Application of Signal Regulatory Protein α (shsp-1) Gene in Myocardial Infarction

Abstract

The invention discloses an application of signal regulatory protein alpha (SIPR alpha, SHPS-1) genes in coronary atherosclerotic heart diseases, belonging to the field of function and application of genes. Mice of which the SHPS-1 genes are knocked out and cardiac-specific SHPS-1 transgenic mice are adopted as experimental subjects; MI (myocardial infarction) models are formed by blocking LAD (left anterior descending coronary artery) of the hearts of the mice, and the result shows that compared with WT (wild type) control mice, the cardiac infarction proportion, cardiac hypertrophy and degree of fibrosis of the mice of which the SHPS-1 genes are knocked out, subjected to an MI operation, are obviously inhibited, and the cardiac functions of the mice are obviously improved; the cardiac infarction proportion, cardiac hypertrophy and degree of fibrosis of the cardiac-specific SHPS-1 transgenic mice are obviously increased, and the cardiac functions of the mice are obviously worsened, so that the result shows that the SHPS-1 genes can promote and worsen the occurrence and development of the coronary atherosclerotic heart diseases; SHPS-1 can be used as a medicament target for screening medicaments which are used for treating the coronary atherosclerotic heart diseases; an inhibitor of SHPS-1 can be used for preparing the medicaments for treating the coronary atherosclerotic heart diseases.

Description

technical field

[0001] The invention belongs to the field of gene function and application, in particular to the function and application of a signal regulatory protein (SIRPα, SHPS-1) in coronary atherosclerotic heart disease. Background technique

[0002] Cardiovascular disease is the disease that causes the highest death rate in the world and is the number one killer of human health. Ischemic heart disease is the leading cause of cardiovascular death. Coronary atherosclerotic heart disease is a disease in which a large amount of lipid deposits on the inner wall of the coronary arteries supplying the myocardium, forming plaques and thrombi that narrow or block the coronary arteries, causing myocardial ischemia, hypoxia or necrosis. Myocardial infarction (MI) is a common type of ischemic heart disease. The coronary artery is occluded and the blood flow is interrupted, resulting in partial necrosis of some myocardium due to severe and persistent ischemia. Within a few minu...

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