Application method of radix paeoniae alba to preparation of drug for treating high blood pressure

An application method and a technology for hypertension are applied in the application field of Radix Paeoniae Alba in the preparation of drugs for treating hypertension, and achieve the effects of improving effectiveness, accelerating blood pressure reduction, and improving antihypertensive curative effect.

Active Publication Date: 2018-11-06
HANGZHOU DANHE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no Chinese patent medicine of Radix Paeoniae Alba to treat hypertension.

Method used

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  • Application method of radix paeoniae alba to preparation of drug for treating high blood pressure
  • Application method of radix paeoniae alba to preparation of drug for treating high blood pressure
  • Application method of radix paeoniae alba to preparation of drug for treating high blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Take 500g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia", grind it into powder, add 70% ethanol with 7 times the total amount of crude drug, and extract it under reflux for 1 hour, and extract twice;

[0029] The residue after alcohol extraction was extracted twice with water: the first water extraction: add water 10 times the total crude drug amount, extract at 100°C for 1 hour; the second water extraction: add water 10 times the total crude drug amount, 100 °C extraction for 1 hour. The aqueous extracts were combined and concentrated.

[0030] Alcohol extraction and water extraction are respectively concentrated, and the extracts are combined, and suitable excipients are added according to pharmaceutical routines to make Paeoniae Alba Tablets. For Example 1 sample. Orally, the daily dosage for adults is equivalent to 8g of crude drug (it can be as small as 2g of crude drug, and can be as large as 32g of crude drug).

Embodiment 2

[0032] Take 500g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia", grind it into powder, add 70% ethanol with 7 times the total amount of crude drug, and extract it under reflux for 1 hour, extract twice, and extract the residue after alcohol extraction twice with water;

[0033] Two gradient heating extraction methods were used for water extraction: the first water extraction: add water 10 times the total amount of crude drugs, extract at 100°C for 1 hour; the second water extraction: add water 10 times the total amount of crude drugs, 121 °C extraction for 1 hour. The aqueous extracts were combined and concentrated.

[0034] After the alcohol extraction and the water extraction are respectively concentrated, the extracts are combined, and suitable excipients are added according to pharmaceutical routines to prepare Baishao granules. Be embodiment 2 samples. Orally, the daily dosage for adults is equivalent to 8g of crude drug (it can be...

Embodiment 3

[0036] Take 500g of Radix Paeoniae Alba in accordance with the 2015 edition of "Chinese Pharmacopoeia", grind it into powder, add 70% ethanol extraction of 7 times the total crude drug amount for 24 hours, extract twice, and extract the residue after alcohol extraction with water;

[0037] Two times of water extraction: the first water extraction: adding water 10 times the total amount of crude drugs, extracting at 100°C for 1 hour; the second water extraction: adding water 10 times the amount of crude drugs, extracting at 100°C for 1 hour. The aqueous extracts were combined and concentrated.

[0038] After the alcohol extraction and the water extraction are respectively concentrated, the extracts are combined, and suitable excipients are added according to pharmaceutical routines to prepare Baishao granules. Be embodiment 3 samples. Orally, the daily dosage for adults is equivalent to 8g of crude drug (it can be as small as 2g of crude drug, and can be as large as 32g of cru...

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Abstract

The invention relates to a preparation technology of a drug and aims at providing an application method of a drug for treating high blood pressure. The preparation technology comprises the following steps: taking radix paeoniae alba, grinding into powder, carrying out alcohol extraction and carrying out water extraction treatment on residues subjected to the alcohol extraction; respectively concentrating an extracting solution and then combining; adding accessories according to a conventional pharmaceutical processing method to obtain a drug dosage form for treating the high blood pressure. According to the preparation method disclosed by the invention, an extract obtained by an alcohol-water extracting method of the radix paeoniae alba has an outstanding curative effect of treating the high blood pressure: after the drug is administrated, the lowering speed of blood pressure is remarkably increased recently, the lowering amplitude is significantly improved, and the antihypertensive effect of the drug can exceed that of western medicine irbesartan. Compared with conventional water extraction, the application method disclosed by the invention has the advantages that the component loss is reduced, further the effectiveness is improved, the radix paeoniae alba is promoted to be completely utilized by a human body through oral medication, and the curative effect is improved. The drug selectively adjusts patients with the high blood pressure and has no influence on normal blood pressure.

Description

technical field [0001] The invention relates to medicine preparation technology, in particular to the application method of Radix Paeoniae Alba in the preparation of medicine for treating hypertension. Background technique [0002] Hypertension is a common high incidence clinically, which has serious harm to the heart, brain, kidney and other important organs. Western medicine treatment of hypertension still lacks the medicine for adjusting body constitution and can adjust blood pressure (depressor). The antihypertensive treatment of modern medicine is all symptomatic treatment. Currently commonly used antihypertensive drugs include calcium channel blockers (CCBs), angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), diuretics, and β-blockers. , still can not completely prevent the progression of hypertension and its secondary lesions. Most hypertensive patients need two or more antihypertensive drugs to reach the target blood pressur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61P9/12A23L33/105
CPCA23V2002/00A23L33/105A23V2200/326A23V2250/21A23V2300/14
Inventor 吴人照吴悦任泽明
Owner HANGZHOU DANHE PHARM CO LTD
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