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Application of ganoderma spore oil to preparation of cardiovascular disease prevention and treatment medicine

A technology of ganoderma lucidum spore oil and prevention and treatment of cardiovascular diseases, applied in the direction of cardiovascular system diseases, drug combinations, medical formulas, etc., to achieve the effect of less toxic and side effects and make up for limitations

Inactive Publication Date: 2016-11-23
GUANGDONG YUEWEI EDIBLE FUNGI TECH +1
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  • Abstract
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AI Technical Summary

Problems solved by technology

So far, the reports about Ganoderma lucidum improving cardiovascular disease are all focused on the triterpenoids and polysaccharides extracted from the fruiting body of Ganoderma lucidum, but there is no report on the improvement of cardiovascular function of Ganoderma lucidum spores and Ganoderma spore oil

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  • Application of ganoderma spore oil to preparation of cardiovascular disease prevention and treatment medicine
  • Application of ganoderma spore oil to preparation of cardiovascular disease prevention and treatment medicine
  • Application of ganoderma spore oil to preparation of cardiovascular disease prevention and treatment medicine

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Embodiment Construction

[0021] In order to verify the application effect of the present invention, the present invention will be described in further detail below in conjunction with examples, but the embodiments of the present invention are not limited thereto. Unless otherwise specified, the reagents, equipment and methods used in the present invention are conventional commercially available reagents, equipment and routinely used methods in this technical field.

[0022] Cardiovascular disease model establishment method: open the mouse chest cavity to expose the descending branch of the left coronary artery, ligate the artery with 6-0 silk suture at 2 mm below the left atrial appendage, suture as usual after ligation, and inject 0.5ml normal saline subcutaneously in the neck to prevent dehydration. Routine care was carried out after the operation. Compared with the sham operation group (the sham operation group only had sutures without knotting), the ultrasound was used to detect whether the model w...

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Abstract

The invention provides an application of ganoderma spore oil to preparation of a cardiovascular disease prevention and treatment medicine. A ligated left coronary artery induced hypertension heart disease model is used for analyzing cardiac functions by taking ventricular wall thicknesses in a contraction period and a relaxation period, inner diameter data, left ventricular ejection fraction and the like as observation indexes, results indicate that separate active components including the ganoderma spore oil extracted from ganoderma spores can improve the cardiac functions under the condition of effective dose 3g / (kg*BW), ejection fraction reaches 66.02 and approximates blank control group values, heart blood output quantity is effectively improved, particularly, left ventricular relaxation capacity is obviously changed, and the ganoderma spore oil has the function of preventing cardiovascular diseases and can be used for preparing the cardiovascular disease prevention and treatment medicine.

Description

【Technical field】 [0001] The invention belongs to the field of medicine and health care, and in particular relates to the application of ganoderma lucidum spore oil in the preparation of drugs for preventing cardiovascular diseases. 【Background technique】 [0002] 16.6 million people die of cardiovascular disease in the world every year. The World Health Organization predicts that this number will increase to 25 million by 2020. Cardiovascular disease will become the first cause of death in the world by 2020. The increase has not only increased the chances of disability and disability, caused huge labor losses, but also accelerated the rise in disease diagnosis and treatment costs. From the perspective of China alone, in 2003, Zhai Yi et al. The economic burden of blood pressure, coronary heart disease and stroke is studied, and the direct economic burden is 20.15 billion, 15.79 billion and 24.297 billion yuan respectively, and the direct economic burden of coronary heart di...

Claims

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Application Information

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IPC IPC(8): A61K36/074A61P9/00A61P9/12
CPCA61K36/074A61K2236/17A61K2236/35A61K2236/37
Inventor 谢意珍杨柏华焦春伟
Owner GUANGDONG YUEWEI EDIBLE FUNGI TECH
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