36 results about "Amlodipine Maleate" patented technology

An amlodipine maleate pharmaceutical composition is provided with good stability when formulated with a pH within the range of 5.5 to 7, when measured as a 20 wt % aqueous slurry. The stability can also be aided by making the pharmaceutical composition from amlodipine maleate particles having an average particle size of greater than 20 microns, preferably greater than 100 microns.

The present invention relates to L-amlodipine besilate dripping pill and its preparation process and belongs to the field of medicine preparing technology. The recipe of the L-amlodipine besilate dripping pill includes L-amlodipine besilate, dripping pill substrate, antioxidant, surfactant, coating material, etc. The preparation process includes the first preparing L-amlodipine besilate into fine powder over 150 mesh, the subsequent melting the substrate, adding fine L-amlodipine besilate powder and supplementary material, mixing to form dispersed liquid, and dropping the dispersed liquid into condensating liquid to form dripping pill with or without coating. Each of the dripping pills contains L-amlodipine besilate in 1.25-15mg and weighs 10-100 mg.

The present invention provides improved, more stable formulations of amlodipine maleate where the formulations comprise from none to a minimal amount of magnesium. Such stable formulations show decreased production of the impurity amlodipine aspartate. Accordingly, the present invention provides formulations of amlodipine maleate comprising lubricants such as sodium stearyl fumarate, dimeticone, macrogol 6000, hydrogenated castor oil, and stearic acid. Methods of making and using the improved formulations are also provided.

The invention relates to an amlodipine and candesartan pharmaceutical composition. The pharmaceutical composition comprises the following components in parts by weight: 2.5-5 parts of amlodipine hydrate crystal, 4-16 parts of candesartan, 5-50 parts of compressible starch, 10-60 parts of microcrystalline cellulose, 15-40 parts of low-substituted hydroxypropyl cellulose, 10-45 parts of cross-linked polyvinyl pyrrolidone and 1-3 parts of magnesium stearate, wherein the amlodipine is amlodipine maleate hydrate crystal with a molecular formula of C24H29ClN2O9.1.5H2O. The pharmaceutical composition has the advantages that: amlodipine maleate has rapid and stable action, and can be stably released within 24 hours; and the pharmaceutical composition has strong synergism, accumulation and complementation effects, and has high bioavailability.

An oral disintegrating tablet of amlodipine maleate is prepared from amlodipine maleate, filler, disintegrant, effervescent agent, flavouring, lubricant and flowing aid through conventional process.

The invention relates to a maleic acid amiloride horizotnal ball and relative preparation, wherein it is formed by active maleic acid amiloride horizontal and relative base; the active component is the maleic acid amiloride horizontal; the base is the carbowax 1500-20000, geoceric acid, sodium stearate, dodecyl sodium sulfate, etc; the ratio between the maleic acid amiloride horizontal and said base is 1:2-10 as g or kg; and the invention also comprises film material whose components are hydroxypropylmethylcellulose at 1.0-1.2g, titania at 0.8-1.0g, talcum powder at 1.0-1.2g, iron oxide yellow at 0.10-0.15g, sorbate-80 at 0.4-0.5g, and 80% alcohol to be 50ml. The invention has simple operation, low cost and high effect.

The invention discloses a preparation method of amlodipine maleate. The preparation method is applied in the field of pharmaceutical synthesis and uses maleic acid and amlodipine free base as starting raw materials. The preparation method comprises the following steps: adding maleic acid in anhydrous methanol or mother liquor, heating to dissolve, filtering to obtain the methanol solution of maleic acid, and adding the solution in a reaction bottle of a finished product area; adding amlodipine free base in anhydrous methanol to dissolve, stirring to ensure that amlodipine free base is completely dissolved and is transparent, and cooling to obtain the methanol solution of amlodipine free base; slowly adding the methanol solution of amlodipine free base in the obtained methanol solution of maleic acid, keeping the temperature and stirring, cooling, and standing to precipitate crystals; and washing the obtained crystals with absolute alcohol, and drying to obtain the finished product. In the preparation method, the solvent used for forming amlodipine maleate is greatly improved, an anhydrous methanol reaction system is established, the crystal form of the finished product is greatly improved, vacuum filtration is easy, and the yield is increased; and the mother liquor obtained through crystallization and filtration is used as the solvent for dissolving the next batch of solid amlodipine, thus the use amount of anhydrous methanol can be reduced, the utilization rate of the solvent can be increased, the treatment cost of the solvent can be saved, the drying time can be shortened and the operation time can be greatly shortened.

