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Compound formulation for treating hypertension

A compound preparation and high blood pressure technology, which is applied in the field of compound preparations for the treatment of high blood pressure, can solve problems such as hypotension and discomfort, and achieve the effects of improving compliance, less adverse reactions, and increasing tolerance

Inactive Publication Date: 2006-07-12
GUANGDONG CARDIOVASCULAR INSITITUTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] Single use of a large dose of drugs to treat high blood pressure sometimes brings some adverse reactions, such as the compensation reaction triggered by the reduction of blood pressure during monotherapy, and fatigue, dizziness, drowsiness, tinnitus, nausea, and vomiting often occur after taking the drug , epigastric discomfort, constipation, and sometimes orthostatic hypotension, muscle cramps, insomnia and other phenomena, although most of these phenomena disappear on their own during continuous medication, they will also bring a lot of inconvenience to patients

Method used

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  • Compound formulation for treating hypertension
  • Compound formulation for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A combination preparation containing the following daily doses of the ingredients:

[0038] Indapamide 1.25mg

[0039] Celery Lol 50mg

[0040] Microcrystalline Cellulose 20mg.

[0041] This embodiment can be made into compound indapamide-celiprolol tablet, and the preparation method can adopt the preparation method of common pharmaceutical preparations.

[0042] The preparation method of the compound preparation of the following examples is the same as Example 1.

Embodiment 2

[0044] A combination preparation containing the following daily doses of the ingredients:

[0045] Indapamide 1.25mg

[0046] Celery Lol 100mg

[0047] Low-substituted hydroxypropyl cellulose 10mg.

Embodiment 3

[0049] A combination preparation containing the following daily doses of the ingredients:

[0050] Indapamide 2.5mg

[0051] Celery Lol 25mg

[0052] Pregelatinized starch 30mg.

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Abstract

The present invention discloses one kind of hypertension treating compound preparation. The compound preparation contains Indapamide in 0.5-2.5 mg and Celiprolol in 25-200 mg as daily dosage. Compared with the single component hypertension treating medicine with relatively great dosage, the present invention has superior blood pressure lowering effect, no negative effect caused by some one medicine component, no compensated reaction, increased patient's tolerance and raised compliance.

Description

technical field [0001] The invention relates to a compound preparation for treating hypertension. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. In 1991, my country conducted a sample survey of 940,000 people over the age of 15. Statistics show that the prevalence of hypertension in my country has reached 11.26%, which is 25% higher than that in the 10 years from 1979 to 1980. There are more than 130 million hypertensive patients in my country. . Moreover, this upward momentum continues. Statistics also show that the treatment rate of hypertension is 17.4% in urban areas and 5.4% in rural areas; the control rate (systolic blood pressure<140mmHg and diastolic blood pressure<90mmHg after treatment) is only 2.9%. From the above statistics, it can be seen that the prevalence of hypertension in my country is constantly increasing, but the treatment rate and control rate are low, forming a h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/404A61P9/12A61K31/155
Inventor 林曙光余细勇郑猛
Owner GUANGDONG CARDIOVASCULAR INSITITUTE
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