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Antihypertensive medicament

A technology for high blood pressure and compound preparations, applied in the field of medicine, can solve the problems of inaccurate clinical drug dosage, affect the efficacy of drugs, increase side effects, etc., and achieve the effects of improving antihypertensive efficacy, reducing adverse reactions, and neutralizing adverse reactions.

Inactive Publication Date: 2010-06-30
JIANGSU JIBEIER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0028] The product of the present invention overcomes that when fosinopril and hydrochlorothiazide are used clinically, the drug dose is increased to ensure the curative effect when a single drug is used alone, resulting in a significant increase in side effects; Inaccurate dosage of clinical medication, defects affecting drug efficacy

Method used

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  • Antihypertensive medicament
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A compound preparation containing the following components:

[0055] Fosinopril 5mg

[0056] Hydrochlorothiazide 12.5mg

[0057] Microcrystalline Cellulose 50mg

[0058] This embodiment can be made into compound fosinopril-hydrochlorothiazide tablets, and the preparation method can adopt the preparation method of common pharmaceutical preparations.

[0059] The preparation method of the compound preparation of the following examples is the same as Example 1.

Embodiment 2

[0061] A compound preparation containing the following components:

[0062] Fosinopril 10mg

[0063] Hydrochlorothiazide 12.5mg

[0064] Low-substituted hydroxypropyl cellulose 30mg

Embodiment 3

[0066] A compound preparation containing the following components:

[0067] Fosinopril 20mg

[0068] Hydrochlorothiazide 12.5mg

[0069] Micronized silica gel 40mg

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PUM

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Abstract

The invention discloses a complex preparation for curing hypertension. The preparation comprises 2 to 50mg of fosinopril and 5 to 30mg of hydrochlorothiazide. The invention overcomes the defect that obviously increased side effects are caused by increasing the medicament dosage to ensure the curative effect in single medicament when the fosinopril and the hydrochlorothiazide are used clinically, and provides the novel compound preparation. By combining the fosinopril and the hydrochlorothiazide, the ntihypertensive medicament has synergic and complementary curative effect. The compound preparation has the advantages of increasing tolerance of patients, improving compliance, reducing dosage and lightening adverse reactions, along with convenient administration and low price.

Description

technical field [0001] The invention relates to the technical field of medicine and discloses a medicine for treating hypertension. Background technique [0002] Hypertension is the most common cardiovascular disease and a major public health problem worldwide. In 1991, my country conducted a sample survey of 940,000 people over the age of 15. Statistics show that the prevalence of hypertension in my country has reached 11.26%, which is 25% higher than that in the 10 years from 1979 to 1980. There are more than 1.3 patients with hypertension in my country. 100 million. Moreover, this upward momentum continues. Statistics also show that the treatment rate of hypertension is 17.4% in urban areas and 5.4% in rural areas; the control rate (systolic blood pressure<140mmHg and diastolic blood pressure<90mmHg after treatment) is only 2.9%. From the above statistics, it can be seen that the prevalence of hypertension in my country is constantly increasing, but the treatment ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/675A61K31/549A61P9/12
Inventor 吴修艮陆梅陈进高瑞银聂丽云
Owner JIANGSU JIBEIER PHARMA
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