9 results about "Left coronary artery" patented technology

The invention relates to the field of biological medicine, in particular to a GDF-15 defect-based modeling method which comprises the following steps: ligating left coronary anterior descending branches of a plurality of GDF-15 knockout mice, and respectively establishing myocardial ischemia reperfusion models based on recombinant GDF-15 and normal saline; the method comprises the following steps: taking a myocardial tissue sample, and treating the sample at a pre-plating temperature and a pre-plating duration to obtain myocardial cells; detecting an AMPK signal channel expressed by the myocardial tissue protein; determining whether the activity of the AMPK signal path is inhibited or not based on the phosphorylation state value, and determining the osmotic pump rate; or, detecting the ROS level of the myocardial cells to obtain a captured image, determining the state of the myocardial cells based on the gray value of the image, and determining the stability of the state of the myocardial cells according to the oxidative stress index of the captured image; carrying out an anoxic experiment to obtain a fluorescence image; and determining the myocardial cell purity based on the fluorescence signal intensity, adjusting the osmotic pump rate, or adjusting the pre-plating time length or the pre-plating temperature, so that the accuracy of GDF-15 defect modeling drug administration is improved.

The invention discloses a method for constructing a chronic heart failure co-disease depression animal model through composite intervention, and belongs to the technical field of disease animal model construction. Firstly, a left anterior descending coronary branch ligation operation is performed on a mouse to construct a heart failure model, and then a depression model is constructed by constraining mouse superposition. After composite modeling, the systolic function of the mouse is obviously reduced, the activity ability is weakened, and myocardial fibrosis and hippocampal tissue damage occur, which indicates that the heart failure co-disease depression model is successfully modeled. The animal model construction method has a good application prospect in research on the pathogenesis, biomarkers and treatment means of heart failure co-disease depression.

The application belongs to the technical field of medical image processing, and discloses a coronary artery origin anomaly automatic identification method, device, equipment and storage medium. The method comprises the following steps: determining an aorta segmentation binary image, a coronary artery multi-class segmentation image, an aortic sinus multi-class segmentation image and an aorta center line according to a coronary CTA image; intercepting the aortic sinus multi-class segmentation image to obtain a maximum aorta cross section; respectively performing inflation processing on a left coronary artery segmentation image and a right coronary artery segmentation image, and determining distances from a left centroid of a left connected domain and a right centroid of a right connected domain to the maximum aorta cross section as a first plane distance and a second plane distance based on the inflated left coronary artery segmentation image, the inflated right coronary artery segmentation image and the aorta segmentation binary image; and determining that the origin anomaly is a coronary artery high position when determining that the first plane distance or the second plane distance is greater than a preset distance. Through the above method, the coronary artery origin anomaly can be automatically identified.

The present invention proposes a coronary artery blood supply evaluation system based on a parabola three-dimensional coordinate system, which includes locating the intersection point A of the parabola corresponding to the blood supply of the left anterior descending coronary artery determined by the coronary angiography results and the parabola corresponding to the blood supply of the right coronary artery in the X-axis plane in the parabola three-dimensional coordinate system. 1， The vertical axis marks the blood flow of the left coronary artery circumflex branch B, and the area S enclosed by the parabola F1(x) passing through the polar coordinates A1 and B is drawn RAC That is, the "coronary artery abundance area". Area S RAC The slope of the tangent line of polar coordinate A1 can intuitively reflect the coronary blood flow characteristics of the sample heart. By simulating different coronary revascularization schemes before implementing revascularization, the effects of different revascularization schemes can be intuitively demonstrated, allowing the optimal revascularization strategy to be selected. Furthermore, this parabolic three-dimensional coordinate system can simultaneously represent multiple sample data, making it suitable for studying coronary blood flow characteristics in large sample sizes.

