Method for processing titanium dioxide nanotubes through rhodium complexes

A technology of rhodium complexes and titanium dioxide, which is applied in the fields of pharmaceutical formulation, drug delivery, and medical science to achieve long-lasting and stable effects, strong antibacterial and anticancer abilities, strong antibacterial and anticancer abilities

Active Publication Date: 2016-04-06
东营市东凯新材料技术研发有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at present, the use of rhodium complexes with antibacterial effects to improve the antibacterial effect of titanium dioxide nanotubes has not been reported. In particular, the rhodium complexes also have anti-cancer, especially anti-bone cancer effects, and can simultaneously endow titanium dioxide nanotubes with antibacterial and antibacterial properties. Anti-cancer, especially anti-bone cancer ability

Method used

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  • Method for processing titanium dioxide nanotubes through rhodium complexes
  • Method for processing titanium dioxide nanotubes through rhodium complexes
  • Method for processing titanium dioxide nanotubes through rhodium complexes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The method for treating titanium dioxide nanotubes with rhodium complexes in this scheme includes the following steps:

[0025] 1) Dissolve 5g of 4-(2-thiazolyl)-benzaldehyde in 10ml of absolute ethanol, add 1g of 4-phenyl-3-thiosemicarbazide, reflux and stir at 65°C, and react for 5h to obtain a purple solution. Dry to 2ml, add 5ml ethanol and 6ml n-hexane, white crystals are precipitated as p-thiazolylbenzaldehyde 4-phenyl-3-thiosemicarbazide with formula (1);

[0026]

[0027] 2) Weigh 25 mg of p-thiazolylbenzaldehyde 4-phenyl-3-thiosemicarbazide and 33 mg of dichloro(pentamethylcyclopentadienyl) rhodium(III) dimer and add CH 2 Cl 2 7ml, stirred at room temperature for 6 hours, the solution was distilled under reduced pressure to 2ml, and a red solid precipitated out as a rhodium complex of formula (2), namely, a chloro-p-thiazolylbenzaldehyde 4-phenyl-3-thio Semicarbazide-pentamethylcyclopentadienyl rhodium(III);

[0028]

[0029] 3) Dissolve the rhodium complex in water ...

Embodiment 2

[0034] The method for treating titanium dioxide nanotubes with rhodium complexes in this scheme includes the following steps:

[0035] 1) Dissolve 3g of 4-(2-thiazolyl)-benzaldehyde in 8ml of absolute ethanol, add 1g of 4-phenyl-3-thiosemicarbazide, reflux and stir at 60-70℃, react for 4h to obtain a purple solution , Spin dry to 1ml, add 5ml ethanol and 5ml n-hexane, white crystals are precipitated as p-thiazolylbenzaldehyde 4-phenyl-3-thiosemicarbazide with formula (1);

[0036]

[0037] 2) Weigh 20 mg of p-thiazolylbenzaldehyde 4-phenyl-3-thiosemicarbazide and 31 mg of dichloro(pentamethylcyclopentadienyl) rhodium(III) dimer and add CH 2 Cl 2 6ml, stirred at room temperature for 6 hours, the solution was distilled under reduced pressure to 1ml, and a red solid precipitated out as a rhodium complex of formula (2), namely, a chloro-p-thiazolylbenzaldehyde 4-phenyl-3-thio Semicarbazide-pentamethylcyclopentadienyl rhodium(III);

[0038]

[0039] 3) Dissolve 2g of rhodium complex in 1...

Embodiment 3

[0044] The method for treating titanium dioxide nanotubes with rhodium complexes in this scheme includes the following steps:

[0045] 1) Dissolve 6g of 4-(2-thiazolyl)-benzaldehyde in 13ml of absolute ethanol, add 2g of 4-phenyl-3-thiosemicarbazide, reflux and stir at 60-70℃, react for 6h to obtain a purple solution , Spin dry to 2ml, add 6ml ethanol and 6ml n-hexane, white crystals are precipitated as p-thiazolylbenzaldehyde 4-phenyl-3-thiosemicarbazide with formula (1);

[0046]

[0047] 2) Weigh 30 mg of p-thiazolylbenzaldehyde 4-phenyl-3-thiosemicarbazide and 38 mg of dichloro(pentamethylcyclopentadienyl) rhodium(III) dimer and add CH 2 Cl 2 7ml, stirred at room temperature for 7 hours, the solution was distilled under reduced pressure to 2ml, and a red solid was precipitated as a rhodium complex of formula (2), namely, a chloro-p-thiazolylbenzaldehyde 4-phenyl-3-thio Semicarbazide-pentamethylcyclopentadienyl rhodium(III);

[0048]

[0049] 3) Dissolve 13g of rhodium complex in...

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Abstract

The invention discloses a method for processing titanium dioxide nanotubes through rhodium complexes. The method includes the following steps that firstly, the rhodium complexes are acquired; secondly, the rhodium complexes are dissolved in water; thirdly, the titanium dioxide nanotubes are soaked in a rhodium complex solution, nitrogen is introduced, and microwave processing is performed; thirdly, the rhodium complex solution stands and is cooled to normal temperature and pressurized to 20-25 Mpa, the pressure is lowered to normal pressure after being kept for 2-3 min, and centrifuging is performed for 30-60 min; fourthly, supernatant liquid obtained after centrifuging is removed, a low-layer solution and solids are placed in 100-120 DEG C and pressurized to 10-25 Mpa, the pressure is kept for 2-3 min and then is lowered to normal pressure, and drying is performed for 20-26 h. The titanium dioxide nanotubes are high in anti-microbial and anti-cancer capacity due to the method, growth of harmful cells can be effectively inhibited for a long time, particularly the anti-bone-cancer effect is more remarkable, and the medical utilizing effect of the titanium dioxide nanotubes can be effectively improved.

Description

Technical field [0001] The invention relates to the technical field of antibacterial and anti-cancer titanium dioxide nanotubes, and more specifically, to a method for treating titanium dioxide nanotubes with a rhodium complex. Background technique [0002] Medical materials, especially orthopedic and dental implants, have developed rapidly in recent years and have played an important role in saving the health of patients. However, the related bacterial infection problem is still a serious problem, leading to the failure of a large number of transplant operations, causing postoperative complications for patients, and bringing about the problems of longer healing time and substantial increase in costs. At present, there have been some reports on improving the antibacterial ability of materials, such as using antibiotics and other antibacterial molecules to improve the antibacterial effect of titanium. Compared with traditional graft materials such as titanium metal, titania nanot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/54
CPCA61L27/047A61L27/54A61L2300/224A61L2300/404A61L2300/416A61L2400/18A61L2430/02A61L2430/12
Inventor 李培源苏炜霍丽妮陈睿
Owner 东营市东凯新材料技术研发有限责任公司
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