38results about How to "Stable and lasting effect" patented technology

The invention discloses a liposome solid preparation of a losartan potassium hydrochlorothiazide pharmaceutical composition and a preparation method thereof. In the invention, active components of losartan potassium and hydrochlorothiazide and specific combined hydrogenated yolk lecithin, cholesterol and poloxamer 188 are prepared into a liposome which is then mixed with other pharmaceutical accessories to prepare the solid preparation, thereby greatly improving the pharmaceutical stability and bioavailability and having stable and lasting effect, small side effect and obvious curative effect.

The invention discloses a preparation method of a composite soft-tissue patch. Sustained-release microspheres containing human cell culture secretion are mixed with gel solution, then the mixture is compounded with an acellular dermal matrix under vacuum, and after drying and sterilization, the composite soft-tissue patch is obtained. The prepared composite patch can improve the biocompatibility and the bioactivity of the dermal matrix effectively. The experiment shows that compared with the single acellular dermal matrix, the patch can promote cell proliferation and collagen formation effectively and has better biocompatibility and better tissue remolding. The patch can be widely applied to closure of various wound surfaces, repair of various soft-tissue defects and reinforcement of weakplaces and can be prepared into micro particles to be used for filling various fine and weak or dented places by injection, thus having wider application prospect in clinic.

The invention relates to an irbesartan-hydrochlorothiazide drug combination liposome solid preparation, which is prepared with irbesartan-hydrochlorothiazide drug combination liposome and other solid preparation auxiliary materials, and the irbesartan-hydrochlorothiazide drug combination liposome is prepared with irbesartan, hydrochlorothiazide, distearoyl phosphatidylcholine and sodium taurocholate. Compared with the conventional preparation, the stability and bioavailability of the preparation are greatly enhanced, release is stable, the side effect is minor, and the treatment effect is more remarkable.

The invention relates to an amlodipine besylate and atorvastatin calcium medicine compound liposome solid preparation which is prepared from amlodipine besylate and atorvastatin calcium medicine compound liposome and other solid preparation auxiliary materials; and the amlodipine besylate and atorvastatin calcium medicine compound liposome is prepared from benzene sulfonic acid amlodipine, atorvastatin calcium, soybean phosphatidyl glycerin, kennedy acute-inflammation sodium and cholesterol. Compared with traditional preparation, the preparation greatly improves the stability and the bioavailability, and has the advantages of stable medicine delivery, small side effect and more significant curative effect.

The invention discloses an oral composition containing desmopressin acetate and a preparation method for the oral composition. The oral composition comprises a composition containing the desmopressin acetate, polymer excipients and a surfactant, a composition containing lactose and cellulose, a diluent, a solubilizer, a penetration enhancer, a flavoring agent, an antioxidant and a lubricant. The oral composition containing the desmopressin acetate has a stable and durable effect and a small side effect; and the oral composition is applicable to oral formulations such as tablets, capsules, pellets and the like. The oral composition has a good effect of treating diseases such as enuresis, nocturia, diabetes insipidus and the like.

A select method for strain preventing and curing endotrophic mycorrhiza in potato. Detect width of bacteriostasis braid and select strains with good effects of endotrophic mycorrhiza, do pot incubation test and field practice, detect effects of prevention and cure and fix planting ability. Detect action of the strain to pathogenetic fungi, and induct antiviral ability to potato. Advanced strain is obtained after the steps.

The invention discloses application of traditional Chinese medicine screwtree root extractives in the preparation of anti-HBV medicament. In the invention, the performance of screwtree root extractives like aqueous extractive, alcohol extractive, and triterpenoid in resisting hepatitis B is studied for the first time. According to results of in-vitro and in-vivo tests, the screwtree root extractives can significantly inhibit HBV, mitigate hepatitis B inflammation, alleviate damage to liver histocyte, and have stable and lasting drug effect and no rebound phenomenon; therefore, the screwtree root extractives are superior to Lamivudine, a western medicine commonly used in clinical practice, and have unique advantages in controlling hepatitis B. The screwtree root extractives provided in theinvention have a very good research and development prospect in the treatment of hepatitis B and can be used to prepare traditional Chinese medicine preparation of various dosage forms like tablets, particulate agents, mixtures, and the like for the treatment of hepatitis B.

