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Application of wild sesame seed extract in preparation of anti-hepatic fibrosis medicament

A technology of hepatic fibrosis and mountain sesame, which is applied in the application field of preparing anti-hepatic fibrosis drugs, can solve the problems that anti-hepatic fibrosis has not been reported, and there are few pharmacodynamic studies, so as to reduce the synthesis of ECM and liver fibrosis. The effect of reducing and inhibiting proliferation

Inactive Publication Date: 2013-05-22
林兴
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, the publicly reported studies on Sesame chinensis mainly focus on the separation and identification of its chemical constituents, while there are few studies on its pharmacodynamics, and no studies on anti-hepatic fibrosis have been reported.

Method used

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  • Application of wild sesame seed extract in preparation of anti-hepatic fibrosis medicament
  • Application of wild sesame seed extract in preparation of anti-hepatic fibrosis medicament
  • Application of wild sesame seed extract in preparation of anti-hepatic fibrosis medicament

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experiment example

[0030] One, the preparation of mountain sesame extract

[0031] 1. Preparation of Sesame water extract:

[0032] Add 10 times the amount of water to extract 1000g of Sesame, twice, each time for 1.5h, combine the extracts, dry under reduced pressure and constant temperature at 60°C to obtain 268.9g of water extract of Sesame.

[0033] 2. Preparation of Sesame triterpenoids:

[0034] Take 1000g of wild sesame, add 60% ethanol to soak for 1h, reflux extraction, extract 8000ml for 2h for the first time, extract 1.5h for the second time with 8000ml, combine the extracts, recover ethanol under reduced pressure until there is no ethanol smell, dissolve and filter the concentrate with distilled water. Put the filtrate on (40mm * 800mm) AB-8 macroporous resin column, wash the resin column with distilled water of 2 times the amount, collect the effluent and washing liquid, and then elute with 2 times the amount of 80% ethanol, and the elution flow rate is 50- 60 drops / min (about 2-2....

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Abstract

The invention discloses a research on the application of traditional Chinese medicine wild sesame seed extract (wild sesame seed water extract and triterpenes compound) in the preparation of an anti-hepatic fibrosis medicament. The invention first carries out the anti-hepatic fibrosis research on the wild sesame seed water extract and the triterpenes compound. The vitro and in vivo experiments show that the wild sesame seed water extract and the triterpenes compound can act on multiple hepatic fibrosis links or multiple hepatic fibrosis target spots, can inhibit the propagation of HSC and induce the apoptosis of HSC, can obviously reduce the synthesis of ECM, and obviously relieves the hepatic fibrosis, thereby achieving unique advantages for preventing and curing the hepatic fibrosis. The application of the wild sesame seed water extract and the triterpenes compound for curing the hepatic fibrosis has very good research and development prospects.

Description

technical field [0001] The present invention relates to the application of the Chinese medicine mountain sesame extract, in particular the application of the mountain sesame water extract and triterpenoids as raw materials in the preparation of anti-hepatic fibrosis medicine. Background technique [0002] my country is a high-incidence area of ​​viral hepatitis. There are tens of millions of patients with chronic hepatitis. In addition, liver damage caused by certain toxic substances may cause liver fibrosis. Liver fibrosis has become one of the main medical problems in the world. . At present, it has been recognized that liver diseases generally develop from acute-chronic-hepatic fibrosis-cirrhosis to liver cancer. Therefore, blocking the occurrence and development of liver fibrosis is of great significance for the prevention and treatment of liver cirrhosis and liver cancer. Many studies have confirmed that liver fibrosis is a dynamic process, which is a reversible disease...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/56A61K36/185A61P1/16A61K125/00
Inventor 林兴何敏黄权芳廖明黄仁彬张士军
Owner 林兴
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