The embodiment of the invention discloses a coronary blood vessel recognition method and device, electronic equipment and a storage medium. The method comprises the following steps: acquiring a coronary artery blood vessel image, and extracting a coronary artery center line from the coronary artery blood vessel image; based on the coronary artery center lines, segmenting coronary artery blood vessels in the coronary artery blood vessel image to obtain a plurality of blood vessel segments, and detecting a left coronary artery center line and a right coronary artery center line in the coronary artery center lines; based on the left coronary artery center line, multiple left coronary artery blood vessel segments corresponding to the left coronary artery center line in the multiple blood vessel segments are identified, and names corresponding to the multiple left coronary artery blood vessel segments are obtained; based on the right coronary artery center line, multiple right coronary artery blood vessel segments corresponding to the right coronary artery center line in the multiple blood vessel segments are recognized, and names corresponding to the multiple right coronary artery blood vessel segments are obtained. According to the technical scheme of the embodiment of the invention, the accuracy of coronary blood vessel recognition can be remarkably improved.

The invention discloses a construction method of an intermingled phlegm and blood stasis type myocardial infarction or cerebral infarction animal model, which comprises the following steps: selecting a healthy mouse, inducing an intermingled phlegm and blood stasis state by adopting a method of combining high-fat feeding with epinephrine hydrochloride subcutaneous injection, and feeding for 28 days; 1 mg / kg of epinephrine hydrochloride is subcutaneously injected every day on the 21th day, and the injection is continued for 7 days; establishing a myocardial infarction model by adopting a left coronary artery anterior descending branch ligation method, and establishing a cerebral infarction model by adopting a middle cerebral artery suture method; the invention further discloses an animal model of phlegm and blood stasis type myocardial infarction or cerebral infarction and application of the animal model to preparation of drugs for preventing or treating phlegm and blood stasis type myocardial infarction or cerebral infarction. According to the method, the phlegm-blood stasis type myocardial infarction or cerebral infarction animal model is successfully induced, the standard and objective judgment of the model state is realized by matching with an evaluation scale, the modeling method is simple, the repeatability is high, the evaluation system is scientific and reasonable, and the method has good research and application prospects.

A coronary perfusion device comprises a first conduit and a second conduit. The first conduit and the second conduit can extend through the coronary ostia into the left and right coronary arteries when the coronary perfusion device is installed downstream of the aortic valve. In some examples, the coronary perfusion device comprises a circumferential channel extending between the first conduit and the second conduit. The circumferential channel can also define a trough to collect retrograde blood flow. The coronary perfusion device can also comprise an annular frame to secure the first conduit, the second conduit, and the circumferential channel relative to the native aorta. In some examples, the annular frame can be radially expandable or compressible to facilitate transcatheter delivery.

The invention relates to the technical field of medical instruments, and discloses a left coronary artery angiography catheter and a using method thereof.The left coronary artery angiography catheter comprises an outer sheath tube, a fixing piece and a plurality of inner core tubes of different shapes; a first injection channel penetrating through the two ends of the outer sheath tube is arranged in the outer sheath tube, and one end of the outer sheath tube is connected with a fixing piece. A second injection channel is formed in the inner core tube, one end of the inner core tube is inserted into the first injection channel, the first injection channel is communicated with the second injection channel, the other end of the inner core tube is located outside the outer sheath tube, the part, located outside the outer sheath tube, of the inner core tube forms a connection section, and a gap is formed between the outer peripheral wall of the inner core tube and the inner peripheral wall of the first injection channel; the fixing piece is inserted into the gap, and the fixing piece is attached to the outer peripheral wall of the inner core pipe and the inner peripheral wall of the first injection channel; the outer sheath tube and any inner core tube are connected in an inserted mode to form the composite radiography tube. According to the left coronary artery radiography tube and the using method thereof, the complex left coronary artery can be rapidly connected, and the connection success rate of the complex left coronary artery is increased.

Provided is a retractor for aortic valve surgery which allows infusion of cardioplegic solution into a coronary artery while the retractor is in an attached state during aortic valve surgery. An aortic valve surgery retractor 100 is a retractor-type device used for aortic valve surgery, and includes: a retractor body 110 having a rectangular shape in a plan view and can be bent into a cylindrical shape in the longitudinal direction; and a first opening 120a and a second opening 120b provided at positions corresponding to an inlet part of the right coronary artery and an inlet part of the left coronary artery in the retractor body 110 for injecting a cardioplegic solution into the right coronary artery and the left coronary artery, respectively.