The invention discloses a traditional Chinese medicine composition for treating leucopenia after chemotherapy. The traditional Chinese medicine composition comprises the following raw materials: herba epimedii, radix morindae officinalis, astragalus membranaceus, herba pyrrosiae, caulis spatholobi, safflower, polygonum cuspidatum, polygonum multiflorum, raw white paeony root, fructus psoraleae, cortex lycii radicis, glossy privet fruit, cistanche, madder, stir-baked squama manitis and root of red-rooted salvia. The traditional Chinese medicine composition has the advantage of dialectical therapy of traditional Chinese medicine, is prepared by mixing the raw materials through multi-time clinical verifications, and has the effects of benefiting vital energy, nourishing blood, tonifying the spleen and kidney and regulating yin and yang of internal organs; after the traditional Chinese medicine composition is taken, the vital energy function of the body can be regulated, the blood can be replenished and activated, the kidney can be nourished, the essence can be strengthened, the marrow can be replenished, the yin and yang can be regulated, and the internal organs can be balanced, so that the immunity function can be improved and the survival and antiviral activity and the like of cell bodies can be enhanced; the hematopoietic system of a human body can be protected and the secretion of hematopoietic factors can be promoted, so that the blood biochemistry process is accelerated; the bone marrow microcirculation is improved, the bone marrow hyperplasia is stimulated, the nucleic acid synthesis of hematopoietic cells and the proliferation and differentiation of multipotential stem cells are promoted, and the leukocytopoiesis is stimulated, so that the clinical treatment standards are met.

The invention discloses bacillus subtilis and application thereof to prevention and treatment of bipolaris maydis. The strain of the bacillus subtilis for preventing and treating bipolaris maydis is DZSY21, the preservation name is bacillus subtilis, the bacillus subtilis is preserved in the China General Microbiological Culture Collection Center (CGMCC) which is located in #3, No.1 Courtyard, West Beichen Road, Chaoyang District, Beijing, the preservation date is November 27, 2015, and the preservation No. is CGMCC NO.11749. The 16S rDNA gene sequence of the bacillus subtilis is a nucleotide sequence as shown in SEQ ID No.1, and the gyrB gene sequence of the bacillus subtilis is a nucleotide sequence as shown in SEQ ID No.2. The bacillus subtilis is high in growth speed, large in sporulation quantity, good in stress resistance and good in antibacterial property, and can be quantitatively colonized in leaves of corn plants.

The invention relates to an oligosaccharide-containing preparation capable of prolonging a flowering period. Contained oligosaccharides are chitosan oligosaccharide and sodium alginate oligosaccharide. The average molecular weight of the oligosaccharides is 500-3000 Da, and the content is 60-300 mg / L. In addition, the preparation also contains trace elements, astaxanthin and citric acid. The flowering period of flowers can be significantly prolonged by spraying or soaking ground-planted flowers, potted flowers and fresh-cut flowers with the preparation. The effective component oligosaccharidesin the flowering period prolonging agent belong to natural products, so the flowering period prolonging agent has no environmental pollution to treated flowers and has no health hazards to a human body; at the same time, the preparation has the advantages of low cost, small application amount, broad flower spectrum, lasting effect and the like, and is simple in application method and easy to promote and apply.

The invention relates to the field of medicaments, in particular to a Chinese medicinal composition for controlling and / or reducing fat content, a preparation and a food. The Chinese medicinal composition is prepared from natural edible raw materials such as mango, lucid ganoderma, fructus crataegi, chrysanthemum and barbary wolfberry fruit, and can be used for regulating the activity of human body metabolic enzymes and accelerating oxidative decomposition of in-vivo fat tissues, and has the effects of improving the body status of an overweight person, and reducing fat and weight. The Chinese medicinal composition has a good curative effect on control and / or reduction of fat content, acts durably and stably, and is free from untoward reactions. As proved by acute toxicity research test, the Chinese medicinal composition, the preparation and the food provided by the invention are free from toxic and side effects.

