6 results about "Hypotensive action" patented technology

The invention discloses a blood protein precise active peptide capable of tonifying qi and blood, improving microcirculation and promoting vasodilation and a preparation method and application thereof, and belongs to the technical field of blood protein peptide. The blood protein precision active peptide comprises at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII or FPHFD. The prepared blood protein precision active peptide has multiple biological activities: an antihypertensive effect is achieved by inhibiting ACE and vasoconstriction substances; vasodilation is promoted by activating a PI3K / AKT / eNOS signal channel; a zebra fish model proves that the traditional Chinese medicine composition has the effects of remarkably improving microcirculation and tonifying qi and blood. The preparation method is low in equipment requirement, simple in process, easy to operate and convenient for industrial large-scale production. The method enriches a bioactive peptide library, and is of great significance in promoting technical progress and industrial upgrading in the field of hemoglobulin peptides.

This application discloses a precise active peptide of hemoglobin with the functions of replenishing qi and blood, improving microcirculation, and promoting vasodilation, as well as its preparation method and application, belonging to the field of hemoglobin peptide technology. The precise active peptide of hemoglobin contains at least one of LGFP, IGFP, FPHFN, LFL, LFI, FESF, ILF, LIF, FLL, FIL, FII, or FPHFD. The prepared precise active peptide of hemoglobin exhibits multiple biological activities: it exerts a hypotensive effect by inhibiting ACE and vasoconstrictive substances; it promotes vasodilation by activating the PI3K / AKT / eNOS signaling pathway; and it has been shown to significantly improve microcirculation and replenish qi and blood in a zebrafish model. The preparation method has low equipment requirements, is simple and easy to operate, and is suitable for large-scale industrial production. This invention enriches the bioactive peptide library and is of great significance for promoting technological progress and industrial upgrading in the field of hemoglobin peptides.

The invention belongs to the technical field of functional food, and particularly relates to a compound oral liquid beneficial to maintaining the healthy level of blood pressure and a preparation method thereof.The compound oral liquid is prepared from, by weight, 4-12 parts of Shanxi mature vinegar, 3-12 parts of folium cortex eucommiae and 3-12 parts of folium apocyni veneti. The traditional Chinese medicine composition contains various antihypertensive active substances such as melanoidins and ligustrazine, two traditional Chinese medicinal materials such as folium cortex eucommiae and folium apocyni veneti which have an antihypertensive effect are matched, the traditional Chinese medicinal materials are rich in antihypertensive components such as flavonoid and phenolic acid, the optimal proportion is obtained through multiple tests, and the efficacy of cooperatively promoting and maintaining the blood pressure health level is achieved. A series of complications caused by hypertension are relieved, the healthy level of blood pressure can be maintained and tends to be stable, and the three components have a remarkable synergistic interaction effect according to the prescription range and the preparation method disclosed by the patent.

The application discloses a polypeptide with blood pressure lowering activity, which has aromatic amino acid and proline as N and C terminals. The polypeptide comprises 3-5 amino acid sequences. The polypeptide is any one of five polypeptides with amino acids FGPW, PFPRP, PFA, NPF and FPPP. The application also provides application of the polypeptide in a blood pressure lowering drug. The application designs five polypeptides with aromatic amino acid and proline as N and C terminals, simulates the interaction between a peptide segment and ACE, and the polypeptide has good blood pressure lowering effect and is non-toxic, and can be used for development of a blood pressure lowering drug.

This invention pertains to bioactive peptide preparation, addressing the challenge of obtaining natto-derived polypeptides with antithrombotic effects. By analyzing a bioactive peptide database, key characteristics of antithrombotic peptides are identified: molecular weight <2000 Da, N-terminal glycine (G), C-terminal lysine (K) or arginine (R), and net charge ±2. The distribution of amino acids preceding glycine and arginine in natto hydrolysates is statistically analyzed. Based on frequency rankings, specific peptide bonds are selected as cleavage sites, and composite proteases (e.g., trypsin-chymotrypsin blends) enzymatically hydrolyze these sites. Low-molecular-weight peptides (±2 net charge) are purified via ultrafiltration and ion-exchange chromatography. The method preserves nattokinase's thrombolytic activity while enriching free L-arginine, synergistically enhancing antithrombotic and hypotensive effects. Applications include mitigating thrombotic cardiovascular diseases through dual thrombolytic and vasoregulatory mechanisms.

The invention discloses a traditional Chinese medicine composition for simultaneously reducing systolic pressure and diastolic pressure as well as a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines: 15-20 parts of radix rehmanniae recen, 10-20 parts of Chinese yam, 10-20 parts of pulp of dogwood fruit, 20-30 parts of astragalus membranaceus, 15-30 parts of kudzu vine root, 12-15 parts of gastrodia elata, 12-15 parts of uncaria rhynchophylla, 30-50 parts of oyster, 20-30 parts of concha haliotidis, 15-30 parts of poria cocos, 15-30 parts of rhizoma alismatis and 9-15 parts of moutan bark. The traditional Chinese medicine composition is prepared by composite compatibility of yin-nourishing, liver-calming and qi-tonifying medicines aiming at common composite pathogenesis of kidney yin deficiency, liver-yang hyperactivity and qi deficiency type hypertension of middle-aged and elderly patients, all the components have a synergistic effect, and experimental results show that the traditional Chinese medicine composition has an obvious antihypertensive effect on systolic pressure and diastolic pressure, and can be used for treating both systolic pressure and diastolic pressure. Compound symptoms such as dizziness, headache, weakness, soreness and weakness of waist and knees, dry mouth and the like can be improved while blood pressure is reduced, and toxic and side effects are avoided.