Compound formulation for treating hypertension

A technology of compound preparations and high blood pressure, which is applied in the field of compound preparations for the treatment of high blood pressure, can solve problems such as discomfort and hypotension, achieve less adverse reactions, improve compliance, and have a good antihypertensive effect

Inactive Publication Date: 2005-04-13
GUANGDONG CARDIOVASCULAR INSITITUTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Single use of a large dose of drugs to treat high blood pressure sometimes brings some adverse reactions, such as compensatory reactions triggered by lower blood pressure during monotherapy, and fatigue, dizziness, drowsiness, tinnitus, nausea, and vomiting often occur after taking the drug , epigastric discomfort, constipation, and sometimes orthostatic hypotension, muscle cramps, insomnia and other phenomena, although most of these phenomena disappear on their own during continuous medication, they will also bring a lot of inconvenience to patients

Method used

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  • Compound formulation for treating hypertension
  • Compound formulation for treating hypertension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A compound preparation containing the following components:

[0039] Indapamide 1.25mg

[0040] Olmesartan 5mg

[0041] Microcrystalline Cellulose 20mg.

[0042] This embodiment can be made into compound indapamide-olmesartan tablet, and the preparation method can adopt the preparation method of common pharmaceutical preparations.

[0043] The preparation method of the compound preparation of the following examples is the same as Example 1.

Embodiment 2

[0045] A compound preparation containing the following components:

[0046] Indapamide 1.25mg

[0047] Olmesartan 20mg

[0048] Pregelatinized starch 30mg.

Embodiment 3

[0050] A compound preparation containing the following components:

[0051] Indapamide 2.5mg

[0052] Olmesartan 2.5mg

[0053] Low-substituted hydroxypropyl cellulose 10mg.

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Abstract

The present invention discloses one kind of hypertension treating compound preparation. The compound preparation contains Indapamide in 0.5-2.5 mg and Olmesartan in 2.5-40 mg as daily dosage. Compared with the single component hypertension treating medicine with relatively great dosage, the present invention has superior blood pressure lowering effect, no negative effect caused by some one medicine component, no compensated reaction, increased patient's tolerance and raised compliance.

Description

technical field [0001] The invention relates to a compound preparation for treating hypertension. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. In 1991, my country conducted a sample survey of 940,000 people over the age of 15. Statistics show that the prevalence of hypertension in my country has reached 11.26%, which is 25% higher than that in the 10 years from 1979 to 1980. There are more than 130 million hypertensive patients in my country. . Moreover, this upward momentum continues. Statistics also show that the treatment rate of hypertension is 17.4% in urban areas and 5.4% in rural areas; the control rate (systolic blood pressure<140mmHg and diastolic blood pressure<90mmHg after treatment) is only 2.9%. From the above statistics, it can be seen that the prevalence of hypertension in my country is constantly increasing, but the treatment rate and control rate are low, forming a h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4178A61P9/12
Inventor 林曙光余细勇郑猛
Owner GUANGDONG CARDIOVASCULAR INSITITUTE
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