The invention discloses a weight-reducing health-care product, which is composed of the following raw materials in parts by weight: 2-4 parts of broadleaf holly leaf, 2-4 parts of hawthorn, 5-7 parts of lotus leaf, 1-3 parts of Chinese wolfberry, 2-4 parts of mango and 1-5 parts of betel palm. In the weight-reducing health-care product disclosed by the invention, the medicine and food homologous pure natural plants of broadleaf holly leaf, hawthorn, lotus leaf, Chinese wolfberry, mango and betel palm are adopted, and the active ingredients in the pure natural plants are utilized, thus the activity of metabolizing enzyme in a human body is adjusted, the induction of noradrenalin to the decomposition of fat in lipocyte is enhanced, the activity of hormone-sensitive lipase is promoted, and oxidative decomposition of in-vivo fat tissues can be accelerated. Therefore, the weight-reducing health-care product has a good weight-reducing curative effect, durable and stable action and no adverse effect, is beneficial for health of the human body after long-term administration, and is a very perfect weight-reducing health-care product.

The present invention discloses one kind of hepatopathy treating orally taken medicine and its preparation process. The hepatopathy treating orally taken medicine is prepared with oriental water plantain, capillary artemisia, plantain seed, Coix seed, wax gourd seed and other 11 kinds of Chinese medicinal materials. It has high curative rate, stable and lasting effect, convenient taking, no toxic side effect and other advantages.

The invention relates to a pharmaceutical oral composition for treating gynaecologic diseases and process for preparation, wherein the raw materials include bark of eucommia, dried rehmannia root, hyacinth bean, gentian root, curculigo rhizome, epimeddium, cnidium fruit, lysimachia christinae, flavescent sophora root, leek seeds and rhizome of Chinese paris.

The invention provides multifunctional viscose containing sea mud and a preparation method of the viscose. The viscose is prepared from a viscose spinning solution and a sea mud colloidal solution, wherein the sea mud colloidal solution is composed of, by weight, 5%-25% of sea mud powder, 1.2%-3.5% of ailanthus altissima flower extracting solution, 1.5%-4.6% anasphalis sinica hance form.peterocaula(Franch.et savat.)ling extract, 0.3%-1.9% of coupling agent and the balance distilled water, the viscose spinning solution accounts for 80%-97% of the total weight of the viscose, and the sea mud colloidal solution accounts for 3%-20% of the total weight of the viscose. The above-mentioned raw materials are treated through multiple ways and mixed, conventional spinning, drawing, purifying and drying are conducted, and the multifunctional viscose containing the sea mud is obtained; the smell is fragrant, the skin adaptability is good, the functions of antibacterial deodorization, ultraviolet protection, acarus killing, mosquito repelling, skin care and health care are given simultaneously, the good spinnability and mechanical property are shown, the fiber forming strength is high, dyeing effect is good, and the wearability is excellent. The sea mud resource is fully utilized, and the economic value is improved.

The invention provides a preparation method of a plant blooming prolonging agent, which belongs to the fields of botany and pesticides. The method comprises the following steps: sequentially carryingout pressurization treatment and decompression treatment on raw materials, and fully mixing the raw materials in a stirrer to obtain the plant blooming prolonging agent. The raw materials include effective components which are chitosan oligosaccharide, a green tea extract and monosilicic acid, wherein the average molecular weight of the chitosan oligosaccharide is 350-3200 Da, with a concentrationof 30-120 mg / L; concentrations of the green tea extract and the monosilicic acid are 5-30 mg / L respectively. The method is simple and low in cost, and the prepared plant blooming prolonging agent hasthe effects of being small in dosage, good in permeability and absorptivity, promoting plant growth, enhancing plant flowering growth vigor, increasing the flowering quantity and prolonging the flowering period.

The invention discloses a holothurian culture method. Culture pool management is involved in the method; according to the method, during a young holothurian stage, ground sargassum thunbergii solutions are used for feeding, during a holothurian growing stage, feed added with selenium is adopted for feeding to provide nutrient substances required by the growth and development of holothurian; obtained holothutian has no toxic and side effects and is not only high in the content of selenium but high in nutrient value, and therefore the double requirements of modern people for health and nutrients are met. The feed added with selenium is prepared from sodium humate, grapefruit peel extracts, deguming kelp powder, gulfweed powder, scallop muscle powder, shrimp shell powder, medical stone powder, squid organ powder, shell powder, sweet potato leaf powder, ulva, palm oil, white vinegar and selenium methionine.