The invention relates to a method for removing maleate of amlodipine maleate, which prepares free base of amlodipine from weak inorganic base, DMF and water as solvent by a settling method. The invention relates to a method for preparing levamlodipine from the amlodipine, which removes dextroisomer through salifying precipitation by using mixed solvent of N, N-dimethylformamide and ethanol and D(-)tartaric acid taken as a chiral reagent, and prepares the levamlodipine through precipitation by adding excessive water. The levamlodipine can be used for preparing levamlodipine besylate.

The invention provides a preparation method of amlodipine besylate tablets. The preparation method comprises the following steps of: employing wet granulation and tabletting, filtering each component in a formula through an 80-mesh sieve, and then drying the filtered components at 50 DEG C for future use; evenly mixing amlodipine besylate, microcrystalline cellulose and crospovidone together, forming a soft material from the mixture by using 5% starch slurry, granulating through an 18-mesh sieve, drying at 50 DEG C, and then shaping the granules through the 18-mesh sieve, thereby obtaining granules I; next, evenly mixing starch with dextrin, forming a soft material from the mixture by using 5% starch slurry, granulating through the 18-mesh sieve and drying at 50 DEG C, and then shaping the granules through the 18-mesh sieve, thereby obtaining granules II; finally, mixing the granules I with the granules II, adding magnesium stearate and evenly mixing all the materials, and then tableting the mixture, thus obtaining the amlodipine besylate tablets. According to the invention, the major component amlodipine besylate tablets are white crystalline powder which is good in fluidity; the prepared granules are excellent in both compressibility and fluidity. The disintegration time of the tablets is appropriate, and the content of the tablets, the content uniformity and the dissolution rate all meet the requirements; therefore, the tablets have high clinical application value. The method provided by the invention is simple and suitable for industrial production.

The invention relates to an L-amlodipine maleate compound, and a preparation method and a medicinal preparation thereof, and belongs to the technical field of medicines. Element analysis, water analysis and thermogravimetric analysis (TGA) detection of the L-amlodipine maleate compound prepared in the invention determines that the molecular formula of the L-amlodipine maleate compound is C20H25ClN2O5.C4H4O4.0.5H2O. Compared with products in the market, the compound has better stability to light, temperature and humidity, is more suitable for preparing various forms of medicinal preparations, such as an L-amlodipine maleate tablet and an L-amlodipine maleate dispersible tablet, as a raw medicine.

The invention relates to an amlodipine and losartan potassium medicinal composition, which comprises the following components calculated according to weight part: 2.5-10 parts of amlodipine, 20-100 parts of losartan potassium, 5-20 parts of pregelatinized starch, 20-60 parts of microcrystalline cellulose, 15-40 parts of low substitution hydroxypropyl cellulose, 1-8 parts of carboxymethyl starch sodium and 1-3 parts of magnesium stearate. The amlodipine is an amlodipine maleate hydrate crystal with a molecular formula of C24H29ClN2O9.1.5H2O. The amlodipine maleate in the medicinal composition can be used for stably releasing the medicinal effect within 24 hours and stably and quickly taking effect. The medicinal composition has strong synergism, accumulation and complementary action and high bioavailability.

An oral disintegrating tablet of levo-amlodipine maleate is prepared from levo-amlodipine maleate, water-soluble filler, disintegrant, lubricant, and optional others.

