Preparation method of compound antihypertensive preparation

Abstract

The invention discloses a compound preparation for treating hypertension, which comprises 10-100mg of metoprolol and 5-50mg of hydrochlorothiazide. The product of the invention overcomes the defect that a side effect is markedly enhanced caused by increasing the medicament dosage for ensuring the curative effect when the metoprolol and the hydrochlorothiazide are clinically used at present and one medicament is singly used, and provides a new compound preparation. The metoprolol and the hydrochlorothiazide are combined, and the curative effect has synergistic and complementary actions; the tolerance of patients is increased, the compliance is improved, the dosage is decreased, an adverse reaction is lightened, and the compound preparation is convenient to take and has low price.

Description

technical field [0001] The invention relates to the technical field of medicine, and discloses a preparation method of a compound antihypertensive preparation. Background technique [0002] Hypertension is a common cardiovascular disease and a major public health problem worldwide. my country currently has about 100 million hypertensive patients. According to the epidemiological survey in 1991, the awareness rate of hypertension in my country's urban and rural areas was 36% and 13%, and the treatment rate was 17% and 5%, respectively. The form of hypertension prevention and treatment is quite severe. According to the forecast of WTO, by 2020, non-communicable diseases will account for 79% of the causes of death in my country, among which cardiovascular diseases will take the first place. [0003] Commonly used drugs for the treatment of hypertension are the beta-blocker metoprolol and the diuretic hydrochlorothiazide. [0004] Metoprolol (Hydrochlorothiazide), the chemica...

AI Technical Summary

Problems solved by technology

[0016] The product of the present invention overcomes that when metoprolol and hydrochlorothiazide are used clinically, the drug dose is increased to ensure the curative effect when a single drug is used alone, resulting in a significant increase in side effects; Inaccurate use of clinical drug dosage, defects affecting the efficacy of drugs

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