The invention relates to the field of medicaments, in particular to a Chinese medicinal composition for controlling and / or reducing fat content, a preparation and a food. The Chinese medicinal composition is prepared from natural edible raw materials such as mango, lucid ganoderma, fructus crataegi, chrysanthemum and barbary wolfberry fruit, and can be used for regulating the activity of human body metabolic enzymes and accelerating oxidative decomposition of in-vivo fat tissues, and has the effects of improving the body status of an overweight person, and reducing fat and weight. The Chinese medicinal composition has a good curative effect on control and / or reduction of fat content, acts durably and stably, and is free from untoward reactions. As proved by acute toxicity research test, the Chinese medicinal composition, the preparation and the food provided by the invention are free from toxic and side effects.

The invention discloses a method for processing titanium dioxide nanotubes through rhodium complexes. The method includes the following steps that firstly, the rhodium complexes are acquired; secondly, the rhodium complexes are dissolved in water; thirdly, the titanium dioxide nanotubes are soaked in a rhodium complex solution, nitrogen is introduced, and microwave processing is performed; thirdly, the rhodium complex solution stands and is cooled to normal temperature and pressurized to 20-25 Mpa, the pressure is lowered to normal pressure after being kept for 2-3 min, and centrifuging is performed for 30-60 min; fourthly, supernatant liquid obtained after centrifuging is removed, a low-layer solution and solids are placed in 100-120 DEG C and pressurized to 10-25 Mpa, the pressure is kept for 2-3 min and then is lowered to normal pressure, and drying is performed for 20-26 h. The titanium dioxide nanotubes are high in anti-microbial and anti-cancer capacity due to the method, growth of harmful cells can be effectively inhibited for a long time, particularly the anti-bone-cancer effect is more remarkable, and the medical utilizing effect of the titanium dioxide nanotubes can be effectively improved.

The invention relates to an amlodipine and fosinopril sodium medical composition, which comprises the following components in parts by weight: 5 to 10 parts of amlodipine, 10 to 40 parts of fosinopril sodium, 5 to 50 parts of compressible starch, 10 to 60 parts of microcrystalline cellulose, 15 to 40 parts of low-substitution hydroxy propyl cellulose, 10 to 45 parts of crospolyvinylpyrrolidone, and 1 to 3 parts of magnesium stearate, wherein the amlodipine is a maleic amlodipine hydrate crystal, and the molecular formula of the maleic amlodipine hydrate crystal is C24H29ClN2O9.1.5H2O. The medical composition has stable and quick action, stable and durable effect and high bioavailability.

The invention discloses a diet health-care product, which is prepared from the following raw materials in part by weight: 1 to 4 parts of folium llicis latifoliae, 2 to 5 parts of hawthorn, 5 to 8 parts of lotus leaves, 1 to 4 parts of medlar and 2 to 5 parts of mango. The invention also provides the preparation method of the diet health-care product. The product disclosed by the invention has a weight-reducing effect, and can be taken by people with essential hypertension, diabetes mellitus, obesity and the like for a long time.

The invention discloses application of traditional Chinese medicine screwtree root extractives in the preparation of anti-HBV medicament. In the invention, the performance of screwtree root extractives like aqueous extractive, alcohol extractive, and triterpenoid in resisting hepatitis B is studied for the first time. According to results of in-vitro and in-vivo tests, the screwtree root extractives can significantly inhibit HBV, mitigate hepatitis B inflammation, alleviate damage to liver histocyte, and have stable and lasting drug effect and no rebound phenomenon; therefore, the screwtree root extractives are superior to Lamivudine, a western medicine commonly used in clinical practice, and have unique advantages in controlling hepatitis B. The screwtree root extractives provided in theinvention have a very good research and development prospect in the treatment of hepatitis B and can be used to prepare traditional Chinese medicine preparation of various dosage forms like tablets, particulate agents, mixtures, and the like for the treatment of hepatitis B.