The invention relates to a medicinal composition by taking amlodipine and atorvastatin calcium as active components, the medicinal composition comprises amlodipine, atorvastatin calcium, a filler, a disintegrant and a lubricant; the active components are composed of 2-20 parts of amlodipine and 5-120 parts of atorvastatin calcium; the amlodipine is a maleic acid amlodipine hydrate crystal. The molecular formula of the maleic acid amlodipine hydrate crystal is C24H29C1N2O9.1.5H2O. The amlodipine in the medicinal composition has the advantages of fast effectiveness and stability, and is capable of steadily releasing the drug effect in 24 hours, the medicinal composition has strong synergy, accumulation and complementary effects, and the bioavailability is high.

The invention relates to a pharmaceutical composition of amlodipine and telmisartan; the pharmaceutical composition comprises amlodipine, telmisartan and a pharmaceutically acceptable carrier; the pharmaceutical composition contains 2.5-10 parts by weight of amlodipine and 20-80 parts by weight of telmisartan; the amlodipine is an amlodipine maleate hydrate crystal. The molecular formula of the amlodipine maleate hydrate crystal is C24H29C1N2O91.5H2O. The amlodipine in the pharmaceutical composition acts quickly and stably, and the pharmaceutical effect can be stably released within 24 h; andthe pharmaceutical composition has strong cooperation, accumulation and complementation, and high bioavailability.

The invention belongs to the novel technical field of medicament and relates to a novel dosage form of amlodipine besylate sustained release capsules used for treating high blood pressure, chronic stable angina and variant angina and composed of amlodipine besylate, sugar spheres, sustained release agent, plasticizer and antisticking agent between which the weight ratio is 10:100:(0-20):(0-20):(0-25). Ethanol is used to prepare slurry, and weight of the antisticking agent is 1% that of the ethanol. The preparation technique comprises steps of preparing medicament containing spheres by granule coater, after drying, coating sustained release coating layer, drying by blowing, packing in hard capsules, thus obtaining the Manidipine sustained release capsules. Each capsule contains Manidipine 10mg-100mg, preferably 20mg-60mg. The inventive Chinese traditional medicine is slowly released so as to maintain relatively stable blood concentration and longer action time, and has advantages of reducing side effect, more convenient administration etc.

Amlodipine fumarate salt compounds are useful as calcium channel blockers and in treating or preventing angina or hypertension. The fumarate salts avoid the formation of certain potential impurities that have been found to be associated with amlodipine maleate.

The invention discloses a preparation method of valsartan and amlodipine tablets and the valsartan and amlodipine tablets. The preparation method comprises the following steps: crushing valsartan andamlodipine benzenesulfonate for 0.5 to 5min at a rotary speed of 10000 to 30000rpm to obtain premix; mixing the premix with other auxiliary materials to obtain a primary mixed material; carrying out dry-process granulation, total mixing, tabletting and coating on the primary mixed material to prepare the valsartan and amlodipine tablets. The surface area of the valsartan is enlarged through a high-speed crushing technology, the cohesiveness is enhanced and the collapsibility is reduced; the valsartan is used for covering amlodipine and preventing the amlodipine from being dissolved out; the dissolving of the amlodipine is similar with that of an RLD, and the technical problems that the dissolving of the valsartan and amlodipine tablets prepared from a new batch of valsartan raw materials in the same factory has remarkable difference so that the dissolving of the valsartan and amlodipine tablets is not similar with that of an originally-researched valsartan and amlodipine tablet reference preparation (RLD) are solved; a preparation technology disclosed by the invention has the characteristics that the technology is scientific and reasonable, the operation is simple and easy, the production cost is relatively low and the like.

The invention relates to an amlodipine and fosinopril sodium medical composition, which comprises the following components in parts by weight: 5 to 10 parts of amlodipine, 10 to 40 parts of fosinopril sodium, 5 to 50 parts of compressible starch, 10 to 60 parts of microcrystalline cellulose, 15 to 40 parts of low-substitution hydroxy propyl cellulose, 10 to 45 parts of crospolyvinylpyrrolidone, and 1 to 3 parts of magnesium stearate, wherein the amlodipine is a maleic amlodipine hydrate crystal, and the molecular formula of the maleic amlodipine hydrate crystal is C24H29ClN2O9.1.5H2O. The medical composition has stable and quick action, stable and durable effect and high bioavailability.