Application of screwtree root extractive in the preparation of anti-HBV medicament

Abstract

The invention discloses application of traditional Chinese medicine screwtree root extractives in the preparation of anti-HBV medicament. In the invention, the performance of screwtree root extractives like aqueous extractive, alcohol extractive, and triterpenoid in resisting hepatitis B is studied for the first time. According to results of in-vitro and in-vivo tests, the screwtree root extractives can significantly inhibit HBV, mitigate hepatitis B inflammation, alleviate damage to liver histocyte, and have stable and lasting drug effect and no rebound phenomenon; therefore, the screwtree root extractives are superior to Lamivudine, a western medicine commonly used in clinical practice, and have unique advantages in controlling hepatitis B. The screwtree root extractives provided in theinvention have a very good research and development prospect in the treatment of hepatitis B and can be used to prepare traditional Chinese medicine preparation of various dosage forms like tablets, particulate agents, mixtures, and the like for the treatment of hepatitis B.

Description

Application of mountain sesame extract in preparation of anti-hepatitis B medicine technical field The present invention relates to the use of the Chinese medicinal herb sage extract, in particular the use of the sage water extract, alcohol extract and triterpenoids as raw materials in the preparation of anti-hepatitis B medicines. Background technique Hepatitis B is a kind of common infectious disease and frequently-occurring disease caused by infecting hepatitis B virus (HepatitisBVirus, HBV), easily transforms into chronic, even develops into liver cirrhosis, liver cancer. The complexity of the disease's onset and its chronic refractory nature, especially the severity of its development to liver cancer, have made it one of the focuses of the current medical community, especially medical staff in my country. Current research shows that the pathogenesis of hepatitis B is mainly related to low immunity, persistent virus infection and progressive liver cell damage, and some...

AI Technical Summary

Problems solved by technology

So far, the publicly reported studies on Sesame chinensis mainly focus on the separation and identification of its chemical components, while there are few studies on its pharmacodynamics, and no studies on anti-hepatitis B have been reported.

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