The invention discloses a liposome solid preparation of a losartan potassium hydrochlorothiazide pharmaceutical composition and a preparation method thereof. In the invention, active components of losartan potassium and hydrochlorothiazide and specific combined hydrogenated yolk lecithin, cholesterol and poloxamer 188 are prepared into a liposome which is then mixed with other pharmaceutical accessories to prepare the solid preparation, thereby greatly improving the pharmaceutical stability and bioavailability and having stable and lasting effect, small side effect and obvious curative effect.

The invention discloses a traditional Chinese medicine composition for treating hyperlipidemia, which is composed of the following raw materials in parts by weight: 200-400 parts of Radix Polygoni Multiflori, 150-300 parts of Sangjishen, 200-400 parts of Semen Cassiae, and 100-200 parts of Capillaris , 100-200 parts of golden cherry, 100-300 parts of motherwort, 150-300 parts of Alisma, 100-200 parts of hawthorn. For hyperlipidemia and atherosclerotic diseases, mulberry, motherwort, hawthorn nourish liver and kidney, lower blood fat, digest food and accumulate, promote blood circulation and remove blood stasis as the main medicine, supplemented with Alisma, Yinchenqing to relieve dampness and heat, diuresis, make Polygonum multiflorum, Semen Cassiae and Fructus Rosa Fructus can invigorate the kidney essence, clear the liver, moisten the intestines and relieve constipation, so as to reduce hyperlipidemia.

The invention provides a dendrobium candidum extract, comprising the materials with the weight percentage: 10-70 % of dendrobium candidum, 10-60% of reishi shell-broken spore powder and 10-60 % of American ginseng; reishi shell-broken spore powder is prepared by breaking the cell walls of reishi spores. The beneficial effect of the invention lies in that the dendrobium candidum extract has high content of active ingredients as well as durable, stable and mild function, can improve the immunity of the human body and is convenient to carry and eat.

The invention relates to an irbesartan-hydrochlorothiazide drug combination liposome solid preparation, which is prepared with irbesartan-hydrochlorothiazide drug combination liposome and other solid preparation auxiliary materials, and the irbesartan-hydrochlorothiazide drug combination liposome is prepared with irbesartan, hydrochlorothiazide, distearoyl phosphatidylcholine and sodium taurocholate. Compared with the conventional preparation, the stability and bioavailability of the preparation are greatly enhanced, release is stable, the side effect is minor, and the treatment effect is more remarkable.

The invention discloses a preparation method of a composite soft-tissue patch. Sustained-release microspheres containing human cell culture secretion are mixed with gel solution, then the mixture is compounded with an acellular dermal matrix under vacuum, and after drying and sterilization, the composite soft-tissue patch is obtained. The prepared composite patch can improve the biocompatibility and the bioactivity of the dermal matrix effectively. The experiment shows that compared with the single acellular dermal matrix, the patch can promote cell proliferation and collagen formation effectively and has better biocompatibility and better tissue remolding. The patch can be widely applied to closure of various wound surfaces, repair of various soft-tissue defects and reinforcement of weakplaces and can be prepared into micro particles to be used for filling various fine and weak or dented places by injection, thus having wider application prospect in clinic.

The invention discloses a weight reducing health care product. The weight reducing health care product is composed of the following raw materials in parts by weight: 1-4 parts of tartary buckwheat, 2-5 parts of okra, 5-8 parts of gynostemma pentaphylla, 1-4 parts of semen cuscutae and 2-5 parts of astragalus membranaceus. The invention further discloses a preparation method for the weight reducing health care product. The weight reducing health care product has a weight reducing effect and can be taken by crowds with primary hypertension, diabetes, obesity and the like for a long term.

The invention discloses a medicinal component to treat nervous system disease and usage in preparing the medicine of depression and neurasthenia, which is characterized by the following: building up the component with medicinal active element, medicinal carrier or shaped agent; building up the medicinal active element with selective serotonin reuptake depressant and quinoa sulfur flat; choosing the selective serotonin reuptake depressant from fustian, Palestine, seatplane, S-seatplane, sheplin and fufsammin; merging the selective serotonin reuptake depressant and quinoa sulfur flat; playing the role of 5-HT1A blocking-up action; decreasing adverse effect of the drug.