relates to the technical field of medical instruments, and discloses a coronary intervention guide wire head end shaper which comprises a shaping mold, the shaping mold comprises a first shaping mold head, a second shaping mold head and a third shaping mold head, the upper surface of the first shaping mold head and the upper surface of the second shaping mold head are fixedly connected with T-shaped plug pins, and the T-shaped plug pins are fixedly connected with the lower surfaces of the first shaping mold head and the second shaping mold head. T-shaped grooves are formed in the lower surfaces of the second shaping die head and the third shaping die head, and triangular insertion holes are formed in the upper surfaces of the first shaping die head, the second shaping die head and the third shaping die head in a penetrating mode. The shaping mold is arranged and comprises the first shaping mold head, the second shaping mold head and the third shaping mold head, and medical staff can deal with lesions at the bifurcation position of the left coronary artery anterior descending branch and the diagonal branch or intervention of coronary artery blood vessels with the normal diameter according to the requirements for different diameters of bending of the head end of the guide wire in the coronary intervention operation. And a proper die head is selected as a die for shaping the head end of the guide wire into a J shape, so that the applicability of the whole shaper in different operation scenes is effectively improved.

A method for simply and reliably determining the left and right coronary artery shunt fraction and a method for calculating FFR, belonging to the field of numerical simulation, comprises the following steps: constructing a personalized three-dimensional model based on a real coronary artery tomographic image; performing model gridding preprocessing based on the personalized model; extracting target parameters based on the preprocessing model and establishing a personalized shunt model, i.e., a personalized shunt model based on cross-sectional area; (based on cross-sectional area) a personalized left and right coronary artery flow method is: #imgabs0# The cross-sectional area refers to the cross-sectional area at the interface with the aorta. Q-flow value, S-cross-sectional area, LCA-left coronary artery, RCA-right coronary artery. The method of the present invention can more accurately calculate the personalized FFR.

A coronary perfusion device comprises a first conduit and a second conduit. The first conduit and the second conduit can extend through the coronary ostia into the left and right coronary arteries when the coronary perfusion device is installed downstream of the aortic valve. In some examples, the coronary perfusion device comprises a circumferential channel extending between the first conduit and the second conduit. The circumferential channel can also define a trough to collect retrograde blood flow. The coronary perfusion device can also comprise an annular frame to secure the first conduit, the second conduit, and the circumferential channel relative to the native aorta. In some examples, the annular frame can be radially expandable or compressible to facilitate transcatheter delivery.

The invention relates to the technical field of medical instruments, and discloses a left coronary artery angiography catheter and a using method thereof.The left coronary artery angiography catheter comprises an outer sheath tube, a fixing piece and a plurality of inner core tubes of different shapes; a first injection channel penetrating through the two ends of the outer sheath tube is arranged in the outer sheath tube, and one end of the outer sheath tube is connected with a fixing piece. A second injection channel is formed in the inner core tube, one end of the inner core tube is inserted into the first injection channel, the first injection channel is communicated with the second injection channel, the other end of the inner core tube is located outside the outer sheath tube, the part, located outside the outer sheath tube, of the inner core tube forms a connection section, and a gap is formed between the outer peripheral wall of the inner core tube and the inner peripheral wall of the first injection channel; the fixing piece is inserted into the gap, and the fixing piece is attached to the outer peripheral wall of the inner core pipe and the inner peripheral wall of the first injection channel; the outer sheath tube and any inner core tube are connected in an inserted mode to form the composite radiography tube. According to the left coronary artery radiography tube and the using method thereof, the complex left coronary artery can be rapidly connected, and the connection success rate of the complex left coronary artery is increased.

Provided is a retractor for aortic valve surgery which allows infusion of cardioplegic solution into a coronary artery while the retractor is in an attached state during aortic valve surgery. An aortic valve surgery retractor 100 is a retractor-type device used for aortic valve surgery, and includes: a retractor body 110 having a rectangular shape in a plan view and can be bent into a cylindrical shape in the longitudinal direction; and a first opening 120a and a second opening 120b provided at positions corresponding to an inlet part of the right coronary artery and an inlet part of the left coronary artery in the retractor body 110 for injecting a cardioplegic solution into the right coronary artery and the left coronary artery, respectively.

Disclosed herein are methods and systems for angiography interpretation. In one particular embodiment a method includes: classifying the primary anatomic structure of one or more angiogram images of a first patient; classifying the projection angle of the one or more angiogram images of the first patient; labeling stenoses within the one or more angiogram images of the first patient classified as including a left or right coronary artery; producing one or more angiogram images of a second patient with corresponding estimated stenoses of the second patient to produce training data; training a machine learning model with the training data; estimating the arterial stenoses severity of the first patient by running the machine learning model on the filtered and labeled one or more angiogram images of the first patient, wherein the machine learning model is only run on angiogram images previously labeled as including stenoses.