Oral composition containing desmopressin acetate and preparation method for oral composition

A technology of desmopressin and composition, which is applied to the oral composition containing desmopressin acetate and the field of preparation thereof, and achieves the effects of reducing pressurization, simple preparation process and convenient application

Inactive Publication Date: 2012-04-25
赵联华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Desmopressin acetate is a peptide compound. In order to avoid being destroyed by gastrointestinal enzymes, oral tablets prepared according to the prior art often increase the dosage of desmopressin acetate, which is still easy to cause pressurized side effects, therefore, the oral composition containing desmopressin acetate which is easy to develop and use, simple in preparation process and low in side effects is the problem to be solved by the present invention

Method used

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  • Oral composition containing desmopressin acetate and preparation method for oral composition
  • Oral composition containing desmopressin acetate and preparation method for oral composition

Examples

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Effect test

Embodiment 1

[0064] The preparation method of the composition containing lactose and cellulose: add 10g α-lactose, add 50g water, stir and dissolve at 90 ℃, cool down to 40 ℃, filter, add 10g 20 μm hydroxymethyl propyl cellulose (HPMC ), stirred, crystallized at 20°C, removed the mother liquor by suction filtration, washed with distilled water at 1°C, dried in vacuum, and pulverized.

Embodiment 2

[0066] The preparation method of the composition containing lactose and cellulose: add 10g β-lactose, add 50g water, stir and dissolve at 90 ℃, cool down to 40 ℃, filter, add 10g 10 μ m hydroxymethyl propyl cellulose (HPMC ), stirred, crystallized at 20°C, removed the mother liquor by suction filtration, washed with distilled water at 3°C, dried in vacuum, and pulverized.

Embodiment 3

[0068] The preparation method of the composition containing lactose and cellulose: add 10g of amorphous lactose, add 50g of water, stir and dissolve at 90°C, cool down to 40°C, filter, add 10g of 25μm microcrystalline cellulose (MCC) in the filtrate, Stir, crystallize at 20°C, remove the mother liquor by suction filtration, wash with distilled water at 5°C, dry in vacuum, and pulverize.

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Abstract

The invention discloses an oral composition containing desmopressin acetate and a preparation method for the oral composition. The oral composition comprises a composition containing the desmopressin acetate, polymer excipients and a surfactant, a composition containing lactose and cellulose, a diluent, a solubilizer, a penetration enhancer, a flavoring agent, an antioxidant and a lubricant. The oral composition containing the desmopressin acetate has a stable and durable effect and a small side effect; and the oral composition is applicable to oral formulations such as tablets, capsules, pellets and the like. The oral composition has a good effect of treating diseases such as enuresis, nocturia, diabetes insipidus and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to an oral composition containing desmopressin acetate and a preparation method thereof. Background technique [0002] Insufficient vasopressin causes the kidneys to produce large volumes of very dilute urine, which can cause severe dehydration. Desmopressin (1-deamino-8-D-arginine vasopressin, dDAVP), an analog of vasopressin, is a nonapeptide derived from two changes in the chemical structure of the natural hormone Obtained, that is, deamination of 1-cysteine ​​and substitution of 8-L-arginine with 8-D-arginine. These structural changes prolong the duration of action of clinical doses of desmopressin acetate without producing pressor side effects. For the treatment of central diabetes insipidus. After taking DDAVP, it can reduce urine excretion, increase urine osmotic pressure, and reduce plasma osmotic pressure, thereby reducing frequent urination and nocturia; it ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/11A61P7/12A61P13/00A61K38/095
Inventor 赵联华
Owner 赵联华
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